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Topic: Clinical trial - testosterone pellets

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Aug 6, 2019 04:20PM - edited Aug 6, 2019 04:21PM by SophiaMarie

SophiaMarie wrote:

From what I'm understanding, this trial looking for the effects of testosterone pellets on breast cancer incidence should've been completed in March of '18. (Correct me if I'm wrong!). I was wondering how long it takes for the final report to be released? Shouldn't it be out by now?? My dr is leaning towards doing this, and I'm trying to do my research beforehand. I'd love to know what the final results are


https://www.ncbi.nlm.nih.gov/pubmed/24028858 this is the half-way through report

Dx 7/2013, IDC, ER+/PR+, HER2- Surgery 8/5/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Dx IDC, 2cm, Stage IIA, Grade 2, 0/1 nodes, ER+/PR+, HER2-
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Aug 6, 2019 04:26PM Beaverntx wrote:

SophiaMarie, Just had a similar conversation with my BS! Do you have any links you could provide? I've searched very briefly without any great success but also have been busy with other things. I'll see her again in November when we are supposed to discuss in more detail. I'd really like to know more before then. Will share whatever I find, if anything. Do you know where the trial was cpnducted?

Diagnosed at age 77-- Oncotype 17, dealing with this bump in the road of life!!🎆 Dx 1/24/2018, IDC, Right, 2cm, Stage IB, Grade 3, 0/9 nodes, ER+/PR+, HER2- (IHC) Dx 1/30/2018, DCIS, Right, <1cm, Stage 0 Surgery 1/30/2018 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 3/11/2018 Whole-breast: Breast Surgery 6/15/2018 Prophylactic ovary removal Hormonal Therapy 6/19/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 6, 2019 05:35PM LoriCA wrote:

The study concluded in December 2018 and it doesn't appear that any results have been posted yet. From what I see it wasn't an actual trial, it was an observational study of women who had previously received testosterone implants because of hormone deficiencies to see if it affected their rate of breast cancer. Pre-existing breast cancer was an exclusion criteria for the study.

https://clinicaltrials.gov/ct2/show/NCT03768258

IBC Stage IV de novo - mets throughout skeleton (bones & now bone marrow), liver, dozens of distant nodes, chest wall/pec muscle, skin, tumor in brachial nerves, thyroid, polycythemia from bone marrow involvement Dx 9/8/2017, IBC, Right, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2+ (IHC) Chemotherapy 9/26/2017 Taxol (paclitaxel) Targeted Therapy 2/6/2018 Perjeta (pertuzumab) Targeted Therapy 2/6/2018 Herceptin (trastuzumab) Chemotherapy 11/26/2018 Taxol (paclitaxel) Radiation Therapy 1/30/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Aug 6, 2019 05:56PM SophiaMarie wrote:

ok - I hadn’t caught that it excluded women with a bc history. It’s so frustrating - it’s so hard to find concrete info.


Dx 7/2013, IDC, ER+/PR+, HER2- Surgery 8/5/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Dx IDC, 2cm, Stage IIA, Grade 2, 0/1 nodes, ER+/PR+, HER2-
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Aug 6, 2019 06:17PM SophiaMarie wrote:

I looked up the dr’s name in the link that LoriCA posted - found some interesting info. Still reading, but here’s a link http://hormonebalance.org/pdf/Rapid_response_of_breast_cancer_to_neoadjuvant.98498.pdf

Dx 7/2013, IDC, ER+/PR+, HER2- Surgery 8/5/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Dx IDC, 2cm, Stage IIA, Grade 2, 0/1 nodes, ER+/PR+, HER2-
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Aug 6, 2019 06:37PM Gussy wrote:

In the past I have read another paper about this treatment and it also had a positive outcome. My PCP does pellet insertion of estrogen, testosterone and maybe something else in non-cancer patients. This is to help them feel better which it evidently does. Next time I see her I'm going to mention these studies and see what she says. If you noticed, the one referenced above was done in 2013. Six years later, nothing more??

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