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Topic: Carboplatin/Taxol side effects?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

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Posted on: Mar 12, 2013 06:25PM - edited Mar 12, 2013 07:12PM by 11tyBillion

11tyBillion wrote:

Through a trial I am participating in, I will be receiving carboplatin and taxol, along with a ABT-888 (aPARP)/ or placebo. Can any one lend some insight to the Side effects they have had while taking carbo and taxol? Do PARPS have SE's?>

dx 11/5/09, age 39, IDC, BRCA+ Dx 11/13/2009, IDC, 2cm, Stage IIB, Grade 3, 1/11 nodes, ER-/PR-, HER2- Dx 2/2013, IDC, Stage IV, ER-/PR-, HER2-
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Mar 13, 2013 08:13AM Latte wrote:

Hi 11tybillion
I would also be interested in this info. I am thinking about this trial www.clinicaltrials.gov/ct2/sho...
Is this the trial you are doing? Can you send me a link to your trial if it is a different one?
Thanks
Latte

30 Dec 2012: It's back! Stage IV, bone mets to spine, hip, femur, rads, Zometa, Letrozole. May 2013: further spread to ribs, skull, iliac, plus suspicious spots in lung and liver. Clinical trial with taxol and carbo plus velaparib/placebo. Dx 5/3/2010, IDC, 2cm, Stage IIIC, 1/2 nodes, ER+/PR+, HER2- Chemotherapy 6/4/2010 AC + T (Taxol) Surgery 10/28/2010 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 12/12/2010 Breast, Lymph nodes Surgery 3/16/2011 Prophylactic ovary removal Hormonal Therapy 3/18/2011 Dx 12/30/2012, IDC, Stage IV, mets, ER+/PR-, HER2- Radiation Therapy 3/3/2013 Bone Hormonal Therapy 3/11/2013 Femara (letrozole) Chemotherapy 5/14/2013 Carboplatin (Paraplatin), Taxol (paclitaxel)
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Mar 13, 2013 08:50AM JeninMichigan wrote:

I had carboplatin and taxotere back in 2008.  The one thing about carbo I didn't like what the garbage metal taste it leaves in your mouth.  It would start about 3-4 days after and last about a week.  It was gross.  Seriously I slept with Lifesavers in my mouth.   I had a lot of fatigue but I think it was more Taxotere related.  I hear that Taxol might be a little easier to tolerate than Taxotere.   Day #4 sucked big time but then the bounce back came pretty quick.  I was on every 3 weeks and I think that makes a difference too. 

Best of luck to you.

Jennifer

Dx 2/22/2008, IDC, 2cm, Stage IV, Grade 3, 4/9 nodes, mets, ER+/PR-, HER2+
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Mar 13, 2013 08:56AM GrandHillMom wrote:

I did carbo/taxol from June to October last year. The carbo is hard on blood counts, especially white counts. I think I only had bad nausea one out of the six rounds. Ativan usually helped me keep the nausea away. Quite a bit of fatigue. I had total hair loss but it is all growing back now.

By the way, am now NED.

Good luck.

3//2006 Rt: IDC, DCS & IDC, ER+PR+HER2- IIIB, Lt: IDC IIA ER+PR-HER2-; ACT, bilateral radiation, Tamoxifen and megace. 3/2010, bone mets skull, spine, ribs, pelvis, femurs, Aromasin and Zometa. 5/2012 clear cell ovarian cancer, carbo/taxol
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Mar 13, 2013 01:39PM GrandHillMom wrote:

Also, be careful about constipation, especially at beginning.  

3//2006 Rt: IDC, DCS & IDC, ER+PR+HER2- IIIB, Lt: IDC IIA ER+PR-HER2-; ACT, bilateral radiation, Tamoxifen and megace. 3/2010, bone mets skull, spine, ribs, pelvis, femurs, Aromasin and Zometa. 5/2012 clear cell ovarian cancer, carbo/taxol
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Mar 13, 2013 11:52PM SAMayoFL wrote:

11ty, I hate to tell you this but I am on day 6 of ABT-888 and it is, without a doubt, the hardest chemo I have taken. I am seriously considering how long I want to do this. I have to take Zofran, two Benadryl, and Compazine to keep it down. The nausea is awful. Plus, all the anti nausea meds make me sleepy all day. I feel like I am hung over morning and night. Taking chemo every morning and every night stinks. So far, I do not like it. The doctor said it gets easier after the first 21 day cycle. I am trying to hang in there but it is tough. Stay in touch and let me know what you do.

Susan BRCA2+. AC+T finished on 03/23/2011. No rads. Bi-lateral DIEP 08/03/11 (one side immediate one side delayed). 11/05/12 mets to ovaries, uterus and peritoneum. Dx 9/15/2010, ILC, 4cm, Stage IIB, Grade 3, 4/11 nodes, ER+/PR+, HER2- Surgery 9/27/2010 Lymph node removal: Right, Sentinel, Underarm/Axillary; Mastectomy: Right Chemotherapy 11/3/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 4/1/2011 Femara (letrozole) Surgery 8/3/2011 Prophylactic mastectomy: Left; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Dx 11/5/2012, ILC, Stage IV, Grade 3, 0/0 nodes, mets, ER+/PR+, HER2- Chemotherapy 11/21/2012 Abraxane (albumin-bound or nab-paclitaxel)

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