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Topic: Breaking Research News from sources other than Breastcancer.org

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 20, 2017 11:31PM - edited Nov 20, 2017 11:35PM by Lumpie

Lumpie wrote:

I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast
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Posts 2671 - 2700 (2,704 total)

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Jun 3, 2021 12:45PM - edited Jun 3, 2021 02:40PM by LillyIsHere

Dr. Winer is one of the best MO. He is my friend's MO and he was not taking new patients when I tried.

“Within five years, cancer will have been removed from the list of fatal maladies.” That was the optimistic promise to U.S. President William Howard Taft in 1910 when he visited Buffalo’s Gratwick Laboratory, “What’s taking so long?” Dx 7/31/2019, ILC, Left, <1cm, Stage IIA, 2/5 nodes, ER+/PR-, HER2- Surgery 9/19/2019 Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 11/29/2019 Femara (letrozole)
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Jun 3, 2021 02:07PM Olma61 wrote:

Yes, Lily, I searched him on YouTube and saw him speak in a few videos, he seems very caring as well as smart

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 4, 2021 01:05AM BSandra wrote:

Dear Olma, yes, I have seen that presentation and have these slides:)P BTW, I have also posted the trial Dana Farber is designing for a HER2+ mbc CURE - but no one reacted:) That comes from SABCS'20. Reposting:) People... there are cures in stage IV already, just they are not proved - time is needed. Drugs are super effective already, now they have to be used wisely and first "official" cures will come... Saulius

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary
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Jun 4, 2021 04:39AM JoynerL wrote:

I have an odd question: Early on (2017-2018), when I was on Ibrance/Faslodex, I recall that the folks on the Ibrance string were mentioning/quoting a revered oncologist whose name was "Saulius" or at least something close thereto. Is that you, Saulius, or am I just totally misremembering? I lost sight of that onc visionary and would love to be reminded of whom he(?) was, anyway. Thanks!!

All of this makes me wish I were HER2+ (I guess)!

--Lynn Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Surgery 1/2/1991 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Saline implant Chemotherapy 1/15/1991 CMF Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 3/5/2017 Faslodex (fulvestrant) Targeted Therapy 3/5/2017 Ibrance (palbociclib) Radiation Therapy 1/9/2019 External: Bone Chemotherapy 1/17/2019 Xeloda (capecitabine) Radiation Therapy 10/27/2020 External: Lymph nodes
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Jun 4, 2021 02:38PM - edited Jun 4, 2021 03:42PM by Olma61

very interesting! Thanks, Saulius. Looks like they would hit the cancer with three systemic therapies, then local, then another systemic. Would they recruit only oligo patients or include those with more widespread mets?

Moth, unfortunately, made a good point. HER2+ is only 20 - 25% of all breast cancer and then metastatic fewer than that and de novo an even smaller subset.

Although anti HER2 therapy has proved useful for a few other cancer types, such as gastric, and now the HER2 low breast cancer studies...I think the original hope was that it would be more widely useful when the HER2 growth factor was first discovered.

But “ precision medicine “. does seem to be the answer, even though we hear frequently about research that could lead to THE cure for all cancer, nothing ever happens. Like that story from Israel a year or two ago and alsoimmunotherapy . Just saw this one the other day, hope it progresses beyond mouse studies - https://medicalxpress.com/news/2021-05-immunotherapy-revolutionize-cancer-treatment.html

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 5, 2021 05:42PM Olma61 wrote:

And on the topic of further personalizing breast cancer treatment, here is a discussion of exactly that. Creating smaller sub-categories based on mutations other than just hormone receptors or lack thereof -

https://perspectives.esmo.org/latest-edition/slider-content/breast-cancer-treatment-should-be-tailored-to-the-tumour-biology-not-to-its-hormone-receptor-status-alone?hit=some

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 6, 2021 04:25AM Karenfizedbo15 wrote:

Thanks for this Olma...an interesting read.

Surgery 9/7/2007 Lymph node removal: Underarm/Axillary; Mastectomy: Right; Reconstruction (right): Latissimus dorsi flap Dx 4/2018, IDC, Right, Stage IV, metastasized to lungs, 1/17 nodes, ER+/PR+, HER2- Dx 2021, Stage IV, metastasized to bone Chemotherapy 2/4/2021 Xeloda (capecitabine) Hormonal Therapy Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Jun 6, 2021 02:22PM BlueGirlRedState wrote:

Olma - thank you for the link. Genetics seems to be the key if we can just learn the markers and targeted therapy. Several years ago when I was sharing my experience with DIY cold capping and how it worked ( how to rotate the caps in the cooler etc) she remarked that she that I was lucky being strongly ER+ and that there were drugs, but she was triple negative with no drugs to treat it. I did not say anything, but I did not feel lucky since estrogen is natural and neccesary even in small amounts after menopause. I wish for ways to attack the cancer without attacking me. This is the 3rd recurrence. Tamoxifen, AIs are all systemic. Do they really work? Would I be much worse off without them?

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Jun 6, 2021 03:34PM AlabamaDee wrote:

Bluegirlredstate

I love the way you said “I wish for ways to attack the cancer without attacking me.“

the truth about anti-estrogens is how much they wreck our bodies- osteopenia, joint degeneration, muscle aches, heart health, dryness-skin, eyes, vaginal etc. we suffer through because they often work.

I am a little miffed when someone said, “at least it’s not chemo.” Yes-I do get to keep my hair and avoid some of the very harsh SE but hormone therapy takes a toll too. It’s not fun to have a golf ball size tumor in my liver, but I am thankful that my trial drug is working to keep the tumors from growing for now.

Dee



Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/29/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/8/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jun 6, 2021 05:45PM - edited Jun 6, 2021 05:46PM by Olma61

Youre welcome ladies, glad you found the articles useful. Quick comment about hormone therapies- I started feeling worse when I began the anastrozole than I did for my six months on Taxol, Herceptin and Perjeta. And, I quickly put on weight in my midsection.

I joke that the steroids in the Taxol infusion had me sohyped up so I “thought" I felt good...but seriously I was a fortunate one who didn't suffer that much on Taxol.

Yes, hated the baldness and I did have fatigue and low Hgb. But..the anastrozole has me fatigued, achy, makes my hands almost useless at times, muscle cramping especially at bed time, etc.

Tamoxifen carries a risk of uterine cancer, etc.

Sure, taking a pill every day is easier than showing up for infusions, but it's still a systemic therapy that effects our entire bodies.

If or when they perfect an immuno therapy that is a one shot deal, doesn't kill us and worksfor most or all of us — well, now, that will really be an achievement

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 6, 2021 06:26PM Kanga_Roo wrote:

Not “breaking research” but the history of the Warburg affect on cancer cells. I read about this nearly four years ago when I was first diagnosed with stage 4 and have been on a keto regime ever since. I started a thread about keto on the site a while back with links to other sites and info if anyone is interested.
https://www.reddit.com/r/ketoscience/comments/nto84d/cbs_this_morning_on_twitter_talks_about_otto/?utm_source=share&utm_medium=ios_app&utm_name=iossmf


Dx 1/24/2018, IDC, Left, 5cm, Stage IV, metastasized to liver, ER+/PR+, HER2- (IHC) Hormonal Therapy 2/11/2018 Femara (letrozole) Targeted Therapy 2/15/2018 Kisqali
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Jun 7, 2021 01:15AM BSandra wrote:

Dear JoynerL, I am not an oncologist - just an ordinary guy from Lithuania who's trying to save his wife. But you know... if I could live my life again (I am not that old- maybe there's still time?:), I could be an oncologist-researcher - what an exciting (and horrible) field. Let's hope it will turn from "horrible" into "exciting-only" soon.

Dear Olma, I am sorry I mostly post on HER2+ MBC because this is the field that is most important to my family. One thing I have to note is that HER2+ drugs (ADCs) are quite quickly making it into HER2low, as they get bystander/pan-inibitor properties. I think in a long term Her2low people will benefit from these drugs, and therefore Her2+ field is so exciting. There are stage IV people already in these threads who got NED on anti-her2 drugs, themselves being her2low (but having her2 mutation).

Saulius

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary
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Jun 7, 2021 01:59AM Olma61 wrote:

Dear Saulius, please don’t apologize, your posts are very helpful and full of good information. And yes, you stay so well informed that you do sound like an oncologist! I am a HER2+ gal also - so all HER2 positive posts are of interest to me. Just the fact that the experts will discuss treating any of us with curative intent is very exciting. I wonder if the Dana Farber study has begun? I see Dr Winer mentioned the 77 patients, it seems to be referring to the planned study on the slide you posted

Kanga_Roo - interesting article. I just happened to come across this paper a few days ago “Hyperglycemic Conditions Proliferate Triple Negative Breast Cancer”

https://www.researchsquare.com/article/rs-520490/v1

It’s a preprint so not peer reviewed yet and it’s just about cells in a Petrie dish but still interesting.


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 8, 2021 09:10AM - edited Jun 8, 2021 09:20AM by BSandra

Dear Olma, thanks a lot for your kind words. It'd be absolutely great if anyone who "attends" Dana Farber, or anyone in Boston, or Massachusetts, or even USA, could ask what is the state of that "possible" trial or trials similar like these? Of course, usually I wait for half a year/one year after something was announced I write and ask. I wrote really to quite a few top oncologists around the world and, to my surprise, got every and each answer. Extremely kind and understanding people. As close to top developments as one can get - trial and clinic wise. Just give them concrete questions, and you'll get all your answers. So dr. Parsons and dr. Lin, you still have half a year until Saulius' letter comes!:)

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary
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Jun 8, 2021 12:19PM BevJen wrote:

Saulius,

I have to echo what you've said. I've sent questions to a number of docs and they do respond, especially if you send very specific questions. They have always been kind.

And I do have to laugh about when your next few letters will be going out!

Microwave Ablations of the Liver: 7/2019; 10/2020; 12/2020 Radiation Therapy for Bone Mets to Femur (Both sides) April 2021 Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/4/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Jun 8, 2021 08:52PM - edited Jun 8, 2021 11:03PM by moth

Phase 3 trial: ultra high single dose radiation was superior to 3 SBRT tx for oligomets

https://doi.org/10.1016/j.ijrobp.2021.01.004

edit: oops ok for reasons I don't understand I can't get the link to work but I think if you copy & paste this into a browser it should work redjournal.org/article/S0360-3016(21)00006-7/fulltext

"The study confirms SDRT as a superior ablative treatment, indicating that effective ablation of oligometastatic lesions is associated with significant mitigation of distant metastatic progression."


I take weekends off

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: https://nevertellmetheodds2017.tumblr.com/

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/2/2021 External: Bone
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Jun 8, 2021 10:42PM illimae wrote:

Moth, sounds like a good finding but I think the link is off somehow unless I’m the problem, which is entirely possible, lol. Would you mind checking, if you have time?

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Targeted Therapy 1/2/2017 Perjeta (pertuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, 5cm, Stage IV, metastasized to brain, Grade 3, 3/13 nodes, ER+, HER2+ (IHC) Radiation Therapy 10/20/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/23/2019 External: Brain Surgery 1/22/2020 Radiation Therapy 2/17/2020 External: Brain Radiation Therapy 7/20/2020 External: Bone Radiation Therapy 12/4/2020 External: Brain Targeted Therapy Tukysa (tucatinib) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jun 8, 2021 11:01PM moth wrote:

argh, I fought with that link 3 times and thought I'd outsmarted it with the DOI link instead but I guess not!

I'm editing it now one more time...

I take weekends off

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: https://nevertellmetheodds2017.tumblr.com/

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/2/2021 External: Bone
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Jun 9, 2021 12:09AM - edited Jun 9, 2021 01:34AM by BSandra

Thanks Bev, it is very nice to see you back here!:) Also, an ASCO summary on her2 ADCs in trials for her2low - looks very very promising! Saulius

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary
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Jun 9, 2021 02:19PM - edited Jun 9, 2021 02:27PM by Olma61

That's great news for those with HER2-low MBC. The drug SYD 985 ( trastuzumab duocarmazine)already finished phase 3 trials for HER2+ (not low)and should be coming to market soon.

https://www.fiercebiotech.com/biotech/dutch-biopharma-byondis-shows-promising-results-phase-3-trial-her2-breast-cancer-drug

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 9, 2021 05:04PM LilyCh wrote:

"Tamoxifen treated BC patients showed a reduced rate of hospitalization and strikingly no fatalities for COVID-19. In vitro experiments confirmed a protective role of tamoxifen while an increased susceptibility to SARS-CoV-2 infection of ER+ cells treated with fulvestrant was observed".

https://www.researchsquare.com/article/rs-598923/v...

Dx 6/5/2018, IDC, Right, 2cm, Stage IA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 7/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 7/12/2018 Perjeta (pertuzumab) Targeted Therapy 7/12/2018 Herceptin (trastuzumab) Surgery 11/20/2018 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy 1/13/2019 Whole-breast: Breast Hormonal Therapy 3/12/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jun 10, 2021 10:19AM GoKale4320 wrote:

Olma61 - I loved the video about bones. I was so encouraged that I stopped by the gym on the way home to lift weights. I’m also increasing my walking. Thank you!



Dx: January 2017, IDC, Stage IIa, 1/23 nodes, <1cm Chemo 2/16/17 Cytoxan Taxotere x4 Radiation 6/8/2017, natural alternative to tamoxifen 3/2021 Stage 4 - mets to bones. Ibrance and Letrozole and Xgeva Dx 1/2017, IDC, Right, <1cm, Stage IIA, Grade 2, 1/23 nodes, ER+/PR+, HER2-
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Jun 10, 2021 11:48AM Olma61 wrote:

Oh, you’re very welcome! Happy to see this,

Heart

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 10, 2021 08:32PM LaughingGull wrote:

Olma61 and GoKale3420, which video is the bones video? Can't find it. Sad

ACx4, THPx4, HP (to complete 1y); Nerlynx (1y); AI (expected 10y), Surgery: BMX + ALND, Reconstruction, Oophorectomy. Radiation. Dx 10/26/2017, IDC, Right, 3cm, Stage IIB, Grade 3, 2/6 nodes, ER+/PR+, HER2+ (IHC)
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Jun 10, 2021 09:06PM Olma61 wrote:

The link I posted was actually in the Bone Mets thread under Stage IV - here's the link on YouTube, might also be on lbbc.org


https://youtu.be/YpFfLrITfEI

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 10, 2021 10:46PM - edited Jun 10, 2021 10:46PM by 2019whatayear

Thanks for Sharing that bone info. That was really educational and helpfu

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020
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Jun 10, 2021 11:14PM Olma61 wrote:

YW and yes, I thought it was so comprehensive, whether for newly diagnosed or or “seasoned” metsters.

By the way, have not seen Lumpie, the OP of this thread posting lately and her last activity shows as May 7th. Hope she is okay, does anyone know her

10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Jun 11, 2021 03:39AM Karenfizedbo15 wrote:

Lumpie sometimes takes a breather for several weeks, just to recharge, so hopefully that’s what’s going on.

Surgery 9/7/2007 Lymph node removal: Underarm/Axillary; Mastectomy: Right; Reconstruction (right): Latissimus dorsi flap Dx 4/2018, IDC, Right, Stage IV, metastasized to lungs, 1/17 nodes, ER+/PR+, HER2- Dx 2021, Stage IV, metastasized to bone Chemotherapy 2/4/2021 Xeloda (capecitabine) Hormonal Therapy Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Jun 11, 2021 08:05AM santabarbarian wrote:

Lumpie, we appreciate you and this super-valuable thread!! Love to you!

pCR after neoadjuvant chemo w/ integrative practices; Proton rads. Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/11/2019 Whole-breast: Breast, Lymph nodes
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Jun 11, 2021 09:53AM Lumpie wrote:

You are so kind to be concerned. Doing ok here! Taking a bit of a breather, visiting some fully vaccinated family at long last, stopping off for some R&R and doing advocacy around access to health care. Plus sometimes I just get in a rut and feel like I read the same studies over and over ... you probably know what I mean ... though I did see something a couple of days ago I thought I should post. As soon as I find it among my billion emails, I will pass it along. Thanks, all! Take care and be well. -Lumpie

"We must be willing to let go of the life we have planned, so as to have the life that is waiting for us." "If adventures will not befall a young lady in her own village, she must seek them abroad." "Buy the ticket, take the ride." Dx 2015, DCIS/IDC, Right, 3cm, Stage IIA, Grade 3, 0/1 nodes, ER-/PR-, HER2+ (IHC) Chemotherapy 1/14/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 1/14/2016 Herceptin (trastuzumab) Dx 2017, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2+ Surgery Lumpectomy: Right Surgery Lumpectomy: Right Radiation Therapy Whole-breast: Breast

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