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Topic: Antibiotic may prevent breast cancer recurrence

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Oct 8, 2018 02:19PM

wallycat wrote:

https://www.medicalnewstoday.com/articles/323262.p...


Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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Oct 8, 2018 04:55PM - edited Oct 8, 2018 05:04PM by mike3121

Interesting article. My wife was recently diagnosed as pCR or NED. Her extensive triple negative mets to spine and hips were totally eliminated by eribulin (Halaven). She has to endure a number of additional cycles of eribulin until the Dr feels it safe to drop all treatment. He said a couple clear PET scans would convince him. This antibiotic doxycycline might be a good addition to treatment. I wonder if this doxycycline has some conflicts with her chemo eribulin treatments? Also, a prescription is necessary (US) for this anti-bacterial malaria drug.

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Oct 8, 2018 08:51PM wallycat wrote:

Yes, a Rx is necessary. It is also used in Rosacea, and Lyme disease treatment, not only malaria, so may be easier to obtain "off label."


Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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Oct 8, 2018 09:33PM DATNY wrote:

Wow. Just wow.I don't even have words. I should pass this to my doc. For years I've been telling her I feel much better after an antibiotics course unrelated to my main problem. Maybe that's why my her2+ cancer got slowed down to a grade 1. Thank you for sharing! Another piece in my puzzle.

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Oct 8, 2018 09:50PM LeesaD wrote:

Wow interesting article...just finished a couple of days ago a 10 day course of doxycycline for bronchitis.
Oncotype Score 3, 2/4 Sentinal Nodes micromestasis so pushed for ALND for 'peace of Mind' and surprise found 2/14 positive axillary nodes Dx 2/3/2017, IDC, Right, 3cm, Stage IIB, Grade 2, 4/18 nodes, ER+/PR+, HER2- Surgery 3/26/2017 Lymph node removal: Right, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 4/16/2017 Lymph node removal: Underarm/Axillary Chemotherapy 5/8/2017 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 8/1/2017 Hormonal Therapy 9/7/2017 Arimidex (anastrozole), Zoladex (goserelin) Surgery 11/16/2017 Prophylactic ovary removal Surgery 1/29/2018 Reconstruction (left): Fat grafting, Silicone implant; Reconstruction (right): Fat grafting, Silicone implant
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Oct 9, 2018 12:15AM PreludeSing wrote:

Um I took doxycycline for years for acne. Um...i only stopped in 2013 and then got BC in 2017....

Dx 6/2/2017, IDC, Left, 4cm, Stage IIB, Grade 2, 2/24 nodes, ER+/PR+, HER2- Surgery 6/5/2017 Lymph node removal: Left, Right, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 6/26/2017 AC + T (Taxol) Radiation Therapy 11/26/2017 Whole-breast: Breast, Lymph nodes Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin)
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Oct 9, 2018 05:21AM Rah2464 wrote:

My PS had me take Doxycycline after my surgery. Fingers crossed it helped clean up any errant cells! Very interesting.

Dx 5/23/2018, IDC, Left, 1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2- (IHC) Surgery 6/27/2018 Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 7/27/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 18, 2018 08:03AM LillyDuff wrote:

Wow! Fantastic! Hope we hear more about this one!

Dx 4/25/2017, IDC, Left, 2cm, Stage IIB, Grade 3, 0/4 nodes, ER+/PR-, HER2+ (FISH) Chemotherapy 5/15/2017 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 5/16/2017 Perjeta (pertuzumab) Targeted Therapy 5/16/2017 Herceptin (trastuzumab) Surgery 11/14/2017 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 1/25/2018 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 7/18/2018 Prophylactic ovary removal Hormonal Therapy 9/30/2018 Arimidex (anastrozole) Surgery 11/16/2018 Reconstruction (right): Fat grafting Surgery Hormonal Therapy Arimidex (anastrozole)
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Oct 22, 2018 09:43PM FarAwayToo wrote:

Rah, similarly, I had Doxycycline after mastectomy.

Dx 8/31/2017, IDC, Right, 2cm, Stage IIA, Grade 2, 0/4 nodes, ER+/PR+, HER2- Dx 9/15/2017, DCIS, Left, 3cm, Stage 0, Grade 1, 0/3 nodes, ER+/PR+, HER2- Chemotherapy 9/29/2017 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxol (paclitaxel) Hormonal Therapy 2/23/2018 Zoladex (goserelin) Surgery 2/28/2018 Mastectomy: Left, Right Surgery 2/28/2018 Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy 4/5/2018 Femara (letrozole) Surgery 8/21/2018 Prophylactic ovary removal; Reconstruction (left): Saline implant; Reconstruction (right): Saline implant
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Oct 23, 2018 01:52AM - edited Oct 23, 2018 08:16AM by Wildplaces

Prof Michael Lisanti has been working on this for more than 5 years.

It seems that combining doxycycline with a second compound - eg Vit C - may be beneficial.

https://www.salford.ac.uk/news/articles/2017/vitam...

What bothers me is given the plausible biological mechanism and the relative high safety profile of doxycycline why dont we have more data on this?? If it works its pure genius.

And it would tie it back to Linus Pauling - the only person to win two unshared Nobel prizes: chemistry and peace, who later fell into disrepute over his beliefs on Vit C, common cold and cancer. Was this man considered to be in the top 20 scientists of all times right after all??

The biggest problem with Vit C is biovailability - anything that does not come out of a fruit/plant has shocking absorption.

History will show us but I so wish we get big number trials in place sooner rather than later.

The big pharma will not subsidize a drug like doxycycline as there is no money in it.

Dx 8/5/2016, DCIS/IDC, Left, 4cm, Stage IIB, Grade 2, 1/13 nodes, ER+/PR+, HER2- Surgery 8/11/2016 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Prophylactic ovary removal Chemotherapy 9/11/2016 AC + T (Taxol) Radiation Therapy 2/21/2017 External: Lymph nodes, Chest wall Hormonal Therapy Arimidex (anastrozole)
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Oct 23, 2018 02:00AM Wildplaces wrote:

It appears the idea was brought ot them by his daughter - a mind with no preconceived ideas on what should or should not work.

https://www.dailymail.co.uk/health/article-2930753...

its a good story ☺️🐣

Dx 8/5/2016, DCIS/IDC, Left, 4cm, Stage IIB, Grade 2, 1/13 nodes, ER+/PR+, HER2- Surgery 8/11/2016 Lymph node removal: Underarm/Axillary; Mastectomy: Left; Prophylactic ovary removal Chemotherapy 9/11/2016 AC + T (Taxol) Radiation Therapy 2/21/2017 External: Lymph nodes, Chest wall Hormonal Therapy Arimidex (anastrozole)
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Oct 23, 2018 05:45AM Rah2464 wrote:

I see my PS and my BS both again in January. I am going to bring this article to their attention. Maybe that post surgery doxy can be made higher strength for future patients.

Dx 5/23/2018, IDC, Left, 1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2- (IHC) Surgery 6/27/2018 Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy 7/27/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 12, 2018 06:52PM Salamandra wrote:

This is such a tiny sample size. But I want to believe!

I am meeting my radiation oncologist for the first time on Friday. I will ask him if I can take this during radiation and see if it might help with the destruction of the whole cancer cells...

Dx at 39. 1.8cm. Oncotype 9. Dx 9/19/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 10/17/2018 Lumpectomy; Lymph node removal: Sentinel Hormonal Therapy 11/1/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 12/2/2018 Whole-breast: Breast Hormonal Therapy 12/18/2019 Fareston (toremifene)
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May 18, 2019 09:10AM - edited May 18, 2019 10:49PM by chocomousse

For those who asked their doctors about this, what was their response?

Dx 4/23/2015, DCIS, Right, 5cm, Stage 0, Grade 3, ER+/PR+ Surgery 8/17/2015 Lymph node removal: Sentinel; Mastectomy: Right Dx 8/18/2015, IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2+ (IHC)

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