Join Us

We are 224,438 members in 83 forums discussing 163,550 topics.

Help with Abbreviations

Topic: The DESTINY-Breast06 trial is enrolling - learn more here!

Forum: Clinical Trials, Research News, Podcasts, and Study Results —

Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.

Posted on: Jul 29, 2021 04:04PM

Moderators wrote:

The DESTINY-Breast06 trial is enrolling people with metastatic hormone-receptor-positive breast cancer with low HER2 levels that has been previously treated with at least two hormonal therapies

The DESTINY-Breast06 trial is for people diagnosed with metastatic hormone-receptor-positive breast cancer with low HER2 levels that has been previously treated with at least two hormonal therapy medicines.

In this study, HER2-low breast cancer means the cancer has a score of 1+ or 2+ on an immunohistochemistry (IHC) HER test and/or a negative result on a in situ hybridization (ISH) HER2 test.

The trial wants to see if fam-trastuzumab-deruxtecan-nxki (brand name: Enhertu) allows people to live longer without the metastatic cancer growing or simply live longer overall, compared to people being treated with standard-of-care chemotherapy. The trial also will collect information on how the treatment affects people's quality of life.

Fam-trastuzumab-deruxtecan-nxki is given intravenously, which means the medicine is delivered directly into your bloodstream through an IV or a port. The medicine usually is given every 3 weeks unless the cancer grows or unacceptable side effects develop.

People are eligible for the DESTINY-Breast06 trial if:

  • they are a legal adult in their country and have been diagnosed with metastatic hormone-receptor-positive, breast cancer with low HER2 levels that was never considered HER2-positive
  • the metastatic cancer has been previously treated with at least two hormonal therapy medicines and has grown while being treated with hormonal therapy
  • the metastatic cancer has not been treated with chemotherapy

The DESTINY-Breast06 trial is being conducted at multiple sites around the world and the United States. For a complete list of sites, visit https://clinicaltrials.gov/ct2/show/NCT04494425.

For more information on detailed eligibility requirements or to enroll https://www.breastcancer.org/treatment/clinical_trials/featured#destiny6)



To send a Private Message to the Mods: community.breastcancer.org/mem...