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Topic: Anyone use an injection instead of AI pills.

Forum: Hormonal Therapy - Before, During, and After —

This is a safe place to share your experiences of others considering or on hormonal treatment.

Posted on: Sep 30, 2021 06:12AM

pabbie wrote:

Hi fellow warriors,

My onc recommended an injection instead of the AI pills because I have a history of not tolerating the AI's., tamoxifen only for 5 years. I keep getting recurrences.

But I forgot the name of the injection. Do you have any ideas.

I'm talking with my onc on Wednesday. Thank you and take care to all.

P

March 2021 Recurrence May 2017 Recurrent 1.1 centimeter IDC with multiple foci, treated with surgery & Aromasin. Dx 2/6/2008, IDC, 2cm, Stage II, Grade 2, 2/19 nodes, ER+/PR+, HER2- Surgery 1/22/2014 Mastectomy: Right Dx 1/23/2014, IDC, Stage I, Grade 1, 0/0 nodes, ER+/PR+, HER2- Dx 5/4/2017, IDC, Right, 1cm, 0/0 nodes, ER+/PR-, HER2-
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Sep 30, 2021 07:49AM ThreeTree wrote:

I had no idea there was some sort of injection. Sorry I can't help, but hopefully someone else here will come along. Personally, I think I'd be wary of an injection. What if you react to it? It's not like a pill that you can just stop right away. I imagine whatever they inject would last awhile. I'd do some serious research first, if it were me.

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Sep 30, 2021 11:47AM pabbie wrote:

ThreeTree,

Thank you so much for reminding me about what could happen. If I have a reaction and end up in the ER with Covid all about. There really are no easy solutions when it comes to the aromatase inhibitors/hormonal therapy. Take care.

March 2021 Recurrence May 2017 Recurrent 1.1 centimeter IDC with multiple foci, treated with surgery & Aromasin. Dx 2/6/2008, IDC, 2cm, Stage II, Grade 2, 2/19 nodes, ER+/PR+, HER2- Surgery 1/22/2014 Mastectomy: Right Dx 1/23/2014, IDC, Stage I, Grade 1, 0/0 nodes, ER+/PR+, HER2- Dx 5/4/2017, IDC, Right, 1cm, 0/0 nodes, ER+/PR-, HER2-
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Sep 30, 2021 01:48PM ShetlandPony wrote:

Hi, pabbie. Was it perhaps Faslodex/fulvestrant your oncologist recommended? My oncologist says, and I found it to be true, that Faslodex has the fewest side effects of all the hormonal therapies. Really! I would not be afraid of giving it a try. If it is Faslodex, I will give you the run-down on how to ease the actual injections. Let me know before your appointment.

(I have been on tamoxifen, the aromatase inhibitor letrozole, and Faslodex.)

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast Surgery Lumpectomy
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Sep 30, 2021 02:00PM ThreeTree wrote:

pabbie - I still feel the same way that I said earlier, but also, I did not mean to scare you, if I did. I just have a thing about injections or oral medications that last a long time. I don't even like these 24 hour slow release tablets of things, if it's something I've never taken before. I wish they still made 4 hour doses - at least for people to take initially to see how they respond to it.

Good luck - looks like ShetlandPony has some good ideas.

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Sep 30, 2021 04:29PM pabbie wrote:

Hi Shetland Pony,

I can't remember if it was faslodex. I'll speak with her on Wed. I don't want the injection to interfere with my ability to take care of my colostomy. I have a permanent colostomy I have to irrigate every other day which uses a lot of bending and such. The bag saved my life when I was 41 years old with colorectal cancer., I'm now 63. Plus I just finished SBRT radiation for lung cancer.

I would appreciate your info on ways to ease the injection site. I'll keep you posted. Take care.


March 2021 Recurrence May 2017 Recurrent 1.1 centimeter IDC with multiple foci, treated with surgery & Aromasin. Dx 2/6/2008, IDC, 2cm, Stage II, Grade 2, 2/19 nodes, ER+/PR+, HER2- Surgery 1/22/2014 Mastectomy: Right Dx 1/23/2014, IDC, Stage I, Grade 1, 0/0 nodes, ER+/PR+, HER2- Dx 5/4/2017, IDC, Right, 1cm, 0/0 nodes, ER+/PR-, HER2-
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Sep 30, 2021 04:31PM pabbie wrote:

ThreeTree,

No worries. I appreciate all info. Take care.

March 2021 Recurrence May 2017 Recurrent 1.1 centimeter IDC with multiple foci, treated with surgery & Aromasin. Dx 2/6/2008, IDC, 2cm, Stage II, Grade 2, 2/19 nodes, ER+/PR+, HER2- Surgery 1/22/2014 Mastectomy: Right Dx 1/23/2014, IDC, Stage I, Grade 1, 0/0 nodes, ER+/PR+, HER2- Dx 5/4/2017, IDC, Right, 1cm, 0/0 nodes, ER+/PR-, HER2-
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Oct 2, 2021 01:24AM - edited Oct 2, 2021 01:42AM by ShetlandPony

Faslodex injections are given in the dorsogluteal muscles (because that is a big muscle), one on each side. So it is on the derrière, high and out toward the side. Most women seem to do fine with just remembering to warm the syringes, but since I had a few episodes of injection site pain and leg pain that were more troublesome, I developed a plan to make it better. Here is a quick run-down based on my experience and research, and others' input as well: Take an ibuprofen a half hour before your injections. Warm up your cheeks with warm packs in your back pockets. Warm up the syringes in a warm blanket or your hands. Whether lying on stomach or sitting, completely relax the cheek that is getting injected and point your toes inward (pigeon-toed). Remind the nurse to inject in the UPPER OUTER quadrant to avoid the sciatic nerve. Have the nurse inject very slowly, at least ten minutes per side; longer if that is better for you. (Don't care if the instructions say two minutes!) Have her pause if it starts to ache. Use warm packs and walk for maybe twenty minutes afterward to prevent the syrup pooling and making a painful lump. Then switch to ice packs for a couple hours, to reduce inflammation. Take another ibuprofen later that day, also to reduce inflammation. Tell yourself congratulations, you are good for four weeks. (There is an extra dose at two weeks, just the first month.)

I don't see why it would interfere with colostomy care, but tell your doctor your concern and I bet you will be reassured. Once you get past the actual injections, which ought to cause only mild soreness for a couple days, I doubt you will notice any side effects other than maybe hot flashes. Faslodex is a SERD, selective estrogen receptor degrader, more similar to tamoxifen which is a SERM, selective estrogen receptor modulator. It is not as similar to aromatase inhibitors.

(All this won't apply if your doctor has a different drug in mind. But I can't think of another.)

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast Surgery Lumpectomy
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Oct 3, 2021 05:57AM pabbie wrote:

Thank you. How much do you pay for the drug. I checked medicare, which I have, and it's over 2000.

Take care.

March 2021 Recurrence May 2017 Recurrent 1.1 centimeter IDC with multiple foci, treated with surgery & Aromasin. Dx 2/6/2008, IDC, 2cm, Stage II, Grade 2, 2/19 nodes, ER+/PR+, HER2- Surgery 1/22/2014 Mastectomy: Right Dx 1/23/2014, IDC, Stage I, Grade 1, 0/0 nodes, ER+/PR+, HER2- Dx 5/4/2017, IDC, Right, 1cm, 0/0 nodes, ER+/PR-, HER2-
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Oct 3, 2021 06:32AM ShetlandPony wrote:

I don't know about cost since mine is paid for by the sponsor of my clinical trial. (The Fas is not the drug being be tested; it is part of a three-drug combo,). There is probably someone at your oncologist's office who can help with payment resources.

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast Surgery Lumpectomy

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