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Topic: Anyone on Arimdex with Elevated Alkaline Phosphatase?

Forum: Hormonal Therapy - Before, During, and After —

Risks and benefits, side effects, and costs of anti-estrogen medications. Note: Please remember that there are good experiences and bad with ALL treatments and this is a safe place to share YOUR experience, not to be influenced or influence others.

Posted on: Jun 30, 2016 10:46PM - edited Jun 30, 2016 10:47PM by chrissie29

chrissie29 wrote:


I had my 3 month check up yesterday, and I noticed my Aklaline Phoshatase level was trending up although not in the high level (1 point away) so I asked my Onc, and he ordered a test to see if coming from the liver or bone. The bone test results came back high (5 points above the top range of normal). He is going to repeat the test in 6 weeks. Dr. Google says this can mean bone cancer. I am a freaking out now. Anyone else have this without bone cancer where it was related to the Arimdex?


Dx 7/24/2014, IDC, Left, 6cm+, Grade 1, ER+/PR+, HER2+ (IHC) Dx 7/24/2014, DCIS, Grade 2, ER+/PR+, HER2+ Targeted Therapy 8/8/2014 Herceptin (trastuzumab) Targeted Therapy 8/8/2014 Perjeta (pertuzumab) Chemotherapy 8/8/2014 Taxotere (docetaxel) Chemotherapy 8/31/2014 Carboplatin (Paraplatin) Surgery 12/16/2014 Lymph node removal: Left, Right; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 12/17/2014, IDC: Mucinous, Left, 6cm+, Stage IIB, Grade 1, 0/5 nodes, ER+/PR+, HER2+ Radiation Therapy 2/2/2015 Breast, Lymph nodes Hormonal Therapy 3/13/2015 Arimidex (anastrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jun 30, 2016 11:43PM MargaretEleanor wrote:

I am entering my sixth year (I'm on the 10 year plan) on Arimidex and my ALP is frequently in the upper range of normal or just a bit elevated, while the other liver numbers are right at normal. My oncologist and NP will also run the liver/bones test and my elevated ALP has always, so far, been from the liver. My next stop is an abdominal ultrasound which has yeilded "unremarkable" results, and from there, a tour of the MRI tube again yeilded "unremarkable" results.

While it is nerve wracking, I am very grateful to be monitored so closely.

There is one time when all my liver numbers were drastically elevated and I was having SEVERE stomach pain along with nausea and vomiting. My primary doc suspected gall stones and after consulting with my oncologist and having both a CT and MRI, I had gall stones. I no longer have a gall bladder, but, my ALP still runs high.

I don't know if the Arimidex causes the elevated ALP, but if it does, I'll live with it as long as it keeps me living. Hope my experience helps you sleep a little easier tonight.

Dx 6/6/2010, IDC, Right, 4cm, Stage IIIA, Grade 3, 0/18 nodes, ER+/PR-, HER2+ (FISH)
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Dec 26, 2018 10:28PM betrn wrote:

Hi Crissie, I have been on arimidex for 4 years and have mildly elevated ALK phosphatase. All of my liver enzymes are fine and dexa scans have been fine. Gall bladder seems fine, so not sure if it's from the arimidex or not. My main concern is the pain in my joints ,bones and muscles. But it could be so much worse.,!!

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Aug 22, 2020 05:23PM RMC19 wrote:

I just started arimidex and having the same problem. I see this is an old post. How is everything? I am terrified

Dx 7/10/2019, LCIS/DCIS/ILC/IDC, Right, 3cm, Stage IIB, Grade 3, 3/21 nodes, ER+/PR+, HER2- (FISH)

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