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Topic: The ELAINE study is recruiting (Lasofoxifene). Read here.

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Dec 10, 2019 06:27PM - edited Dec 10, 2019 06:30PM by Moderators

Moderators wrote:

The ELAINE study is evaluating an investigational oral drug, Lasofoxifene, in postmenopausal women diagnosed with locally advanced or metastatic estrogen-receptor-positive, HER2-negative breast cancer with an ESR1 mutation who have had the cancer grow while being treated with an aromatase inhibitor in combination with a CDK4/6 inhibitor.

People are eligible to participate in the ELAINE study if they:

are postmenopausal women

have been diagnosed with locally advanced or metastatic estrogen-receptor-positive, HER2-negative breast cancer with an ESR1 mutation

have had the cancer grow while being treated with an aromatase inhibitor in combination with a CDK4/6 inhibitor

The ELAINE trial is being conducted at multiple sites around the United States.

For more information, to find a trial site near you, or to enroll, visit the ELAINE Trial page on Breastcancer.org:https://www.breastcancer.org/treatment/clinical_trials/featured/elaine

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Mar 16, 2020 10:51AM AlabamaDee wrote:

Here is another newstudy for ESR1 mutation

https://clinicaltrials.gov/ct2/show/NCT04256941

Primary neuroendocrine breast cancer Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)

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