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Topic: San Antonio BC Symposium ‘19! It’s here!

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Dec 10, 2019 03:35PM

voraciousreader wrote:

https://www.sabcs.org/2019-SABCS


Dec 10-14

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Posts 1 - 29 (29 total)

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Dec 10, 2019 04:35PM Peregrinelady wrote:

I hope we hear about new guidelines on antihormonals and more treatments for preventing and treating MBC. Any studies that we may be hearing about? Are they finished with TailorX or are there more results expected?
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Surgery 5/17/2015 Mastectomy: Left Hormonal Therapy 5/31/2015 Liquid tamoxifen (Soltamox) Surgery 4/18/2016 Mastectomy: Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole) Hormonal Therapy 7/19/2020 Femara (letrozole)
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Dec 11, 2019 12:14AM voraciousreader wrote:

TailorX “results” will continue to be published for years to come. While the initial, long awaited results were presented a year ago, subsequent results continue....here is one that was published two months ago in JAMA....

https://www.ptcommunity.com/wire/new-tailorx-data-published-today-jama-oncology-add-strong-evidence-base-reinforcing-





REDWOOD CITY, Calif., Sept. 30, 2019 /PRNewswire/ -- Genomic Health, Inc. (NASDAQ: GHDX) today announced results from a new analysis of the Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, which reinforce the unique value of the Oncotype DX Breast Recurrence Score® test to guide the use of adjuvant chemotherapy for women with hormone receptor-positive (HR+), HER2-negative, early-stage breast cancer and identify those patients who derive a significant benefit from treatment. The findings, published today in JAMA Oncology1 and presented at the ESMO 2019 Congress2, are consistent with results from the B20 trial3 and show that, in patients with high Recurrence Score results (26-100) treated with endocrine therapy plus chemotherapy, outcomes were better compared to what would be expected with endocrine therapy alone. The analysis also provides details on the outcomes of different chemotherapy regimens for the minority of patients who benefit from chemotherapy.
......




furthermore....for those patients with 1-3 positive nodes, with respect to the OncotypeDX test, the trial is “closed”, so hopefully in 2021 we should start seeing those results....


https://www.swog.org/clinical-trials/s1007




i haven’t had the time to look at an outline of the presentations, but I am sure there should, as always, be some outstanding info to chew on!



Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 11, 2019 12:53PM Peregrinelady wrote:

Thanks, voracious! I am looking forward to hearing any new information, as well.
Dx 4/24/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 1/2 nodes, ER+/PR+, HER2- Surgery 5/17/2015 Mastectomy: Left Hormonal Therapy 5/31/2015 Liquid tamoxifen (Soltamox) Surgery 4/18/2016 Mastectomy: Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 7/31/2016 Arimidex (anastrozole) Hormonal Therapy 7/19/2020 Femara (letrozole)
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Dec 12, 2019 03:49AM Spoonie77 wrote:

I'm looking forward to the news as well! Thanks for sharing. :)

"Spoonie" who entered BC World @ 41. DXd w/MS & Thyroid Cancer @42. Treatment: LX/SLNB/RADs. Plan A: 5mg Tamox = 0 QOL. Plan B: OS/AI = Rare allergy to OS meds. Plan C: Only option left,  Diet & Exercise. PS: Not a dr, just a Googler. Dx 7/20/2018, IDC, Left, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 8/29/2018 Lumpectomy: Left; Lymph node removal: Left, Sentinel Dx 8/30/2018, DCIS, Left, 1cm, Stage 0, Grade 2 Radiation Therapy 9/30/2018 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 3/29/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 7/1/2019 Zoladex (goserelin)
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Dec 12, 2019 02:35PM voraciousreader wrote:

https://www.fiercebiotech.com/biotech/sabcs-astrazeneca-daiichi-s-adc-keeps-breast-cancer-at-bay-for-16-months

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 12, 2019 02:36PM voraciousreader wrote:

https://www.mysanantonio.com/news/texas/article/New-drugs-show-rare-promise-against-advanced-14898697.php

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 12, 2019 02:40PM voraciousreader wrote:

https://www.streetinsider.com/Accesswire/Celcuity+Presents+Results+at+the+2019+San+Antonio+Breast+Cancer+Symposium+Evaluating+a+Sub-Group+of+PIK3CA+WT+Breast+Cancer+Patients+Who+Have+Hyperactive+Signaling+Tumors+Responsive+to+PI3K+Inhibitors/16235695.html

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 12, 2019 02:43PM voraciousreader wrote:

https://www.oncnet.com/news/adding-capecitabine-standard-adjuvant-chemo-improves-dfs-patients-tnbc

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 12, 2019 02:49PM voraciousreader wrote:

https://www.journalofclinicalpathways.com/news/cost-effectiveness-neoadjuvant-adjuvant-therapy-combinations-her2-positive-breast-cancer

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 13, 2019 12:13PM voraciousreader wrote:

https://www.targetedonc.com/conference/sabcs-2019/preventative-breast-cancer-effect-maintained-with-anastrozole-in-longterm-followup-data

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 13, 2019 12:15PM voraciousreader wrote:

https://www.eurekalert.org/pub_releases/2019-12/no-1ro121219.php

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 13, 2019 12:19PM voraciousreader wrote:

https://www.prnewswire.com/news-releases/new-evidence-from-large-studies-highlights-value-of-oncotype-dx-breast-recurrence-score-to-guide-chemotherapy-treatment-in-young-patients-with-node-negative-or-node-positive-early-stage-breast-cancer-300973702.html

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 13, 2019 12:22PM voraciousreader wrote:

https://www.onclive.com/conference-coverage/sabcs-2019/extended-followup-shows-continued-olaparib-benefit-in-brca-mbc

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 13, 2019 02:43PM illimae wrote:

Following

Thanks for sharing :)

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Targeted Therapy 1/2/2017 Perjeta (pertuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, 5cm, Stage IV, metastasized to brain, Grade 3, 3/13 nodes, ER+, HER2+ (IHC) Radiation Therapy 10/20/2017 External: Brain Radiation Therapy 4/18/2018 External: Brain Radiation Therapy 5/23/2019 External: Brain Surgery 1/22/2020 Radiation Therapy 2/17/2020 External: Brain Radiation Therapy 7/20/2020 External: Bone Targeted Therapy Tukysa (tucatinib) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 14, 2019 10:52AM voraciousreader wrote:

https://www.biospace.com/article/releases/briacell-announces-clinical-data-as-presented-at-the-2019-san-antonio-breast-cancer-symposium-/

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 10:52AM voraciousreader wrote:

https://www.cancertherapyadvisor.com/home/news/conference-coverage/san-antonio-breast-cancer-symposium-sabcs/sabcs-2019/breast-cancer-maintenance-durvalumab-shows-activity-certain-subgroups/

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 10:54AM voraciousreader wrote:

https://www.cancertherapyadvisor.com/home/news/conference-coverage/san-antonio-breast-cancer-symposium-sabcs/sabcs-2019/breast-cancer-drugs-study-finds-lack-substantial-clinical-benefit/

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 10:55AM voraciousreader wrote:

https://www.cancertherapyadvisor.com/home/news/conference-coverage/san-antonio-breast-cancer-symposium-sabcs/sabcs-2019/breast-cancer-paclitaxel-trastuzumab-offers-same-survival-outcomes/

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 10:57AM voraciousreader wrote:

https://www.cancertherapyadvisor.com/home/news/conference-coverage/san-antonio-breast-cancer-symposium-sabcs/sabcs-2019/breast-cancer-tnbc-detection-ctdna-worse-clinical-outcomes/

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 11:05AM voraciousreader wrote:

https://www.ajmc.com/conferences/sabcs-2019/age-associated-to-benefit-derived-from-chemotherapy-for-women-with-luminal-breast-cancer-mindact-trial-finds-

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 11:10AM voraciousreader wrote:

https://www.nbcnews.com/health/womens-health/breast-cancer-risk-some-menopause-hormones-may-last-decades-n1101646

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 11:12AM voraciousreader wrote:

https://www.curetoday.com/conferences/sabcs-2019/awareness-for-men-with-breast-cancer-is-starting-to-take-hold-at-major-conferences

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 11:23AM voraciousreader wrote:

https://www.onclive.com/conference-coverage/sabcs-2019/neoadjuvant-olaparib-combo-safe-in-breast-cancer

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 14, 2019 11:24AM voraciousreader wrote:

https://www.onclive.com/conference-coverage/sabcs-2019

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 15, 2019 03:51AM voraciousreader wrote:

https://eurekalert.org/pub_releases/2019-12/mc-mcr120919.php

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 15, 2019 03:53AM voraciousreader wrote:

there are some great studies being reported...

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 15, 2019 03:53AM voraciousreader wrote:

https://www.ajmc.com/conferences/sabcs-2019/personalizing-breast-cancer-how-liquid-biopsy-testing-for-ctdna-ctcs-can-promote-preventive-care

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 15, 2019 03:56AM voraciousreader wrote:

https://www.eurekalert.org/pub_releases/2019-12/no-bt121319.php

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Dec 15, 2019 03:58AM voraciousreader wrote:

https://www.globenewswire.com/news-release/2019/12/14/1960639/0/en/Myriad-s-Polygenic-Risk-Score-Personalizes-Risk-of-Breast-Cancer-for-Woman-with-a-Genetic-Mutation-in-Important-Breast-Cancer-Genes.html

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)

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