Jun 7, 2020 07:50PM - edited Jun 7, 2020 10:02PM by ElaineTherese
I did chemo (Adriamycin + Cytoxan, then Taxol + Herceptin + Perjeta), and I've now done over five years of ovulation suppression/hormonal therapy (Zoladex + Aromasin -- I'm on the 7-10 year plan). I found AC chemo to be the most debilitating because it gave me chemo brain, and I had to write everything down in order to function. Taxol + Herceptin + Perjeta gave me fatigue and diarrhea, which I controlled with Imodium. Zoladex + Aromasin gave me osteoporosis (treated with Prolia), mood swings (treated with Celexa), and hot flashes.
I'd say that chemo was worse than hormonal therapy for quality of life, but at least with chemo, you know it's going to be over in a matter of months. So, you go through chemo with a fixed end-date in mind. It might suck, but it will suck and be over.
With respect to hormonal therapy, the thought that you'll be on it for years is a real drag. Even though I'm pretty far along (MO and I will decide whether to stop at year seven), it feels like forever. If you're struggling with hormonal therapy, I can imagine thinking, "No way am I going to feel this way for the next five/seven/ten years!" I'm lucky that OS + AI hasn't been too bad for me; for others, that certainly isn't the case.