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Feb 12, 2020 10:00AM
Feb 12, 2020 10:01AM
Hi everyone... I was 41 when Diagnosed and am now am turning 45. Here's what my doctor recommended.
1) I take Tamoxifen for 10 years given my age when diagnosed. I handle Tamoxifen fine (it feels like a sugar pill), I'm an ultrarapid Metabolizer of Tamoxifen's enzyme pathway, so I know it works well for me.
2) Because Tamox was giving me increased Uterine lining I chose to have my Uterus, Cervix, and Tubes removed... BUT I KEPT MY OVARIES. Why? Because studies are now showing that most ovarian cancer originates in the tubes (70%) and a new standard is keeping the ovaries but removing everything else. Additionally, one of the most comprehensive studies on removing ovaries shows there is no survival benefit, but an actual survival DECREASE across the board. In addition, I want to stay as youthful as possible and there are so many side effects with losing your ovaries early.
For women younger than 50 at the time of hysterectomy, bilateral oophorectomy was associated with significantly increased mortality in women who had never-used estrogen therapy. At no age was oophorectomy associated with increased overall survival. Oophorectomy was associated with higher mortality from CHD (multivariable hazard ratios [HR] HR=1.23;95% confidence interval[CI], 1.00–1.52), lung cancer (HR=1.29;95%CI, 1.04–1.61), colorectal cancer (HR=1.49;95%CI, 1.02–2.18), total cancers (HR=1.16;95%CI, 1.05–1.29) and all-causes (HR=1.13;95% CI, 1.06–1.21). Results were not statistically different for any of the mortality outcomes when stratified by age at hysterectomy. Though there were insufficient numbers to analyze some cause-specific deaths in women age 60 and older, risk estimates associated with bilateral oophorectomy remained elevated for all-cause, total cancer, and CVD mortality in these older women. Among women with hysterectomy before age 50, oophorectomy was associated with significant increases in risk of deaths from CHD, colorectal cancer, total cancers, and all-causes.
Oncotype =20, ER 95%, PR 5%, ki67= 30%, Mammoprint = Low, Blueprint = Luminal A!!!! TEs= Iron Bra of Death - not worth all the complications for foobs that I'll never feel. Flat and fealess now.
5/11/2016, IDC, Right, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR+, HER2-
6/1/2016 Lymph node removal: Sentinel
6/14/2016 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
7/7/2016 Mastectomy: Left, Right
7/14/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)