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Jul 17, 2019 12:57PM
Help! Just looking for some guidance as I am basically clueless. Recent Guardant360 blood test results:
Alteration % of DNA or Amplification Associated FDA approved therapies Clinical Trial Availability
ESR1 D538G 0.04% Fulvestrant Yes
TP53 A159P 2.5% None Yes
TP53A151G 2.4% None Yes
The list goes on with other TP53 letters/numbers but all are at or below 0.2%. I asked onc what the super low percentage on the ESR1 meant and she said she didn't know but had reached out to the company to ask. She is tentatively recommending a trial of oral Fulvestrant and Femara/Ibrance or Aleseritib/Faslodex (not sure if spelling is correct.
First line treatment was Faslodex and Ibrance for about 38 cycles. Some progression in ribs so she switched to Affinitor/Aromasin. Been on that regimen since late October 2018. Recent scan indicated mild abdominal ascites, but this problem is worsening daily and I have an US scheduled for August 1st. As of now, I am still considered bone only mets.
Looking for any info on the Guardant blood test as well as your thoughts about my abdominal ascites/tenderness/pain. This is also from the CT report:
Abdomen / Pelvis: Physiologic FDG activity is identified in the
genitourinary tract and bowel. Small foci of air in the right pericolic
gutter is favored to represent intraluminal gas. There are thickened loops
of small bowel in the lower abdomen (image 177), concerning for enteritis.
No metabolically active abdominal or pelvic lymphadenopathy. No
intraperitoneal masses. Small volume ascites is new from prior. Anasarca.
I take Lasix daily for fluid buildup but no relief in the abdomen......
TIA for your feedback and hope everyone has a great day!
1/6/2001, DCIS, Right, 1cm, Stage 0, 0/2 nodes, ER+/PR-
7/2015, Stage IV, metastasized to bone, ER+/PR+, HER2-
Lumpectomy: Right; Lymph node removal: Sentinel