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Topic: DIM

Forum: Complementary and Holistic Medicine and Treatment — Complementary medicine refers to treatments that are used WITH standard treatment. Holistic medicine is a term used to describe therapies that attempt to treat the patient as a whole person.

Posted on: Jun 19, 2009 11:11PM

idaho wrote:

What is DIM and where do I get it?  How does it work- thanx in advance for your help!  I am trying tamoxifen but not liking it.   Tami

There's no place like home......There's no place like home Dx 2/1/2009, IDC, 1cm, Stage I, Grade 2, 0/1 nodes, ER+/PR+, HER2-
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Jun 25, 2016 07:46AM dtad wrote:

I get mine on Amazon...

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jun 25, 2016 09:31AM labelle wrote:

I order mine from Amazon too. Smoky Mountain Naturals DIM + BioPerine. I also take Natrol brand Calcium D-Glucarate to help modulate estrogen.

Dx 9/29/2014, IDC: Tubular, Left, <1cm, Stage IIA, Grade 1, 1/11 nodes, ER+/PR+, HER2- (FISH) Surgery 11/13/2014 Lumpectomy: Left; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast
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Jul 19, 2016 12:10AM sarahrae wrote:

HI All~

those of you that are using DIM(and/or other natural alternatives to tam, AI, gos): are you regularly monitoring your estrogen(estradiol) levels? I would love to chart my levels while using DIM, calcium d-glucarate, as well as a large amounts of cruciferous vegetables.

what kind of testing are you doing??

thanks for all of your great info!!

sarah rae Dx 2/19/2016, IDC, Right, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 3/9/2016 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy Whole-breast
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Sep 21, 2018 07:18PM Golden01 wrote:

Sorry to be slow, turns out the University of Arizona DIM study I was in published their results about a year ago. Here you go! The abstract is below. I do not have a free link to the full article.

Bottom line (and confirmed in the letter they sent me about the results):

"Finally, the reduction in endoxifen and other metabolites of tamoxifen are concerning given the presumptive relationship between these metabolites and tamoxifen efficacy. Additional studies are needed prior to recommending DIM supplementation for breast cancer patients receiving tamoxifen."

They let me know that I was on the placebo.

Link to abstract:

Breast Cancer Res Treat. 2017 August ; 165(1): 97–107. doi:10.1007/s10549-017-4292-7

A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen

Cynthia A. Thomson1,2, H.H. Sherry Chow2, Betsy C. Wertheim2, Denise J. Roe2,3, Alison Stopeck4, Gertraud Maskarinec5, Maria Altbach6, Pavani Chalasani2, Chuan Huang7, Meghan B. Strom8, Jean-Philippe Galons2,6, and Patricia A. Thompson4,9


Purpose—Diindolylmethane (DIM), a bioactive compound found in cruciferous vegetables, has proposed breast cancer chemoprevention activity. There is limited evidence of clinically relevant activity or long-term safety. A randomized, double-blind, placebo-controlled trial was conducted to determine the activity and safety of combined use of DIM (BR-DIM) with tamoxifen.

Methods—Women prescribed tamoxifen (n=130) were assigned to receive BioResponse-DIM® (BR-DIM), providing 150 mgs DIM twice daily, or placebo, for 12 months. The primary study endpoint was change in urinary 2/16 -hydroxyestrone (2/16 -OHE1) ratio. Change in 4- hydroxyestrone (4-OHE1), serum estrogens and sex hormone-binding globulin (SHBG), breast density, and tamoxifen metabolites also were assessed.

Results—Ninety-eight women (51 placebo, 47 DIM) completed intervention; compliance with treatment was >91%. DIM increased the 2/16 -OHE1 ratio (+3.2[0.8, 8.4]) compared to placebo (−0.7 [−1.7, 0.8], p <0.001). Serum SHBG also increased with DIM as compared to placebo

(+ 25±22 and +1.1 ±19 nmol/L, respectively). No change in breast density measured by mammography or by MRI was observed. Plasma tamoxifen metabolites (endoxifen, 4-OH tamoxifen, and N-desmethyl-tamoxifen) were reduced in women receiving DIM versus placebo (P <0.001). Minimal adverse events were reported and overall did not differ by treatment arm.

Conclusion—In patients taking tamoxifen for breast cancer, daily DIM promoted favorable changes in estrogen metabolism and circulating levels of SHBG. Further research is warranted to determine whether decreases in tamoxifen metabolites, including endoxifen, with DIM would attenuate the clinical benefit of tamoxifen.

Mucinous Carcinoma, Hypercellular Variant; Oncotype DX 27, Dx 7/8/2011, <1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR-, HER2- Hormonal Therapy 7/20/2014 Arimidex (anastrozole)
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Feb 22, 2021 08:49AM purple32 wrote:

RE: DIM Wopuld it not have similar SEs to aromatase inhibitors ? I cant promote any more bone loss...I have osteopporososi. PMs welcomed as well . THANK YOU@!

BILAT LE! from 5.12.12.LX DX 3/2012 IDC <1 cm stage 1 GR 1 ( 0/2 nodes) ER PR pos HER2- RECURRENCE same breast Jan 2020 LX FEB 2020 . NO rads or hormones. Dx 3/2012, IDC, Left, <1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2+ Surgery 4/30/2012 Lumpectomy: Left

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