Apr 10, 2022 07:44PM racheldog wrote:

I feel like Nanna asking the same question of when the SE effects kick in. I have fought going on these but agreed to give them a try. I just started Letrozole today and will see how this goes. I am a pessamist about being on these toxic drugs with so , so many SE and if I cannot tolerate them I will stop. I already have some major arthritis issues in knees and shoulders and cannot imagine more pain. I am older and early stage breast cancer but HER2+. Did chemo, radiation and herceptin. Now these drugs.

Living alone with dogs and a house and property to maintain is paramount to me. Plus I need a second knee replacement and have to be feeling in shape to head into that. Has anyone had a joint replacement while on these AI drugs? If so, did you stop for the surgery?

Apr 11, 2022 11:44PM racheldog wrote:

jrnj: Thanks for answering. I plan on stopping prior to knee TKR. That is a major surgery with rehab and if I am not feeling well from AI's there is no way I want to head into PT, etc. I would do the same and not go back on again until I feel ready either.

Apr 24, 2022 12:32AM llthomp2 wrote:

yes after taking Letrozole for 4 years , I am in pain every day, burning pain in my legs from the knee to the foot. On Mobic and Tylenol and it doesn't help. I have read a couple of posts that said they had knee replacements and still have pain due to Letrozole. I am feeling so hopeless. Would like to hear from those that have had knee replacements during treatment with AI's about your outcome.

Apr 28, 2022 11:02PM racheldog wrote:

I have not had the knee replacement yet. I had a right knee replacement before being diagnosed with breast cancer. It was a breeze, great surgeon and rehab. I only wish I had done the other one a year later. Because I waited the breast cancer diagnosis came next. I worry about these aromatase inhibitors causing bone loss and causing any implant to loosen or not be as successful. I do plan on stopping the AI about 3 weeks before surgery this summer.

May 13, 2022 06:36PM racheldog wrote:

Yes, lumpectomy, stage 1, chemo, herceptin and radiation and Letrozole is the worst so far. I stopped this week for a couple doses while I got my booster and to see if my head fog clears up. There are articles about this and "need more studies" so I assume others are having issues with this. I would like to see real studies on those who elected never to take AI drug and the stats on recurrences in those women by grade, path, etc. But then, that might keep women from taking them and big Pharma would not fund research on this.