Topic: Anyone taking Curcumin AND Tamoxifen?

Forum: Complementary and Holistic Medicine and Treatment — Complementary medicine refers to treatments that are used WITH standard treatment. Holistic medicine is a term used to describe therapies that attempt to treat the patient as a whole person.

Posted on: Feb 11, 2013 04:35PM

Posted on: Feb 11, 2013 04:35PM

Chrys23 wrote:

Hi --

I'm sure this has been asked before, but I really want to take Life Extensions Super Bio-Curcumin because I'm having some severe back issues. My sister takes it and it really helps with pain and inflammation.

However, I'm on Tamoxifen and I don't know if I can take it. I consulted my Onc's office today, and they said since they aren't sure about the interaction, that I shouldn't take it. She did recommend Condroitin and Glucosamine. She said that they refer to patients on Tamox.  I don't know if that helps w/inflammation but I'll give it  a try.

Anyone else taking Curcumin and Tamox? or Condroitin/Glucosamine?

Best,

Chrys

Lumpectomy & SNB 6/9/11; Re-excision 7/21/11; Chemo started 8/10/11 (TC 4x - every 3 weeks); Radiation sometime in November Dx 5/17/2011, IDC, 2cm, Stage IIA, Grade 2, 1/6 nodes, ER+/PR+, HER2-
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Jul 27, 2013 11:58AM TarheelMichelle wrote:

Newtobc, because you asked, I took DIM for about 2 weeks. It gave me moderate to severe hot flashes. To me, on a non-scientific level, that showed it was doing something to my estrogen levels. However, I was about to switch traditional treatments (from Faslodex to Tamox) so I stopped the DIM so I could monitor the SE of Tamox. (I'm very side effect sensitive). If I can tolerate Tamox, I plan to add DIM back.

Ronda - Extensive mets to lungs & bones. My life is Stage IV precious. Celebrating 10 years with Stage IV 12/2021 Dx 2/14/2008, IDC, Left, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 3/11/2008 Lumpectomy: Left; Lymph node removal: Left, Sentinel Radiation Therapy 4/17/2008 Dx 12/19/2011, Stage IV, metastasized to bone/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 1/31/2012 Aromasin (exemestane) Hormonal Therapy 12/18/2012 Faslodex (fulvestrant) Hormonal Therapy 7/16/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 4/24/2014 Reconstruction (left) Radiation Therapy 11/21/2014 External: Bone Targeted Therapy 11/17/2015 Afinitor (everolimus) Targeted Therapy 5/19/2016 Hormonal Therapy 5/31/2016 Femara (letrozole) Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Faslodex (fulvestrant)
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Oct 5, 2013 08:07PM sophie456 wrote:

I came across this post while searching for Curcumin benefits. I gave my oncologist a list of all of the supplements I am taking and she said it is ok to take Curcumin. I take Jarrow Curcumin 95 500 mg every day. Does anyone else take this one?

I take several supplements (including fish oil, magnesium, EGCG, calcium, Vitiman D3 and glucosamine) and I hope they don't interfere with the tamoxifen absorption.

Dx 5/6/2011, DCIS, Stage 0, ER+/PR+, HER2- Surgery 6/5/2011 Lumpectomy: Left Radiation Therapy 9/9/2011 Breast Dx 5/10/2013, IDC, <1cm, Grade 2, ER+/PR+, HER2- Surgery 6/19/2013 Mastectomy: Left; Prophylactic mastectomy: Right Hormonal Therapy 9/1/2013 Dx 1/17/2014, IDC, <1cm, Grade 2, ER+/PR+, HER2- Surgery 1/23/2014 Lumpectomy: Left Chemotherapy 2/28/2014 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 6/14/2014 Breast, Lymph nodes Surgery 11/15/2014 Prophylactic ovary removal Hormonal Therapy 2/28/2015 Femara (letrozole)
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Jun 13, 2016 01:10AM HugoTorres wrote:

Sorry, but you didn't understand the article.Please, read the next line after the bold phrase: "The enhanced bioavailability of tamoxifen by curcumin may be mainly due to inhibition of the CYP3A4-mediated metabolism of tamoxifen in the small intestine and/or in the liver and to inhibition of the P-gp efflux transporter in the small intestine rather than to reduction of renal elimination of tamoxifen"

This means that Curcumin boosts the bioabailability of Tamoxifen!!!!! Biovailability is: The proportion of a drug or other substance that enters the circulation when introduced into the body and so is able to have an active effect.

It seems you misunderstood the whole report. Curcuming, according to that article and other scientific studies, Curcumine and Tamoxifen are synergestic, that is work very well together: www.mdpi.com/1420-3049/18/1/701/pdf

http://www.sciencedirect.com/science/article/pii/S...

http://www.tandfonline.com/doi/abs/10.4161/cbt.11....

Please read carefully the studies and also the sources.

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Nov 30, 2016 08:40PM alternativelycurious wrote:

Tamoxifen is a prodrug of 4-hydroxytamoxifen, meaning an enzyme in the body modifies tamoxifen to create 4-hydroxytamoxifen. 4-hydroxytamoxifen is 50-100 times more potent than tamoxifen in its anti-cancer effects. The authors hypothesize that the increase in tamoxifen bio-availability is a direct result of curcumin's prevention of tamoxifen being converted into its more potent metabolite 4-hydroxytamoxifen.

While I haven't had a chance to read the full article, based on the abstract Timothy was quite right in his assessment.

That said, there are always going to be conflicting results. Trying to sort through everything and decide how much weight to give to each result is the hard part.

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Dec 1, 2016 04:27PM Bounce wrote:

I hope I remember this correctly - somewhere there is a thread by a lady who had her blood checked before and while taking Curcumin (and Tamoxifen) and she found it did interfere with the Tamoxifen.

I was very impressed by her thread when I read it - although she is a study of 1 and I always say I want 15,000 people in any study - I was impressed with her thoroughness and she isn't a mouse. I hate studies done on mice.

I will keep looking for the thread and post a link to it if I find it.


Dx 8/5/2013, IDC, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 9/1/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 11/4/2013 Breast Hormonal Therapy 1/1/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 1, 2016 04:36PM - edited Dec 1, 2016 04:45PM by Bounce

I found it:

The relevant post is the start of the thread - Maggs09.

Link

I suggest anyone taking Curcumin and Tamoxifen also read JohnSmith's post in the same thread. He has a February 2016 update that would make me stop taking Curcumin if I was on it and has prevented me from taking Curcumin despite my doctor and pharmacist saying I could.



Dx 8/5/2013, IDC, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 9/1/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 11/4/2013 Breast Hormonal Therapy 1/1/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 23, 2016 09:51PM - edited Dec 26, 2016 08:28PM by gardengypsy

This Post was deleted by gardengypsy.
Surgery 12/3/2015 Lymph node removal; Mastectomy; Reconstruction (Left): Tissue Expander Chemotherapy 1/9/2016 AC + T (Taxol) Surgery 5/23/2016 Hormonal Therapy 5/28/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 6/6/2016 Whole breast: Breast, Lymph nodes, Chest wall Dx 2/2021, Other, Stage IV, metastasized to other, ER+/PR+, HER2- Targeted Therapy Verzenio
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Dec 23, 2016 09:59PM gardengypsy wrote:

When I asked about the herbs I take, my Dana Farber pharmacist recently stated that Cannabis (high THC, not CBDs), Elderberry, Echinacea,Valerian and Tumeric interfere with Tamoxifen.

Surgery 12/3/2015 Lymph node removal; Mastectomy; Reconstruction (Left): Tissue Expander Chemotherapy 1/9/2016 AC + T (Taxol) Surgery 5/23/2016 Hormonal Therapy 5/28/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 6/6/2016 Whole breast: Breast, Lymph nodes, Chest wall Dx 2/2021, Other, Stage IV, metastasized to other, ER+/PR+, HER2- Targeted Therapy Verzenio

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