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Topic: Does anyone here get Lupron shots?

Forum: Hormonal Therapy - Before, During, and After —

Risks and benefits, side effects, and costs of anti-estrogen medications. Note: Please remember that there are good experiences and bad with ALL treatments and this is a safe place to share YOUR experience, not to be influenced or influence others.

Posted on: Oct 27, 2019 09:22AM

peridot180 wrote:

Hello everyone,

I have a question about Lupron. Does anyone here get the shots to prevent ovulation and periods? If so, how are your side effects? I have heard horror stories about it and am really curious about peoples' experiences with it on here. I have to make a decision about whether or not I want to take it. I am still getting my periods (I am 36) and my oncologist wants me to take Lupron to stop them. I am already taking Tamoxifen, which I have been doing pretty well with the past month or two.

I have just heard awful things about Lupron when researching online, so I just wanted to hear what other think.

Thank you so much for any advice you may have.

~Stephanie

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 27, 2019 10:22AM voraciousreader wrote:

there are a number of threads devoted to Lupron and/or ovarian suppression...just do a word search and you will find them. I did it for 3 years. I was much older, but the few side effects that I had, I was able to overcome or deal with. My team helped me. If you do have issues, you should discuss them with your team.good luck

Doctor told me regarding my prognosis that I WASN'T on the Titanic! Hmmm...Really?....Okay! 02/2010 Pure Mucinous Breast Cancer, Oncotype DX 15, Stage 1, Grade 1, 1.8 cm, 0/2 nodes, ER+ 90% /PR+ 70% HER2- (+1)
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Oct 27, 2019 11:03AM finallyoverit wrote:

I’ve been getting Lupron shots for about 2.5 years. No side effects at all. The only PIA part is that I have to go to the hospital to get them every month. Small pinch of the needle.. but I don’t have any side effects from it

Dx 10/2011, IDC, Stage IIA, 0/4 nodes, ER+/PR+, HER2- Dx 5/2017, Stage IV, metastasized to bone
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Oct 27, 2019 04:09PM peridot180 wrote:

Thank you both for your answers. I looked at a few of the older threads, but just wanted to see if anyone is currently on Lupron and what their side effects have been.

I hope I am one of those with few side effects. I am just really scared about this. My MO is giving me a choice and I'm just not sure what to do yet. I struggle a lot with depression and anxiety, which I am really scared will just get worse. I'm already on Lexapro, but antidepressants only do so much (I was on Prozac for over 20 years).

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 28, 2019 12:38PM AngelaMia wrote:

My oncologist wants me to start monthly Lupron shots, then add Exemestane pills daily, but I am nervous and uncertain. I've rescheduled my first shot appointment twice already. I am thinking about having my ovaries removed instead. Currently waiting for a referral for a surgical consult. Please keep us posted on how you do on the Lupron.

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Oct 28, 2019 12:58PM SondraF wrote:

Im getting my first one tomorrow morning so I can let you know how it goes! Im 42 but frankly I tend to have better days when I'm not on the monthly estrogen high, so here's hoping I dont get side effects and maybe it levels me out a bit.

Frankly I wish they would have given me the option of ovary removal, but that is perhaps a discussion down the line. Essentially I will get the shot + bloods + onc visit all in one go,so hopefully cut down on too many hospital trips.


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Oct 28, 2019 03:17PM peridot180 wrote:

Let me know how it goes AngelMia. I discussed ovary removal with my MO, but she doesn't seem keen on the idea at my age. She would rather I do the non-permanent option (Lupron) since she said I would only need to stay on Lupron two years.

Keep us updated, SondraF. : ) I really hope you don't get any bad side effects. I wish you luck!

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 29, 2019 06:21AM SondraF wrote:

They finally shot me up this morning and it took literally five minutes. It felt like a tiny staple, pretty sure the punch biopsies they did on my tumor were more, how to say, pressureful? Louder?

Should take a few weeks for the side effects to kick in I suppose, but I will let folks know! Probably most concerned about tumor flare as I already have issues with joints and the low back. Let's see...

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Oct 29, 2019 09:58AM peridot180 wrote:

I wish you the best of luck, SondaF! I hope your side effects are minimal, if any.

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 29, 2019 10:25AM Prahan wrote:

Hi I got my 2nd shot today, 6 more pending. More hot flushes and sore throat are my side effects

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Oct 29, 2019 11:03AM OCDAmy wrote:

I had the shots prior to chemo and then chemo put me into menopause so they stopped.I didn’t find the side effects to be too bad. Mostly hot flashes. It’s the AI they put me on later that is tough with side effects.

Dx 2/2017, IDC, Left, 4cm, Stage IIB, Grade 2, 2/13 nodes, ER+/PR+, HER2- Surgery 11/14/2018 Reconstruction (left): Fat grafting; Reconstruction (right): Fat grafting, Silicone implant Hormonal Therapy Arimidex (anastrozole) Surgery Reconstruction (left): DIEP flap Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery Lymph node removal; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Oct 29, 2019 12:23PM peridot180 wrote:

Thank you Prahan and OCDAmy for the replies.

Did anyone have any digestive issues with Lupron? I have IBS, so that kind of concerns me. Other than that, I am concerned about increased depression. I am going to discuss this with my MO when I see her next.

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 29, 2019 01:05PM Lexica wrote:

I've been getting Lupron shots for almost 2 years. It is a pain in the butt to go in every month. I have side effects like joint pain muscle tightness and constipation/digestive discomfort but it's hard to tell what drug all of those are from. I am on Lupron, prolia, exemestane, and ibrance. Overall my side effects are very tolerable... the joint and muscle pain is the worst, and I really doubt that that is from the Lupron. Here's hoping your side effects are minimal or, even better, non-existent 😊

Diagnosed at 34. 2 years of Ibrance via PALLAS trial (ends 4/2019) Dx 7/2017, IDC, Left, Stage IIIC, Grade 2, ER+/PR+, HER2- (IHC) Surgery 12/14/2017 Lymph node removal: Sentinel; Mastectomy: Left; Prophylactic mastectomy: Right Dx 12/27/2017, DCIS/IDC, Left, 6cm+, Stage IIIA, Grade 3, 5/11 nodes, ER+/PR+, HER2- (IHC) Radiation Therapy 1/15/2018 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy Aromasin (exemestane) Chemotherapy AC + T (Taxol)
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Oct 29, 2019 08:05PM Prahan wrote:

I do feel throat tightness , i am on Tamoxifen and lupron. Aged 36 at the time of diagnosis.

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Oct 30, 2019 02:23PM peridot180 wrote:

Thank you for sharing your experience, Lexica. And thank you for wishing me well. I hope I don't have many (or any) side effects. Still scared, but I'm going to take it one step at a time. I really appreciate everyone sharing their experiences.

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 31, 2019 11:02PM Twinklemom wrote:

Peridot180,

I was diagnosed at 36 (now 37) and have been doing Lupron shots for several months now. My docs don't want my one remaining ovary out because of my age as well. I haven't had many side effects. I feel like the hot flashes were worse with my chemo than with the shot. My depression got worse for a while, BUT I'm 99% positive that it was because I had to switch my antidepressant at the same time I started shots. Apparently, the one I was currently on, had a high interference rate with my Tamoxifen. I've had joint and muscle pain, but that actually started with the Tamoxifen, and just got a touch worse with the Lupron (but definitely tolerable). I haven't had any digestive issues, but then, I don't generally have any, and didn't have any with my chemo either.

Let me know if you have any other questions!

"You never know how strong you are until being strong is the only choice you have." Dx 10/18/2018, IDC/IDC: Tubular, Left, 1cm, Stage IB, Grade 3, ER+/PR-, HER2- (IHC) Surgery 12/17/2018 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Hormonal Therapy Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Chemotherapy Chemotherapy AC + T (Taxol)
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Nov 3, 2019 09:36AM peridot180 wrote:

Thank you Twinklemom for telling me your experience with Lupron. That is really helpful and makes me feel a bit better.

Going to talk to my MO hopefully this week about it some more. I am still really scared about it, especially since my depression and anxiety seems to have gotten worse on the Tamoxifen and I really don't want to add anything else that might make it worse. I will see.

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 3, 2019 09:57AM SondraF wrote:

Im what, day 6 (including injection day) out on this and while I've felt fine for the most part, today is the first time I've started to feel kinda out of it. I don't have anything to be anxious about and yet its been a day of flushed face and feeling squirrly/on edge. Like I feel when Im starting to get sick but Im not sick. I've also been really sleepy the last day or so, and my pelvis/hip joint is playing up significantly (please note, though, this is a long-running, pre-diagnosis problem that may only be tangentially related to the start of this), so I have spent the last three days either sitting up or laying down and not out of the house, which could be contributing to feeling weird.

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Nov 3, 2019 10:17AM Cpeachymom wrote:

SondraF-

It’s not your imagination. I’ve been on Zoladex for a year now after 6months on Lupron. It’s a similar medication. I just had my shot Wednesday, and sure enough, woke up feeling like I’d been hit by a ton of bricks today. It’s usually day 5 for me, lasts for about a week, then improves until the next shot. Took me a while to figure this out because over the last year I’d had three surgeries, so it was hard to connect the dots. Some months it’s worse than others.

Now that I know what it is, I can expect it and cut myself some slack. And also not worry about why I’m suddenly sooo tired. I know it’ll pass and I can get back to kicking butt in a week or so.

Hope you feel better soon!



39 at Dx. Fate whispers to the warrior, 'You can not withstand the storm.' The warrior whispers back, 'I am the storm.' Dx 6/21/2017, IDC, Right, 4cm, Stage IIB, Grade 1, 1/3 nodes, ER+/PR+, HER2- Surgery 7/5/2017 Lymph node removal: Sentinel; Mastectomy: Right Hormonal Therapy 9/10/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 9/17/2017 Lymph nodes, Chest wall Surgery 10/9/2018 Reconstruction (right): Tissue expander placement Surgery 3/24/2019 Reconstruction (right): Saline implant Hormonal Therapy Zoladex (goserelin)
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Nov 3, 2019 06:30PM Acucindy wrote:

I had my first lupron shot 4 days ago. I was awakened from sleep this morning with left jaw pain that felt like I had been punched! My arms ache and my back hurts. It is a huge relief to read that it may just be cyclical. I am supposed to start arimidex in 2 more weeks. I am nervous about it!!!

Dx 7/5/2019, DCIS/IDC, Left, 2cm, Stage IIA, Grade 2, 0/1 nodes, ER+/PR+, HER2- (FISH) Radiation Therapy Surgery Lumpectomy: Left; Lymph node removal: Sentinel
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Nov 4, 2019 12:08AM SondraF wrote:

I should have clarified that Im on zolodex not lupron. So - checks out?? :)

If I could just walk like a normal human I wouldn't care as much about being tired but this back and hip pain man, its gotta go. Its really cramping my style. A little pain is one thing but this ongoing issue with being mobile is no fun. I do get up and 'walk' around during the day and stretch, so I'm not completely a slug!

I have been tracking symptoms since the first injection, so hopefully I can spot a trend in the next couple weeks.

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Nov 4, 2019 11:32AM peridot180 wrote:

I hope you start to feel better soon, SondraF and Acucindy. I'm already getting some muscle and joint pain on Tamoxifen, so I am not looking forward to Lupron possibly making it worse. : ( I really do not want to take this drug.

Dx at 35. Dx 11/19/2018, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2+ (IHC) Targeted Therapy 12/17/2018 Herceptin (trastuzumab) Chemotherapy 12/18/2018 AC + T (Taxotere) Surgery 6/14/2019 Lumpectomy: Left Radiation Therapy 7/18/2019 Whole-breast: Breast Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Nov 6, 2019 06:11PM cathy67 wrote:

I just met with my MO today, I will have this every three months.

Oncotype 6, Dx 08/06/2019, IDC, Right, 2.1 cm, Grade2, 1/1 nodes,ER+/PR+, HER2- Surgery 9/10/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast, Lymph nodes
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Nov 8, 2019 12:56AM - edited Nov 8, 2019 12:57AM by SondraF

Alright, it seems like its starting to ease up.I think I read somewhere that you can have a flare of symptoms in 72 hours with peak at 7 to 10 days. I am right on that timeline. Also,my only problem has been where I have known arthritis/degeneration/mets in my back - I havent had problems in my knees or wrists, etc. No issues either with other side effects (yet).

Hoping this isn't going to be every month, I cant take the time off life for this.

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Nov 8, 2019 06:05AM cathy67 wrote:

Hi Acucindy,

Can we walk after the shot? Shall I ask my friend to go with me that day?

Oncotype 6, Dx 08/06/2019, IDC, Right, 2.1 cm, Grade2, 1/1 nodes,ER+/PR+, HER2- Surgery 9/10/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast, Lymph nodes
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Nov 8, 2019 07:38AM Prahan wrote:

You can just walk. Side effects will be felt only later

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Nov 8, 2019 07:51AM cathy67 wrote:

Thanks Prahan,

Is the shot very painful? Similar feeling as biopsy?

Oncotype 6, Dx 08/06/2019, IDC, Right, 2.1 cm, Grade2, 1/1 nodes,ER+/PR+, HER2- Surgery 9/10/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast, Lymph nodes
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Nov 8, 2019 09:36AM Prahan wrote:

No not painful. But injection site may go reddish after a day.

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Nov 8, 2019 09:56AM Cpeachymom wrote:

Cathy- are you getting Lupron or Zoladex? Lupron is in your backside in the muscle, not too bad. Zoladex is in your stomach under the skin. I’m thin, so that shot sucks and about half the time leaves a nasty bruise. Both are available as one month or three months injections.


39 at Dx. Fate whispers to the warrior, 'You can not withstand the storm.' The warrior whispers back, 'I am the storm.' Dx 6/21/2017, IDC, Right, 4cm, Stage IIB, Grade 1, 1/3 nodes, ER+/PR+, HER2- Surgery 7/5/2017 Lymph node removal: Sentinel; Mastectomy: Right Hormonal Therapy 9/10/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 9/17/2017 Lymph nodes, Chest wall Surgery 10/9/2018 Reconstruction (right): Tissue expander placement Surgery 3/24/2019 Reconstruction (right): Saline implant Hormonal Therapy Zoladex (goserelin)
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Nov 8, 2019 10:26AM cathy67 wrote:

Hi peachymom, I don't know. Will ask nurse when they call me for appointment. Thanks.

Oncotype 6, Dx 08/06/2019, IDC, Right, 2.1 cm, Grade2, 1/1 nodes,ER+/PR+, HER2- Surgery 9/10/2019 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast, Lymph nodes

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