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Topic: Breast cancer vaccine is being tested ...

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Mar 21, 2018 09:52AM

cp418 wrote:

https://mynorthwest.com/932711/breast-cancer-vacci...


Breast cancer vaccine is being tested at University of Washington Log in to post a reply

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Posts 1 - 18 (18 total)

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Mar 21, 2018 10:35AM marijen wrote:

Thank you cp418. That’s a trial I would like to get on

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Mar 21, 2018 10:38AM Joyseeker wrote:

This is so hopeful. Grateful heart.

Dx 9/14/2017, IDC, Right, 6cm+, Stage IIB, Grade 3, 2/4 nodes, ER+/PR+, HER2- (FISH) Surgery 9/19/2017 Lymph node removal: Right, Sentinel; Mastectomy: Right Chemotherapy 10/24/2017 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Chemotherapy 12/27/2017 Taxotere (docetaxel) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast, Lymph nodes
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Mar 21, 2018 10:41AM marijen wrote:

Here’s a link to vaccine trials


https://clinicaltrials.gov/ct2/results/map/click?map.x=156&map.y=72&term=Breast+cancer+vaccine&recrs=a&map=NA%3AUS&mapw=1020


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Mar 22, 2018 09:20AM Bosombuddy101 wrote:

Marijen,

Thank-you for the link. It appears they are recruiting stage 3 and up breast cancer patients. This vaccine could potentially hold the key to eradicate metastatic breast cancer. This would be HUGE!

“Trouble that can’t be named, tigers waiting to be tamed” ----Coldplay Dx 7/4/2017, IDC: Mucinous, Right, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 7/19/2017 Lumpectomy: Right; Lymph node removal: Sentinel Surgery 8/30/2017 Mastectomy: Right; Prophylactic mastectomy: Left
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Mar 22, 2018 09:50AM klvans wrote:

Encouraging. I wonder what drug companies are involved in it? Might be a nice investing opportunity.

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Apr 16, 2019 09:47PM DiagnosisDisruption wrote:

I ended up being accepted into this trial. I go on May 8th to meet with the doctor and sign the consent form and then have an ECHO. I'm scared to death about side effects and the like. I don't even get flu shot vaccines and I'm signing up for THIS? The Department of Defense is funding it, according to the paperwork I received (with all the scary side effect language).

Dx 12/8/2017, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ Targeted Therapy 1/23/2018 Herceptin (trastuzumab) Targeted Therapy 1/23/2018 Perjeta (pertuzumab) Chemotherapy 1/23/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 5/22/2018 Lumpectomy: Left Surgery 6/12/2018 Lumpectomy: Left Radiation Therapy 7/18/2018 Whole-breast: Breast Hormonal Therapy 10/10/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 16, 2019 11:16PM Peregrinelady wrote:

Thanks for letting us know, DD. Good luck and please keep us posted.
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Surgery 5/18/2015 Mastectomy: Left Hormonal Therapy 6/1/2015 Liquid tamoxifen (Soltamox) Surgery 4/19/2016 Mastectomy: Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 8/1/2016 Arimidex (anastrozole) Hormonal Therapy 7/20/2020 Femara (letrozole)
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Apr 17, 2019 01:15AM - edited Apr 17, 2019 01:27AM by Meow13

I might be wrong but I think the vaccine is for her2 positive patients. I stand corrected it says her2 negative. A couple years ago there was a trial vaccine for her2 positive patients.

I hope it is really successful!

This is the her2 positive one:

https://www.cancernetwork.com/her2-positive-breast...


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Apr 17, 2019 03:42AM TerrySB wrote:

I had the vaccine and participated in HER2+ Clinical Trial at the Univ of Wash 5 years ago...unfortunately my liver mets has just come back...and I thought I was cured!!! What a disappointment!

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Apr 17, 2019 09:00AM DiagnosisDisruption wrote:

TerrySB, That is a disappointment! What stage, etc were you during the trial? Side effects from the vaccine? I want real people's answers, not necessarily the doctor's. This is either for WOVAC or DC1 vaccine.

The one I am on is for HER2 Positive. I spoke with the oncologist and she said other patients had tried to get in, but they didn't qualify. I don't know if it's good or bad that I qualified :)


Dx 12/8/2017, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ Targeted Therapy 1/23/2018 Herceptin (trastuzumab) Targeted Therapy 1/23/2018 Perjeta (pertuzumab) Chemotherapy 1/23/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 5/22/2018 Lumpectomy: Left Surgery 6/12/2018 Lumpectomy: Left Radiation Therapy 7/18/2018 Whole-breast: Breast Hormonal Therapy 10/10/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 17, 2019 09:28AM SpecialK wrote:

I participated in a Her2+ recurrence prevention vaccine trial, linked below, from 2012-2017. I traveled from Florida to Washington, DC for this trial - initially once a month for 6 months, then four times yearly for the following two years, then the remaining time period was phone consults backed up with records from my oncologist. My only side effects were at the time of the injections - two to the upper thigh - itchy local reaction, then some fatigue and flu-like feeling for a couple of days, otherwise fine. I did find out at the five year point that I was in the active arm of the GP2 vaccine, which I was happy about as it performed very well. The one thing to remember about most trials is that you have an equal chance of being in the placebo arm, no guarantee of actually getting the vaccine. Also important to note, there have been vaccine trials that have performed well, but are still not on the market - it is a long and expensive process, with no guarantees of success.

https://clinicaltrials.gov/ct2/show/NCT00524277

https://ascopubs.org/doi/abs/10.1200/jco.2013.31.15_suppl.3005

https://www.ascopost.com/News/17570

BMX w/ TE 11/1/10, ALND 12/6/10. 15 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC)
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Apr 17, 2019 10:35AM DiagnosisDisruption wrote:

SpecialK, Thank you for the reality aspect of it! They can tell me all sorts of things, but I like to hear from people who have actually gone through it. My understanding (I haven't spoken with the consultant yet, that's in May) is that this is not the placebo. It's either DC1 or WOKVAC, randomly chosen. My husband keeps saying, just wait for the vaccine to come out and get it then. Sounds like that is a ways out.

And I thought my drive would be bad, one hour each way. Florida to Washington DC! It's quite the time commitment after all the cancer treatments last year.

Dx 12/8/2017, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ Targeted Therapy 1/23/2018 Herceptin (trastuzumab) Targeted Therapy 1/23/2018 Perjeta (pertuzumab) Chemotherapy 1/23/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 5/22/2018 Lumpectomy: Left Surgery 6/12/2018 Lumpectomy: Left Radiation Therapy 7/18/2018 Whole-breast: Breast Hormonal Therapy 10/10/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 17, 2019 10:44PM - edited Apr 18, 2019 12:26AM by SpecialK

The issue with Her2+ recurrence prevention vaccines is that they need to be given soon after treatment since Her2+ driven recurrence generally occurs within 2-3 years. Waiting for a vaccine to come to the market for a currently diagnosed Her2+ breast cancer wouldn't be pragmatic.

BMX w/ TE 11/1/10, ALND 12/6/10. 15 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC)
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Oct 30, 2019 03:48AM Kmbates102476 wrote:

I am looking to hear others experience with the WOKVAC vaccine. I was recently admitted to the trial and I am wanting to know side effects and general experience.

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Oct 30, 2019 09:27AM Moderators wrote:

Hello, Kmbates, and welcome to Breascancer.org! You'll find our community a very supportive and helpful place.

Until you get responses from other members here, you may want to listen to the podcast Where Are We With Immunotherapy for Breast Cancer? ESMO 2019 Coverage, from our main site, where Dr. Jennifer Litton talks about current immunotherapy research for breast cancer in general.

Please, come back to let us all know about your experience with the trial!

Best wishes,

From the Mods




To send a Private Message to the Mods: community.breastcancer.org/mem...
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Nov 1, 2019 09:08PM DiagnosisDisruption wrote:

Kimbates - I was accepted into the trial, but chose not to do it. I was told possible flu like symptoms for 24-48 hours and possible damage to auto-immunity (?) which they said they could reverse (also ?). I am curious as to what the side effects really were. The way it was explained to me was that I was there to find out what the side effects would be.

Dx 12/8/2017, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ Targeted Therapy 1/23/2018 Herceptin (trastuzumab) Targeted Therapy 1/23/2018 Perjeta (pertuzumab) Chemotherapy 1/23/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 5/22/2018 Lumpectomy: Left Surgery 6/12/2018 Lumpectomy: Left Radiation Therapy 7/18/2018 Whole-breast: Breast Hormonal Therapy 10/10/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 12, 2019 10:25AM - edited Nov 12, 2019 10:30AM by Healing_Journey

I've recently been accepted into the Phase 1 trial for WOKVAC recurrence prevention for HER2-. I expect to start late this month or early Dec. I am curious to hear from other participants as well

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Nov 12, 2019 11:26AM janky wrote:

Welcome to this site - amazing information and support!

Healing_ - Let us know how the trial goes (really, really well I hope!) I also hope the SEs are minimal.

Dx 11/7/2016, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 12/16/2016 Chemotherapy 2/9/2017 Radiation Therapy 5/16/2017

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