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Topic: Breaking Research News from sources other than Breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 20, 2017 09:31PM - edited Nov 20, 2017 09:35PM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Page 87 of 87 (2,599 results)

Posts 2581 - 2599 (2,599 total)

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Mar 16, 2021 10:05AM BevJen wrote:

Moth,

No worries. I am hyper fixated on keytruda bc that's what I'm on, so I scoured all of the reports on that.

I am surprised by the atezo, because my center was one of the testers of that. Plus, that's what you are on, correct? And you seem to be doing well on it.

Bev

Microwave Ablations of the Liver: 7/2019; 10/2020; 12/2020 Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Mar 16, 2021 02:39PM moth wrote:

the atezo trial results have been all over the place. Atezo+abraxane seemed to have some good prelim results, atezo+ taxol was a dud in the trials (though there was some subgroup analysis that again showed some benefit for a subpopulation....but it was underpowered & not part of study design). Atazo + taxol is what I started on & have had good response - I think I've beat the median pfs. I think the more mature atezo+abraxane data might be coming this year.

some onco twitter chatter was that they were wondering if PD-L1 had to be a certain threshold (not just positive/negative) for it to work but I think also some think there's another mutation that it's targetting. There are a few good responders with durable response so ... fingers crossed that I'm one of the unicorns. I've technically had two oligoprogressions on it but my liver mets continue to slowly shrivel up - which apparently is classic immunotherapy response: slow to start, longer duration rather than wham/bam/tumor dead (& then resistance) that you get from effective chemo.


Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Mar 17, 2021 09:51AM 2019whatayear wrote:


Time to Revisit Distant Nodal Status in Breast Cancer Curability? — Comparable survival for distant and regional nodal involvement, when treated similarly

by Charles Bankhead, Senior Editor, MedPage Today March 16, 2021

You may need to set up a free account to view the article.


https://www.medpagetoday.com/hematologyoncology/br...

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020
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Mar 17, 2021 01:38PM - edited Mar 17, 2021 01:40PM by moth

eribulin PLUS pembrolizumab for mTNBC phase 1b/2 reporting https://pubmed.ncbi.nlm.nih.gov/33727258/

higher ORR (34.5% ) and OS (21 mo) in PDL1+ 1L pts

there were a number of complete responses in the trial (Stratum 1 was 1st line); there were complete responses in stratum 2 as well (2nd or 3rd line tx)

Image

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Mar 17, 2021 04:09PM ShetlandPony wrote:

2019whatayear, that looks like an important article that relates to questions I have seen BCO members post, about whether contralateral node involvement makes them stage iv or not. I read it as saying that contralateral lymph node involvement should be treated with curative intent, as stage III or oligometastasis.

2011 Stage I ILC 1.5cm grade1 ITCs sn Lumpectomy,radiation,tamoxifen. 2014 Stage IV ILC mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD
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Mar 18, 2021 05:27PM 2019whatayear wrote:

Yes SP a lady I follow on Twitter posted it. Really interesting seems like in these cases if I was the patient I’d push for the aggressive curative intent

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020
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Mar 20, 2021 05:00PM idkwhatsnext wrote:

As someone with Her2+ cancer, I have found the topic "Articles of Interest" on Her2Support.org helpful for research news too.

https://her2support.org/vbulletin/forumdisplay.php?s=0224bf18cca3db2e508558a147904455&f=31

Dx 8/27/2020, Left: IDC + Calc, 5+cm, Right: LCIS, 0/5 nodes, ER+/PR+, HER2++, Grade 3 Targeted Therapy 10/8/2020 Herceptin (trastuzumab) Targeted Therapy 10/8/2020 Perjeta (pertuzumab) Chemotherapy 10/8/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 2/25/2021 Mastectomy: Left; Prophylactic mastectomy: Right Targeted Therapy 3/25/2021 Kadcyla (T-DM1, ado-trastuzumab)
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Mar 22, 2021 10:32AM moth wrote:

Oral taxane tesetaxel is being withdrawn from development

https://finance.yahoo.com/news/odonate-therapeutic...

"clinical data package for tesetaxel is unlikely to support FDA approval." ... so it turns out it didn't actually work all that well :(

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Mar 22, 2021 06:42PM LillyIsHere wrote:

In fact, women appear hardwired to experience COVID-19 and the vaccines differently. Data from the CDC suggests side effects from the vaccines are worse in women; for example, 63 of the total 66 reported cases of anaphylaxis happened in women.

Why Women Experience COVID and the Vaccines Differently Than Men
“Within five years, cancer will have been removed from the list of fatal maladies.” That was the optimistic promise to U.S. President William Howard Taft in 1910 when he visited Buffalo’s Gratwick Laboratory, “What’s taking so long?” Dx 7/31/2019, ILC, Left, <1cm, Stage IIA, 2/5 nodes, ER+/PR-, HER2- Surgery 9/19/2019 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 11/30/2019 Femara (letrozole)
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Apr 2, 2021 11:20AM - edited Apr 2, 2021 11:21AM by AlabamaDee

Antibody drug conjugates article on Springer

Clinical Development of New Antibody–Drug Conjugates in Breast Cancer: To Infinity and Beyond
https://link.springer.com/content/pdf/10.1007/s40259-021-00472-z.pdf


I have skimmed the paper. Lots of hope for ADCs including ER/PR + Her2-


Dee

Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/29/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/8/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Apr 2, 2021 02:26PM PAKNC wrote:

Research article associating breast adipocyte size and COX-2 expression in DCIS cells with higher potential for DCIS to develop into invasive breast cancer.

https://www.nature.com/articles/s41523-021-00232-w

I don't yet understand all of the details but it reinforces that looking at BMI primarily is not always a good answer.


Diagnosed at 56. Did active surveillance in clinical trial + Tamoxifen for 6 months, cryoablation in 02/21 due to DCIS progression. Stopped Tamoxifen, per provider's ok - turned prediabetic, poor responder. Weighing AI options. Dx 3/23/2020, DCIS, Left, Stage 0, Grade 2, ER+/PR+ Dx 5/29/2020, DCIS, Left, Stage 0, Grade 2, ER+/PR+ Hormonal Therapy 7/1/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 3, 2021 03:01PM BlueGirlRedState wrote:

PKNC - is breast adipocyte the same as "dense breast". I wonder if that is why I have had so much trouble

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Apr 3, 2021 08:00PM PAKNC wrote:

I’m not sure, but what I think this article is getting at, is that the size of the breast fat cells, which tend to be larger in obese and post menopausal women (any weight) due to inflammation, are associated with cancer progression.

Diagnosed at 56. Did active surveillance in clinical trial + Tamoxifen for 6 months, cryoablation in 02/21 due to DCIS progression. Stopped Tamoxifen, per provider's ok - turned prediabetic, poor responder. Weighing AI options. Dx 3/23/2020, DCIS, Left, Stage 0, Grade 2, ER+/PR+ Dx 5/29/2020, DCIS, Left, Stage 0, Grade 2, ER+/PR+ Hormonal Therapy 7/1/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 5, 2021 09:12AM Lumpie wrote:

BlueGirlRedState: No, breast adiposity is NOT the same as dense breasts. In fact, it is sort of the opposite. On imaging, fat, aka "adiposity," is very translucent, so it is relatively easy to see tumors and high risk tissue in fatty or adipose breasts. Dense tissue looks like solid white on imaging. It is hard to see through, so it is difficult to see tumors hiding in dense tissue. The benign dense tissue and a tumor look very much the same. That is why mammograms are not as effective at finding breast cancer in women with dense breasts. Research and development is looking at techniques to combat these challenges... things like artificial intelligence and thermography. I may be able to scrape up a link to some propaganda from GE on their R&D which discusses this a bit if anyone is interested. As someone with dense breasts - which unquestionably hid my BC for *at least* a year if not longer - I am very glad to know that work is being done to try to overcome this screening challenge.

PS: Anyone else find it amusing and frustrating that many of us spend too much time, effort and distress on trying to rid our bodies of fat elsewhere, but that fat, which comprises the majority of healthy, mature, female breasts is deemed cosmetically desirable? Not everyone, but many....a la "Why can't my muffin tops relocate to my breasts?"

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Apr 5, 2021 02:54PM Karenfizedbo15 wrote:

🤔😂 Lumpie!

Surgery 9/6/2007 Lymph node removal: Underarm/Axillary; Mastectomy: Right; Reconstruction (right): Latissimus dorsi flap Dx 4/2018, IDC, Right, Stage IV, metastasized to lungs, 1/17 nodes, ER+/PR+, HER2- Dx 2021, Stage IV, metastasized to bone Chemotherapy 2/3/2021 Xeloda (capecitabine) Hormonal Therapy Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Apr 7, 2021 04:58PM BlueGirlRedState wrote:

Lumpie - thank you for the laugh. One person posted that her DR told her that changes she was seeing in her fingers were because she was losing fat there, rather than in her "handles". It just is not fair. I was considering DIEP at one time, turning love handles into boobs sounded good. But I was not a good candidate, not the right kind of fat in the right places.

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Apr 7, 2021 05:05PM Lumpie wrote:

BlueGirlRedState: Oh dear. I am so glad no one told me I had "the wrong kind of fat" at an inopportune moment. That could have been dangerous!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Apr 7, 2021 05:06PM - edited Apr 7, 2021 05:08PM by Springdaisy

since starting letrozole in early January I have gone down some brassiere sizes.


Dx 9/2020, ILC, Right, <1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (IHC) Surgery Lumpectomy: Right Radiation Therapy Hormonal Therapy
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Apr 8, 2021 09:08AM Lumpie wrote:

Sharing FYI:

You may qualify for our sponsored post-mastectomy bra program {from AnaOno} powered by Natrelle Inspires!

Enter your information to submit your request. Bra requests will be fulfilled on a first-come-first-serve basis, and quantities are based on the number of Natrelle Inspires bras sold. The program is available to newly-diagnosed (within one year) patients, processing fees such as shipping and handling may apply.

https://anaono.typeform.com/to/MTU5gpeb?utm_source...

Gratuitous comment: I have purchased from AnaOno before. I love their products (comfortable, high-quality) and, in my experience, they have great customer service.

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast

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