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Topic: Hormones after breast cancer: Not fuel for the fire after all?

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Nov 5, 2020 10:42PM

Tajmari wrote:

Anybody hear about this? AI is making me feel crippled. I've been on anastrozole for two years. Some days I can barely walk, the pain in my legs is so bad.

New research suggests a different route:

I'd be interested if anyone is considering this type of treatment. Cheers!

We're like the dreamer who dreams and then lives inside the dream. -- Monica Belucci in Twin Peaks. Dx 5/2018, IDC, Left, 2cm, Stage IB, Grade 2, 3/14 nodes, ER+/PR+, HER2- (FISH) Surgery 8/9/2018 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Saline implant, Tissue expander placement Hormonal Therapy 9/10/2018 Arimidex (anastrozole), Aromasin (exemestane) Hormonal Therapy Radiation Therapy Breast, Lymph nodes
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Nov 6, 2020 04:59AM Jelson wrote:

noting this study has only been done in mice, I certainly hope that this model continues to be researched because the side-effects of AIs can truly destroy quality of life.

Dx 4/17/2009, DCIS, <1cm, Stage 0, Grade 3, 0/0 nodes, ER+/PR+
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Nov 6, 2020 07:51AM mightlybird01 wrote:

I am triple negative so don't have to take any hormone blockers, but I am still very interested and will discuss this with my team at the University. I can definitely see how this could be true.

Dx 4/12/2019, IDC/IDC: Medullary, Right, 2cm, Stage IIA, Grade 3, 0/3 nodes, ER-/PR-, HER2- (FISH) Chemotherapy 5/21/2019 AC + T (Taxol) Surgery 11/7/2019 Mastectomy: Right
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Nov 6, 2020 10:42AM buttonsmachine wrote:

Wow, thanks for posting this! It would be great if science found a better solution than simply depriving us of our hormones. I hope this research can continue.

Diagnosed at 32. Local recurrences one year later, probably due to needle seeding at inital biopsy. Now dealing with MBC. Dx 8/2016, IDC, Right, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 10/1/2016 Lumpectomy: Right; Lymph node removal: Sentinel Chemotherapy 11/1/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 2/1/2017 Whole-breast Hormonal Therapy 4/1/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 10/2017, IDC, Right, Grade 3, 2/12 nodes, ER+/PR+, HER2- Surgery 11/1/2017 Lymph node removal; Mastectomy: Right Chemotherapy 12/1/2017 AC Surgery 4/1/2018 Lymph node removal; Mastectomy: Right Radiation Therapy 5/1/2018 External: Lymph nodes, Chest wall Chemotherapy 7/1/2018 Xeloda (capecitabine) Hormonal Therapy 7/30/2018 Zoladex (goserelin) Hormonal Therapy 2/1/2019 Aromasin (exemestane) Hormonal Therapy 9/30/2019 Faslodex (fulvestrant) Dx 8/2020, IDC, Stage IV, metastasized to bone/other, Grade 3, ER+/PR+, HER2- Targeted Therapy 8/30/2020 Ibrance (palbociclib) Dx 1/2021, IDC, Stage IV, metastasized to liver/lungs Chemotherapy 1/15/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Nov 6, 2020 11:30AM Beesie wrote:

Interesting concept but unfortunately I wouldn't put much hope in a mouse study from 2014. Mouse studies are where most research starts, and key advancements develop from there, but the vast majority of mouse studies end up not yielding positive results once they move to the next step.

Since this came out in 2014, I looked to find more recent studies that reference this study; I wondered if there was any follow-up research. Perhaps there is, but none of the studies I found that included a reference to this study followed up on same premise. I also checked the clinical trials database and found a couple of interesting, somewhat related studies:

ER Reactivation Therapy for Breast Cancer (POLLY)

Estrogen for Triple Negative Breast Cancer

Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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Nov 6, 2020 04:31PM exbrnxgrl wrote:

I’m not the researcher that beesie is but I too would not put much weight on a mouse study from six years ago

Bilateral mx 9/7/11 with one step ns reconstruction. As of 11/21/11, 2cm met to upper left femur Dx 7/8/2011, IDC, Left, 4cm, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Surgery 9/7/2011 Lymph node removal: Left; Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Dx 11/2011, IDC, Left, 4cm, Stage IV, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 11/21/2011 Arimidex (anastrozole) Radiation Therapy 11/21/2011 Bone Hormonal Therapy 6/19/2014 Femara (letrozole) Hormonal Therapy Aromasin (exemestane)
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Nov 7, 2020 04:35PM - edited Nov 7, 2020 04:36PM by WC3

The great cancer/hormone puzzle. It's like someone has given us a safe with an 6 digit combination of unique numbers, told us all of the digits in the combination and we have to determine the order. Doable but who's doing it?

Pathologic complete response (pCR) to chemotherapy. Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 5/31/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/14/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy Arimidex (anastrozole), Zoladex (goserelin) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant

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