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Topic: Did anybody else see this?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Metastatic breast cancer (MBC; also called stage IV) is breast cancer that has spread to other parts of the body, most commonly the bones, liver, brain, or lungs. Metastatic breast cancer can be treated but not cured. Metastatic disease is NOT hopeless. There are a wide variety of treatment options for metastatic breast cancer, and new medicines are being tested every day. More and more people are living life to the fullest while being treated for metastatic breast cancer.

Note: Please contact your doctor for any specific concerns about symptoms you are experiencing or your course of treatment.

Learn more about living with MBC.

Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Jun 15, 2013 07:02PM - edited Jun 15, 2013 08:18PM by Moderators

sincitydealer wrote:

I just saw an interview with somebody from Duke University on Fox news.  He made it sound like this is the Holy Grail for estrogen positive women who've failed on Tamoxifin and Aromatase Inhibitors.  I sure hope he's right!  This has been approved in Europe and will most likely be approved here.  He said it was right under their noses all along, and it's expected to work well on late stage breast cancer.  This would be the next step after failure of the anti-hormonals instead of going on to chemo.  It completely shuts down the estrogen receptors.  Some of you may qualify for the trial.

Osteoporosis Drug Stops Growth of Breast Cancer Cells, Even in Resistant Tumors

About This Article

Article Details

Published: June 15, 2013
Updated: June 15, 2013

By Duke Medicine News and Communications

DURHAM, N.C. -- A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

The findings, presented June 15, 2013, at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction.

"We found bazedoxifene binds to the estrogen receptor and interferes with its activity, but the surprising thing we then found was that it also degrades the receptor; it gets rid of it," said senior author Donald McDonnell, PhD, chair of Duke's Department of Pharmacology and Cancer Biology.

In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer. Currently, if breast cancer cells develop resistance to these therapies, patients are usually treated with toxic chemotherapy agents that have significant side effects.

Bazedoxifene is a pill that, like tamoxifen, belongs to a class of drugs known as specific estrogen receptor modulators (SERMs). These drugs are distinguished by their ability to behave like estrogen in some tissues, while significantly blocking estrogen action in other tissues. But unlike tamoxifen, bazedoxifene has some of the properties of a newer group of drugs, known as selective estrogen receptor degraders, or SERDs, which can target the estrogen receptor for destruction.

"Because the drug is removing the estrogen receptor as a target by degradation, it is less likely the cancer cell can develop a resistance mechanism because you are removing the target," said lead author Suzanne Wardell, PhD, a research scientist working in McDonnell's lab.

Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.

"We discovered that the estrogen receptor is still a good target, even after it resistance to tamoxifen has developed," he said.

The investigators tested a variety of breast cancer cell types, including tamoxifen-sensitive cells that are resistant to the drug lapatinib, another targeted therapy that is used to treat patients with advanced breast cancer whose tumors contain the mutant HER2 gene. These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance. In this cell type, bazedoxifene also potently inhibited cell growth.

Paradoxically, in bone tissue, bazedoxifene mimics the action of estrogen, helping protect it from destruction. Because bazedoxifene has already undergone safety and efficacy studies as a treatment for osteoporosis, it may be a viable near-term option for patients with advanced breast cancer whose tumors have become resistant to other treatment options, Wardell reported. In clinical trials, the most often reported side effect was hot flashes in the bazedoxifene treatment groups.

The study was funded by a research grant from Pfizer Pharmaceuticals, maker of bazedoxifene.

In addition to Wardell and McDonnell, Erik Nelson and Christina Chao of the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, contributed to the research.

Edited by Mods to tidy up imported formatting

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Jul 17, 2013 11:13AM sciencegal wrote:

Blainejennifer- I am so sorry to post on this forum since I am not yet stage IV (but very likely will be in the next couple of years)- I wonder if you might post that letter in a new thread to ask all of us on this board to help you all contact Pfizer?

We need the power of numbers for this mission.

I happened acros this because I am a research scientist and very interested in the upcoming drugs (hi Wardells- thank you!) but most of us would never see it. Many of us would modify your template letter and help contact Pfizer. I kow that the big companies DO listen to the voices of the patients. Many who are not on the stage IV forms will want to help.

Hugs to all

My friends saved my hair through chemo with Penguin Cold Caps. Thank you capping crew!! Now NED 5 years out. Hang in there! Dx 10/19/2012, IDC, 6cm+, Stage IIB, Grade 3, 3/4 nodes, ER-/PR-, HER2+ Surgery 11/2/2012 Lymph node removal: Left, Sentinel Targeted Therapy 11/7/2012 Herceptin (trastuzumab) Chemotherapy 11/7/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 3/19/2013 Lymph node removal: Left, Underarm/Axillary Surgery 3/19/2013 Mastectomy: Left; Reconstruction (left): Tissue expander placement Surgery 5/23/2013 Reconstruction (left) Radiation Therapy 6/27/2013 Breast Surgery 9/26/2014 Reconstruction (left); Reconstruction (right)
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Jul 17, 2013 11:35AM olisad wrote:

Yes. I will join you. Lisa

Best friend has mets to liver, bone, brain.
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Jul 17, 2013 12:10PM 4myangels wrote:

Who are you sending the letters to?

I would send it directly to the guy in charge of oncology drugs:

Geno Germano, President and General Manager, Specialty Care and Oncology

He'll never open the letters himself and doubt he will read them, but if he gets a deluge of letters, maybe we'll get enough of his attention that he'll ask one of his subordinates to look into this. It's better than just sending a "to whom it may concern" letter to their communications department.



Dx 5/21/2012, IDC, 2cm, Stage IV, Grade 2, mets, ER+/PR+, HER2-
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Jul 17, 2013 12:20PM wardells wrote:

I might also suggest Robert Abraham, Chief Scientific officer in the Oncology Research Unit in research and development.  And then he will get it from both sides...

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Jul 17, 2013 12:37PM chickydee wrote:

Blainejennifer-Thank you so much for posting your weekly letter. It has given me many ideas of composing my own since writing is not my forte. 4myangels and wardells-Thank you for supplying the names so our letters get the attention they need. Every time I read these posts it gives me such hope to keep hanging on. Thanks to all.

Dx 4/28/2011, IBC, <1cm, Stage IV, Grade 3, mets, ER+/PR-, HER2- Chemotherapy 5/17/2011 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 11/27/2011 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Radiation Therapy 2/15/2012 Breast, Lymph nodes Hormonal Therapy 4/2/2012 Hormonal Therapy 3/20/2013 Faslodex (fulvestrant) Hormonal Therapy 3/20/2013 Arimidex (anastrozole)
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Jul 17, 2013 02:01PM cburke51986 wrote:

I just read about this last week! I hope the clinical trials are able to move along pretty quickly so that people can start benefiting from it. I know a lot of clinical trials take years to complete and be approved, but hopefully this one will move faster since it's already approved by the FDA for osteoporosis. It is really exciting, without a doubt!

Dx 3/19/2013, IDC, 2cm, Stage IV, Grade 2, mets, ER+, HER2+ Targeted Therapy 4/8/2013 Herceptin (trastuzumab) Targeted Therapy 4/8/2013 Perjeta (pertuzumab) Chemotherapy 4/8/2013 Taxotere (docetaxel) Surgery 11/4/2013 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Radiation Therapy 12/21/2013 Breast, Lymph nodes Hormonal Therapy 2/23/2014 Radiation Therapy 3/18/2014 Bone Targeted Therapy 3/21/2014 Herceptin (trastuzumab)
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Jul 17, 2013 02:05PM olisad wrote:

Wardells, have you heard of any success regarding compassionate use granted by Pfizer in the US?

Best friend has mets to liver, bone, brain.
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Jul 17, 2013 08:27PM Dianarose wrote:

I have been reading all these posts and had a thought. If we all posted on our facebook pages all of our friends and loved ones who want us to be around for a long time could write as well. I am not a big user of facebook for socializing, but this could help us all.

blainejennifer-your letter is well written. Would you mind writing a generic letter that would be sent from a loved one or a friend that could be copied and posted on facebook? The mail carrier isn't going to be happy with us.

6/10/13 mets to ovary now. Now mets. To peritoneal stage IV Dx 3/22/2012, ILC, Both breasts, 1cm, Stage IV, metastasized to bone/other, Grade 2, 17/17 nodes, ER+/PR+, HER2- Chemotherapy 5/31/2012 CMF Radiation Therapy 12/3/2012 3DCRT: Breast, Lymph nodes Hormonal Therapy 8/10/2013 Aromasin (exemestane) Targeted Therapy
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Jul 18, 2013 05:29AM GatorGal wrote:

Was just alerted to this thread ny someone on another thread. Does anyone know if you could use this drug even after being on chemo? I will definitely start a letter campaign! Thanks, Blainejennifer.

When people asked how old she was, she would say 1009365 more or less because she was so glad to be alive that she counted every day a birthday! (Brian Andreas, Storypeople) Dx 5/2008, IDC, Right, Stage IV, metastasized to bone/liver/lungs, 11/27 nodes, ER+/PR+, HER2- Chemotherapy 4/10/2011 Taxotere (docetaxel) Chemotherapy 8/13/2011 Gemzar (gemcitabine) Chemotherapy 6/12/2012 Doxil (doxorubicin) Chemotherapy 12/11/2012 Taxol (paclitaxel) Chemotherapy 9/10/2013 CMF Chemotherapy 4/15/2014 Carboplatin (Paraplatin) Chemotherapy 12/16/2014 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 9/8/2015 Navelbine (vinorelbine) Chemotherapy 12/22/2015 Halaven (eribulin) Chemotherapy 4/12/2016 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 6/14/2016 Ixempra (ixabepilone) Hormonal Therapy 7/26/2016 Arimidex (anastrozole)
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Jul 18, 2013 08:36AM wardells wrote:

Yes, the drug could be used after chemotherapy, just like faslodex or aromatase inhibitors are often used after chemo.

Olisad, I am not sufficiently in the loop to know for sure about compassionate use, but I do know that they have noticed the influx of requests.

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Jul 18, 2013 08:51AM wardells wrote:

If you want to go the facebook route, it might help to include the original Fox news release.  The original press release is at the top of the thread.

http://video.foxnews.com/v/2487495634001/osteoporosis-drug-blocks-growth-of-breast-cancer-cells/

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Jul 18, 2013 10:04AM - edited Jul 18, 2013 10:08AM by DivineMrsM

wardells, thanks for posting the Fox news video.  It was informative.  The only thing I couldn't find was when did it air?  I always like to know those kinds of things, and wish the page would include that information.  Maybe I'm overlooking it?

Okay, wait, I see SinCityDealer posted that it was aired June 15th.

found lump 12/22/10~er+/pr+/her2- stage iv bone mets------------- Chemo~lumpectomy~radiation~arimidex------------- March2019/Ibrance-Aromasin---------- Sept2019/Verzenio-Aromasin
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Jul 18, 2013 10:10AM blainejennifer wrote:

Dianarose,

I've posted it to FB as well, and asked my friends to share it. I think I'm going to repost monthly or bimonthly. Don't want to get people bored with the message.

I followed a pretty generic letter template.

Paragraph 1: Identify letter topic. Bazedoxifene is yummy. Gimme.

Paragraph 2: Why I care. Stage 4 yada yada.

Paragraph 3 and 4: An ideal outcome for me and the lovely drug. Thank you, Wardells, for the marketing angle.

Paragraph 5: Gratitude.

It's not so much what we are writing in the letters that sways corporate honchos, but that we are actually taking the time and trouble to write. And call. My local Senator said that she takes the letter volume she receives and adds a zero to the number to figure out how many of her constituents feel a certain way. I'm thinking that maybe pharmaceutical executive types follow the same rubric. Squeaky wheel and all that.

So I plan on squeaking like a mouse on speed.

ER/PR+, HER2-, Grade 3. Stage 4, July 2012. Currently on Gemzar/Carboplatin Dx 5/2006, IDC, 4cm, Stage IIB, Grade 3, 4/12 nodes, ER+/PR+, HER2- Dx 3/2012, IDC, Stage IV, 4/12 nodes, ER+/PR+, HER2- Chemotherapy 6/27/2012 Taxol (paclitaxel) Hormonal Therapy 6/4/2013 Faslodex (fulvestrant) Chemotherapy 7/1/2014 Xeloda (capecitabine) Hormonal Therapy 8/14/2015 Femara (letrozole) Chemotherapy 1/31/2016 Halaven (eribulin) Chemotherapy 8/31/2016 CMF Chemotherapy 11/1/2016 Halaven (eribulin) Chemotherapy Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Jul 18, 2013 09:00PM Inky wrote:

Thanks, Jennifer, for starting this letter campaign. When I first read this thread, I thought about doing the same thing, but that's as far as I got with it. I did show the original post and all of Dr. Wardell's comments to my MO, for whatever that was worth. I now plan to do my own version of your letter, and then send it out by snail mail tout suite.


Ingrid Dx 7/2009, IDC, 3cm, Stage IIB, 1/17 nodes, ER+/PR-, HER2+ Dx 3/2012, IDC, 2cm, Stage IV, 1/17 nodes, mets, ER+/PR-, HER2-
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Jul 20, 2013 11:13PM sandilee wrote:

Would it be possible for patients to order it online?



http://www.selleckchem.com/products/bazedoxifene-hcl.html

Dx 11/2007, IDC, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR-, HER2- Hormonal Therapy 1/10/2008 Aromasin (exemestane) Dx 6/2011, IDC, mets Radiation Therapy 6/30/2011 Bone Hormonal Therapy 7/15/2011 Faslodex (fulvestrant) Hormonal Therapy 4/10/2015 Femara (letrozole) Targeted Therapy 4/20/2015 Ibrance (palbociclib) Chemotherapy 8/4/2015 Xeloda (capecitabine) Hormonal Therapy 3/11/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Chemotherapy 10/13/2016 Doxil (doxorubicin) Chemotherapy 4/4/2018 Navelbine (vinorelbine) Hormonal Therapy 6/6/2018 Faslodex (fulvestrant) Targeted Therapy 6/6/2018 Verzenio Chemotherapy 4/23/2019 Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Jul 22, 2013 12:07AM sciencegal wrote:

Interesting that no one wrote back to you Sandilee. I think we all just do not know. That looks like a legitimate chemical sales site (in contrast to some that sell viagra, etc). I dont know if it is formulated for human consumption. Or needs to be?

I know we all hesitate to take things without our doctors knowing, or the "GMP" seal of approval, but I have to confess that I sometimes take antibiotics sold for fish aquariums...and have not developed gills yet.

Others thoughts on selleckchem? Wardells?

My friends saved my hair through chemo with Penguin Cold Caps. Thank you capping crew!! Now NED 5 years out. Hang in there! Dx 10/19/2012, IDC, 6cm+, Stage IIB, Grade 3, 3/4 nodes, ER-/PR-, HER2+ Surgery 11/2/2012 Lymph node removal: Left, Sentinel Targeted Therapy 11/7/2012 Herceptin (trastuzumab) Chemotherapy 11/7/2012 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 3/19/2013 Lymph node removal: Left, Underarm/Axillary Surgery 3/19/2013 Mastectomy: Left; Reconstruction (left): Tissue expander placement Surgery 5/23/2013 Reconstruction (left) Radiation Therapy 6/27/2013 Breast Surgery 9/26/2014 Reconstruction (left); Reconstruction (right)
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Jul 22, 2013 01:59AM Kathy044 wrote:

Sandilee, did you read the very last line in small print at the bottom of the page? They do not sell to patients.

Dx 2009, ILC, Right, 1cm, Stage IIA, Grade 2, 1/15 nodes, ER+/PR+, HER2- Surgery 10/28/2009 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 12/15/2009 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil), Taxotere (docetaxel) Radiation Therapy 5/1/2010 Whole-breast: Breast Hormonal Therapy 6/3/2010 Arimidex (anastrozole)
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Jul 22, 2013 06:26AM Heidihill wrote:

It seems bazedoxifene is an indole-based compound (according to the Sellekchem page). While we wait for things to move, we can start eating a whole bunch of cruciferous vegetables everyday:

arugula, broccoli, Brussels sprouts, broccoli sprouts, cabbage, cauliflower, collard greens, horseradish, kale, kohlrabi, mustard greens, radishes, rutabaga, turnips and turnip greens, and watercress.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/24/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 22, 2013 09:50AM wardells wrote:

Unfortunately, Kathy044 is correct - this is research grade drug.  But you raise an interesting question.  I wonder if we could find a physician in Europe who would be interested in seeing US patients and prescribing, if the drug could be obtained from a mail-order pharmacy.  However, I doubt that the HMOs would approve it... not an in network Dr.

Heidihill, I wish it was that easy.  bazedoxifene is not a naturally occuring metabolite of the indole-rich veggies.  While these are certainly healthy, it probably won't mimic BZA.

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Jul 22, 2013 10:56AM Heidihill wrote:

I suppose it would be easier if a person already had osteoporosis, as it is approved for that in Europe.

Thanks for the info. I'm glad I don't have to feel I have to eat those veggies everyday.



Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/24/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 23, 2013 02:57PM cp418 wrote:

I'm wondering if the valuable information in this post is being missed by many readers here.  Maybe heading change?

Anyway I was wondering if it would be beneficial to setup an online petition regarding the status of BZA? Any thoughts on this?  A petition to use for Pfizer and FDA?  I don't get the sense that many patients are aware of this drug not being available here - - yet available in Europe only.  I don't know if a few emails or letters will make a difference to the individuals in charge at Pfizer.  Somehow our needs and voices must be heard LOUDLY. 

Dr Wardells - I want to thank you for coming to this site and explaining your remarkable research, hx of this drug, and current status of treatment use and availability.  There are too many hormone positive patients who are relapsing post Tamoxifen and AI treatments with metastatic dx.  Our lives and survival depend upon access to the best medications and treatments currently available.  For many patients, time is the enemy as they cannot wait years for the extended review and approval process of future treatments.  If a current medication may have an additional efficacy indication by all means let us have it.  There are many here who will GLADLY pop this pill after having gone through the debilating affects of chemo. Again - Many thanks to you and your research team!  Looking forward to hearing more about SERDS for the future.

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Jul 23, 2013 03:31PM wardells wrote:

A petition would probably be an attention getter!  We are also continuing to lobby Pfizer to at least have the drug registered in the US.

The editors of the site actually asked me to integrate all of the many posts I had done here into a blog spot to be posted on its own.  That should hopefully take care of the wider audience as well.

And "your welcome" rings hollow.  I am humbled by the welcome and kind words directed my way here, especially since it doesn't feel like I have actually done anything yet.  When someone posts that they have received the drug, then I will rejoice.

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Jul 23, 2013 05:05PM Inky wrote:

Thank you so much, Dr. Wardells! On those days that I despair over this awful disease, I am reminded that there are wonderful researchers like you who are fighting everry bit as hard as we are to extend our lives.

I sometimes think that the advanced BC community needs to take a page from ACT UP and the activism shown by the AIDS community in the 1990s. If there is anything that we can do to make promising drugs like BZA available for trial, let us know what that is. A petition sounds like a grand start! I also love your idea of finding a physician in Europe who would be interested in seeing US patients and prescribing BZA. Does anyone know how we go about finding such a physician?

A thousand thanks to you and your research team!

Ingrid Dx 7/2009, IDC, 3cm, Stage IIB, 1/17 nodes, ER+/PR-, HER2+ Dx 3/2012, IDC, 2cm, Stage IV, 1/17 nodes, mets, ER+/PR-, HER2-
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Jul 23, 2013 06:14PM Craftylass wrote:

Someone just brought this thread to my attention.  (I don't come to BCO very often as it's just really too big for me!  Laughing )

I read about this study a while back and have it bookmarked.  Dr. Wardells, I appreciate your comments and input into the discussion.  Very insightful to have the author on hand so that we don't have to second guess or wonder "what does this mean?"  I will be following this discussion with extreme interest as I just found out last week that Tamoxifen is no longer working for me and that I not only have worsening bone mets, but new lesions as well.  Fortunately, it's all still in my spine and hip. 

Is it common for a drug company to pursue two drugs at the same time for FDA approval for the same disease?  The reason I ask is that I'm closely following the Pfizer CDK (palbociclib (PD-0332991) ) trials and am even being considered as one of the Phase 3 participants.  Would Pfizer want to have two trials for breast cancer drugs (ER+) going on at once?  Perhaps this is why they are holding off on the BZA.  

Hoping for the best, 

Craftylass

"Today is the day!" Dx 1/31/2012, IDC, 5cm, Stage IIIB, Grade 2, 0/2 nodes, ER+/PR+, HER2- Chemotherapy 2/14/2012 AC Chemotherapy 5/29/2012 Taxotere (docetaxel) Surgery 9/5/2012 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 10/18/2012 Breast Hormonal Therapy 12/21/2012 Dx 1/3/2013, IDC, Stage IV, Grade 2, mets, ER+/PR+, HER2- Radiation Therapy 1/24/2013 Bone
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Jul 23, 2013 09:52PM cp418 wrote:

I would like to start a petition to Pfizer to get BZA registered in the USA. We need to get the same access to this drug as patients in Europe treated for osteoporosis.  This first step in access may help get addition clinical trials started for use in breast cancer. 

Please post or forward to me your wording, ideas, suggestions for how to write and word this petition.  Writing is not my strength and I want to clearly communicate and include your thoughts, feelings, concerns for breast cancer patients in the USA to get the same access to this medication.  I feel it is critical that the Pfizer executives hear us loud and clear, in addition to our individual letters.  We need to get their attention to hear our request. 

Moderators - please any help in this endeavor is greatly appreciated.

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Jul 24, 2013 01:12AM poedake wrote:

hello my mets sisters, I am new to the bco community. I have been reading this topic for a few days and I got so excited about this

treatment that I had to join & be here sign the petition once it's written. And thank you Dr. Wardells for sharing your expertise regarding this

drug, you really make it feel real and not just hype!

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Jul 25, 2013 09:42AM Heidihill wrote:

Am wondering if patients with prescriptions from their US doctors could not have them fulfilled by a Swiss pharmacy by mail. It seems it is legal for consumers to import new unapproved drugs (according to wikipedia) for personal use. I will check with my local pharmacy tomorrow.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/24/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 25, 2013 11:02AM - edited Jul 25, 2013 11:23AM by AmyQ

Wow - such promise! I'm on the Femara and monthly Xgeva track but it's great to know there may be more firepower should these fail at some time. My husband is a physican and cancer researcher so knows the ins and outs of the IRB's, clinical trials etc so I'll see what he says and report back. 

Dx 2/7/2013, IDC, 1cm, Stage IV, Grade 2, 2/3 nodes, mets, ER+/PR+, HER2- Chemotherapy 4/9/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 7/19/2013 Femara (letrozole) Radiation Therapy 11/25/2015 External: Bone Hormonal Therapy 1/10/2016 Faslodex (fulvestrant)
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Jul 26, 2013 12:47PM - edited Jul 26, 2013 12:49PM by Heidihill

Ok, I talked to a pharmacist and was told they will sell Conbriza (Bazedoxifene) with your doctor's prescription for off-label use but they can't guarantee it will get through U.S. Customs (and they will not take responsibility for it, obviously). They have had many problems in this regard. She told me the big online European pharmacies do not sell to U.S. residents for this reason. The sure way to get the drug is to travel to Europe with your prescription and take it home with you. Make that travel to Switzerland as I only know about the situation here. Maybe others from the UK or elsewhere can chime in.

Dx 8/2007, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 2, 2/19 nodes, mets, ER+/PR+, HER2- (FISH) Hormonal Therapy 3/24/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 26, 2013 01:04PM wintersocks wrote:

Hello Ladies,

I live in the UK. I have never heard of this drug. I can tell you how our medicines are dispensed here if that might help? 

Dx 2/20/2012, IDC, 6cm+, Stage IIIA, Grade 2, 4/11 nodes, ER+/PR-, HER2- Chemotherapy 3/23/2012 Doxil (doxorubicin), Taxotere (docetaxel) Surgery 8/29/2012 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Hormonal Therapy 9/10/2012 Femara (letrozole) Radiation Therapy 9/16/2012 Breast, Lymph nodes

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