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Topic: dim, curcumin, vitamin d and tamoxifen

Forum: Complementary and Holistic Medicine and Treatment — Complementary medicine refers to treatments that are used WITH standard treatment. Holistic medicine is a term used to describe therapies that attempt to treat the patient as a whole person.

Posted on: Jan 21, 2015 05:09AM

Scotty wrote:

I have just read about some studies which suggest dim, vitamin d and curcumin inhibit the effects of tamoxifen and resveterol and melatonin enhance the effects. Sorry I didn't save the links, I'll have a look for them. Tamoxifen didn't work for me and I was taking dim and curcumin, i have always slept with a light on which inhibits melatonin production. Just wondering if anyone else took these supplements and tamoxifen didn't work for them.

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Jan 21, 2015 08:49AM labelle wrote:

Not sure about DIM or vitamin D w tamoxifen, but a recent study showed Tamoxifen does not work well if you do not sleep in the dark, for whatever reason, but quite possibly due to lack of melatonin production.

Dx 9/29/2014, IDC: Tubular, Left, <1cm, Stage IIA, Grade 1, 1/11 nodes, ER+/PR+, HER2- (FISH) Surgery 11/12/2014 Lumpectomy: Left; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast
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Jan 24, 2015 10:36AM katcar0001 wrote:

My SO and MO both concurred last night that they did not want me taking any supplements or vitamins as they are "too paranoid about what possibly may interact with Tamoxifen."

Really? So, no fish oil for my joints and heart, no vitamin D, no turkey tail mushrooms, no MCP, no selenium, no daily aspirin? I just can't bring myself to cut these things out. Some of them I am taking just in case Tamoxifen is doing nothing for me. Did anyone's onc tell them differently?

IDC left side, ER+/PR+/AR+. Oncotype 17, Ki-67 - 4%, MAPK1 and PIK3CA mutations. UMX 12/4/14, no chemo or rads. Tamoxifen 1/7/2015. Benign tumor removed from rt. side on 2/25/15. Started Anastrozole/Arimidex 7/4/17. Dx 11/22/2014, IDC, Left, 1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- (IHC) Surgery 12/3/2014 Lymph node removal: Left, Sentinel; Mastectomy: Left Hormonal Therapy 1/6/2015 Arimidex (anastrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 2/22/2015 Lumpectomy: Right Surgery 8/2/2015 Reconstruction (left): Tissue expander placement Surgery 11/18/2015 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jan 24, 2015 10:59AM - edited Jan 24, 2015 11:01AM by annieoakley

Scotty, I did not take any of those supplements and tamoxifen failed me so I'm not sure why it didn't work for me? I felt I would be protected for 5 years but that was not the case. Came to learn later there is a test to see how you metabolize tamoxifen.  Wondering if I was a poor metabolizer and that's why it didn't work for me. Best of luck to you, I know alot of women it did work for.

Surgery 5/7/2012 Lumpectomy: Left; Lymph node removal: Left, Sentinel Surgery 8/22/2012 Mastectomy: Left; Reconstruction (left): Tissue expander placement Hormonal Therapy 9/27/2012 Surgery 1/31/2013 Prophylactic mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery 6/11/2013 Prophylactic ovary removal Surgery 9/3/2013 Reconstruction (left); Reconstruction (right) Dx 9/3/2014, IDC, 1cm, Stage IV, Grade 1, 0/0 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 9/3/2014 Femara (letrozole) Radiation Therapy 11/30/2014 Bone
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Jan 24, 2015 11:03AM exbrnxgrl wrote:

katcar,

I take Femara and am stage IV, so my situation is different, but I take some supplements, with my mo's approval. I currently take Vitamin D3, melatonin and turmeric. In the past I have also taken boswellia, glucosimin/chondroitin and pro-biotics. I think the evidence for supplements interfering, or not, with Tamoxifen or AI's, is not clear so mo's may err on the side of caution

Bilateral mx 9/7/11 with one step ns reconstruction. As of 11/21/11, 2cm met to upper left femur Dx 7/8/2011, IDC, Left, 4cm, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Surgery 9/7/2011 Lymph node removal: Left; Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right) Dx 11/2011, IDC, Left, 4cm, Stage IV, Grade 1, 1/15 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 11/21/2011 Arimidex (anastrozole) Radiation Therapy 11/21/2011 Bone Hormonal Therapy 6/19/2014 Femara (letrozole) Hormonal Therapy Aromasin (exemestane)
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Feb 9, 2015 10:06AM - edited Feb 9, 2015 10:10AM by katcar0001

scotty, exbrnxgrl, annieoakley and labelle--I am meeting with new onc in SF today and will see what he says about supplements and pass on any interesting information. Thank you for sharing your experiences.

IDC left side, ER+/PR+/AR+. Oncotype 17, Ki-67 - 4%, MAPK1 and PIK3CA mutations. UMX 12/4/14, no chemo or rads. Tamoxifen 1/7/2015. Benign tumor removed from rt. side on 2/25/15. Started Anastrozole/Arimidex 7/4/17. Dx 11/22/2014, IDC, Left, 1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- (IHC) Surgery 12/3/2014 Lymph node removal: Left, Sentinel; Mastectomy: Left Hormonal Therapy 1/6/2015 Arimidex (anastrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 2/22/2015 Lumpectomy: Right Surgery 8/2/2015 Reconstruction (left): Tissue expander placement Surgery 11/18/2015 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Feb 9, 2015 11:04AM - edited Feb 9, 2015 11:06AM by SelenaWolf

@katcar.... My MO told me quite frankly that a pharmacist was the best person to consult about any interactions between tamoxifen and other drugs/supplements as they have access to the most up-to-date information. My pharmacist has been great that way and has, on occasion, phoned my MO to confer on things.

"... good girls never made history ..."
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Feb 9, 2015 11:13AM katcar0001 wrote:

Thank you, Selena. I will have to find a good pharmacist in the Bay Area while I am here. The ones in Mexico are not well trained. They never know about interactions.

IDC left side, ER+/PR+/AR+. Oncotype 17, Ki-67 - 4%, MAPK1 and PIK3CA mutations. UMX 12/4/14, no chemo or rads. Tamoxifen 1/7/2015. Benign tumor removed from rt. side on 2/25/15. Started Anastrozole/Arimidex 7/4/17. Dx 11/22/2014, IDC, Left, 1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- (IHC) Surgery 12/3/2014 Lymph node removal: Left, Sentinel; Mastectomy: Left Hormonal Therapy 1/6/2015 Arimidex (anastrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 2/22/2015 Lumpectomy: Right Surgery 8/2/2015 Reconstruction (left): Tissue expander placement Surgery 11/18/2015 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Dec 7, 2015 10:24PM Farmlovergrl wrote:

Hi Scotty, I take 10 mg of Tamoxifen a day along with lots of supplements. I take 1200 mg curcumin, 1/2 tsp. Ginger, about 1/4 tsp. black pepper mixed in a tsp. Cold pressed olive oil. I also take selenium, olive leaf extract. Co enzyme q-10. Ester C, vitamin D3 and some other things. I don' t know how the supplements are affecting the Tamoxifen. I also take calcium d glucerate. I have DIM and just don' t whether to add it or not. I also take a little coconut oil, unrefined virgin cold pressed.


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Dec 7, 2015 10:52PM Farmlovergrl wrote:

Also I wanted to add that Benedryl prohibits Tamoxifen.

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Dec 7, 2015 11:57PM ksusan wrote:

My MO and naturopath want me taking D, curcumin, melatonin and tamoxifen.

Mutant uprising quashed. Dx 1/2015, IDC, Right, Stage IIA, 1/1 nodes, ER+/PR+, HER2- Dx 1/2015, DCIS, Left, Stage 0, Grade 3, 0/2 nodes Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal: Sentinel; Mastectomy: Left, Right Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel)
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Nov 18, 2018 01:01PM Palesa2018 wrote:

I'm keen to hear more on this topic, especially DIM with Tamoxifen. I'm thinking of adding DIM to my supplements. My MO said it's ok and my Integrated Medicine Dr says DIM enhances the effect of Tamoxifen. Checking if others have same experience?

Dx 6/7/2018, DCIS/IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 6/12/2018 Lymph node removal: Sentinel Surgery 7/9/2018 Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 8/9/2018 Hormonal Therapy 9/12/2018 Zoladex (goserelin) Radiation Therapy 9/16/2018 Whole-breast: Breast, Chest wall Hormonal Therapy 11/4/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 13, 2018 08:26PM Palesa2018 wrote:

bump

Dx 6/7/2018, DCIS/IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 6/12/2018 Lymph node removal: Sentinel Surgery 7/9/2018 Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 8/9/2018 Hormonal Therapy 9/12/2018 Zoladex (goserelin) Radiation Therapy 9/16/2018 Whole-breast: Breast, Chest wall Hormonal Therapy 11/4/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 14, 2018 12:21AM Roaming_Star wrote:

Hi there - i take DIM and Indole-3-carbinol every other day as i can't take Letrozole every day due to the muscle and joint pain i experience. I know that you are asking about tamoxifen and i just thought i would chime in to share what i am doing. I hope that the DIM/ I3C will hopefully pick up some of the slack for the part time usage of letrozole.

Diagnosed at age 46. Taking low dose naltrexone as 30% of cancer patients have low endorphins impacting the body's immune system to kill cancer stem cells. Dx 5/24/2017, IDC, Left, 2cm, Stage IIIB, Grade 3, ER+/PR+, HER2- Chemotherapy 6/9/2017 AC + T (Taxol) Surgery 11/24/2017 Lymph node removal: Underarm/Axillary; Mastectomy Dx 12/6/2017, LCIS/IDC/IDC: Tubular, Left, 1cm, Stage IIIA, Grade 2, 6/16 nodes, ER+/PR+, HER2- Radiation Therapy 2/5/2018 Whole-breast: Lymph nodes, Chest wall Hormonal Therapy 3/14/2018 Femara (letrozole)
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Dec 17, 2018 09:26AM Palesa2018 wrote:

Thanks Roaming Star. I've decided to start DIM/I3C in the new year. In addition to Tamoxifen. The Tamoxifen is treating me well, no overt side effects. Will monitor over time. The reason I want to add DIM is just extra precaution. So desperate to keep the cancer at bay.

Take care

Dx 6/7/2018, DCIS/IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 6/12/2018 Lymph node removal: Sentinel Surgery 7/9/2018 Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 8/9/2018 Hormonal Therapy 9/12/2018 Zoladex (goserelin) Radiation Therapy 9/16/2018 Whole-breast: Breast, Chest wall Hormonal Therapy 11/4/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 17, 2018 02:01PM Spoonie77 wrote:

I'm starting DIM as well in the new year as I cannot take Tamoxifen.

Wishing us all the best as we good forward on this journey.

"Spoonie" who entered BC World @ 41. DXd w/MS & Thyroid Cancer @42. Treatment: LX/SLNB/RADs. Plan A: 5mg Tamox = 0 QOL. Plan B: OS/AI = Rare allergy to OS meds. Plan C: Only option left,  Diet & Exercise. PS: Not a dr, just a Googler. Dx 7/20/2018, IDC, Left, 3cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Dx 8/30/2018, DCIS, Left, 1cm, Stage 0, Grade 2 Surgery 8/30/2018 Lumpectomy: Left; Lymph node removal: Left, Sentinel Radiation Therapy 10/1/2018 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 3/30/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 7/2/2019 Zoladex (goserelin)
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Dec 23, 2018 06:10PM BCat34 wrote:

The only anomaly in my bloodwork when I was diagnosed was a major vitamin D deficiency I didn’t know I had. My family doctor put me on 5,000 iu/day of D3 for 6 months and I still take 4,000 iu/day. I’m now 6.5 years out and almost 6/10 years on tamoxifen. I don’t have any genes which impact my tamoxifen.

Dx 6/30/2012, IDC, Left, 6cm+, Stage IIB, Grade 3, ER+/PR-, HER2- Chemotherapy 7/15/2012 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 1/24/2013 Mastectomy: Left; Reconstruction (left): Nipple reconstruction, Nipple tattoo, Silicone implant, Tissue expander placement Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 24, 2018 10:25AM Palesa2018 wrote:

Spoonie77, hoping that DIM works well for you! My integrative medicine Dr holds it in high regard.

BCat34, thank you for sharing. So encouraging to hear a positive long term Tamoxifen story!

All the best to you all!

Dx 6/7/2018, DCIS/IDC, Right, <1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 6/12/2018 Lymph node removal: Sentinel Surgery 7/9/2018 Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Surgery 8/9/2018 Hormonal Therapy 9/12/2018 Zoladex (goserelin) Radiation Therapy 9/16/2018 Whole-breast: Breast, Chest wall Hormonal Therapy 11/4/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 5, 2020 02:50AM Gardengirl72 wrote:

I have researched extensively regarding contraindications and Tamoxifen.

No:

Milk Thistle - lowers tamoxifen effectiveness

Paxil- lowers tamoxifen effectiveness

Turmeric- lowers tamoxifen effectiveness

Benadryl- lowers tamoxifen effectiveness


I take 10-15g of pure Ascorbic Acid a day along with:

Vitamin D w/k2 4,000iu

Selenium 200mcg

Lugol’s iodine 50mg

delta and Gamma Tocotrienols 150mg

Lions Mane extract 1000mg

B12

B3

B6

Zinc

Magnesium

Vitamin A

Boron




Dx 1/2016, LCIS, Right, ER+ Surgery 1/20/2016 Hormonal Therapy 2/22/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Mar 5, 2020 10:15AM purple32 wrote:

RE: DIM
I read about it here yrs ago but I have forgotten a lot
Can anyone pls message me who is using DIM?

I cannot take the Als due to osteporosis with 6 breaks and I am a high risk for a blood clot or else I would take Tamoxifen. Thanks for any detailed info on DIM>
Laurie

LE on left from 5.12.12.LX DX 3/2012 IDC <1 cm stage 1 GR 1 ( 0/2 nodes) ER PR pos HER2- Dx 3/2012, IDC, Left, <1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2+ Surgery 4/30/2012 Lumpectomy: Left

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