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Topic: Hormone therapy question

Forum: Hormonal Therapy - Before, During, and After —

This is a safe place to share your experiences of others considering or on hormonal treatment.

Posted on: Oct 13, 2021 07:29PM

marinochka wrote:

Hello, dear All

I want to ask question for my friend, who lives in Eastern Europe.

She was diagnosed 2 years ago with breast cancer, stage 2B, hormones +. She had left breast mastectomy, chemo and radiation.

She is now 62 years old. She tried tamoxifen for a while, but after that switched to Anastrozole.

She is diabetic for more than 10 years, and has blood pressure issues(before breast cancer diagnosis).

After few months taking anastrozole, her blood pressure is out of control even with medication, sugar is up also.

Does anyone have those issues. I have read here about sugar elevation, bone/muscle pain, but I did not hear about blood pressure issues.

Today there was a consultations with a team of doctors for her. And decision is to stop Anastrozole without any substitution.

I am very worried about her. I hope something can be done in this case instead of just not taking anything.

Please let me know if anyone had similar situation and what was the solution?

thank you!



Dx 11/4/2019, DCIS, Right, Stage 0, Grade 2, ER+/PR- Surgery 12/19/2019
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Oct 13, 2021 09:04PM kathabus wrote:

Hi--

I'm sure someone here knows the answer to this....if it were me, I would ask if I could take Tamoxifen.

Diagnosed at 43 Years Old, Oncotype DX 10 Dx 2/17/2020, IDC, Right, 2cm, Stage IB, Grade 2, 1/1 nodes, ER+/PR+, HER2- Surgery 3/24/2020 Lumpectomy; Lymph node removal Radiation Therapy 5/15/2020 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 7/21/2020 Prophylactic ovary removal Hormonal Therapy 8/21/2020 Femara (letrozole)
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Oct 13, 2021 10:21PM bcincolorado wrote:

The main site here has a good chart with all side effects for all of the hormonal meds if you have not seen it. I know I found it helpful myself. https://www.breastcancer.org/treatment/hormonal/comp_chart

Dx 8/2009, IDC, Left, 5cm, Stage IIA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 1/6/2010 Lumpectomy: Left; Lymph node removal: Left Hormonal Therapy 1/14/2010 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/29/2016 Femara (letrozole)
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Oct 14, 2021 11:39AM marinochka wrote:

thank you for your answers!

I hope anyone else will give some input on this issue

Dx 11/4/2019, DCIS, Right, Stage 0, Grade 2, ER+/PR- Surgery 12/19/2019
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Oct 14, 2021 12:13PM CBK wrote:

My blood pressure went through the roof on anastrozole. I was placed on a calcium channel blocker and it went back in normal range. Anastrozole is known to elevate blood pressure and I continue to take it with blood pressure med (benicar).

Dx 3/26/2017, IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR+, HER2- Surgery 5/11/2017 Mastectomy: Left, Right; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 7/21/2017 AC + T (Taxol) Surgery 1/25/2018 Prophylactic ovary removal Hormonal Therapy 2/17/2018 Arimidex (anastrozole) Surgery 4/9/2018 Reconstruction (right): Latissimus dorsi flap, Silicone implant Surgery 9/28/2018 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 4/3/2019 Reconstruction (left): Nipple reconstruction, Silicone implant; Reconstruction (right): Nipple reconstruction, Silicone implant
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Oct 14, 2021 04:20PM - edited Oct 14, 2021 04:30PM by marinochka

thank you CBK, it is very helpful

did you have high blood pressure before anastrozole? did you take any medication for blood pressure before?

because my friend was already on some type of medication, but now she takes double dose, and with anatrazole, blood pressure is still not under control.


Dx 11/4/2019, DCIS, Right, Stage 0, Grade 2, ER+/PR- Surgery 12/19/2019
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Oct 25, 2021 09:01PM MicheleH57 wrote:

So glad to find this topic and comments! I had high(er) BP before my BC diagnosis. So have been taking 25 mg of hydrochlorothiazide and 50 mg of atenolol.

But since I started anastrozole, it is nuts! I take my BP at home and it is 130/90 or so, and some days it is about 140/90.

BUT I go to a doctor appointment and it's like 160 or 170. And the med tech who takes the BP is ANGRY AT ME! I have assumed it's classic "white coat syndrome" because the doctor now is not my friend at all (even knowing what I'm up against with cancer, but this is not a happy place) and the examining room is cold and bright and has lots of sharp edges. Wonderful ambiance.

I wondered if the hormone therapy had something to do with it, but didn't even know how to ask!

Something to bring up with the oncologist for sure.

I was thinking that this is all on ME and my "fault," so if I could figure out how to lose 10 or 20 pounds (a good move, anyway), it'd help the BP.

And keep the med tech from being so flip and sighing with disappointment after taking my BP.

The oncologist has not addressed my weight directly or the high BP. Not yet. But I know it's coming.

I am exercising and working on breathing exercises to try and lower the BP. What I do need to do is just eat less. In November I'll finally get a consultation with a nutritionist to discuss how I can get the best nutrition BUT also cut the food intake and by how much. I'm am taking a multivitamin with D3 and lots of calcium already.

Yeah, this is a far distance from the surgery and recovery portion of this "cruise" when I was encouraged to snack (!) [altho the foods on the list were high protein for healing.]

Dx 10/2020, IDC, Left, <1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Radiation Therapy 12/9/2020 Whole-breast: Breast Hormonal Therapy 12/30/2020 Arimidex (anastrozole)
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Oct 25, 2021 09:59PM marinochka wrote:

MicheleH57

My friend with BP issue -she is not overweight at all. She eats well. she is also diabetic, so it makes follow the diet.

And still her BP is high even with medication when she takes Anatrasole.


Dx 11/4/2019, DCIS, Right, Stage 0, Grade 2, ER+/PR- Surgery 12/19/2019
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Oct 25, 2021 10:49PM - edited Oct 25, 2021 10:50PM by Olma61

When I started on hormone therapy (anastrozole) my blood pressure was controlled with a moderate dose of Losartan HCTZ. After a year, I had to go up to the highest dose, then they added another drug. My BP was still too high after a few months. I saw a cardiologist, changed drugs, and now with two drugs at highest dose BP is under control.

Both my onc and the cardiologist say it's not due to anastrozole but other sources say anastrozole can cause hypertension, including an article on this very website -

https://www.breastcancer.org/treatment/side_effects/high_blood_press


my glucose readings are also higher than before

I am 4 years older nowand am on two other cancer drugs, one of which can cause high BP ... so can't definitively blame anastrozole but...it is a possibility


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Oct 26, 2021 01:44PM gb2115 wrote:

My blood pressure was higher on tamoxifen. Not super high, but higher than normal. Once I came off tamoxifen it came back down. Now that I'm on chemo and super stressed all the time, it manages to stay normal. I think it was definitely the tamoxifen!

Dx IDC in Oct 2016, stage 2A, 1.2 cm ER/PR+ Her2-, Grade 2, 1/3 nodes, Lumpectomy + rads + tam. Age 38. 5/21 Dx IDC. 1.6 cm ER/PR+, Her2 -. Gr 2. 2/2 nodes positive. AC/T. Age 42
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Oct 27, 2021 09:05AM moodyblues wrote:

It's been a very long time since I have been on this site, a very long time. I recently changed over to Exemestane last week after being on Letrazole for almost 4 years and I'm having terrible issues with sleep now. I am hoping that someone can give me some tips on what they did to get some rest, maybe the magic time that worked for them to take this med. I've tried it right before I dropped in bed, I've tried it a half hour before bed. I am tired! When I do finally fall off to sleep, I wake up over and over; I do fall right back to sleep though, thankfully. I work and was afraid how it may affect me if I took it during the day. Anyone?

Thanks!

Dx 2/2017, IDC, Left, 2cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 3/31/2017 Lymph node removal: Sentinel; Mastectomy: Left; Reconstruction (left): Silicone implant Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Herceptin (trastuzumab)
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Nov 1, 2021 08:41AM macdebbie wrote:

Olma61, all of the AIs have the side effect of hypertension. I hate it when docs dismiss known side effects. There are recent reports also that all of the hormone blockers raise glucose, and that there is an increase in diabetes with patients who never had diabetes before. I think the AIs were 3x as likely to cause diabetes as Tamoxifen.

Dx 7/29/2021, IDC, Right, <1cm, Grade 2, ER+/PR+, HER2- (IHC) Surgery 9/13/2021 Lumpectomy: Right; Lymph node removal: Sentinel Hormonal Therapy
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Nov 1, 2021 08:45AM macdebbie wrote:

Marinochka - Yes, AIs definitely have side effect of hypertension. Check drugs.com Professional Page and it lists the % for each of them. They also raise blood sugar. AIs are 3x more likely to cause diabetes in patients without any prior history of diabetes.

Do you know why she was taken off of Tamoxifen? I have high blood pressure and diabetes as well as osteoporosis, so have chosen to try Tamoxifen vs and AI as I haven't seen any literature that states hypertension is an issue with Tamoxifen. Could she perhaps try a lower dose or switch back to Tamoxifen?

Dx 7/29/2021, IDC, Right, <1cm, Grade 2, ER+/PR+, HER2- (IHC) Surgery 9/13/2021 Lumpectomy: Right; Lymph node removal: Sentinel Hormonal Therapy

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