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Topic: Dying of something else....

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Jul 27, 2019 10:29AM

wallycat wrote:

https://www.wired.com/story/cancer-treatment-darwi...

fascinating article on managing cancer rather than trying to eradicate it.

Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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Jul 27, 2019 11:13AM Peregrinelady wrote:

Thanks for posting, Wallycat. Fascinating, indeed! Darwin has always been my hero and this is so interesting how his work has been used for studying how cancer cells behave. This gives me hope and I also wonder if this applies to the antihormonals. I had an oncologist say something about taking breaks with the AI after 5 years, but still keep taking it. I am afraid to skip a day right now, but if my osteopenia worsens, I may consider taking short breaks.
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Surgery 5/18/2015 Mastectomy: Left Hormonal Therapy 6/1/2015 Liquid tamoxifen (Soltamox) Surgery 4/18/2016 Mastectomy: Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole) Hormonal Therapy 7/20/2020 Femara (letrozole)
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Jul 27, 2019 11:21AM BevJen wrote:

wow -- such an interesting read!

Dx 11/2003, ILC, Left, Stage IIIC, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+ Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 8/1/2019 Ibrance (palbociclib) Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Jul 27, 2019 11:38AM edj3 wrote:

Thanks for sharing, fascinating article!

Tried the tamoxifen, no thanks. Dx 4/9/2019, IDC, Left, <1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2- (IHC) Dx 5/6/2019, LCIS, Left, <1cm, 0/1 nodes Surgery 5/6/2019 Lumpectomy; Lymph node removal: Sentinel Radiation Therapy 6/2/2019 Whole-breast: Breast Hormonal Therapy 9/23/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 27, 2019 12:22PM GG27 wrote:

Great article. I think this is similar to the program my MO has me on. I am taking 500mg of Xeloda 2x a day for 14 days on/ 7 off. When I get my CT & bone scans at 12 weeks we will access & make a decision what to do. My MO knows that I have a really tough time on new meds & usually need either a dose reduction almost immediately or like with alpelisib, I couldn't tolerate it at all, lasted 10 days which felt like 10 months.

Dx 10/2008, IDC, Both breasts, 3cm, Stage IIB, Grade 2, 3/9 nodes, mets, ER+/PR+, HER2- Surgery 1/8/2009 Lymph node removal; Mastectomy: Left, Right Chemotherapy 2/1/2009 Other Radiation Therapy 7/5/2009 Whole-breast: Breast, Lymph nodes Dx 5/14/2014, IDC, Both breasts, Stage IV, metastasized to bone, 9/20 nodes, mets, ER+/PR+, HER2- Chemotherapy Doxil (doxorubicin)
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Jul 27, 2019 12:53PM Momchichi wrote:

I think all of us would be excited by a less is more approach to chemo for the long-term. I think it fits in well with the positive trend toward individualized medicine and focus on the body’s microenvironment. Best article I’ve read in awhile - thanks for sharing!

Dx at 38, TN in breast, HER2 + in some nodes. TN met to L2 at 40. Dr thinks I was never HER2+ & it was a false + from neoadjuvant chemo - whaaat??? Dx 7/19/2017, DCIS/IDC, Right, 4cm, Stage IIIC, Grade 3, 16/19 nodes, ER-/PR-, HER2+ (FISH) Chemotherapy 8/9/2017 AC Chemotherapy 9/27/2017 Taxol (paclitaxel) Surgery 1/18/2018 Lumpectomy: Right; Lymph node removal: Underarm/Axillary Targeted Therapy 2/16/2018 Perjeta (pertuzumab) Targeted Therapy 2/16/2018 Herceptin (trastuzumab) Chemotherapy 2/16/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Radiation Therapy 6/23/2018 Whole-breast: Breast, Lymph nodes, Chest wall Dx 6/19/2019, Stage IV, metastasized to bone, Grade 3, ER-/PR-, HER2- (IHC) Radiation Therapy 8/12/2019 External: Bone Chemotherapy 9/4/2019 Xeloda (capecitabine) Dx 11/22/2019, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 12/6/2019 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 1/6/2020 Abraxane (albumin-bound or nab-paclitaxel) Immunotherapy 1/10/2020 Tecentriq (atezolizumab) Targeted Therapy Trodelvy (sacituzumab govitecan-hziy)
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Jul 27, 2019 07:34PM Jsniffs wrote:

Great article!! Thanks for sharing.

Original dx at 36 while pregnant. My daughter and family give me hope. You never know what you can get through until you have to. Dx 1/2016, IDC, Right, Stage IIIA, 7/39 nodes, ER+/PR+, HER2- (IHC) Dx 12/2018, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2-

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