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Topic: Avastin like drugs may tender tumors Radiosensitiv

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

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Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Jun 27, 2007 10:02AM

Shepgirl wrote:

Blocking Angiogenesis May Render Tumors Radiosensitive

NEW YORK (Reuters Health) Jun 20 - Treatment with angiogenesis inhibitors may overcome the resistance that tumors often develop to radiotherapy, according to results of an animal study reported in the June 7th online issue of The Journal of Clinical Investigation.

Previous research has shown that tumors can develop resistance to radiation by increasing vessel formation through hypoxia-inducible factor 1 (HIF-1)-regulated cytokines.

In the current study, Dr. Claire Magnon, from Mount Sinai School of Medicine in New York, and colleagues show that combining radioiodide therapy with angiogenic inhibitors, like canstatin, can overcome HIF-1-dependent tumor survival pathways and enhance tumor cell apoptosis in vitro and in a murine mammary tumor model.

The results indicate that angiogenesis inhibitors can play a key role in shifting radiation-induced HIF-1 activity from promoting radioresistance to causing apoptosis, the authors state.

"This study provides a basis for developing new biology-based clinically relevant strategies to improve the efficacy of radiation oncology, using HIF-1 as an ally for cancer therapy," Dr. Magnon's team concludes.

J Cin Invest 2007.
Dx 12/23/2004, IDC, 2cm, Stage IV, Grade 2, 2/22 nodes, mets, ER+/PR-, HER2-
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Jun 29, 2007 08:42AM RoxanneNJ31 wrote:

Hi Shepgirl,

I read your post but really don't understand it. Can you explain what it means?
Dx 6/5/2007, 4cm, Stage IV, Grade 3, 2/30 nodes, mets, ER+/PR-, HER2-
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Jul 1, 2007 07:58AM Shepgirl wrote:

Sure

Tumors build resistance to many treatments. Radiation is no exception. Avastin might help prevent this resistance to Radiation by making the tumors sensitive to the radiation...therefore Radiation still can be used as a tool to control the cancer.
Dx 12/23/2004, IDC, 2cm, Stage IV, Grade 2, 2/22 nodes, mets, ER+/PR-, HER2-
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Jul 2, 2007 09:14AM RoxanneNJ31 wrote:

Great thanks!!!

Dx 6/5/2007, 4cm, Stage IV, Grade 3, 2/30 nodes, mets, ER+/PR-, HER2-
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Jul 2, 2007 10:29AM Marsha56 wrote:

Shepgirl,

How are you?? Where is your cancer tretments at? I have missed staying in touch with you! Hope all is well.

Marsha B
Marsha56 Dx 7/25/1996, IDC, 6cm+, Stage IV, Grade 3, 17/21 nodes, mets, ER+/PR+, HER2+
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Jul 2, 2007 11:43AM Shepgirl wrote:

Hi Marsha!--- this post will help get you up to speed.

http://community.breastcancer.org/ubbthr...ge=0#Post644496

Still fighting the fight and its in its early rounds!
Dx 12/23/2004, IDC, 2cm, Stage IV, Grade 2, 2/22 nodes, mets, ER+/PR-, HER2-

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