I posted this under "melatonin and tamoxifen" topic, but then I though that it maybe a good idea to copy both my posts to a new topic related to curcumin and tamoxifen.
Again, this is only my experience, proved by medical tests
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24 hours ago Maggs09 wrote:
I posted a while ago about tamoxifen (on tamoxifen from Dec/12) and curcumin. But after reading sime of your recent posts, I decided to share my experience.
I started using curcumin in spring, 2013. I was very excited about this supplement after reading about it's anti cancer benefits. I also increased my calcium and vit D intake after being dx with osteopenia.
Before this, (in February), I had CYP2D6 testing done (in my third month of tamoxifen), which confirmed that I'm a very good metabolizer of the drug and my blood endoxifen level (active form of tamoxifen), was higher then normal. I was happy! Before buying Curcumin capsules, I've asked my individualized hormonal therapy dr about any possible interaction between tamoxifen and curcumin and he said it should be fine, even though curcumin may slightly inhibit the enzyme required to metabolize tamoxifen. So you can imagine my disappointment when I had endoxifen level checked again in the summer and it dropped by almost 50%. My dr advised me then to stop curcumin and limit calcium supplement to morning and lunch, so it's gone/absorbed before my evening tamoxifen dose.
We just repeated the blood test last week and tomorrow I will find out if in my case giving up curcumin increased my absorption of tamoxifen.
I haven't tried melatonin out of fear that it may reduce tamoxifen efficacy.
This is all so stressful and difficult to deal with. What is your experience with melatonin? Does it also use the same liver enzyme as tamoxifen?
Dx 5/14/2012, ILC, 6cm+, Stage IIIc, Grade 2, 16/18 nodes, ER+/PR+, HER2-Surgery 05/02/2012 Lumpectomy (Right)Surgery 06/27/2012 Mastectomy (Right); Lymph Node Removal: Axillary Lymph Node Dissection (Right)Chemotherapy 08/01/2012 Adriamycin, Cytoxan, TaxolRadiation Therapy 12/12/2012 ExternalHormonal Therapy 12/28/2012 Tamoxifen
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6 minutes ago Maggs09 wrote:
Just a short update on my endoxifen results after stopping curcumin. They are back to the same level from before starting supplementing with curcumin. Doubled since fall, after giving up curcumin. Dr was very happy with the results but also very suprised that it made such a huge difference. He is running a study on drugs and supplements interactions, (mostly drugs), and a lot of his work focuses on tamoxifen. Curcumin was the only new thing I added after 4 months from starting tamoxifen and over the next 2 months my levels dropped from 28 to below 14. Three months after stopping this supplement, active endoxifen in my blood increased to 30.
The brand I took is: BELL. CURCUMIN 2000X #67, 550mg (ingredients: 300mg of turmeric extract 25:1, cayenne pepper 100mg, Hawthorne berries 100mg, vit E 90UI). I only took 1 capsule daily, usually in the morning, while tamoxifen always after 9-10pm.
Just to make it clear, I didn't see any naturopath for advice on how to supplement, so it is possible that I was taking it incorrectly, on my own. I basically don't take a lot of stuff, just basic calcium with magnesium and vit D, (about 600mg daily), vit C 500, additional 1000UI VIT D, vit B6 50mg and high quality fish oil (1 capsule).
We don't know if this specific brand reduced tamoxifen absorption and metabolism in my body, but just in case - no more curcumin for me for as long as I'm on tamoxifen. It could have a totally different effect on another person, maybe if combined with something else, who knows?
5/1/2012 Lumpectomy: Right
5/14/2012, ILC, 6cm+, Stage IIIC, Grade 2, 16/18 nodes, ER+/PR+, HER2-
6/27/2012 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right
8/1/2012 AC + T (Taxol)
12/12/2012 Breast, Lymph nodes
12/27/2012 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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