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Topic: Halaven - Day 1

Forum: Stage IV and Metastatic Breast Cancer ONLY — A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only or those posting on behalf of a Stage IV patient. There is a separate forum for Stage IV Caregivers/Family in "Support and Community Connections".

Posted on: Dec 14, 2010 03:05PM

PJB wrote:

So, I'm the first person on this newly approved chemo at my med center. Lots of people who told me side effects.... They had a fancy dinner put on by the drug company last night so they all would know about it... :) Funny, no one gave ME steak and shrimp.  

Anyway, got hooked up to some saline as usual (altho, my onc's nurse wasn't sure why. She suggested since they charge so much, they had to do something... Apparently, it's unnecessary) The drug itself comes in a little syringe and they put it into the line over 5 minutes. Then, unhook you and you're done. All told, getting hooked up and waiting for pharmacy to get the drug over, etc., took about 30 minutes. 

Main SE's are neuropathy (have it, thanks to Ixempra), drop in blood counts (they say to plan on it next week), hair loss (already have that...), they'll watch liver enzymes (they're up from when I had my last Ixempra, but not too bad and tumor markers are the same... 

So, we'll see... I'll let you guys know what comes up down the road. I'll have it again next week, then a week off. Hopefully, it'll kill cancer like gangbusters.

Thanks for all your good wishes,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 14, 2010 03:16PM jeanne46 wrote:

Keep in touch Paula.  You will be our Halaven guru!  I'm so hoping the hair loss is minimal.  Now that mine's starting to grow back in, I DO NOT want to lose it all again.  Hope the rest of your week is easy and comfortable.  

And yeah, why didn't the pharma company take you out to a fancy dinner last night!!

Dx 12/05, Stage IV, Grade 3 ER-/PR-Her2- YOU NEVER KNOW HOW STRONG YOU ARE UNTIL BEING STRONG IS THE ONLY OPTION YOU HAVE. -anonymous
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Dec 14, 2010 04:31PM PJB wrote:

Yes, mine has sort of (I think, or maybe I'm just hopeful) started to fill in a tiny bit. Hoping it grows back with this. We'll see. Hope the rads are treating you OK, Jeanne....

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 14, 2010 05:10PM konakat wrote:

Hey, this is great it's a short treatment, and that the SEs sound like ones we're very familiar with.  Thanks for starting this thread!

Elizabeth

Elizabeth's Mantra: When in doubt, eat cake. When you haven't a clue, add ice cream. Elizabeth's Mets: Liver, bones, brain (yuck), and lungs (more yuck). Dx 5/2007, ILC, 3cm, Stage IV, Grade 3, 13/19 nodes, mets, ER+/PR+, HER2+
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Dec 14, 2010 05:28PM chainsawz wrote:

I hope this stuff kicks your cancer square in the butt...keep us updated!! 

Lisa -mets to lungs & brain - clear lymph nodes.....the weakest step toward the top of the hill, toward sunrise, toward hope, is stronger than the fiercest storm. Dx 7/21/2008, IDC, 3cm, Stage IV, Grade 3, 0/2 nodes, mets, ER-/PR-, HER2+
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Dec 14, 2010 05:44PM Leah_S wrote:

Paula, I hope the SE's turn out to be as easy as the treatment itself.

Best of luck.

Leah

Dx 11/3/2008, IDC, 1cm, Stage IV, Grade 3, 6/17 nodes, ER+/PR+, HER2-
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Dec 14, 2010 09:37PM Fitztwins wrote:

Paula, I am so excited for you getting this.. When I researched the SE, I was Pissed about hair loss. I kept thinking. Why do they always have to take our hair!???

What no special dinner? Honey I hope you went and got some great take out!

hang in.

Enjoy Every Sandwich. Dx 12/12/2004, IDC, Left, 3cm, Stage IV, metastasized to bone/lungs, Grade 2, mets, ER+/PR+, HER2+ (FISH) Surgery 1/19/2005 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): Free TRAM flap Chemotherapy 2/1/2005 AC + T (Taxol) Radiation Therapy 5/1/2005 Breast, Lymph nodes Targeted Therapy 6/1/2005 Herceptin (trastuzumab) Hormonal Therapy 1/1/2006 Femara (letrozole) Hormonal Therapy 6/2/2008 Aromasin (exemestane) Targeted Therapy 7/1/2008 Herceptin (trastuzumab) Hormonal Therapy 6/15/2013 Arimidex (anastrozole) Targeted Therapy 9/5/2015 Perjeta (pertuzumab)
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Dec 14, 2010 09:42PM MJLToday wrote:

Woot!  My onco mentioned this as the next treatment, even before Xeloda.  Big pharma must be pushing it hard :lol:

 And yeah, I want a steak&shrimp too!  Money mouth

MJ '98 Stage 2 ER+/PR-/Her-, AC+Tam: Sep 08 bone/liver mets. Arimidex,Faslodex,Zometa thru 12/09, Aromasin+Everolimus thru 03/10, Abraxane thru 3/11,Xeloda 8/11,Armed Activated T cell trial 9/11, Taxotere/Gemzar now
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Dec 15, 2010 10:03AM leprechaun wrote:

I hope you have a great response and as minimal SE's as possible!

Olga Simkin (November 1976 - March 2011). Rest In Peace. Dx 6/16/2008, IDC, 6cm+, Stage IV, Grade 3, 1/24 nodes, ER-/PR-, HER2-
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Dec 15, 2010 10:13AM justpayton1 wrote:

Why no fancy dinner for you?

Treat yourself..keeping my fingers and toes crossed for you.

I echo the others hoping the Se's are minimal and this kicks it to the curb.

Dx 2/9/2009, IDC, 6cm+, Stage IV, Grade 3, 2/13 nodes, mets, ER-/PR-, HER2-
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Dec 15, 2010 04:18PM Lowrider54 wrote:

Ok, I found you over here...Paula - our Official G-Force Captain...going where no man (or bc patient) has gone before! 

We shall expect a 'Captain's Log' as often as you see fit and here's to SUCCESS!!!!

Cyber-space Hugs....LowRider

Smile...it will make people wonder what you are up to...Initial dx 04/99 - CMF; 9/2009 bone mets Arimidex; 6/2010 Faslodex/Xgeva; 8/2011; abdominal wall invaded, ER/PR flipped to TN, Abraxane/Avastin//Xgeva 09/02/2011; 11/2011Xeloda/Avastin/Xgeva. Dx 9/16/2009, Stage IV, 5/25 nodes, mets, ER-/PR-, HER2-
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Dec 16, 2010 10:02AM PJB wrote:

Day 3. So far, still OK. No nausea, sleep problems, taste changes, fatigue. Neuropathy isn't worse yet. Keeping an eye out for, you know, the ability to go.... I guess treatment two next week will be the real test. 

I did start taking an extra Norco (hydrocodone/acetaminophen) a day to fight the leftover Ixempra pains, and I swear that helps me be less tired during the day (another holdover from Ixempra). I've actually been NOT ready to go to sleep at 5:30. So that's been great, especially since my husband is working nights all week. 

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 16, 2010 10:34AM SusanR wrote:

Paula,here's to great results and minimal SEs.  Thanks for bringing us along on your journey so if and when any of us receive this drug, we'll have you and your posts to educate us!

Hang in there

Cyber ((Hugs))    SusanR

IDC 2002 Stage II Grade 3 4/29 nodes ER/PR+ Her2- Stage IV Dec 2008 Bone ER+/PR-/Her2- Bone Progression Oct.2011 to Spine,Skull and Rib Dx 11/22/2002, IDC, 6cm+, Stage IIIC, Grade 3, 4/29 nodes, mets, ER+/PR+, HER2- Surgery 11/25/2002 Lumpectomy: Right; Lymph node removal: Right, Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 1/7/2003 Adriamycin (doxorubicin) Chemotherapy 1/7/2003 Cytoxan (cyclophosphamide) Chemotherapy 1/7/2003 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 7/5/2003 Breast Radiation Therapy 1/20/2009 Bone
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Dec 16, 2010 12:16PM JeninMichigan wrote:

Paula

So far so good ... and I am so glad!!   You are a brave girl with this new drug.    (I always hate when people tell me ... you're so brave ... like we have any choice).  However, you really are since you are leading the way on this new drug without the benefit of hearing a lot lot of others experiences and support.      I am hoping and praying this drug kicks your cancer to the curb so hard it would never dare think of returning.

((((hugs)))) 

Jennifer 

Dx 2/22/2008, IDC, 2cm, Stage IV, Grade 3, 4/9 nodes, mets, ER+/PR-, HER2+
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Dec 17, 2010 03:47PM PJB wrote:

Day 4 and I slept most of the day. Not like the Ixempra fatigue, I was just sleepy! Very weird. Feel fine otherwise, besides the continuing Ixempra ache that my onc's nurse says "should" go away eventually. Now I'm thinking I'll take my son to the store to do some last Xmas shopping after I pick him up from school. 30% off coupon!

Take care, girls

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 17, 2010 04:16PM justpayton1 wrote:

Glad to hear you are feeling good and up to last minute shopping :)

Thanks for keeping us posted..

Dx 2/9/2009, IDC, 6cm+, Stage IV, Grade 3, 2/13 nodes, mets, ER-/PR-, HER2-
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Dec 17, 2010 05:31PM jeanne46 wrote:

Paula, so glad to hear you are still doing well after the first Halaven infusion.  It gives me hope.

Just had my hair cut (!) - it was about an inch long with little tufts and fuzzy things sticking out.  I was in a constant state of "bed head" look.  So my husband's haircutter evened out the hair on the sides and the back of my neck and cut off the fuzzy things.  All this to say, I hope your hair doesn't fall out!!!

Dx 12/05, Stage IV, Grade 3 ER-/PR-Her2- YOU NEVER KNOW HOW STRONG YOU ARE UNTIL BEING STRONG IS THE ONLY OPTION YOU HAVE. -anonymous
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Dec 18, 2010 05:05AM konakat wrote:

You sound great Paula!! 

Elizabeth's Mantra: When in doubt, eat cake. When you haven't a clue, add ice cream. Elizabeth's Mets: Liver, bones, brain (yuck), and lungs (more yuck). Dx 5/2007, ILC, 3cm, Stage IV, Grade 3, 13/19 nodes, mets, ER+/PR+, HER2+
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Dec 18, 2010 12:47PM Ready2Win wrote:

This is exciting!  Good Luck to you.  Hoping for great results for you. Keep us posted.

Dx 12/20/2008, IDC, 1cm, Stage IV, 0/0 nodes, mets, ER+/PR+, HER2+
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Dec 18, 2010 03:55PM PJB wrote:

Day 5 started out very sleepy again. Then, well, I had lunch. I have to admit I haven't really had an appetite for anything in months and sometimes do a poor job of making myself eat. After a carb-filled french bread pizza and a hydrocodone, I feel much, much better. 

Note to self: do a better job of grocery shopping.

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 18, 2010 04:03PM konakat wrote:

Mmmmm, pizza.  I don't see a problem with that!

Elizabeth's Mantra: When in doubt, eat cake. When you haven't a clue, add ice cream. Elizabeth's Mets: Liver, bones, brain (yuck), and lungs (more yuck). Dx 5/2007, ILC, 3cm, Stage IV, Grade 3, 13/19 nodes, mets, ER+/PR+, HER2+
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Dec 18, 2010 04:08PM PJB wrote:

Elizabeth, you're right. I'm lucky I found that sucker buried in my freezer. Otherwise, my lunch prospects were pretty dim. How many peanut butter sandwiches can one person eat? And I'm out of bread! :)

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Dec 18, 2010 04:10PM konakat wrote:

OMG -- peanut butter sandwiches are my stand-by too!  And toast!

Elizabeth's Mantra: When in doubt, eat cake. When you haven't a clue, add ice cream. Elizabeth's Mets: Liver, bones, brain (yuck), and lungs (more yuck). Dx 5/2007, ILC, 3cm, Stage IV, Grade 3, 13/19 nodes, mets, ER+/PR+, HER2+
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Dec 18, 2010 04:12PM Leah_S wrote:

Paula, I'm glad to hear you're doing well.

I must admit, I'm used to people haveing beer (or at least coke) with pizza, not hydrocodone.

All the best.

Leah

Dx 11/3/2008, IDC, 1cm, Stage IV, Grade 3, 6/17 nodes, ER+/PR+, HER2-
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Dec 19, 2010 12:23AM lwd wrote:

Paula,

It sounds like you're doing very well!  So glad!  Keep up the good work.  Hope this drug does some serious damage to cancer cells!

Lane

Lane Dx 2/4/2009, IDC, Stage IV, Grade 2, 0/11 nodes, ER+/PR+, HER2- Hormonal Therapy 2/7/2009 Femara (letrozole) Hormonal Therapy 4/17/2012 Hormonal Therapy 11/7/2012 Faslodex (fulvestrant)
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Dec 19, 2010 12:32AM leprechaun wrote:

Go Paula Go!

Olga Simkin (November 1976 - March 2011). Rest In Peace. Dx 6/16/2008, IDC, 6cm+, Stage IV, Grade 3, 1/24 nodes, ER-/PR-, HER2-
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Dec 19, 2010 12:51AM chrissyb wrote:

WOW Paula, you sound like you are managing very well with this new drug.  Hope the trend continues for you and it kicks some serious cancer butt!

I found my peace which gave me strength. 52 at dx. (Sugar Glitter Cheeks) Dx 12/8/2003, IDC, 4cm, Stage IV, Grade 2, 0/12 nodes, mets, ER+/PR+, HER2-
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Dec 19, 2010 12:56AM ibcmets wrote:

Paula,

It's great to hear from a pioneer here.  I'm glad you're doing so well on this and wish you much success with the results.

Terri

6/2009 stage IV diagnosis w bone mets ,Xgeva , 2015 brain mets, liver metastasis
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Dec 19, 2010 10:40AM - edited Aug 20, 2013 06:26AM by jleigh

im do glad halaven is treating you well so far.  i am very interested to see how it works for you.  after my first ixempra, i have felt shitty so i am not sure if i want to take it.  i hate to cut out a chemo but whats worth living if you feel like crap?  so i am curious about this new drug and will mention it to my doc.  keep us up to date and good luck!

jenn phelps Dx 2/12/2010, IDC, Stage IV, mets, ER+/PR+, HER2-
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Dec 19, 2010 01:42PM justjudie wrote:


Alright Paula!! This sounds really good!  Not bad S/E's, at least so far!  I am so glad and I hope it is killing that cancer like its never been killed before! 
 
Go Paula and Halaven!!
 
Judie 
Judie Dx 3/31/2010, IDC, Stage IV, mets, ER+/PR+, HER2-
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Dec 20, 2010 06:11PM PJB wrote:

Well, tomorrow is treatment number 2 if my bloodwork comes back fine. Counts were down as expected, but "I'm still eligible for chemo," as the nurse said. Gosh, I wish I got a free lottery ticket too, or something, when I got bloodwork. I'd rather be eligible to win the lottery.

The rest of the results weren't in yet. I guess they're waiting to see how the liver enzymes are, as I had one a bit high last time and Halaven is known apparently to mess with them. I'll also be interested to see if tumor markers came down any, altho I don't know if that's likely to show up just a week after the last TMs were done.

I've been a little tired the last couple days, but nothing a well-deserved nap couldn't take care of. My son and I put up the tree last night (note to self: next year, just by a real tree not an assemble by numbers one.) Tonight, the fun part: ornaments. AFTER we go walk the dogs on this beautiful, warm day. 

Our cat is loving the Christmas decorations coming out. She likes to pretend she's one herself.

The drag? Looks like the sprouts of hair coming back during the weeks since I quit Ixempra are now falling out. Hair loss is sort of a 50-50 proposition on this drug, as far as I can tell. So I guess I'll be one of the have-nots.

Jeanne, if you see this, how are your rads going? I know you said you'd be starting Halaven next month. I hope you're doing well.  

Hugs to you all,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-

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