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Topic: First New Drug in Years ... Receptor Positive Early BC

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Sep 21, 2020 02:59PM

nnguyen wrote:

I usually post only Her2Positive and late Met articles. But I was caught by the phrase "…first time in 20 years…" in the articles below so here we are. By the way, my wife Her2+++ is taking Abemaciclib at a lower dose.

Definition of "high risk" early stage ER+ Her2- bc: "…High risk was defined as patients with four or more positive pathologic axillary lymph nodes or one to three positive axillary lymph nodes and at least one of the following: tumor size ≥ 5 cm, histologic grade 3, or centrally assessed Ki-67 ≥ 20%..."

Ki-67 protein (nuclear proliferation marker): < 10% low, 10-20% < moderate ; > 20% high; higher percentage = faster proliferation. Unfortunately (or fortunately) as are the cases of ER/PR receptors (12-15% discordance) and Her2 (6-8%) it is possible to have discordance between primary site and metastatic site.




The easy to read version.

https://www.esmo.org/newsroom/press-...he-abemaciclib

The detail version.

https://ascopubs.org/doi/full/10.1200/JCO.20.02514

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