A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.
Posted on: Jul 11, 2010 08:30AM
Have any of you heard about a new trial for a vaccine for ER+ bc? EVERY detail you have heard regarding this would be appreciated. I'm assuming it would be a treatment and not a prevention because it is being studied with Stage IV bc. Can't wait to hear from the "BC Investigative Team".
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Posts 1 - 23 (23 total)
Jul 11, 2010 12:13PM BaseballFan wrote:
What a great age we live in!!! Seriously! Russian internet!!! That's awesome...but what do you know...and what about here?
Jul 11, 2010 02:04PM Irina wrote:It was from in Russian Internet from Russian Newspaper about trial on mouse in Ohio. Vaccine 100% kills breast cancer cells in mouse .In 2011 they plan to start trial with people
Jul 11, 2010 02:16PM BaseballFan wrote:
What hospital in Ohio? I live in NE Ohio. Two of the biggies are Cleveland Clinic and University Hospital in Cleveland.
Jul 11, 2010 04:14PM sincitydealer wrote:
I posted a couple of articles about this study. The topic title was "Hang in there ladies". I'll see if I can find it and bump it. The study is at the Cleveland Clinic. I don't think it mentioned specific tumor types. Just BC tumors in general.
Jul 11, 2010 04:22PM Irina wrote:Russian Internet didn't tell about tumor types. But they told if resold will be same with people is doing to revolution in the Tx of BC. They told also that they plan to use Vaccine for Tx and prevention for BC. Prevention is only for people who is in high risk.
Jul 11, 2010 05:11PM - edited Jul 11, 2010 05:11PM by Enjoyful
I'm participating in a clinical trial for a different breast cancer vaccine out at Washington University in St. Louis. The vaccine targets a protein called mammaglobin-A. You can google it or find it on clinicaltrials.gov.
I've finished the shots and had NO side effects other than a sore arm and sore butt. :-)
Edited to add: I think they are still enrolling!
Jul 13, 2010 06:37AM BaseballFan wrote:
I just scheduled an appointment for July 20 at Cleveland Clinic to learn more about this new vaccine trial. Any sleuths out there who have learned anything new?
Jul 13, 2010 06:45AM Enjoyful wrote:
I don't think the Cleveland Clinic is ready to go to trial with their vaccine yet. From what I heard, it will be at least a year before it does.
Did anyone hear anything different?
Jul 13, 2010 07:10AM ElaineD wrote:
There's a lot of ground still to cover before this becomes available-even at human trial stage. The pertinent statement seems to be-
"It will be several years before this vaccine can be tested fully to assess its safety and effectiveness as a way to stop the disease developing in women."
There are many trials available-see the excellent section on the forum-"Clinical trials,research, news and study results", where you may find a trial which is suited to your specific needs, and which is actually recruiting. Good luck.
Jul 13, 2010 07:14AM BaseballFan wrote:
Now I'm really confused....because I was under the impression that the vaccine that is "years away", i.e. 10.....is the vaccine to "prevent" bc from starting....similar to the chicken pox vaccine.
The trial I'm looking at is in Phase I and is starting all over the country. Am I grasping for a straw that doesn't exist....or is there really 2 different angles to this?
Jul 13, 2010 07:18AM lisa34lisa wrote:
What did they tell you when you called to make your appt? Did you tell them that is why you were wanting to be seen there? Either way, I think you should go. If anyone has the answers to the many questions, it will be them.
Best of luck to you! :) And of course, keep us up to date on what you find out!
Jul 13, 2010 07:20AM ElaineD wrote:
Right-that makes sense-extra special good luck with that one. There are so may trials. all of which hold out promise to greater or less degree,that it's hard to keep abreast (no pun intended!). Sorry for adding to the confusion!
Jul 13, 2010 09:22AM sincitydealer wrote:
Yes, The Cleveland Clinic will be able to answer all your questions. From what I heard on TV and what was in the articles, it said this vaccine also stopped tumor growth, but the clinic will be able to answer all that. It's good that you live so close and can get first-hand information. They did say it was going to take at least a year before human trials start. Please keep us up-to-date on anything you learn.
Good luck with your appointment. Hopefully, you'll have something positive to report.
Jul 13, 2010 11:47AM BaseballFan wrote:
When I scheduled my appointment, we didn't get into trial info. The schedulers are just about making your appt., setting up a chart and instructions on getting records sent. I would imagine that recommendations on treatment, trials, etc. will be discussed at my appt. with the onc. The Cleveland Clinic, like all major hospitals, is a "city within itself". The person I talked with was VERY helpful and obviously accustomed to referral situations. It was straight-forward and easy from that end...but I definitely had more trouble with my current hospital releasing records.
Jul 13, 2010 11:57AM dianaleo wrote:
Best of luck with this, Baseballfan. You are moving fast on this and I think that is very empowering. Keep us posted step by step of how you make out at the Cleveland Clinic.
Jul 29, 2010 10:48PM mohonda wrote:
I just found out about a P53 clinical trial. Has anyone heard of it. It is a vaccine which uses your own blood to activate the P53 protien to fight the cancer. I was told its in the 2 phase of trials and looking promising. You have to contain the P53 protien in your body to qualify. I need to have my tissue checked if I have it then I will also get in the trial. My onc said there are only 2 hospitals in the country who are doing the study. Moffitt of Tampa is 1 I don't know the other. Hope this helps.
Jul 30, 2010 06:48PM Enjoyful wrote:
Maryiz - Sorry, I just now saw your question about the trial I'm in! I don't know if it's working or not since I was NED to start with. The trial needs 2 more participants and they don't expect to finish it up until summer 2011. Hope this helps!
Jul 30, 2010 09:03PM MJLToday wrote:
I hate to be a wet blanket on all this, but I've been in cancer-land a long, long time. In 1998, when I was first diagnosed, TIME ran a front page story about how angiogenesis inhibitors (like Avastin) "cured" cancer in mice. Woo Hoo! A human cure around the corner.
12 years later, and Avastin has been fast-tracked approved, but is being consider for disapproval because of marginal effectivness. Very disappointing, and 40,000 people still die of breast cancer each year.
There are many BC vaccines in trial now. This link shows 42 trials that are recruiting patients:
I hope this new one gets to trial stage soon. We really do need trials to find out if these treatments are effective or not. Besides the potentially harmful side effects of these treatments, which are unknown until Phase 1 (first in humans, limited in number) trials, putting many people on unproven treatments means that their cancers could progress in the absence of other, better proven treatments.
That's what happened to me in the Everolimus/RAD001 study--I progressed during those 3 months. I don't regret participating in the study -- I'm just glad they kept very close tabs on me while I was on the study, so I didn't progress too far before switching to a different treatment.
So, please check with your oncologists, breastcancertrials.org, clinicaltrials.gov, and many other sites to enroll in thee trials that are already approved and ready to go.
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