Topic: Halaven - Day 1

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Dec 14, 2010 01:05PM

Posted on: Dec 14, 2010 01:05PM

PJB wrote:

So, I'm the first person on this newly approved chemo at my med center. Lots of people who told me side effects.... They had a fancy dinner put on by the drug company last night so they all would know about it... :) Funny, no one gave ME steak and shrimp.  

Anyway, got hooked up to some saline as usual (altho, my onc's nurse wasn't sure why. She suggested since they charge so much, they had to do something... Apparently, it's unnecessary) The drug itself comes in a little syringe and they put it into the line over 5 minutes. Then, unhook you and you're done. All told, getting hooked up and waiting for pharmacy to get the drug over, etc., took about 30 minutes. 

Main SE's are neuropathy (have it, thanks to Ixempra), drop in blood counts (they say to plan on it next week), hair loss (already have that...), they'll watch liver enzymes (they're up from when I had my last Ixempra, but not too bad and tumor markers are the same... 

So, we'll see... I'll let you guys know what comes up down the road. I'll have it again next week, then a week off. Hopefully, it'll kill cancer like gangbusters.

Thanks for all your good wishes,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
Log in to post a reply

Page 286 of 293 (2,925 results)

Log in to post a reply

Jan 3, 2022 10:03PM piksie wrote:

Sadie, Munroe, Denny, welcome. I hope we're all here for a LOOOONNGGG time!

Latte, Susan, great news! I've also responded well so far based on CA153 and bone/lung symptoms. I could hardly take 100 steps in November, but I had my 3rd cycle/day 8 infusion on Tuesday then hopped on a plane to Vegas! MO mentioned a CT "after a few cycles" but I feel so refreshed, I'm not even going to ask. Part of me wants to read all about the great things going on, but I really just kinda want to let it ride. A day without MO is a good day.

Munroe, hair loss… I hope MO is right in your case, but brace yourself. I was told 35% chance, and well…. Based on my experience and other forums, day 15 seems to be the magic day if it's going to fall. But I've also read of people getting their hair back during treatment. Fingers crossed for both of us! (I'm also a single mom of two; strength, love, peace, and good hair vibes to you.)

Regarding mutations, we haven't biopsied the new lung mets, but from my understanding, it might offer new treatment options. I had a great bone response to Xeloda while the lung mets raged. But I'm responding well to Halaven, so I don't know when we'll do that. What a crazy adventure we're on.

Best wishes to those of you starting soon. Here's to great success with minimal SEs!

Dx 12/12/2015, DCIS, Left, 6cm+, Stage 0, Grade 3, ER+/PR+, HER2- Dx 12/12/2015, IDC, Left, 6cm+, Stage IIB, Grade 2, 0/6 nodes, ER+/PR+, HER2- Surgery 1/27/2016 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left): Silicone implant Surgery 10/13/2016 Reconstruction (Left): Silicone implant; Reconstruction (Right): Silicone implant Dx 7/17/2018, IDC, Left, <1cm, Stage IIB, Grade 2, 18/18 nodes, ER+/PR+, HER2- Hormonal Therapy 7/28/2018 Zoladex (goserelin) Hormonal Therapy 7/28/2018 Arimidex (anastrozole) Surgery 8/16/2018 Lymph node removal; Lymph node removal (Left); Reconstruction (Left): Silicone implant Chemotherapy 9/11/2018 AC + T (Taxol) Dx 12/25/2018, IDC, Other, Stage IV, metastasized to bone, 18/18 nodes, ER+/PR+ Radiation Therapy 1/27/2019 Whole breast: Breast, Lymph nodes, Chest wall Local Metastases 1/27/2019 Radiation therapy: Bone Targeted Therapy 3/25/2019 Ibrance (palbociclib) Hormonal Therapy 6/13/2021 Faslodex (fulvestrant) Chemotherapy 9/30/2021 Xeloda (capecitabine) Chemotherapy 11/15/2021 Halaven (eribulin) Chemotherapy 4/1/2022 Gemzar (gemcitabine), Carboplatin (Paraplatin) Radiation Therapy 7/18/2022 Other part Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Jan 6, 2022 09:42AM denny10 wrote:

Thanks Pixsie, I hope we will all stay on this thread for a long time.

I have just returned from my first infusion of halaven: drip to clear port, steroid, 10 mins of halaven, then I asked for rest of saline . I was in the hosptal for an hour , which will be shorter in future, as this time they explained the timetable of treatments and blood tests [2 weeks on, 1 week off] ,what they would be checking on and possible side effects. Then booking in next 2 blood tests and treatments and talking with oncology pharmacist who gave me some anti emetics. I feel a bit 'odd' now, but that could be psychosomatic , a new treatment is a step into the unknown, which I find stressful.

Good luck, Sadiesservant, with your first round of halaven.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Jan 6, 2022 01:10PM susaninsf wrote:

Sadiesservant and Denny,

Hoping Halaven will work for both of you without side effects!

Hugs, Susan

Mets to brain, lung, liver, eye, bone. Currently on Epirubicin. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy; Lumpectomy (Left); Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel; Reconstruction (Right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy; Mastectomy (Right) Dx 3/29/2014, DCIS, Left, 4cm, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External Local Metastases 4/28/2014 Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External Local Metastases 1/8/2015 Radiation therapy: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External Local Metastases 11/27/2017 Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External Local Metastases 10/23/2019 Brain Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Chemotherapy 11/2/2021 Gemzar (gemcitabine) Hormonal Therapy 12/3/2021 Aromasin (exemestane) Targeted Therapy 1/6/2022 Targeted Therapy 6/24/2022 Enhertu (fam-trastuzumab deruxtecan-nxki) Chemotherapy 9/8/2022 Ellence (epirubicin) Targeted Therapy Verzenio Immunotherapy Tecentriq (atezolizumab)
Log in to post a reply

Jan 6, 2022 01:39PM sadiesservant wrote:

Thanks All. At this point, I'm just hoping to make it to my appointment! LOL. We had a big dump of snow last night which threw a wrench into my schedule for bloodwork. No way I could drive. I know folks from the East Coast laugh at us in Victoria but our snow is horrible slushy stuff most of the time which makes for slippery driving conditions. Plus, we get so little snow that it's hard to justify snow tires. I normally just work from home or call it a snow day when the occasional snow flake falls. Hopefully it will be gone by tomorrow as they are predicting rain.

I find it interesting the difference between centres in how they manage the premeds. I don't think they will give me a steroid although I have had it with some treatments. I've also had them give me benadryl in the past for other treatments. Hoping that's not the case here as it always puts me to sleep. I guess there is nothing to do but wait and see. Like you Denny, I expect that it will be a longer appointment than typically would be the case as they run through all the ins and outs of this treatment. Smile

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/21/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
Log in to post a reply

Jan 6, 2022 04:15PM denny10 wrote:

hi SusaninSF, thanks for your good wishes.

I send the same to you on the ARX788 trial, well done for being a trailblazer and helping forward treatment for MBC patients \o/

Sadiesservant, I hope you have a safe journey and to get your appointment.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Jan 7, 2022 06:05PM sadiesservant wrote:

First infusion done and I feel fine. Thankfully the weather cooperated so there were no issues getting there. As I suspected, no premeds and I haven’t needed to take any anti nausea drugs. So far so good

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/21/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
Log in to post a reply

Jan 7, 2022 09:14PM susaninsf wrote:

Sadiesservant,

Glad you made it there safely! Love that the infusion is so fast.

Hugs, Susan

Mets to brain, lung, liver, eye, bone. Currently on Epirubicin. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy; Lumpectomy (Left); Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel; Reconstruction (Right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy; Mastectomy (Right) Dx 3/29/2014, DCIS, Left, 4cm, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External Local Metastases 4/28/2014 Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External Local Metastases 1/8/2015 Radiation therapy: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External Local Metastases 11/27/2017 Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External Local Metastases 10/23/2019 Brain Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Chemotherapy 11/2/2021 Gemzar (gemcitabine) Hormonal Therapy 12/3/2021 Aromasin (exemestane) Targeted Therapy 1/6/2022 Targeted Therapy 6/24/2022 Enhertu (fam-trastuzumab deruxtecan-nxki) Chemotherapy 9/8/2022 Ellence (epirubicin) Targeted Therapy Verzenio Immunotherapy Tecentriq (atezolizumab)
Log in to post a reply

Jan 12, 2022 06:15AM denny10 wrote:

Round 1, day 7 of havalen. Hair ok, occaional slight blood in nose, mouth ok , appetite ok ,but some acid reflux, neuropathy same, energy levels low and so weepy. I am not the crying type ,but found tears streaming this morning ,just putting my shoes on and I wasnt having a problem!

Bloods ok, so I will have second dose tomorrow. I have asked about dropping the steroid before the infusion. I was awake until 3 the next morning and had a very red face for 24 hours( which I have had with steroids before) .I am going to take omeprazole in the morning, to offset the heartburn that started on the car journey home.

This sounds negative, but I think once I understand the cycle and get some strategies in place I can manage this.

Good luck to Sadiesservant on your next treatment. Hope everyone else is doing well.


12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Jan 13, 2022 07:05AM daywalker wrote:

Hi wonderful ladies, I want to introduce myself before I read through these posts… I am starting this treatment next week hopefully after some significant progression showed up in my liver, and my tumor marker went from 190 in September to over 800 yesterday…. Anyhow, I’m grateful for this forum and hope that all of us benefit tremendously from this drug. I’m er and her2 positive with liver met since Feb 2017, this will be my third chemo in 5 years with maintenance treatments in between xxx

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/9/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/12/2017 Taxotere (docetaxel)
Log in to post a reply

Jan 13, 2022 11:50AM s3k5 wrote:

Daywalker, I too am new to this Halaven forum but not new to Stage IV forum. Just found out that I'll be starting this drug from next week. I have been reading the experiences of some of the ladies here - each one has a different side effect but neuropathy and hair loss seem to be common.

I don't know if icing before, during and after injection would help, considering it takes only 5 minutes to get the drug injected. I am concerned about the neuropathy since I already have this. My hair has just started to grow !

Sadiesservant, how are you feeling after a week of your first infusion? Any nausea?

SusaninSF how long have you been on this drug? How are you doing?

I have had 15 lines of treatment but for some reason this upcoming Eribulin next week is making me nervous.

S3K5 Dx 3/24/2008, IDC, Right, 3cm, Stage IIIA, Grade 2, 5/10 nodes, ER+/PR+, HER2- Chemotherapy 4/14/2008 AC + T (Taxol) Targeted Therapy 5/29/2013 Ibrance (palbociclib) Hormonal Therapy 8/31/2014 Faslodex (fulvestrant) Chemotherapy 1/31/2019 Xeloda (capecitabine) Chemotherapy 4/4/2019 Taxol (paclitaxel) Chemotherapy 10/29/2019 CMF Targeted Therapy 7/6/2020 Piqray (alpelisib) Dx 10/19/2020, IDC, Right, Stage IV, metastasized to bone/liver, ER-/PR-, HER2- Chemotherapy 12/9/2020 Doxil (liposomal doxorubicin) Hormonal Therapy Femara (letrozole) Chemotherapy Gemzar (gemcitabine)

Page 286 of 293 (2,925 results)

Scroll to top button