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Topic: Genome study links DNA changes to risks of specific BC subtypes

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: May 19, 2020 06:07PM

wallycat wrote:

https://www.sciencedaily.com/releases/2020/05/2005...



Dx 4/07 1 month before turning 50; ILC 1.8cm, ER+/PR+, HER2 neg., Stage 1, Grade 2, 0/5 nodes. Onco score 20, Bilateral Mast., tamoxifen 3-1/2 years, arimidex-completed 4/20/2012
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May 20, 2020 05:03PM BlueGirlRedState wrote:

wallycat - than you for posting this. I am going to repost this to breaking research. In Sept 2019 my DR ordered a genetic profile specific to BC, looking at 20+markers. This is the 3rd time for BC, DR thinks each incidence is a new cancer rather than recurrence, but admits theres is know way of really knowing. Fighting the denial from insurance who claims it is not relevant to diagnosis or treatment.

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Dec 20, 2020 11:03AM chocomousse wrote:

Do you have access to the full article? If so, can you post the names of the genes that are linked to each breast cancer subtype?

"In all, the analysis identified 32 new risk variants for breast cancer generally. Of these, 15 variants were also linked independently to one or more specific breast cancer subtypes. Seven of the 15 were linked to estrogen receptor status, seven to the tumor grade, four to HER2 receptor status and two to progesterone receptor status."

Dx 4/23/2015, DCIS, Right, 5cm, Stage 0, Grade 3, ER+/PR+ Surgery 8/17/2015 Lymph node removal: Sentinel; Mastectomy: Right Dx 8/18/2015, IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2+ (IHC)
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Dec 20, 2020 11:08AM MelissaDallas wrote:

Here is more specific information

https://www.nature.com/articles/nature11412


LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor. Dx 5/20/2012, LCIS, Stage 0, 0/0 nodes
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Dec 20, 2020 12:50PM moth wrote:

The study the original article was talking about is this one https://www.nature.com/articles/s41588-020-0609-2

I have the full text if someone wants it. pm me

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/2/2021 External: Bone

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