Topic: mets to lung

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Jan 6, 2012 08:53AM - edited Oct 12, 2013 07:32AM by bhd1

Posted on: Jan 6, 2012 08:53AM - edited Oct 12, 2013 07:32AM by bhd1

bhd1 wrote:

hello. i got scan rusults yesterday. looks like abraxane is not working, since cancer is spreading. i am going on navelbine now. any words of encouragement? thanks. i am new to the boards, happy to find you all

barb

barb Dx 9/22/2011, IDC, 3cm, Stage IV, Grade 3, ER-/PR-, HER2+
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Jun 19, 2014 05:26AM tryn2staycalm wrote:


Thanks hoping I get the real thing too!  Scans were clear but the lungs and one lymph node in/by lungs.  Going today again and hopefully if all goes well will get my first drug trial treatment!

Cathy

A strong woman won't let anyone get the best of her, but a woman of strength gives the best of herself to everyone Dx 7/27/2010, IDC, 5cm, Stage IIIC, Grade 3, 1/5 nodes, ER+/PR-, HER2- Radiation Therapy 3/1/2011 Breast, Lymph nodes Dx 5/2012, IDC, Left, Grade 3 Hormonal Therapy 3/23/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 3/26/2015, Stage IV Chemotherapy 6/11/2015 Taxol (paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Chemotherapy Taxotere (docetaxel)
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Jun 19, 2014 06:35PM tryn2staycalm wrote:


Mameme - yes ty got all the scans and answered all the questions and had the 3 required EGC's and bloodwork Tuesday and again today.   Started the trial drugs today.... whew been a busy few weeks!

Cathy

A strong woman won't let anyone get the best of her, but a woman of strength gives the best of herself to everyone Dx 7/27/2010, IDC, 5cm, Stage IIIC, Grade 3, 1/5 nodes, ER+/PR-, HER2- Radiation Therapy 3/1/2011 Breast, Lymph nodes Dx 5/2012, IDC, Left, Grade 3 Hormonal Therapy 3/23/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 3/26/2015, Stage IV Chemotherapy 6/11/2015 Taxol (paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Chemotherapy Taxotere (docetaxel)
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Jun 20, 2014 04:10PM Adnerb wrote:

LiquidBiopsy Result:

This is intended only for those of you who showed interest.

I was shown a graph that illustrated the number of tumor cells in every milliliter of blood that was collected from me.

I am copying, word for word what I read under "result" on page 1 and page 2.

Page 1:

"Result Interpretation: Result numbers below the reference line indicate that sample tested revealed the quantity of nucleated cytokeratin positive and CD45 negative cells is within the range found in general population. Purity numbers above 10% represent good candidate samples for further analysis, if such analysis is selected. 1.9 target cells per ml were identified in the analysis. Results below 9 cells/ml show greater variation upon repeat analysis and hence are reported as <9 cells/ml."

Page 2:


"Results: No Mutation(s) detected."

So I am being told once again that I have no disease or not enough disease to evaluate so I can use more targeted treatment approaches.

This happened to me before. I was 4 weeks into treatment when I went to the imaging place to get a ct-guided needle biopsy of the numerous tumors in the lining of my left lung. Alas, the tumors were all gone and there was nothing to biopsy.

I know I should be glad that the blood biopsy did not say I had 200 mutations and no known available treatment. But when will I get to know this beast better?

My MO said if (God forbid) I progress again, we shall do another liquid biopsy even before treatment starts.

Thank you for your interest.

Hugs,

Brenda

Brenda S. "Do not go gentle into that good night...Rage, rage against the dying of the light!" ~Dylan Thomas Dx 7/16/2005, IDC, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Chemotherapy 10/1/2005 AC Radiation Therapy 3/14/2006 Breast Dx 7/28/2009, IDC, 3cm, Stage IIB, Grade 3, 0/6 nodes, HER2- Chemotherapy 10/1/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 9/11/2013, IDC, Stage IV, 1/0 nodes, mets, ER+/PR-, HER2- Chemotherapy 10/1/2013 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 3/7/2014 Carboplatin (Paraplatin), Gemzar (gemcitabine) Hormonal Therapy 11/7/2014 Faslodex (fulvestrant) Chemotherapy 3/1/2015 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 7/7/2015 Ixempra (ixabepilone)
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Jun 20, 2014 07:39PM tryn2staycalm wrote:


Wow Brenda!  I won't pretend to know all of what that said but I think that is good new!?!

Cathy

A strong woman won't let anyone get the best of her, but a woman of strength gives the best of herself to everyone Dx 7/27/2010, IDC, 5cm, Stage IIIC, Grade 3, 1/5 nodes, ER+/PR-, HER2- Radiation Therapy 3/1/2011 Breast, Lymph nodes Dx 5/2012, IDC, Left, Grade 3 Hormonal Therapy 3/23/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 3/26/2015, Stage IV Chemotherapy 6/11/2015 Taxol (paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Chemotherapy Taxotere (docetaxel)
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Jun 20, 2014 09:20PM GatorGal wrote:

Brenda,

Sounds confusing but overall good news.  I always have trouble deciphering the medical jargon when I read my scans.  Somehow they always sound worse to me than my onc relates.  No progression is always a good thing!

Glena

When people asked how old she was, she would say 1009365 more or less because she was so glad to be alive that she counted every day a birthday! (Brian Andreas, Storypeople) Dx 5/2008, IDC, Right, Stage IV, metastasized to bone/liver/lungs, 11/27 nodes, ER+/PR+, HER2- Chemotherapy 4/10/2011 Taxotere (docetaxel) Chemotherapy 8/13/2011 Gemzar (gemcitabine) Chemotherapy 6/12/2012 Doxil (doxorubicin) Chemotherapy 12/11/2012 Taxol (paclitaxel) Chemotherapy 9/10/2013 CMF Chemotherapy 4/15/2014 Carboplatin (Paraplatin) Chemotherapy 12/16/2014 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 9/8/2015 Navelbine (vinorelbine) Chemotherapy 12/22/2015 Halaven (eribulin) Chemotherapy 4/12/2016 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 6/14/2016 Ixempra (ixabepilone) Hormonal Therapy 7/26/2016 Arimidex (anastrozole)
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Jun 20, 2014 10:52PM susaninsf wrote:

"No mutations detected" has got to be good, right?  Your previous experience with them finding no tumors just before your needle biopsy is an amazing story as well.

So happy for you!

Mets to brain, lung, liver, eye, femur bone. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy; Lumpectomy (Left); Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel; Reconstruction (Right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy; Mastectomy (Right) Dx 3/29/2014, DCIS, Left, 4cm, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External Local Metastases 4/28/2014 Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External Local Metastases 1/8/2015 Radiation therapy: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External Local Metastases 11/27/2017 Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External Local Metastases 10/23/2019 Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Other Chemotherapy 11/2/2021 Other Targeted Therapy 1/6/2022 Targeted Therapy 6/24/2022 Enhertu (fam-trastuzumab deruxtecan-nxki)
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Jun 20, 2014 11:38PM Adnerb wrote:

Thanks, Cathy, Glenna and Susan.

So it looks like the Carbo/Gemzar combo is working very well.  Do I keep doing it until it stops working?  I don't know.  My hemoglobin was dangerously low last week.  I had to have my first blood transfusion last Monday.  But now I am afraid to stop because it is working so well.

My MO's plan is to move on to monthly faslodex if I show major regression or NED.  Do I take that chance?

Brenda

Brenda S. "Do not go gentle into that good night...Rage, rage against the dying of the light!" ~Dylan Thomas Dx 7/16/2005, IDC, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Chemotherapy 10/1/2005 AC Radiation Therapy 3/14/2006 Breast Dx 7/28/2009, IDC, 3cm, Stage IIB, Grade 3, 0/6 nodes, HER2- Chemotherapy 10/1/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 9/11/2013, IDC, Stage IV, 1/0 nodes, mets, ER+/PR-, HER2- Chemotherapy 10/1/2013 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 3/7/2014 Carboplatin (Paraplatin), Gemzar (gemcitabine) Hormonal Therapy 11/7/2014 Faslodex (fulvestrant) Chemotherapy 3/1/2015 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 7/7/2015 Ixempra (ixabepilone)
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Jun 21, 2014 07:38AM tryn2staycalm wrote:


Good question Brenda, one good thing is if one thing doesn't work as well we can always try what was or what may!  I guess we have to trust our MO but keep being a part of our choices.  Wishing you continual good results!

Cathy

A strong woman won't let anyone get the best of her, but a woman of strength gives the best of herself to everyone Dx 7/27/2010, IDC, 5cm, Stage IIIC, Grade 3, 1/5 nodes, ER+/PR-, HER2- Radiation Therapy 3/1/2011 Breast, Lymph nodes Dx 5/2012, IDC, Left, Grade 3 Hormonal Therapy 3/23/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 3/26/2015, Stage IV Chemotherapy 6/11/2015 Taxol (paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Chemotherapy Taxotere (docetaxel)
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Jun 21, 2014 11:58AM Adnerb wrote:

Thanks, Cathy.  My MO says if I show major regression (which is what I think is happening) I move on to faslodex, which has less side effect and not infused, just shot on a monthly basis.  If this does not work I will on a different chemo.  How's the trial going?

Brenda

Brenda S. "Do not go gentle into that good night...Rage, rage against the dying of the light!" ~Dylan Thomas Dx 7/16/2005, IDC, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Chemotherapy 10/1/2005 AC Radiation Therapy 3/14/2006 Breast Dx 7/28/2009, IDC, 3cm, Stage IIB, Grade 3, 0/6 nodes, HER2- Chemotherapy 10/1/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 9/11/2013, IDC, Stage IV, 1/0 nodes, mets, ER+/PR-, HER2- Chemotherapy 10/1/2013 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 3/7/2014 Carboplatin (Paraplatin), Gemzar (gemcitabine) Hormonal Therapy 11/7/2014 Faslodex (fulvestrant) Chemotherapy 3/1/2015 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 7/7/2015 Ixempra (ixabepilone)
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Jun 21, 2014 03:18PM tryn2staycalm wrote:

Brenda
Can you ask him why change now if working? Are you doing ok with the s/e's? 

I am so grateful to be in this trial!  I know I am getting the Letrozole (Femara) and if I'm in the lucky 66% I am also getting the palbo.  At least I know I'm receiving treatment now.  Day 2 I had some nausea and it was persistent for over an hour or so .. so I took a the nausea meds my MO gave me... and it worked.  I have been sleeping long and well so that is not a bad s/e!  Hope it keeps being this easy but others have said (both in trial and just Letrozole) that it can take awhile to see what s/e's you get and they can come and go. 

Cathy

A strong woman won't let anyone get the best of her, but a woman of strength gives the best of herself to everyone Dx 7/27/2010, IDC, 5cm, Stage IIIC, Grade 3, 1/5 nodes, ER+/PR-, HER2- Radiation Therapy 3/1/2011 Breast, Lymph nodes Dx 5/2012, IDC, Left, Grade 3 Hormonal Therapy 3/23/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 3/26/2015, Stage IV Chemotherapy 6/11/2015 Taxol (paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Chemotherapy Taxotere (docetaxel)

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