Topic: Breaking Research News from sources other than Breastcancer.org

Mar 16, 2021 02:39PM moth wrote:

the atezo trial results have been all over the place. Atezo+abraxane seemed to have some good prelim results, atezo+ taxol was a dud in the trials (though there was some subgroup analysis that again showed some benefit for a subpopulation....but it was underpowered & not part of study design). Atazo + taxol is what I started on & have had good response - I think I've beat the median pfs. I think the more mature atezo+abraxane data might be coming this year.

some onco twitter chatter was that they were wondering if PD-L1 had to be a certain threshold (not just positive/negative) for it to work but I think also some think there's another mutation that it's targetting. There are a few good responders with durable response so ... fingers crossed that I'm one of the unicorns. I've technically had two oligoprogressions on it but my liver mets continue to slowly shrivel up - which apparently is classic immunotherapy response: slow to start, longer duration rather than wham/bam/tumor dead (& then resistance) that you get from effective chemo.

Mar 17, 2021 01:38PM - edited Mar 17, 2021 01:40PM by moth

eribulin PLUS pembrolizumab for mTNBC phase 1b/2 reporting https://pubmed.ncbi.nlm.nih.gov/33727258/

higher ORR (34.5% ) and OS (21 mo) in PDL1+ 1L pts

there were a number of complete responses in the trial (Stratum 1 was 1st line); there were complete responses in stratum 2 as well (2nd or 3rd line tx)

Mar 18, 2021 05:27PM 2019whatayear wrote:

Yes SP a lady I follow on Twitter posted it. Really interesting seems like in these cases if I was the patient I’d push for the aggressive curative intent

Mar 22, 2021 10:32AM moth wrote:

Oral taxane tesetaxel is being withdrawn from development

https://finance.yahoo.com/news/odonate-therapeutic...

"clinical data package for tesetaxel is unlikely to support FDA approval." ... so it turns out it didn't actually work all that well :(

Apr 2, 2021 11:20AM - edited Apr 2, 2021 11:21AM by AlabamaDee

Antibody drug conjugates article on Springer

Clinical Development of New Antibody–Drug Conjugates in Breast Cancer: To Infinity and Beyond
https://link.springer.com/content/pdf/10.1007/s40259-021-00472-z.pdf

I have skimmed the paper. Lots of hope for ADCs including ER/PR + Her2-

Dee

Apr 3, 2021 03:01PM BlueGirlRedState wrote:

PKNC - is breast adipocyte the same as "dense breast". I wonder if that is why I have had so much trouble

Apr 5, 2021 09:12AM Lumpie wrote:

BlueGirlRedState: No, breast adiposity is NOT the same as dense breasts. In fact, it is sort of the opposite. On imaging, fat, aka "adiposity," is very translucent, so it is relatively easy to see tumors and high risk tissue in fatty or adipose breasts. Dense tissue looks like solid white on imaging. It is hard to see through, so it is difficult to see tumors hiding in dense tissue. The benign dense tissue and a tumor look very much the same. That is why mammograms are not as effective at finding breast cancer in women with dense breasts. Research and development is looking at techniques to combat these challenges... things like artificial intelligence and thermography. I may be able to scrape up a link to some propaganda from GE on their R&D which discusses this a bit if anyone is interested. As someone with dense breasts - which unquestionably hid my BC for *at least* a year if not longer - I am very glad to know that work is being done to try to overcome this screening challenge.

PS: Anyone else find it amusing and frustrating that many of us spend too much time, effort and distress on trying to rid our bodies of fat elsewhere, but that fat, which comprises the majority of healthy, mature, female breasts is deemed cosmetically desirable? Not everyone, but many....a la "Why can't my muffin tops relocate to my breasts?"

Apr 7, 2021 04:58PM BlueGirlRedState wrote:

Lumpie - thank you for the laugh. One person posted that her DR told her that changes she was seeing in her fingers were because she was losing fat there, rather than in her "handles". It just is not fair. I was considering DIEP at one time, turning love handles into boobs sounded good. But I was not a good candidate, not the right kind of fat in the right places.

Apr 7, 2021 05:06PM - edited Apr 7, 2021 05:08PM by Springdaisy

since starting letrozole in early January I have gone down some brassiere sizes.