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Apr 9, 2021 05:04PM
Just posting some things I found online re: Estrogren and weight gain/loss. Note that my intent is to stay on Tamoxifen and try to find what to eat, how to exercise, etc. to help counter a weight gain impact. But also this one month break that my oncologist suggested (which I get the COVID vaccine) might be helpful to jump-starting weight loss again. We will see! I will post my progress on this thread. https://www.bioagehealth.com/lose-weight-this-year... "ESTROGEN
Estrogen is directly involved in metabolism and maintaining a healthy weight, including helping to regulate glucose and lipid metabolism. When your estrogen levels drop, your metabolic rate declines and your body begins to store fat. In other words, you gain weight.
An estrogen deficiency also contributes to insulin resistance, which turns your body into a fat-storage machine. In addition to triggering weight gain, low estrogen affects where fat settles in your body. When estrogen levels fall, you begin to accumulate belly fat, even if you don't gain weight overall.
One form of estrogen called estradiol decreases at menopause. This hormone helpsTrusted Source to regulate metabolism and body weight. Lower levels of estradiol may lead to weight gain.
How to manage weight gain
Maintaining a healthy weight, even if it is related to an estrogen imbalance, begins with eating well and staying active.
A healthful diet to manage weight means:
- avoiding processed foods
- eating lots of fruits and vegetables each day
- staying hydrated by drinking lots of water
- avoiding soda, juice, and alcohol
- including whole grains and lean proteins along with healthful plant-based fats
Being active is also very important for managing (lack of) estrogen-related weight gain. In addition to regular cardio exercise, such as jogging, swimming, or walking, people should add in strength training to help build muscle and promote healthy bones."
"The impact of estrogen. In animal studies, estrogen appears to help control body weight. With lower estrogen levels, lab animals tend to eat more and be less physically active. Reduced estrogen may also lower metabolic rate, the rate at which the body converts stored energy into working energy. It's possible the same thing happens with women when estrogen levels drop after menopause. Some evidence suggests that estrogen hormone therapy increases a woman's resting metabolic rate. This might help slow weight gain. Lack of estrogen may also cause the body to use starches and blood sugar less effectively, which would increase fat storage and make it harder to lose weight.
Actual study of weight gain and Tamoxifen https://pubmed.ncbi.nlm.nih.gov/22588672/
All three trials demonstrate that weight gain occurs primarily within the first 12 months of active treatment in a subset of patients. In the prevention trials, weight gain does not differ between anastrozole, tamoxifen and placebo and also did not differ between anastrozole and tamoxifen in the treatment trial."
Encouraging (or not?) study that says that despite being obese or not, Tamoxifen can still be as effective regardless of weight... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46767...
"The hazard of breast cancer recurrence was the same among obese (BMI ≥30.0 kg/m2) women as compared with underweight and normal-weight women (BMI <25.0; hazard ratio [HR] = 0.98, 95% confidence interval [CI] = 0.80 to 1.18).
For women with lymph node–negative, ER-positive breast cancer, obesity was not associated with a material increase in recurrence risk or a change in tamoxifen efficacy. However, because obesity was associated with increased risks of contralateral breast cancer, of other primary cancers, and of overall mortality, it may influence long-term outcomes for breast cancer survivors."
And finally one woman's personal story of how she managed to lose weight while on Tamoxifen...https://pinkhope.org.au/tamoxifen-one-womens-exper...
"The most upsetting side effect that I have experienced while taking Tamoxifen is the weight gain. I have spoken to many women regarding this and it is the BIG one!... I have researched the effects of Tamoxifen and weight gain countless times. I can say that MANY women report weight gain but my Oncologist keep saying it is not due to the medication... Then I heard about "Clean Eating" which I started this year. Why did I not know about this earlier? I decided to try it for nine weeks to look good for my best friend's wedding, while also doing my two personal training sessions per week. Outcome = I dropped 7kgs and my body fat dropped nearly 4%."
Anything italicized is a quote from that article. As for me, will report back in on how I far with a month break from Tamoxifen. If I'm able to lose weight this month, but can't when I start Tamoxifen again despite doing the same things from an eating (trying to eat cleaner, less processed, cut carbs and sugar) and exercise (swimming and weights for me!) standpoint then we know Tamoxifen is definitely the culprit! Hopefully during this month I can jump start the weight loss and then keep it up post-Tamoxifen, even if its at a slower rate would be better than nothing or gaining, which is what happened to me originally.
The pups (Domino and Finley) are cheering me on LOL!
9/7/2018, IDC, Right, 1cm, Stage IIA, Grade 2, 2/2 nodes, ER+/PR+, HER2- (FISH)
9/19/2018 Lumpectomy: Right; Lymph node removal: Sentinel
10/29/2018 Whole-breast: Breast, Lymph nodes
Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)