We are 228,650 members in 84 forums discussing 159,786 topics.

Help with Abbreviations

Topic: Breaking Research News from sources other than breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 20, 2017 09:31PM - edited Nov 20, 2017 09:35PM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

Page 69 of 69 (2,054 results)

Posts 2041 - 2054 (2,054 total)

Log in to post a reply

May 20, 2020 08:40PM Bliss58 wrote:

Shetland, MO said the pathologist told her she labeled me HER2 negative because there were fewer than 10% cells; the report says 8%. Does that mean non-amplified? MO is keeping me on current tx for now.

Dx 56, married, 1 DD. 4/20: "Here I go again & so it goes." Back on Letrozole + Tykerb 12/19; Dx liver mets 4/20. Orig. 6 rounds TCHP to 10/15. Zometa 11/15 qtrly ended 5/18. Started qtrly Xgeva 7/19. Quit Letrozole for Aromasin 1/18. Dx 6/1/2015, IDC, Left, 4cm, Stage IIIA, Grade 2, ER+/PR+, HER2+ (FISH) Dx 6/30/2015, Stage IV, metastasized to bone Radiation Therapy 12/16/2015 External: Bone Surgery 2/16/2016 Lymph node removal: Sentinel; Mastectomy: Left Radiation Therapy 5/8/2016 External: Lymph nodes, Chest wall Hormonal Therapy 2/1/2018 Aromasin (exemestane) Dx 4/2020, IDC, Stage IV, metastasized to liver, Grade 3, ER+/PR+, HER2+ (FISH)
Log in to post a reply

May 21, 2020 03:26PM BlueGirlRedState wrote:

Reading all the posts in various forums, it is increadible what is covered/what it not, the care, advice etc people get. The denial is being appealed, and one patient support advocate felt confident that insurance would cover all or most of it. Contacting my representatives is a waste of time. I have contacted them on several issues including health, and their replies often do not address what I wrote about, or are non-commital, or tell me why I am wrong. We passed an initiative on the ballot to expand Medicaid in this state, and legislators made an attempt to weaken or get rid of it (they failed). They also made an attempt to make the initiative process much more difficult. ( We know more than you do). So far that has failed as well. I do not celebrate the idea of "Medicare for All", because the focus is on insurance/who pays/how much, and not on health care itself. I know some people have no or poor coverage and this would be a chance to pay for treatment they cannot afford. So Medicare is certianly is part of the equation. The other day there was an interview on NPR with a woman whose surgery for BC had been postponed because of covid-19. Her tumor has grown a lot, and the treatment she now requires, is much more invasive. It sounded less hopeful as well.

Log in to post a reply

May 25, 2020 10:58PM BSandra wrote:

Dear all, these are not breaking news but we have to keep an eye on Tesetaxel, an oral Taxane. It achieved high response rates in clinical trials even in patients pretreated with other taxanes. I know ow amazing Docetaxel was for my wife, and Tesetaxel (not to mention it is oral) seems very promising:

https://www.ascopost.com/issues/july-25-2018/oral-...

https://www.odonate.com/tesetaxel.

Saulius

Since Dec 2019: NED. Feb 2019: local recurrence in left breast, IBC. May 2018-Feb 2019: NED. Jun 2018: Omega3:Omega6, Cp lowering, CBD/CBDA, DC/CIK. Aug 2017: stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/26/2017 Taxotere (docetaxel) Targeted Therapy 8/27/2017 Perjeta (pertuzumab) Targeted Therapy 8/27/2017 Herceptin (trastuzumab) Chemotherapy 3/11/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/8/2019 Whole-breast: Lymph nodes, Chest wall
Log in to post a reply

May 26, 2020 03:35AM JoynerL wrote:

Saulius, thanks so much for the article. I was not aware of Tesetaxel. I will investigate further with my own MO. Very encouraging!

--Lynn Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Surgery 1/2/1991 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Saline implant Chemotherapy 1/15/1991 CMF Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Targeted Therapy 3/5/2017 Ibrance (palbociclib) Hormonal Therapy 3/5/2017 Faslodex (fulvestrant) Chemotherapy 1/17/2019 Xeloda (capecitabine) Targeted Therapy
Log in to post a reply

May 26, 2020 10:03AM Lumpie wrote:

DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

May 23, 2020

Publication: Cells (Open access)

Trastuzumab emtansine (T-DM1) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugated to the microtubule-targeting agent emtansine (DM1). T-DM1 is an effective agent in the treatment of patients with HER2-positive breast cancer whose disease has progressed on the first-line trastuzumab containing chemotherapy. However, both primary and acquired tumour resistance limit its efficacy. Increased levels of the phosphorylated form of Translationally Controlled Tumour Protein (phospho-TCTP) have been shown to be associated with a poor clinical response to trastuzumab therapy in HER2-positive breast cancer. Here we show that phospho-TCTP is essential for correct mitosis in human mammary epithelial cells. Reduction of phospho-TCTP levels by dihydroartemisinin (DHA) causes mitotic aberration and increases microtubule density in the trastuzumab-resistant breast cancer cells HCC1954 and HCC1569. Combinatorial studies show that T-DM1 when combined with DHA is more effective in killing breast cells compared to the effect induced by any single agent. In an orthotopic breast cancer xenograft model (HCC1954), the growth of the tumour cells resumes after having achieved a complete response to T-DM1 treatment. Conversely, DHA and T-DM1 treatment induces a severe and irreversible cytotoxic effect, even after treatment interruption, thus, improving the long-term efficacy of T-DM1. These results suggest that DHA increases the effect of T-DM1 as poison for microtubules and supports the clinical development of the combination of DHA and T-DM1 for the treatment of aggressive HER2-overexpressing breast cancer.

https://www.meta.org/papers/dha-affects-microtubule-dynamics-through/32438775?utm_medium=email&utm_source=transactional&utm_campaign=digests%40meta.org

https://www.mdpi.com/2073-4409/9/5/1260

https://doi.org/10.3390/cells9051260

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

May 26, 2020 02:03PM Lumpie wrote:

PD-L1 And What It Means In Cancer Treatement

https://www.whatnext.com/blog/posts/pd-l1-and-what-it-means-in-cancer-treatement

{Not research, per se, but an brief and accessible article about PD-L1, a bit of history of immunotherapy research, and a very brief explanation of how immunotherapy attempts to work.}

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

May 26, 2020 02:09PM morrigan_2575 wrote:

As of May 2019 TDM-1 is now used for residual disease after neoadjuvant treatment in early stage HER2+ BC.

I did also see a study that TDM-1 (Kadcyla) and Perjeta cuts Risk Reccurance in half compared to Herceptin/Perjeta. I'm not sure if that's for very small/low risk BS where they just give H/P without Chemo.

I am wondering if there isn't any eventual plan to replace TCHP and AC+THP with Kadcyla (instead of Herceptin)

Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IA, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel)
Log in to post a reply

May 26, 2020 02:39PM Lumpie wrote:

morrigan_2575:

I am not aware of any standard protocols for giving H&P without a cytotoxin (chemo). (There may be instances in which physicans moderate or minimize the chemo for particularly frail or intolerant patients. There may have been clinical trials on this.)

Regarding "replace TCHP and AC+THP with Kadcyla," I personally think this would have many advantages; however, a recent clinical trial found that Kadcyla did not provide better outcomes than TCHP, nor was it deemed meaningfully less expensive, so they plan to make patients keep on getting TCHP. This assessment makes a huge error in appreciating patient experience, in my opinion. While "everyone is different" my experience of TCHP was on a different planet vs Kadcyla. Kadcyla was much easier for me to tolerate. Plus there is the issue of hair loss vs. not - which has implications beyond mere vanity. The trial was reported on this board. It would probably show up by searching for Kadcyla for early stage BC or something similar.

I thought AC was only given for TNBC now, but maybe that is not the case.

Thanks.

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

May 26, 2020 03:38PM Lumpie wrote:

BlueGirl: I'm still catching up from an overwhelming schedule. I know it is very frustrating. Sorry you are dealing with that. I am very disappointed that your/our legislative representatives are so unresponsive. The interview you mentioned sounds just heartbreaking. We all keep plodding along.

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

May 26, 2020 04:33PM morrigan_2575 wrote:

" am not aware of any standard protocols for giving H&P without a cytotoxin (chemo). (There may be instances in which physicans moderate or minimize the chemo for particularly frail or intolerant patients. There may have been clinical trials on this.)"

I read a post here or maybe on a Facebook group I belong too where the person mentioned her IDC was so small the MO felt she didn't need Chemo, just a year of Herceprin. But honestly I can't recall if this was recent or an older post.

"thought AC was only given for TNBC now, but maybe that is not the case."

I went to 3 MOs (ended up going with the first one). 2 of the 3 told me TCHP. The 3rd gave me the option of TCHP or AC+THP. She said the results were the same but, TCHP had more toxicity. I was planning on doing Cold Capping which doesn't work well with AC+T. Plus the money of doing weekly taxol with Cold Capping would have been too expensive.😁

I'm happy to hear Kadcyla treated you better than TCHP that seems to be the majority sentiment on the Kadcyla thread. I didn't have any awful time with TCHP, tolerated it well but, I'm worried about 14 Cycles of Kadcyla since it's got Chemo in there. I'm hoping for a pCR when I get my surgery so I can avoid Kadcyla but, I'll do it if I have to, no question



Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IA, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel)
Log in to post a reply

May 26, 2020 05:52PM Lumpie wrote:

morrigan_2575: Good luck! Hope all goes well and you have no repeats!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right
Log in to post a reply

May 26, 2020 07:22PM Kanga_Roo wrote:

An interesting read
https://www.technologynetworks.com/cancer-research/news/how-carcinogens-trigger-development-of-breast-cancer-335197?utm_

Dx 1/24/2018, IDC, Left, 5cm, Stage IV, metastasized to liver, ER+/PR+, HER2- (IHC) Hormonal Therapy 2/11/2018 Femara (letrozole) Targeted Therapy 2/15/2018 Kisqali
Log in to post a reply

20 hours ago sunandsea wrote:

Lumpie - thank you so much for posting the results from the FAST-Forward trial aka “Hypofractionated Breast Radiotherapy for 1 Week Noninferior to 3 Weeks“. I just emailed my radiation oncologist about it (I’m still going through chemo but plan to start radiation in late July/August). This couldn’t come at a better time for so many given the costs (both real and time-related) and possible COVID-19 exposure from repeated visits to the clinic for radiation.

Dx at 40. Mama to 2 boys ages 13 and 11. Dx 1/31/2020, IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery 3/11/2020 Lumpectomy: Left Chemotherapy 4/30/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
Log in to post a reply

5 hours ago - edited 5 hours ago by Lumpie

sunandsea: Glad that is helpful. If widely adopted, that treatment option would be huge news for lots of people. Less travel, less time off work, and away from family and other obligations. Less reconstruction - or less going without reconstruction. Many forgo the less invasive option of lumpectomy because of challenges with accessing radiation therapy. We can hope that this may make the entire array of options more accessible to the people who need them. Good luck with your treatment!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/13/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Radiation Therapy Whole-breast: Breast Surgery Lumpectomy: Right Surgery Lumpectomy: Right

Page 69 of 69 (2,054 results)