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Topic: Breaking Research News from sources other than Breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 21, 2017 12:31AM - edited Nov 21, 2017 12:35AM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Posts 2491 - 2520 (2,564 total)

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Jan 1, 2021 08:11PM Springdaisy wrote:

moth, thank you for the info. How could you have stage four if you only had stage one three years ago? My god that’s scary.

Dx 9/2020, ILC, Right, <1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery Lumpectomy: Right Radiation Therapy Hormonal Therapy
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Jan 1, 2021 08:50PM moth wrote:

Hi Springdaisy - I guess I drew the short straw. When I ran the stats in Predict https://breast.predict.nhs.uk/tool 89% of women with my stats were alive at 5 years. I used that as a proxy for metastatic recurrence... so 1/10 like me would recur with terminal disease. Tried to do my best to lessen the risk - the only evidence based interventions seem to be exercise and maybe green tea. I did that. I exercised before I got stage 1 too so didn't work then either. Didn't work to prevent progression so I guess there's some powerful cancer genetics at work & I got to be one out of 10 :(

triple neg has a different mets timeline than hormone positive. We're more likely to recur at all but if we do, it's in the first 5 years so if we make it past 5, the risk starts falling. Hormone positive has this long tail of ongoing risk so a different risk profile. This cancer thing sucks all around & part of what's missing in breast cancer discussions is that it still kills very many of us. So much talk of 'survivors' and pink ribbons that sometimes it's easy to forget it's fatal to many.


Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Dx 12/10/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Jan 1, 2021 09:01PM Springdaisy wrote:

thank you for replying, moth. I wish you and everybody in this forum the best of luck. Yes, you are right, cancer sucks no matter what kind. Someone brought up the point the other day that they have rushed through the Covid vaccine so what about rushing through cures for cancer and other things? I never thought of it before but that’s a very good point. Although I don’t want cures that have been rushed through the system but they claim Covid was tested upon thousands of people and went by the rules of the CDC.

Dx 9/2020, ILC, Right, <1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery Lumpectomy: Right Radiation Therapy Hormonal Therapy
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Jan 2, 2021 08:56AM YesIamaDragon wrote:

The trouble is cancer is not a disease any more than "virus" is a disease. Even within breast cancer effective treatments are radically different for all the different subtypes. So there will never be one cure for "cancer" any more than there will be one cure for all viruses, from cold viruses to polio to HIV.

I just finished a year and a half of chemo, which brings my 3 year "risk" of disease-free survival to 89% Improved, but not great.

My oncologist is very honest with me, "the only way to know you are a survivor is to die of something else" Breast cancers suck.

Dx 6/2019, IDC, Right, 2cm, Grade 2, ER+/PR+, HER2+ Hormonal Therapy Arimidex (anastrozole) Radiation Therapy Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab) Surgery Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab)
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Jan 7, 2021 10:28AM illimae wrote:

Anyone heard about this? Sounds great, I love to see a bigger trial group though.


https://www.targetedonc.com/view/fda-grants-fast-track-designation-for-her2-positive-metastatic-breast-cancer

“A clinical update on ARX788 was announced in December during a presentation for the 2020 San Antonio Breast Cancer Symposium (SABCS) demonstrated an objective response rate (ORR) of 74% with ARX788 in the phase 1 HER2-positive breast cancer trial in China, which included responses in 14 of 19 patients and a disease control rate (DCR) of 100%. The ORR was 67% in the phase 1 HER2-positive pan tumor trial in the United States and Australia with responses in 2 of 3 patients and a DCR of 100%. Both these findings were found with the 1.5 mg/kg dose.2“



Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Chemotherapy 1/1/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/1/2017 Herceptin (trastuzumab) Targeted Therapy 1/1/2017 Perjeta (pertuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, 5cm, Stage IV, metastasized to brain, Grade 3, 3/13 nodes, ER+, HER2+ (IHC) Radiation Therapy 10/19/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/22/2019 External: Brain Surgery 1/21/2020 Radiation Therapy 2/16/2020 External: Brain Radiation Therapy 7/20/2020 External: Bone Radiation Therapy 12/4/2020 External: Brain Targeted Therapy Tukysa (tucatinib) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 7, 2021 03:18PM AlabamaDee wrote:

Preliminary study of how adiposity influences breast cancer biology, treatment resistance, and disease progression shows High BMI related to effectiveness of doxataxel!

This is a surprise revelation and shocking to me, 😳 Since my BMI was much higher when I was on taxotere. Hope they study this more.

Dee

https://www.medpagetoday.com/reading-room/asco/breast-cancer/90523?xid=NL_ASCORR_2021-01-07&eun=g20811420d39r&pos=

Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 7, 2021 10:52PM Olma61 wrote:

seems like the evidence so far is pointing to higher BMI = less taxane effectiveness

Well, I was in the high overweight BMI when I did Taxol and I had a great response, then again I was also on Herceptin and Perjeta so maybe that matters.

This definitely needs further study.

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/29/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/29/2019 External: Bone
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Jan 8, 2021 09:13AM JoynerL wrote:

This is interesting:

Gut Microbe May Promote Breast Cancer

--Lynn Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Surgery 1/2/1991 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Saline implant Chemotherapy 1/15/1991 CMF Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 3/5/2017 Faslodex (fulvestrant) Targeted Therapy 3/5/2017 Ibrance (palbociclib) Radiation Therapy 1/9/2019 External: Bone Chemotherapy 1/17/2019 Xeloda (capecitabine) Radiation Therapy 10/27/2020 External: Lymph nodes
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Jan 9, 2021 05:52PM santabarbarian wrote:

Lumpie, How're you doing? We who appreciate this thread thank you and wish you a happy new year!

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/13/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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Jan 9, 2021 06:32PM Lumpie wrote:

Hi santabarbarian! I am ok, thank you for checking....and I am very glad that you and others appreciate the topic/board. I have a couple of things I need to post. The new-ish med I am on is doing a job on my digestive system and I feel like I am always behind/moving in slow motion. Hope you are well and.... at this point, I am almost reluctant to speculate about how the year might ging.... but hope you ... and eveyone else, too!.... have a healthy and happy new year!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Jan 10, 2021 08:49AM TectonicShift wrote:

I say thank you too. This is the thread I check on nearly every day. Often the only one I check. I appreciate the work it takes to aggregate this information.

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Jan 10, 2021 02:02PM MinusTwo wrote:

Me too - Thanks Lumpie.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Jan 10, 2021 02:07PM NorCalS wrote:

Lumpie,

I hope you’re feeling better. I wanted to chime in and agree with the rest of the group that I definitely appreciate all the effort you put into this topic. Thank you

Dx: 06/2019, left breast, ER/PR-, Her2-. Treatment: 06/2019 - 11/2019 AC/T. Surgery: Lumpectomy with axillary dissection in 12/2019. Radiation: 01/2020-03/2020. Xeloda - 03/2020-09/2020
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Jan 10, 2021 02:19PM buttonsmachine wrote:

Yes. Thank you, Lumpie!

Diagnosed at 32. Local recurrences one year later. Now dealing with MBC. Dx 8/2016, IDC, Right, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 10/1/2016 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 11/1/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 2/1/2017 Whole-breast Hormonal Therapy 4/1/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 10/2017, IDC, Right, Grade 3, 2/12 nodes, ER+/PR+, HER2- Surgery 11/1/2017 Lymph node removal; Mastectomy: Right Chemotherapy 12/1/2017 AC Surgery 4/1/2018 Lymph node removal; Mastectomy: Right Radiation Therapy 5/1/2018 External: Lymph nodes, Chest wall Chemotherapy 7/1/2018 Xeloda (capecitabine) Hormonal Therapy 7/30/2018 Zoladex (goserelin) Hormonal Therapy 2/1/2019 Aromasin (exemestane) Hormonal Therapy 9/30/2019 Faslodex (fulvestrant) Dx 8/2020, IDC, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR+, HER2- Targeted Therapy 8/30/2020 Ibrance (palbociclib) Chemotherapy 1/15/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Jan 10, 2021 02:55PM JoynerL wrote:

Me, too, Lumpie...thanks so very much! A much-needed forum!

--Lynn Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Surgery 1/2/1991 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Saline implant Chemotherapy 1/15/1991 CMF Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 3/5/2017 Faslodex (fulvestrant) Targeted Therapy 3/5/2017 Ibrance (palbociclib) Radiation Therapy 1/9/2019 External: Bone Chemotherapy 1/17/2019 Xeloda (capecitabine) Radiation Therapy 10/27/2020 External: Lymph nodes
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Jan 10, 2021 04:57PM BlueGirlRedState wrote:

Thank you for the post on gut health. We are complex animals and many things seemed to get overlooked, dismissed, or are poorly understood. The bacdterium mentioined, Bacteroides fragilis, normally in the colon wrecks havoc elsewhere, unsurprisingly. But does it escape unnoticed? Lifestyle is so important. Is kimchi, sour kraut, yogurt etc enough for a healthy gut?

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Jan 11, 2021 11:08AM mysticalcity wrote:

https://www.sciencealert.com/cancer-cells-can-go-into-a-bear-like-hibernation-to-evade-chemotherapy

Dx 3/22/2018, ILC/IDC, Left, 2cm, Stage IIA, Grade 2, ER+/PR-, HER2- Hormonal Therapy 6/1/2018 Arimidex (anastrozole) Surgery 6/26/2019 Cryotherapy: Left Radiation Therapy
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Jan 11, 2021 01:02PM 2019whatayear wrote:

Thank you Lumpie for your tending of this post! I too sometimes come to the site just to read the latest updates on this post

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020
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Jan 11, 2021 03:19PM LaughingGull wrote:

Adding my voice to the choir thanking Lumpie. I also follow this thread closely.

ACx4, THPx4, HP (to complete 1y); Nerlynx (1y); AI (expected 10y), Surgery: BMX + ALND, Reconstruction, Oophorectomy. Radiation. Dx 10/26/2017, IDC, Right, 3cm, Stage IIB, Grade 3, 2/6 nodes, ER+/PR+, HER2+ (IHC)
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Jan 11, 2021 03:24PM 2019whatayear wrote:

NCI aims to track BC recurrenceSharing this - long overdue -


5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020
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Jan 11, 2021 06:43PM Karenfizedbo15 wrote:

As always Lumpie, you know we appreciate you! And also the growing group of folk who regularly post here...you’ve inspired them!

Surgery 9/7/2007 Lymph node removal: Underarm/Axillary; Mastectomy: Right; Reconstruction (right): Latissimus dorsi flap Dx 4/2018, IDC, Right, Stage IV, metastasized to lungs, 1/17 nodes, ER+/PR+, HER2- Dx 2021, Stage IV, metastasized to bone Chemotherapy 2/4/2021 Xeloda (capecitabine) Hormonal Therapy Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Jan 11, 2021 06:56PM YesIamaDragon wrote:

I will add my thanks Lumpie. I check this thread at least once a day!

Dx 6/2019, IDC, Right, 2cm, Grade 2, ER+/PR+, HER2+ Hormonal Therapy Arimidex (anastrozole) Radiation Therapy Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab) Surgery Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab)
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Jan 11, 2021 08:41PM 7of9 wrote:

Thank you Lumpie!

If you're going through hell, keep on going. You might get out before the devil even knows you're there. Dx 1/18/2012, IDC, Left, 2cm, Stage IIB, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 5/31/2012 Lymph node removal: Left; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/31/2012 Reconstruction (left); Reconstruction (right) Dx 12/23/2015, IDC, Left, 2cm, Grade 2, 10/14 nodes, ER+/PR+, HER2- Surgery 1/18/2016 Lymph node removal: Left, Underarm/Axillary Surgery 1/18/2016 Prophylactic ovary removal Radiation Therapy 2/10/2016 Whole-breast: Breast, Lymph nodes, Chest wall Chemotherapy 3/31/2016 Taxotere (docetaxel) Hormonal Therapy Arimidex (anastrozole)
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Jan 11, 2021 09:29PM AlabamaDee wrote:

t Lumpie- glad to “see” you - we missed you while you were out recuperating .


Recommended treatment graph for metastatic

https://www.esmo.org/content/download/395915/7703117/1/Clinical%20Practice%20Guidelines%20Slideset%20Advanced%20Breast%20Cancer.pdf

Dee


Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 12, 2021 07:15AM helenlouise wrote:

thanks Lumpie and all who contribute. That flow chart for metastatic BC was very interesting thanks Dee.

Dx 1/2013, DCIS, Left, <1cm, Stage 0, Grade 3, ER+/PR+ Surgery 2/3/2013 Lumpectomy: Left Surgery 2/10/2013 Lumpectomy: Left Radiation Therapy 2/28/2013 Whole-breast: Breast Dx 2/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/8 nodes, ER-/PR-, HER2- Chemotherapy 2/24/2018 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 7/23/2018 Mastectomy: Left; Prophylactic mastectomy: Right Chemotherapy 8/27/2018 Xeloda (capecitabine) Radiation Therapy 8/27/2018 Dx 4/2/2019, IDC, Left, 2cm, Stage IIIC, Grade 3, 1/8 nodes, ER-/PR-, HER2- Dx 4/16/2019, IDC, Left, 2cm, Stage IV, metastasized to other, Grade 3, 1/8 nodes, ER-/PR-, HER2- (DUAL) Dx 3/2020, IDC, Left, Stage IV, metastasized to other, ER-/PR-, HER2+ (DUAL) Targeted Therapy 3/18/2020 Herceptin (trastuzumab) Chemotherapy 3/18/2020 Taxol (paclitaxel) Targeted Therapy 3/19/2020 Perjeta (pertuzumab)
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Jan 12, 2021 12:38PM Lumpie wrote:

Thank you so much, everyone, for your kind and encouraging comments! You have made my week and I truly appreciate it.

-Lumpie

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Jan 12, 2021 12:40PM Lumpie wrote:

Shorter radiotherapy promising in breast cancer

Women with early invasive breast cancer who underwent one-week high- or low-dose hypofractionated adjuvant whole-breast radiotherapy regimen had similar five-year ipsilateral breast tumor relapse rates and safety outcomes, compared with those who received the standard three-week regimen, according to a study presented at the European Society for Radiology and Oncology 2020 Online Congress and published in The Lancet. The findings suggest the safety and efficacy of hypofractionated radiotherapy regimen as the new standard for early invasive breast cancer, said researcher Joanne Haviland.

https://www.mdedge.com/hematology-oncology/article...

https://www.thelancet.com/journals/lancet/article/...(20)30932-6/fulltext

DOI:https://doi.org/10.1016/S0140-6736(20)30932-6

{Report courtesy of AANP Smart Brief; Lancet article appears to be available w/o charge.}

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Jan 12, 2021 06:56PM Lumpie wrote:

COVID-19 Vaccine & Patients with Cancer

ASCO commentary on the covid-19 vaccine for cancer patients.

In short...

Are there people who should not be vaccinated?

At this time, only those with contraindications to a specific vaccine component should not be offered vaccination with that specific product. These contraindications are described in detail on the CDC's vaccination clinical considerations page.

... patients undergoing treatment may be offered vaccination against COVID-19 as long as any components of the vaccine are not contraindicated.

https://www.asco.org/asco-coronavirus-resources/co...

{I believe that this page is publicly available. If not, let me know and I can post details.}

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Jan 12, 2021 09:06PM Lumpie wrote:

Older women with early breast cancer may be able to avoid radiation after surgery

The omission of radiation therapy after breast-conserving surgery did not affect survival among certain older women with early breast cancer, according to results presented at the virtual San Antonio Breast Cancer Symposium.

Radiation therapy reduced the rate of ipsilateral breast tumor recurrence among women aged 65 years or older with hormone receptor-positive disease who underwent wide local excision and were receiving adjuvant hormonal therapy.

However, radiation therapy receipt did not affect rates of distant metastases, contralateral breast cancer or OS, 10-year data from the randomized phase 3 PRIME II trial showed.

https://www.healio.com/news/hematology-oncology/20...

Source: Kunkler IH, et al. Abstract GS2-03. Presented at: San Antonio Breast Cancer Symposium (virtual meeting); Dec. 8-11, 2020.

{Access to coverage should be free of charge. Registration may be required.}

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Jan 12, 2021 09:09PM Lumpie wrote:

Symptoms often underrecognized among patients receiving radiotherapy for breast cancer

Symptoms such as pain, fatigue and pruritus often went underrecognized among patients with breast cancer treated with radiotherapy, according to study results presented at the virtual San Antonio Breast Cancer Symposium.

Black patients and younger patients appeared at significantly higher risk for symptom underrecognition, results showed.

"We were disappointed to find that physicians frequently didn't recognize the severity of the symptoms patients themselves reported they were experiencing," Reshma Jagsi, MD, DPhil, Newman family professor and deputy chair of the department of radiation oncology and director of Center for Bioethics and Social Sciences in Medicine at University of Michigan, told Healio.

"Because physicians cannot help patients if they don't know who is suffering, improving symptom detection appears to be a way to improve the quality of care and to reduce disparities in cancer treatment experiences and outcomes," Jagsi added. "The findings also suggest that clinical trials should not rely on physician reports alone to evaluate the side effects of treatments; patient-reported outcomes provide an important complement to physician evaluations."

https://www.healio.com/news/hematology-oncology/20...

Source: Jagsi R, et al. Abstract GS3-07. Presented at: San Antonio Breast Cancer Symposium (virtual meeting); Dec. 8-11, 2020.

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"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast

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