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Topic: How long does Femara stay in your system?

Forum: Hormonal Therapy - Before, During, and After —

Risks and benefits, side effects, and costs of anti-estrogen medications. Note: Please remember that there are good experiences and bad with ALL treatments and this is a safe place to share YOUR experience, not to be influenced or influence others.

Posted on: Nov 7, 2007 09:22AM - edited Nov 7, 2007 09:22AM by amg

amg wrote:

I am going to take at least a little break from Femara, and I was wondering if anyone knows how long it takes to completely leave your system??  Thanks so much!!

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Nov 7, 2007 01:45PM planetstrands wrote:

i am curious about that, but i can't help. while we're at it, i have been wondering the same thing about aromasin. how long for the SEs to ease off?


lancaster, pa 

"i will carry you through the hurricane waters", citizen cope Dx 4/1/2003, IDC, 1cm, Stage II, Grade 1, 3/14 nodes, ER+/PR+, HER2-
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Nov 8, 2007 01:12AM Hana wrote:

I finished Femara end of August this year. I was taking also Didrocal for bones. Since I finished that one now too, I went to my doctor to confirm that I don't need to take it any more since I am finished with Femara.

NOT SO.... She said that because it takes long time for my body to get rid of Femara, I still have to take Didrocal for minimum another 6 months. So I guess we can  presume, that at least 6 more months after stopping taking it, we still have Femara in our system.

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Nov 8, 2007 05:03AM amg wrote:

Thanks so much for your response, and congratulations on finishing up with Femara!!

I haven't quite decided what I am going to do yet.  I am premenopusal and have been receiving Zoladex/Femara shots for the past two years.  I know this is controversial, and so I am going for one more opinion.

Congrats again!

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Nov 8, 2007 09:10PM Simone wrote:

Hana are you sure that it take 6 months.

I would have said not very long because when you read the medical sites describing the medication you understand that femara works on a day our two day basis.   That is why they say that if you have forgotte you pill wait for the day after.  And that is why the advise you  also to try not to forget to take it.  And that all the sides effects go as soon as you stop taking femara.

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Nov 8, 2007 11:55PM Hana wrote:

I don't know. I trust my doctor as she is a "Smart Cookie" as I was told by Emergency Staff in the hospital.Smile

What you are saying sounds right too. Then again - the bone pills I am advised to take for another 6 months are not going to cause me any harm. So be it.

I was happy to stop Femara. I was feeling great within couple weeks but I think it was more less hopeful wish because my hair didn't stop falling out and I had to start Tylenol for back pain, or joint pain or hands pain again - you know the drill. Of course - it has been only two months since I stopped.

So - jury is still out Undecided

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Nov 12, 2007 06:05PM biondi wrote:

been off femara 6 mo, after taking it 6 mo. most all side effects have diminished, except for trigger thumbs, sore joints/bone pain. that is still going strong.. never had any pain before femara.

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Nov 14, 2007 09:57PM colleenperry_1 wrote:

In 1999 my cancer  was stage 1, node neg. estrogen/ pro positve. I was on Tomixifen for 4 years and have been on Femara 2 1/2. I am now not able to afford it. I am 54. Any ideas if I have been on adj. therapy long enough?

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Nov 14, 2007 10:02PM colleenperry_1 wrote:

ALso I did 8 rounds of chemo-CMF and 30 days of radiation. I had a lumpectomy Thanks for any info or info where I can get femara free or very very low cost.

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Sep 2, 2010 02:25PM janatoo wrote:

I still had triple triggers in both painful/useless thumbs until I started taking an Omega 3, 6, 9 blend. Within 3 days I could tell they were going to heal. 2 months later I'm happy to say my thumbs are back to the same thumbs I had all my life, before Femara. I stopped taking Femara (after 6 months) 6 months ago, but I didn't know if my thumbs would ever be ok again, so I'm very happy. I wish someone had told me sooner. Best of luck to you..

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Sep 17, 2010 08:47PM - edited Sep 17, 2010 08:48PM by vhqh

I got free samples of Femara from my oncologist for nearly a year.  Aparently the free sample program has ended and the onc is saving what they have left for the ladies with no insurance at all.  Now there is a program where you can get your prescription filled for $10.  Here is a link -


IDC, er+/pr +, her2 +++, stage IV
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Jun 7, 2017 02:41AM Red38 wrote:

I wondered where there are clinical reports on the risk factors of returning cancers with Aromasstaseversus not using an aromastase therapy.

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Jun 7, 2017 06:00AM dtad wrote:

Red38....Hi there. There are no studies on those of us who refuse aromatase inhibitors and probably never will be. Who would pay for it? Certainly not the pharmaceutical companies. That being said I'm not against anti hormone therapy in general. it's just not the right decision for me. We all have to make our own informed decisions. Good luck to all.

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jun 7, 2017 06:20AM Djcvuono wrote:

I too, have recently stopped Letrozole, after experiencing the following side effects:

3 months after starting- vaginal bleeding (address by prescribing a vaginal cream- took 6 months for Onc to approve, no improvement)

5 months after- developed Lymphedema in my right arm. ( 3 breast nodes removed, BS was/is confused as to how, as she didn't touch/remove beyond need and there was not cancer activity.

6months after- leg pain/skeletal pain. Nightly leg cramps/numbness in right leg. (attributed to CMF treatments, should go away. Has not) 12 month after,on my own I began taking 250mg of magnesium, all leg/skeletal pain gone within a week.

15 months after- developed a fluid sac on my abdomen. Was scanned, it was just fluid. No explanation.

18months after- UIT's 3 in a 2 months. Also my normally low B/P 117/70 has risen to 148/95.

It will be 2 weeks Friday when I return to Onc. Since stopping, no vaginal bleeding, no feeling of UTI, all swelling gone; my arm, hand, and my abdomen all normal. Able to stay awake, no pain. My real concern is the remaining High Blood Pressure.

Don't want to return to drug or take alternate, as they all have similar side effects.

Wondering if others experienced more side effects then pluses on usage and have decided not to continue.

I am estrogen and progesterone positive. Had CMF rounds prescribed only had 7, as I developed facial Shingles.


DX1/6/15-Rt 1cm-ER+, PR+. Surgery 2/11/15 2cm., bi-lateral mastectomy, rt. sentinel nodes removed, expanders placed. 3/15/15 CMF 7 rounds. 12/31/15 exchange of expanders to silicone implant. 4/11/15 Nipple sharing
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Jul 11, 2018 01:47PM mcraig wrote:

I have taken Femara for 4 years and 4 months...if the meds stay in system I often question why not take every other day?

Dx 7/25/2013, ILC, Right, 6cm+, 0/3 nodes, ER+ Surgery 11/12/2013 Mastectomy: Left, Right
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Jul 12, 2018 09:19AM AnnetteW1 wrote:

I have made the decision to stop taking it also. I had many of the side effects not realizing it. How long until you felt better? I am looking forward to feeling like myself again.

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Jul 12, 2018 02:23PM wintersocks wrote:

Those who had hair loss whilst on Femara, did it come back fuller after it was stopped? I have many of the symptoms described here and i am 6 years on it; but scared to stop it

Dx 2/20/2012, IDC, 6cm+, Stage IIIA, Grade 2, 4/11 nodes, ER+/PR-, HER2- Chemotherapy 3/23/2012 Doxil (doxorubicin), Taxotere (docetaxel) Surgery 8/29/2012 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Hormonal Therapy 9/10/2012 Femara (letrozole) Radiation Therapy 9/16/2012 Breast, Lymph nodes

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