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Topic: Can I take DIM with Femara?

Forum: Complementary and Holistic Medicine and Treatment — Complementary medicine refers to treatments that are used WITH standard treatment. Holistic medicine is a term used to describe therapies that attempt to treat the patient as a whole person.

Posted on: May 29, 2016 07:26PM

KABCochrun wrote:

Does anyone have information about taking DIM with Femara? I'm post menapause/post bc. Just started Femara a month ago and I'm curious if DIM would help metabolize/flush estrogen, and if that would help with the side effects. Or if there are any negative interactions that anyone knows of. My docs look at me like I have three heads when I ask about any natural/holistic support or supplements. Ugh.


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May 29, 2016 09:15PM MelissaDallas wrote:

The Femara should prevent you making any estrogen to flush/metabolize

LCIS, extensive sclerosing adenosis, TAH/BSO & partial omentectomy for mucinous borderline ovarian tumor.
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Apr 14, 2017 10:32AM - edited Apr 14, 2017 10:34AM by geohart

This Post was deleted by geohart.
Dx 12/2016, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR-, HER2- Surgery 1/23/2017 Lymph node removal: Left, Sentinel, Underarm/Axillary Radiation Therapy 1/30/2017 Balloon-catheter: Breast Hormonal Therapy 4/17/2017 Femara (letrozole)
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Apr 14, 2017 10:34AM geohart wrote:

I am wondering the same thing. I am about to start femara and really nervous about it due to osteopenia. I was thinking of taking half dose and supplementing with DIM. I can't find any information of drug interactions. My Onc is not open to Complementary therapies either.

Dx 12/2016, IDC, Left, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR-, HER2- Surgery 1/23/2017 Lymph node removal: Left, Sentinel, Underarm/Axillary Radiation Therapy 1/30/2017 Balloon-catheter: Breast Hormonal Therapy 4/17/2017 Femara (letrozole)
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Apr 15, 2017 07:53AM dtad wrote:

High guys. IMO there is no need to take DIM with Femara. I take DIM inlleu of anti hormone treatment to avoid the SEs. Not saying that's what everyone should do. Jus my opinion...

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Apr 15, 2017 02:30PM - edited Apr 15, 2017 02:33PM by labelle

That was my first thought too, that someone taking an AI would not have any estrogen to metabolize, but AI therapies like Femara prevent only about 1/2 of expected recurrences. What about everyone else?

In women who take an AI and have a recurrence, what happens? Does the AI somehow fail to block all the estrogen production? If so, perhaps taking DIM might not be a bad idea. Because AI therapy obviously doesn't work for everyone,(although I'm not exactly sure why) and it doesn't prevent anywhere close to all expected recurrences, using DIM as a back-up might make sense. By nearly all reports taking DIM is as safe as eating lots and lots of brocolli and as far as supplements go, it is pretty affordable.


I take DIM with tamoxifen, but that is a whole different ballgame, it works (when it works) quite differently and taking DIM makes a lot of sense to me.

Dx 9/29/2014, IDC: Tubular, Left, <1cm, Stage IIA, Grade 1, 1/11 nodes, ER+/PR+, HER2- (FISH) Surgery 11/13/2014 Lumpectomy: Left; Lymph node removal: Sentinel Radiation Therapy Whole-breast: Breast
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Apr 16, 2017 06:46AM dtad wrote:

labelle...as usual your post makes a lot of sense. You are right!

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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May 7, 2017 08:20PM 2FUN wrote:

my MO says that AI only decrease the estrgen, not eliminate it. So there is still some estrogen present. What is DIM?

Hormonal Therapy Surgery
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May 7, 2017 08:37PM ChiSandy wrote:

I’ve read the reason for ER+ recurrence is not that the AI inadequately reduces estrogen (AI “failure”), but that the tumor cells can evolve to synthesize their own estrogen. Also, new research (recommended by the Mods) indicates that older women (IIRC, >60) with less-aggressive tumors can safely stop AIs after 5 yrs. because our life expectancies are shorter—we’d die of other age-related natural causes before ER+ mets would get us. Although it is true that for us old farts, continuing to suppress estrogen after 5 yrs lessens the chance of mets, apparently, it doesn’t extend life.

Diagnosed at 64 on routine annual mammo, no lump. OncotypeDX 16. I cried because I had no shoes...but then again, I won’t get blisters.... Dx 9/9/2015, IDC, Right, 1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2- (IHC) Surgery 9/23/2015 Lumpectomy: Right Radiation Therapy 11/2/2015 3DCRT: Breast Hormonal Therapy 12/31/2015 Femara (letrozole)
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Jul 8, 2017 12:55AM Sonya9 wrote:

Iabelle you said you take DIM with tamoxifen? I started tamoxifen 2 months ago and my oestrogen levels have tripled- so I'm looking for a natural supplement I can take with it. My onc ignores all discussion of natural treatments. Did DIM + tamoxifen work for you?

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Jul 8, 2017 01:06AM Momine wrote:

The AI prevents your body from converting testosterone into estrogen. So there is no need to "flush" any estrogen. However, from stuff I read (albeit a long time ago) a high-fibre diet and probiotics can help eliminate any residual estrogen.

Dx 6/1/2011, ILC, 5cm, Stage IIIB, Grade 2, 7/23 nodes, ER+/PR+, HER2- Chemotherapy 6/20/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 9/13/2011 Mastectomy: Left, Right Radiation Therapy 1/9/2012 Surgery 3/8/2012 Prophylactic ovary removal Hormonal Therapy 4/1/2012 Femara (letrozole)
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Jul 22, 2017 05:47PM Entap325 wrote:

I recently but can't find now saying something about they use the same receptors and Dim may block Famera's effectiveness anyone know anything about this?


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Jul 28, 2017 06:55AM Momine wrote:

I didn't find anything about femara, but found the following on possible interaction between Tamox and DIM:

http://cebp.aacrjournals.org/content/26/3/435.1

Dx 6/1/2011, ILC, 5cm, Stage IIIB, Grade 2, 7/23 nodes, ER+/PR+, HER2- Chemotherapy 6/20/2011 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Surgery 9/13/2011 Mastectomy: Left, Right Radiation Therapy 1/9/2012 Surgery 3/8/2012 Prophylactic ovary removal Hormonal Therapy 4/1/2012 Femara (letrozole)
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Mar 24, 2020 09:08AM Entap325 wrote:

Iread this also somewhere, and to don't remember where.

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