Topic: Halaven - Day 1

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Dec 14, 2010 02:05PM

Posted on: Dec 14, 2010 02:05PM

PJB wrote:

So, I'm the first person on this newly approved chemo at my med center. Lots of people who told me side effects.... They had a fancy dinner put on by the drug company last night so they all would know about it... :) Funny, no one gave ME steak and shrimp.  

Anyway, got hooked up to some saline as usual (altho, my onc's nurse wasn't sure why. She suggested since they charge so much, they had to do something... Apparently, it's unnecessary) The drug itself comes in a little syringe and they put it into the line over 5 minutes. Then, unhook you and you're done. All told, getting hooked up and waiting for pharmacy to get the drug over, etc., took about 30 minutes. 

Main SE's are neuropathy (have it, thanks to Ixempra), drop in blood counts (they say to plan on it next week), hair loss (already have that...), they'll watch liver enzymes (they're up from when I had my last Ixempra, but not too bad and tumor markers are the same... 

So, we'll see... I'll let you guys know what comes up down the road. I'll have it again next week, then a week off. Hopefully, it'll kill cancer like gangbusters.

Thanks for all your good wishes,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Feb 3, 2022 11:35AM denny10 wrote:

Hi Daywalker, sorry to hear you have a delay in your treatment. Hopefully with a few extra days off the neutrophils will bounce back and you can continue with the next infusion.

I had my second infusion of second round. No steroids today as I coped without them last time. Not much has changed; mouth ok'ish ,no sickness or other gastric issues, not excessively fatigued, but I am definitely slowly saying goodbye to my hair. Is this a sign it's working? I hope so.

Sadiesservant, hope you are well and get your next dose of Halaven.

Best wishes to everyone reading this thread.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 3, 2022 01:49PM sadiesservant wrote:

Hi Denny. So.. is your hair coming out in chunks or? I haven't seen any obvious signs of hair loss but do think it looks a bit thin on top. I'm doing well - infusion #2 of round #2 tomorrow assuming my blood is cooperating.

Sorry to hear about your delay Daywalker. I know I always worry when there are delays although I suspect it is not as crucial as I imagine. Hopefully you blood bounces back and you get the next infusion under your belt asap.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Feb 4, 2022 09:04AM denny10 wrote:

Hi Sadiesservant, the hair on my head is thinning, no clumps yet. My eye brows and lashes and body hair seem ok, but more residue in the bottom of the shower tray!! Hope you dont feel too fatigued this time round.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 5, 2022 12:00AM - edited Feb 5, 2022 12:00AM by nickie69

Hi everyone. I've been here a long time but don't post very often. I started this treatment this week after being on vinorelbine which hadn't worked. Had to have a blood transfusion before the treatment so took quite a while in the hospital. Hopefully next week shouldn't be there long. I managed to work yesterday (day after treatment) and have felt ok. It does seem to have affected my taste. A few things I've tried to eat that I normally like taste awful. Fingers crossed this treatment works for us all

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Feb 5, 2022 02:14AM daywalker wrote:

Hi Nicky! Sorry to hear about your tastebuds, ugh..I use an anti-bacterial mouthwash (tastes like cheap medicine yuck), so not sure if that is what is helping my tastebuds to work decently. I have come across quite a few ladies on this forum who have had tastebud issues, so it can to be a thing on this drug :( all the best, and may you soon enjoyall your favourite flavours xx

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)
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Feb 5, 2022 09:23AM denny10 wrote:

Hi Nickie69, wow, well done for working the day after the infusion. I am not having too many problems with my mouth, but as a precautionary measure I have been using Diflam oral rinse, milder than Corsydol which was recommended to me in the past and was too strong for me. I am about to try Oralieve toothpaste, expensive, but it has helped a friend who had mouth issues for ages. Sorry, I am not sure these products are available other than in the UK. I hope everyone can find some relief from side effects.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 15, 2022 12:54AM nickie69 wrote:

I've been trying the Oralieve toothpaste and mouthwash and the dry mouth is a lot better so thank you for suggesting those. Most food tastes bland so I’m having spicy foods.The main side effect I have now is sleep (someone else mentioned it up thread). I thought it may of been the steroids but after a week of 1-3 hours sleep a night I was struggling to function. I ended up going to the doctors and being prescribed sleeping tablets. Am managing 5-6 hours sleep now. The doctor would only give me enough for a week so I will speak to my oncologist this week to see if I can stay on them. Hope everyone is doing well

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Feb 17, 2022 07:22AM denny10 wrote:

Hi Nickie69, glad to hear the Oralieve products are hepling. I hope the oncologist was able to give you something to help with your sleep problems.

I am on day 1, round 3, I found out today my neutrophils were down to 1. I was given the Halaven, but on day 3 and 4 I am going to have to inject myself with Filgrastim; to stimulate growth of white blood cells. This has not happened on previous 2 types of chemo and I am not looking forward to injecting myself. I have the nurses at the hospital on standby in case I cannot do it. If anyone has any tips about mitigating side effects [apart from taking painkillers] I will be grateful.

Hope everyone is getting the treatment they need on time.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 17, 2022 12:13PM sadiesservant wrote:

Sorry to hear about the blood issue Denny. I had my bloodwork this morning and so will see how mine look. The numbers were great after my first cycle but I must admit that I am feeling the fatigue even more post cycle 2 so wonder if things have tanked a bit. I don't think they do the injections here typically. Instead they lower dose (although I am still at 80%) or delay by a week. I had a one week delay when I was on Vinorelbine but that was after they increased my dose. I'll know later today if all is well for infusion #1 of round #3...

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Feb 17, 2022 01:46PM daywalker wrote:

Hi Denny, I had a three week gap between my first and second infusion of round 1 due to low neutrophils, and I still have the Fulgastrim injections… happily I could get treatment two days ago and have been injecting myself. The one thing that made such a difference to the bone pain caused by the injection is Clarityne, apparently the bone pain is caused by a release of histamine. Hope this helps!
Well my hair is mostly gone after two infusions, and I’m very tired for about three days but trying to manage it with lots of water and health shakes.


Keep well Ladies x

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)

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