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Mar 17, 2010 04:45PM
Found this info:
Objective: To measure the association between alcohol intake and 11 hormones and peptides in postmenopausal breast cancer survivors and to evaluate whether this association differs by tamoxifen use.
Methods: Self-reported alcohol intake was assessed via food frequency questionnaire on average 30 months post-breast cancer diagnosis in 490 postmenopausal women from three western states. Concurrently, a fasting blood sample was obtained for assay of estrone, estradiol, free estradiol, testosterone, free testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), leptin, C-peptide, insulin-like growth factor-I (IGF-I), and IGF-binding protein-3. Adjusted means of these hormones and peptides were calculated for categories of alcohol intake, overall and stratified by tamoxifen use.
Results: The association between alcohol intake and serum hormone and peptide levels differed by tamoxifen use. We found statistically significant inverse associations between alcohol intake and both leptin and SHBG values but only among tamoxifen users. In women not using tamoxifen, we found a positive association between alcohol intake and DHEAS but no association in tamoxifen users.
Conclusion: Tamoxifen may modify the association between alcohol intake and serum hormones and peptides. The significant associations found for DHEAS and SHBG are in a direction considered unfavorable for breast cancer prognosis. Postmenopausal breast cancer survivors may benefit from decreasing their alcohol intake.
ALCOHOL AND BREAST CANCER Alcohol may effect the way estrogen is secreted and broken down. estrogen in our bodies makes us absorb alcohol more readily and break it down less. At the same rate, alcohol affects how estrogen is secreted and broken down. Thus, by drinking alcohol your estrogen levels will increase significantly both pre-menopausally and post-menopausally. As a result, after you drink you get spurts of estrogen that can be as high as 300 percent within 30 minutes of consumption. This is similar to the spurt of estrogen just prior to ovulation and may be responsible for a breast cancer-promoting effect. In other words, there¹s one thing to have a constant amount of estrogen and occasionally have a rise before you ovulate, but if you get these rises in estrogen every time you drink, this may potentiate breast cancer.
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