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Topic: How are people with liver mets doing?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Metastatic breast cancer (MBC; also called stage IV) is breast cancer that has spread to other parts of the body, most commonly the bones, liver, brain, or lungs. Metastatic breast cancer can be treated but not cured. Metastatic disease is NOT hopeless. There are a wide variety of treatment options for metastatic breast cancer, and new medicines are being tested every day. More and more people are living life to the fullest while being treated for metastatic breast cancer.

Note: Please contact your doctor for any specific concerns about symptoms you are experiencing or your course of treatment.

Learn more about living with MBC.

Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Aug 16, 2013 12:02PM

blondie1 wrote:

I continue to be very scared once I found my liver mets progressed after having to go off doxil. I am hoping to find some support in alleviating my deep seated fears by hearing other stories of people living and dealing with liver mets. My onc says I have such a petite frame (105) that an enlarged liver will definitely cause me some pain until chemo takes care of it.

How are others doing and getting through this with a positive attitude?

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Jan 22, 2021 03:12AM BevJen wrote:

BlueGirl RedState,

I am eligible for keytruda because I have what's known as tumor mutation burden high. The FDA has approved the use of keytruda as a single agent across all solid cancer types for TMB-High and also for something known as micro satellite instability high.

These mutation "markers" (not sure if that's the right word) must be demonstrated via one of the approved genomic tests, based upon a tumor biopsy. Think Foundation One (mentioned here before). I've had two different genomic tests -- Foundation One and Tempus -- as well as a liquid F1 biopsy. I'm seen at a major cancer center. You say that you've had a "genetic" test -- those will only show inherited BC genes, not things that may have developed during your cancer (known as somatic mutations). I've had genetic testing done in the past, too -- and it basically showed nothing. But my cancer has clearly mutated while I've had it, and that's what these genomic tests show.

I would discuss the possibility of a surgical biopsy with your MO to see what else could be used. Also, I've seen that some people move from Ibrance to Verzenio (there are several people on the boards who have done that) and Verzenio, which is taken every day, has help them some.

Also, you may want to consider a second opinion on your whole situation. If you cannot travel to a major cancer center (not sure where you live) you can try to arrange such a consult via Telehealth. It would require gathering all of your scans (when you have your PET, ask for a disk as well as the report -- you will need both for a second opinion) and making contact in advance to try and set this up.

Good luck.

Microwave Ablations of the Liver: 7/2019; 10/2020; 12/2020 Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Jan 22, 2021 04:17AM Husband11 wrote:

Nicole, what a terrible situation. I am praying for your recovery.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Jan 22, 2021 05:11AM SandiBeach57 wrote:

Nicole, the fact that you are posting is a positive sign that you are inching your way back from a scary and painful experience. For you to take any pain meds, tells me a lot on how bad you are feeling

It sounds like your MO wants you back to baseline and stable. You are strong, focused and smart. This pain and delay of treatment is a temporary set back. You will get back on your feet..that is who you are.


2016: MBC with liver mets (DCIS in 2006 & 2007), AC followed by Ibrance, Letrozole. Grade 3 ER+PR-, HER2-. 2020: progression liver mets, Xeloda, Grade 3 ER+PR+HER2-
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Jan 22, 2021 05:44AM Rosie24 wrote:

Nicole, So sorry you are going through so much from the Y90. My thoughts are with you and I hope your recovery has already started without you knowing it.

Dx 1/23/2019, DCIS/IDC, Left, 3cm, Stage IV, metastasized to liver, Grade 2, ER+/PR-, HER2- (FISH) Hormonal Therapy 1/24/2019 Femara (letrozole) Targeted Therapy 1/24/2019 Ibrance (palbociclib) Surgery 12/3/2019 Lumpectomy: Left Surgery 12/3/2019 Lymph node removal: Sentinel Radiation Therapy Whole-breast
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Jan 22, 2021 06:43AM AlabamaDee wrote:

Nicole

I am so sorry your body reacted terribly to the y-90. I pray that each day is better. Just want you to know you are in my thoughts and prayers 🦋🦋🦋🦋

I hope you can find some help managing your issues with palliative care. Their purpose is to make your quality of life better. Can they get you a pain patch? My sister with stage 4 lung canceruses that method and it works well for her. She goes to the pain clinic.

Please give updates when you can. I care.

Dee


Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 22, 2021 08:03AM candy-678 wrote:

Nicole- So sorry you are going thru all this. I have thought about the possibility of local liver treatments for me, even though I have not discussed it with my MO. But... I would definitely not go into it lightly after hearing your experience with it. Wow. I think I will stick to systemic treatment for now. Take care and post when you feel up to it.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Also using Xgeva injections for bone mets Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal: Sentinel; Mastectomy: Left
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Jan 22, 2021 08:50AM moth wrote:

Nicole, thinking of you. It is so easy to go to a dark place when our bodies betray us and when we feel so ill. Our minds are weird - I know when I'm in pain and feeling ill, I cannot remember how it feels to not be ill and in pain. I have to keep reminding my brain that it's not always been like this and it won't be like this forever. Hour by hour, day by day. Hang in there. You'll get strong again.

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Dx 12/10/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Jan 22, 2021 11:37AM Kattysmith wrote:

Dear Nicole, I wish with all my heart and soul that we could take away your pain and your fear and your understandable feeling of hopelessness. All I can do offer you my concern my care for you and my prayers.

May the One who was a source of blessing for our ancestors, bring blessings of healing upon those who are suffering, a healing of body and a healing of spirit. May those in whose care they are entrusted, be gifted with wisdom and skill, and those who surround them, be gifted with love and trust, openness and support in their care. And may they be healed and comforted along with all those who are in need. Blessed are You, Source of Compassion. Amen.

First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Jan 22, 2021 12:01PM HopeandGratitude wrote:

Nicole - You have been on my mind and in my heart. I ache for what you must be going through and I pray for your healing and your release from pain. Seeing that you posted lifted my spirits! I know you are regaining your strength and on the road to recovery. Take time for yourself to heal - body, mind and spirit.

Dear Lord, in whatever way is Your will, please bring comfort and healing to Nicole in her time of need. Let her feel Your presence and know that she is never alone and she can never be separated from You. Watch over her and let her feel Your tenderness and love.

Dx 3/1/2002, ILC, Left, 6cm+, Stage IIIB, Grade 3, 0/14 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 3/27/2002 CEF Chemotherapy 6/5/2002 AT Surgery 8/29/2002 Mastectomy: Left; Reconstruction (left): Free TRAM flap, Nipple reconstruction, Nipple tattoo Radiation Therapy 10/15/2002 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 1/5/2003 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 1/12/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 2/15/2018 Lumpectomy: Left; Lymph node removal: Left Chemotherapy 4/3/2018 CMF Chemotherapy 8/6/2018 Taxol (paclitaxel) Radiation Therapy 10/10/2018 External: Breast, Lymph nodes, Chest wall Dx 3/13/2019, IDC, 1cm, Stage IV, metastasized to liver, Grade 3, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/14/2019 Femara (letrozole) Targeted Therapy 3/24/2019 Ibrance (palbociclib) Targeted Therapy 10/24/2019 Verzenio Dx 3/18/2020, IDC, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/20/2020 Aromasin (exemestane) Hormonal Therapy 4/7/2020 Faslodex (fulvestrant)
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Jan 23, 2021 08:56AM txmom wrote:

Hi, I had quarterly scans last week as I have MBC triple posit to my bones de novo. I’ve been bone only for 5 1/2 years. My CT report indicates a hypodense 1.3 cm lesion on my liver. My tumor markers are up 25 points in 3 months. I’m getting an MRI next week. I’m just really nervous and sad. Hoping I can get some responses of hope and what to expect. I’m currently on Kadcyla which has been a rough go for me. I’ve been on it since June. My liver seems not to like it at all as my liver numbers have been high since June but were normal for the past 5 years. Kadcyla is my second line of treatment. I think Falsodex is my next line.If you read this, thanks so much. I look forward to your responses.

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Jan 23, 2021 10:59AM - edited Jan 23, 2021 11:05AM by AlabamaDee

Txmom

I am sorry for what seems to be progression. It is scary and emotional. The people here are great encouragers and have lots of experience.

May I suggest a very important next step is a liver biopsy with NGS from one of the companies offering it.(foundation one, TEMPUS, etc). Once you get that data, you will know if your tumor has mutations and what therapies would be best. Your oncologist can order it and an interventional radiologist will perform it.

If they can't get a liver biopsy, then you could ask for a liquid biopsy, FDA approved Foundation One

Please consider local therapy to the one liver lesion. There is a thread for that here. If the tumor is in a good spot for local treatment then you could qualify for ablation, y-90 etc. esp if your bone mets are stable

I am not Her2 so I can't speak to that, but there are several here who are. They may offer experience in that area. I hope you soon get the answers you need to proceed with as much confidence as possible o this rollercoaster ride

Dee

Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 23, 2021 11:43AM B-A-P wrote:

Hey everyone,

Just checking in. Feeling decent on my current treatment Abraxane. On a 1,8,15,(then break to 28) dose schedule which is fine. Currently only fatigued the night of treatment and end of days for the next day or two ( so far). Finally got my Liver biopsy done. The first pass was painless, but the second was unpleasant since they had to biopsy the left lobe and apparently they irritated the capsule. Either way they have two great samples they said, so hopefully I'll know my markers soon, though it'll probably be a few weeks. I am trying not to think about the possible results because I really just need some good news in all this mess ( like it's not mutated to triple neg). I can't see it been 100% ER + 50% PR + this whole time and just completely switching, but I Suppose it's possible ( please don't comment that it is possible, I'd rather be ignorant for now).

My current MO has a great interest in mutant drivers and said she'd look into Foundation 1 but not to expect much since I have so many lines of treatment on the table first ( which I guess is comforting but at the same time I know it's dependent on my markers). My curiosity lies in the fact that my Paternal Aunt has the brac2 mutation like myself and is on her fourth PRIMARY cancer( Breast, uterine, lung, and likely colon now with lots of metastatic deposits from each cancer). If that doesn't scream a mutation in her DNA somewhere, I don't know what does. She does not want the genomic testing. I think she's fairly over it all. Anyway, it's all very frustrating . I can't really afford foundation 1 or any of the testing but I do think it's vital to know.

And I'm currently jealous that it seems like most here get their Tumour markers monitored frequently and I can't even get them to test at all. " We go by scans and how you feel" If that's the case and If I was anything but stage 4 to begin with, I'd be far more advanced as I am now. I don't know what it hurts for them to test it , but whatever. I'm over being told no. Here's to positive results .

Hope everyone is doing as well as they can be !


Dx 8/17/2018, IDC, Left, Stage IV, metastasized to liver, ER+/PR+, HER2- (FISH) Chemotherapy 9/17/2018 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Surgery 2/25/2019 Mastectomy: Left, Right Radiation Therapy 4/28/2019 Whole-breast: Breast, Lymph nodes, Chest wall Dx IDC, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Chemotherapy Abraxane (albumin-bound or nab-paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Prophylactic ovary removal
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Jan 23, 2021 12:18PM txmom wrote:

Hi Dee,

Thanks so much for your response. In Oct my Dr said she would do a biopsy with the next progression. She did say she took a blood test and sent it out to see what treatment would be effective for my next line of treatment. Do you know what test that is? I’m just having a tough day today.

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Jan 23, 2021 12:21PM txmom wrote:

B-A-P, my Dr initially did not take tumor markers either and went by scans. I think I didn’t have my taken tumor markers taken for years. Now she does both.

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Jan 23, 2021 01:29PM - edited Jan 24, 2021 06:46AM by AlabamaDee

B-A-P

Glad you had a decent liver biopsy. Sorry it was a bit tough. My first one was too.
I am a bit confused, You said they sent off the biopsy to know markers, but youcould not afford NGS like Foundation one. I think TEMPUS has a self pay where you fill out the form and their test is under $200.

Your aunt's case is really amazing-4 primaries. I can’t imagine going down her path.

Hoping the best for you and answers to help you move forward

Dee.

Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 23, 2021 05:07PM - edited Jan 23, 2021 05:09PM by Grannax2

Nicole, it sounds like you're making wise decisions about no chemo and no y90 until you feel much better. I'm so sorry the one % thing happened to you. I feel the same 1% thing happened to me with my MWAs. I think it sort of traumatized me like none of my other TX has.

I did have my second infusion of Eribulin on the 21st. My magnesium got even lower with the first infusion so they had to give me some IV. Not a good combination for both magnesium and potassium to be low. Although it is an SE along with heart rhythm problems, which I also have.

So far, no appetite and fatigue have been my main SE. I have next week off. I'm glad for the break. My next cycle will start on February 3.

I'm hoping all of us can keep doing our best to cope with all the unexpected issues we are having to experience. It's a difficult full-time job we have.

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Jan 24, 2021 11:36AM B-A-P wrote:

Hi Dee,

I'm in Canada so doing biopsies for Hormone and Her 2 status does not cost me anything. Testing like foundation 1 is private and from their website it appears to be $6000. Genetic testing for things like BRCA status is also public sector but it was going to take a year for the test and so I did digging and found the Women's College of Toronto was doing a study and that cost me $200 and I had an answer within a month ( Turns out BRCA2 +) My aunts BRCA status was never mentioned to her when she was first dx'd with Breast cancer. I think she was 53 at dx and triple positive which I believe my MO said is not usually associated with the mutation. Her lung cancer is BRCA2 positive ( same exact mutation as mine) and I don't believe lung is even on the radar of that mutation.They only tested it because she mentioned me. My uncle ( her brother) also has pancreatic cancer from the mutation so it's doing a number on us. It's just too bad I was the second one to get sick so I was dx'd late based on my young age (30 at the time) and "weak family history " My dad and all of his siblings are Positive and only two of them at the moment have cancer.

I will look into Tempus and see what that is all about :)

Dx 8/17/2018, IDC, Left, Stage IV, metastasized to liver, ER+/PR+, HER2- (FISH) Chemotherapy 9/17/2018 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Surgery 2/25/2019 Mastectomy: Left, Right Radiation Therapy 4/28/2019 Whole-breast: Breast, Lymph nodes, Chest wall Dx IDC, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Chemotherapy Abraxane (albumin-bound or nab-paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Prophylactic ovary removal
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Jan 24, 2021 01:22PM theresa45 wrote:

Nicole - Thanks for the update! I'm so very sorry that you've experienced so much pain after the y90 procedure. I will be praying that you will be feeling much better soon. I agree with Grannax that you are wise to recover before you undergo a second y90 or restart eribulin. It's very nice that the IR wants to check in on you weekly!

Grannax - I hope that Eribulin is very effective against your cancer and that your oncologist can work out the magnesium and potassium issues. I hope that your week off will allow you to regain your energy and appetite.

Dx 4/20/2009, IDC, <1cm, Stage I, Grade 2, 0/4 nodes, ER+/PR+, HER2-
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Jan 24, 2021 04:02PM moth wrote:

BAP, foundation one in Canada may be willing to work with you and any extended health insurance for coverage of the costs. I saw them responding on Twitter to a Cdn pt to contact them and see what could be worked out.

Mine was paid for by the clinical trial but I still don't have results. Hopefully by the Feb meeting with my MO.

Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/9/2020 External Dx 12/10/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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Jan 24, 2021 07:41PM BSandra wrote:

Dear Nicole, we all pray for you to get better. No words can tell what you go through but this group of people is kind of closest to understand your situation. Hugs, Saulius

Since Sep2019:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall
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Jan 24, 2021 08:08PM - edited Jan 24, 2021 08:12PM by Bliss58

Hi Txmom. Sorry you've had progression and find yourself here, but it's nice to see you. I remember you from the bone mets thread. I was NEAD 4.5 yrs with bone only, then whammo with liver progression 13 mos ago. Still searching for the right treatment, but I'm currently on Verzenio. They tell me I'm now low Her2+, so no longer on H. It was unnerving for me to progress in the liver, but I'm surprised it's already been more than a year. Hoping it all settles for you and Kadcyla works tho it sounds like you've had a rough time of it. I'm also taking Faslodex, and so far, it's treated me well.


Dx at 56 06/2015, IDC left, 4cm, de novo mets to bone; dx 04/2020 progression to liver. Dx 6/1/2015, IDC, Left, 4cm, Stage IIIA, Grade 2, ER+/PR+, HER2+ (FISH) Dx 6/30/2015, Stage IV, metastasized to bone Radiation Therapy 12/16/2015 External: Bone Surgery 2/17/2016 Lymph node removal: Sentinel; Mastectomy: Left Radiation Therapy 5/9/2016 External: Lymph nodes, Chest wall Hormonal Therapy 2/1/2018 Aromasin (exemestane) Dx 4/2020, IDC, Stage IV, metastasized to liver, Grade 3, ER+/PR+, HER2+ (IHC)
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Jan 25, 2021 10:51AM B-A-P wrote:

Thanks Moth!

I looked into it and I'm going to give my oncologist the forms so she can check to see if I'd be covered. I feel like it never hurts to check ! Thanks for pointing me in that direction ... I went on the wrong website before hand.


I also looked at Tempus and it's $2500 for "international" patients and they don;'t have assistance for non US patients

Dx 8/17/2018, IDC, Left, Stage IV, metastasized to liver, ER+/PR+, HER2- (FISH) Chemotherapy 9/17/2018 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Surgery 2/25/2019 Mastectomy: Left, Right Radiation Therapy 4/28/2019 Whole-breast: Breast, Lymph nodes, Chest wall Dx IDC, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Chemotherapy Abraxane (albumin-bound or nab-paclitaxel) Hormonal Therapy Femara (letrozole) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Prophylactic ovary removal
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Jan 25, 2021 12:59PM - edited Jan 25, 2021 01:00PM by Husband11

That dna testing is expensive for out of pocket. I remember back around 3 years ago there was an article about a B.C. company, Contextual Genomics, that was offering free testing for Canadians, but I looked into it, and basically your province gets allotted a certain number of tests, and a board of provincial oncologists decides who gets them. Apparently breast cancer patients were bottom of the barrel for getting them because they didn't believe there was much information that would benefit therapy choices.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Jan 26, 2021 05:25AM Grannax2 wrote:

I went for my annual physical with my PCP. She has referred me to a cardiologist to manage the heart rhythm problem I already have, SVT, and the ones that could become problematic during my TX of Eribulin. The SE’s are already causing low magnesium which can also cause heart muscle contraction problems. As I continue TX, he can monitor anymore issues that come up.

I think it’s a wise idea to have a cardiologist on my team with this drug and the SEs it’s already caused. Even though I hate to have to go to another doc, I think it’s the right thing to do.

Nicole, try to keep your spirits up. I know that’s easier said than done. Don’t make any important decisions during this time. I urge you to wait until you are out of pain from your y90 complications to decide important issues.

You are still in recovery from the yttrium in your colon. You will get better and, therefore, have a better outlook on your future.

I have so many liver mets that they cannot count them. I’m on Eribulin, like you were. I won’t find out until April if my tumors, in my lung and liver are responding. I’m hoping they will respond like yours did. I’m not having any pain right now so it’s easy for me to say all this.

But, I was in horrible pain a month ago. It’s amazing what a month can do as your body heals.

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Jan 26, 2021 08:46AM AlabamaDee wrote:

grannax- sounds like you are being well cared for. Good to hear from you

May I suggest trying slo-mag supplements? My MO was worried about the multiple infusions per month of IV mag I was getting. He said my body was beginning to depend on the IV and not making/using its own mag. I tried many different mag supplements and got the D issue, I found slo-mag to work the best. I am taking 9 pills a day ugh. I also read that HZTC can have a rare side effect of low mag so I stopped taking that. Last labs my Mag was normal!!

Waiting for scans is hard. I’m with you there.

Dee

Primary neuroendocrine breast cancer, on SERD trial ARV-471, failed Pfizer’s CDK 2/4/6 trial after 8 weeks Dx 5/23/2013, Right, 1cm, Stage IIB, Grade 2, 1/22 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 7/28/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Dx 4/2019, Stage IV, metastasized to liver, ER+/PR+, HER2- Targeted Therapy 10/7/2020 Radiation Therapy External Chemotherapy Doxil (doxorubicin) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole), Aromasin (exemestane), Fareston (toremifene), Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Verzenio Chemotherapy Xeloda (capecitabine)
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Jan 26, 2021 02:29PM Grannax2 wrote:

Good information.

I’ve been taking magnesium supplements for four years but not the one you mentioned.

I just changed to a different one. Taking 800 mg daily. NatureMade extra strength. It sure is better at helping with constipation than the other one. I’ll have more labs on February 3. My doc said she could RX one if needed.

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Jan 27, 2021 01:39AM Kattysmith wrote:

Dee, I am so sorry to hear that you are having to cope with Covid, and I hope it is a mild case.

I got my first Pfizer vaccination and will get the booster on February 6th. My husband will get his first shot on February 2nd, so we will both be fully vaccinated by the end of February. We live in a huge over-populated county and distribution has been very erratic and chaotic so we are very lucky.

Best to everyone here,

Katty

First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Jan 27, 2021 02:23AM - edited Jan 27, 2021 02:25AM by Bliss58

Got this invite in my email this morning about clinical trials and thought I'd share.

Join us for our free webinar: Clinical Trials 101

Join Ciitizen members Sheila McGlown, Alyson Tischler and Abigail Johnston along with our friends at Survivingbreastcancer.org this Sunday, January 31st at 4 PM ET for a lively and interactive discussion on clinical trials.

Dx at 56 06/2015, IDC left, 4cm, de novo mets to bone; dx 04/2020 progression to liver. Dx 6/1/2015, IDC, Left, 4cm, Stage IIIA, Grade 2, ER+/PR+, HER2+ (FISH) Dx 6/30/2015, Stage IV, metastasized to bone Radiation Therapy 12/16/2015 External: Bone Surgery 2/17/2016 Lymph node removal: Sentinel; Mastectomy: Left Radiation Therapy 5/9/2016 External: Lymph nodes, Chest wall Hormonal Therapy 2/1/2018 Aromasin (exemestane) Dx 4/2020, IDC, Stage IV, metastasized to liver, Grade 3, ER+/PR+, HER2+ (IHC)
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Jan 27, 2021 03:15AM BevJen wrote:

Bliss --

Thanks for posting this information about the webinar on clinical trials. Very useful.

Microwave Ablations of the Liver: 7/2019; 10/2020; 12/2020 Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Jan 27, 2021 04:01AM HopeandGratitude wrote:

Thank you Bliss

Dx 3/1/2002, ILC, Left, 6cm+, Stage IIIB, Grade 3, 0/14 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 3/27/2002 CEF Chemotherapy 6/5/2002 AT Surgery 8/29/2002 Mastectomy: Left; Reconstruction (left): Free TRAM flap, Nipple reconstruction, Nipple tattoo Radiation Therapy 10/15/2002 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 1/5/2003 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 1/12/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 2/15/2018 Lumpectomy: Left; Lymph node removal: Left Chemotherapy 4/3/2018 CMF Chemotherapy 8/6/2018 Taxol (paclitaxel) Radiation Therapy 10/10/2018 External: Breast, Lymph nodes, Chest wall Dx 3/13/2019, IDC, 1cm, Stage IV, metastasized to liver, Grade 3, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/14/2019 Femara (letrozole) Targeted Therapy 3/24/2019 Ibrance (palbociclib) Targeted Therapy 10/24/2019 Verzenio Dx 3/18/2020, IDC, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/20/2020 Aromasin (exemestane) Hormonal Therapy 4/7/2020 Faslodex (fulvestrant)

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