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Topic: DIM dosage for pre menopause

Forum: Complementary and Holistic Medicine and Treatment — Complementary medicine refers to treatments that are used WITH standard treatment. Holistic medicine is a term used to describe therapies that attempt to treat the patient as a whole person.

Posted on: Jun 20, 2018 11:30AM

Katzi17 wrote:

what is the best dosage of DIm for a pre menopausal woman looking for combat breast cancer ? Can too much DIM actually increase estrogen ?

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Jun 21, 2018 06:29AM dtad wrote:

Hi Katzi17...I just answered this question on another thread. The theory behind DIM is that it decreases the bad estrogen that causes breast cancer. However it increases the good estrogen we all need for virtually every organ in our bodies. The dosage would be the same pre or post menopausal. Ive been taking DIM in leu of an aromatase inhibitor and have been NED for over 3 years. good luck to all.

Dx 3/20/2015, IDC, Left, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Dx 4/10/2015, ILC, 1cm, Stage IA, Grade 2, ER+/PR+, HER2- Surgery 5/21/2015 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Jun 27, 2018 08:28PM Warrior2018 wrote:

Hi! Searching around I found this site- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059820/

DIM has limited bioavailability because of its extreme insolubility in water and oil. Pure, crystalline DIM is poorly soluble and poorly absorbed upon ingestion. Supplementation with specialized formulations of DIM is necessary to achieve these higher exposures and, in turn, to evaluate the potential chemopreventive activity of DIM in humans. While there are several different DIM formulas available, the majority of monitored and placebo-controlled trials have used BioResponse-DIM (BR-DIM), a dietary supplement containing microencapsulated DIM. Compared with a pure crystalline formulation, BR-DIM is suggested to have 50% higher bioavailability.26 The half-life of DIM ranges from 2.6 to 4.5 hours, and there is a significant increase in the maximum concentration of plasma DIM at supplementation levels between 100 and 200 mg/d.78 The recommendation for a tolerable single dose of DIM from BR-DIM has been established as 300 mg (4.3 mg/kg/d).79 After a single dose of 300 mg of BR-DIM, peak plasma levels of DIM were 236 ng/ml, equivalent to a concentration of 0.94μM DIM.78


AKA- Paleo Unicorn 🦄😊 Dx 3/14/2018, IDC, Left, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR+, HER2- (FISH) Surgery 4/25/2018 Lumpectomy: Left; Lymph node removal: Sentinel; Reconstruction (left); Reconstruction (right)

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