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Topic: Tykerb/lapatinib anyone?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Metastatic breast cancer (MBC; also called stage IV) is breast cancer that has spread to other parts of the body, most commonly the bones, liver, brain, or lungs. Metastatic breast cancer can be treated but not cured. Metastatic disease is NOT hopeless. There are a wide variety of treatment options for metastatic breast cancer, and new medicines are being tested every day. More and more people are living life to the fullest while being treated for metastatic breast cancer.

Note: Please contact your doctor for any specific concerns about symptoms you are experiencing or your course of treatment.

Learn more about living with MBC.

Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Jul 27, 2007 07:26PM

tooyoungtohavebc wrote:

doc says new lumps near collar bone are also HER2 positive. Since I already did herceptin for a year he wants to try tykerb. Seems like a newly approved drug. Anyone try it? did it work? side effects? He says I will not be doing chemo...woo hoo...rads and this drug I think.

Dx 6/2005, IDC, 6cm+, Stage IV, Grade 3, 1/7 nodes, ER+/PR+, HER2+
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Jul 27, 2007 07:32PM awjkej wrote:

Hi,

I just started tykerb and xeloda, finishing up my first week. I am told that there is lower GI issues with the combo, but nothing so far. I have mild nausea, but I am not sure to which drug I can point for that!

I was on herceptin for over 2 years, and it worked great for my bone mets. I switched to tykerb/xeloda b/c the mass/node in my upper chest is more active, and I had been experiencing wheezing and coughing...hence the switch to the new meds. So we shall see how everything is working in a few months when I get the next PET/CT scan.

I hope tykerb works for you!

Anne
www.faithhopecourage.com / Faith is the bird that feels the light when the dawn is still dark.--Rabindranath Tagore Dx 1/10/2003, IDC, Left, 2cm, Stage IIIB, Grade 3, 0/14 nodes, mets, ER+/PR+, HER2+ (FISH) Surgery 2/3/2003 Mastectomy: Left; Prophylactic mastectomy: Right Chemotherapy 3/27/2003 AC Targeted Therapy 10/1/2004 Herceptin (trastuzumab) Hormonal Therapy 12/1/2004 Arimidex (anastrozole) Chemotherapy 11/4/2005 Taxotere (docetaxel) Radiation Therapy 11/21/2005 Bone Hormonal Therapy 6/16/2006 Aromasin (exemestane) Targeted Therapy 8/9/2007 Tykerb (lapatinib) Chemotherapy 8/9/2007 Xeloda (capecitabine) Radiation Therapy 10/17/2007 Bone Chemotherapy 4/8/2008 Navelbine (vinorelbine) Radiation Therapy 11/10/2010 Lymph nodes
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Jul 27, 2007 08:01PM LuAnnH wrote:

Is this in a clinical trial? I had heard they were doing trials of the two together. One woman who was on tykerb/herceptin/xeloda and had amazing responses with it. She is now just taking herceptin/xeloda, her onc wanted to save the tykerb in case she quit responding to the herceptin.

LuAnn
LuAnn -- Dx 7/2/2006, IDC, 2cm, Stage IV, mets, ER+/PR+, HER2+
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Jul 27, 2007 08:46PM awjkej wrote:

Hi LuAnn,

No it isn't a clinical trial. It was one of the "standard options" I was given. I had the choice to participate in a clinical trial of tykerb and avastin but for a variety of reasons the timing isn't good for me right now. If the tykerb/xeloda doesn't to the job, I can see if the trial is still available for me at that time.

Herceptin worked great on my bone mets, but it didn't do anything to the spot in my chest, so we are trying this combo to see if it works..hopefully it will!

Was the tykerb/herceptin/xeloda a trial???

Anne
www.faithhopecourage.com / Faith is the bird that feels the light when the dawn is still dark.--Rabindranath Tagore Dx 1/10/2003, IDC, Left, 2cm, Stage IIIB, Grade 3, 0/14 nodes, mets, ER+/PR+, HER2+ (FISH) Surgery 2/3/2003 Mastectomy: Left; Prophylactic mastectomy: Right Chemotherapy 3/27/2003 AC Targeted Therapy 10/1/2004 Herceptin (trastuzumab) Hormonal Therapy 12/1/2004 Arimidex (anastrozole) Chemotherapy 11/4/2005 Taxotere (docetaxel) Radiation Therapy 11/21/2005 Bone Hormonal Therapy 6/16/2006 Aromasin (exemestane) Targeted Therapy 8/9/2007 Tykerb (lapatinib) Chemotherapy 8/9/2007 Xeloda (capecitabine) Radiation Therapy 10/17/2007 Bone Chemotherapy 4/8/2008 Navelbine (vinorelbine) Radiation Therapy 11/10/2010 Lymph nodes
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Jul 28, 2007 08:29AM LuAnnH wrote:

tykerb and xeloda was a trial but is now FDA approved tx. That has been having good responses also. I hope this does the trick for you.

LuAnn
LuAnn -- Dx 7/2/2006, IDC, 2cm, Stage IV, mets, ER+/PR+, HER2+
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Jul 28, 2007 06:06PM cneal318 wrote:

Hello everyone, my mother is 54 and bc with mets to liver and more recently to the bone also, she was switched to tykerb and xeloda, and she also gets monthy zometa infusion for bones. she has been on it for almost two months now and is doing very well, she recently two weeks ago went back to work after being off since January, she has experienced the foot syndrome the most but she has been able to deal with it. I hope this works for all of you as well as it has worked for my mother.

Hugs Crystal
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Jul 30, 2007 07:09AM CTG wrote:

I have been taking Tykerb Xeloda since March. It�s important to know that there can be side effects related to the dosage level of each of these drugs. Your oncologist should monitor your response to see if you experience any side effects of diarrhea or the hand and foot syndrome. Lowering the doses relieves the side effects for most people.

You will find more on the www.her2support.org website. There is a link for those taking Tykerb there. Good Luck to you.

Hugs
CTG
dx fall05 stage4 liver and bone mets
dx fall06 brain mets / spring07 brain mets gone

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