A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.
Posted on: Sep 4, 2008 09:00AM
gandl wrote:Study suggests cancer cells may metastasize earlier than previously believed.
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Posts 1 - 7 (7 total)
Sep 4, 2008 06:45PM pip57 wrote:
This addresses my suspicions that there is still so much we need to learn about bc. Others seem to put so much stock in their staging, especially early cancers, when deciding on tx. They assume that this disease follows certain known rules and decline tx based on this belief. Of course, the staging is one part of the tx decision, but I have always suspected that there is so much that we don't know. That is probably why so many of our bc sisters have been dx stage IV after having an early staged cancer.
Sep 4, 2008 06:59PM LumiPojo wrote:
That would explain the metastasis cases where no primary tumor was detected. Normal cells from an organ travel to another organ, where they happen to become cancerous, and then spread further. A biopsy would show that the cancer cells are breast cells, for example, and they think that must have been a breast tumor that initiated the spread.
This is soooo complex. So many variables, so many ways in which cancer can be turned on... Years back, a colleague told me that cancer is a probabilistic phenomenon (there is a certain probability that any one cell will become cancerous, at a given time), and as such we will need a lot more math involved in preventing it from occuring. If we could figure out how to prevent a cell from becoming cancerous, even after onset in a certain tissue, then there would be no more mets. If we could figure out a vaccine to also prevent any onset, then it would be goodbye cancer. Forever.
Sep 4, 2008 07:47PM LisaF wrote:
How interesting! Do you think this means that chemo should be done for even lower level cancers? Also, does the newer Oncotype DX take any of this information into consideration?
Sorry if these are silly questions, but I'm just waiting to see if chemo and such is in my future..,
Sep 4, 2008 07:55PM AusAla wrote:
hells bells, I could have told them that!!!! huge tumor in same spot in breast only six months after lumpectomy, chemo, and full breast rads, plus booster rads....not to mention spread to my skull, spinal cord lining and lower back. Moved AND grew back sooner than I ever expected.
Sep 4, 2008 08:49PM - edited Sep 4, 2008 08:54PM by Gitane
LisaF, The questions you are asking are the same as mine. I found this on the web. These are the presentations that were made at the Southwest Oncology Group Meeting this spring. There is a slide that is part of the presentation made by Kathy Albain. The title on the slide is "Comparison of CAF-T to Tamoxifen Alone, DFS adjusted for nodal Status" It shows SWOG 8814 patients DFS rates broken down by Oncotype DX RS and for "First 5 Years" and "Greater than 5 Years" Looking at this slide it appears that Low RS patients treated with Chemo benefit from that chemo treatment in the "Greater than 5 Years" period just like the Intermediate and High RS groups. If you get a chance to look at this, tell me what you think.
Group Meeting The following presentations were given at the Plenary Session of the Spring 2008 Group Meeting in Atlanta, Georgia, "Southwest Oncology Group Showcase 2008." They are in Windows Media Video format, and should automatically start in the default player for .wmv files on your computer when you click the icon at the right of the presentation title.
SWOG-8814: Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal, node-negative, ER-positive breast cancer (SWOG-8814, TBCI-0100)
Kathy S. Albain, M.D.
Professor of Medicine, Hematology and Oncology, Loyola University, Maywood, Illinois
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