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Topic: How are people with liver mets doing?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Posted on: Aug 16, 2013 07:02PM

blondie1 wrote:

I continue to be very scared once I found my liver mets progressed after having to go off doxil. I am hoping to find some support in alleviating my deep seated fears by hearing other stories of people living and dealing with liver mets. My onc says I have such a petite frame (105) that an enlarged liver will definitely cause me some pain until chemo takes care of it.

How are others doing and getting through this with a positive attitude?

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Mar 25, 2021 07:31AM Kattysmith wrote:

Nicole, dogs are angels on earth and Ayla certainly fits the bill! What a precious baby, and you will have so much happiness together!


First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Mar 25, 2021 08:15AM NicoleRod wrote:

Saulius I take probiotics.

Hope. I have had this liver pain since the Y90 not since the Verzenio

I literally do not want to take the pill today I am in so much pain.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Mar 25, 2021 08:48AM candy-678 wrote:

Nicole- Wait to hear from your MO. Like BSandra said, maybe a dose reduction? Or something else to help the stomach? Do you have Palliative Care that could give suggestions? I just hate to see you stop the Verzenio altogether. And keep coming here. We will try to help you any way we can.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 8/1/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Hormonal Therapy 9/4/2021 Zoladex (goserelin) Targeted Therapy 9/4/2021 Lynparza
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Mar 25, 2021 09:23AM HopeandGratitude wrote:

Nicole - please wait to talk to your MO. The verzenio may not impact your pain one way or the other, so maybe no reason to stop it.

Dx 3/1/2002, ILC, Left, 6cm+, Stage IIIB, Grade 3, 0/14 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 3/27/2002 CEF Chemotherapy 6/4/2002 AT Surgery 8/28/2002 Mastectomy: Left; Reconstruction (left): Free TRAM flap, Nipple reconstruction, Nipple tattoo Radiation Therapy 10/15/2002 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 1/4/2003 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 1/12/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 2/14/2018 Lumpectomy: Left; Lymph node removal: Left Chemotherapy 4/3/2018 CMF Chemotherapy 8/5/2018 Taxol (paclitaxel) Radiation Therapy 10/9/2018 External: Breast, Lymph nodes, Chest wall Dx 3/13/2019, IDC, 1cm, Stage IV, metastasized to liver, Grade 3, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/13/2019 Femara (letrozole) Targeted Therapy 3/24/2019 Ibrance (palbociclib) Targeted Therapy 10/24/2019 Verzenio Dx 3/18/2020, IDC, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/20/2020 Aromasin (exemestane) Hormonal Therapy 4/6/2020 Faslodex (fulvestrant)
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Mar 25, 2021 09:28AM BevJen wrote:

Nicole,

I second that you need to talk to you MO first before discontinuing the Verzenio. Hope makes a good point -- the Verzenio may not even be impacting your pain at all -- and so why discontinue it? Also maybe shoot the pain management doc a note and see what have to say.

You also said that you know your liver is enlarged from the Y90 -- has it shown up as enlarged on scans? Try not to self diagnose based on what you think you know -- this is again one time you need to talk to your MO and maybe your IR.

I hope you can find a solution to your pain. This has gone on far too long. Thinking good thoughts for you.

Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Mar 25, 2021 11:41AM Husband11 wrote:

Nicole, really sorry to hear that you are having continuing stomach problems and that you suspect it is the verzenio. I agree with talking to your Oncologist, and if you really do suspect it is the verzenio, then I would test the theory by taking no more than a week off, and seeing if that brings you relief. I wouldn't give up on it permanently, but test to see whether it comes and goes with the verzenio. As others have suggested, if its not the verzenio, then it would be a shame to give it up.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Mar 25, 2021 12:11PM NicoleRod wrote:

Thanks for all your replies..I absolutely could not take the dose today. I was in so much pain I almost had to go to the hosptial. I chugged down more Pepto and I am back to about a 6. I know its the verzenio bc this started yesterday after I took the morning pill...then finally after hours of pain I started to feel a little better then it was time for the night dose ..took it ...and a 45 min later pain again bad.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Mar 25, 2021 12:28PM BevJen wrote:

Nicole,

Again, so sorry for the pain. Did you try to call your MO? I think patient portals are great, but once you send your messages through them, then your message is lost in the great internet abyss until you get a response.

Also, perhaps there is something you can do to manage your food intake with the pill. I believe that Verzenio can be taken with or without food. I take some meds for other stuff that say that. But if I don't get something in my stomach shortly after taking those pills, I feel terrible. Even a few saltine or graham crackers can help. I'd ask about that, especially because you know that you are sensitive to a lot of meds.


Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Mar 25, 2021 01:02PM jhl wrote:

Nicole,

In my opinion, I don't think you should be taking Pepto Bismol. The chemical name is bismuth subsalicylate which is a derivative of salicylic acid which is also aspirin. It has anti-inflammatory & bactericidal properties. So, you are irritating the lining of your stomach as well as decreasing the bacteria of your GI tract. Do you have ringing in your ears? That & abdominal pain are classic symptoms of salicylism which occurs when you take too much aspirin or Pepto Bismol.

Try using Tums when you need some immediate relief. If your stomach looks irritated or ulcerated on endoscopy there is a prescription medication you can use.

Good luck,

Jane

Dx 11/15/2019, IDC: Cribriform, Right, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2- (FISH)
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Mar 25, 2021 01:04PM moth wrote:

Nicole, just letting you know I'm thinking of you & hoping you find some relief. Do keep coming here to complain -- this is the place for it. We get it.

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External: Chest wall Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone
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Mar 25, 2021 01:08PM - edited Mar 25, 2021 01:09PM by NicoleRod

Thanks moth...Jhl....I am on a perscription med already Protonix... I do not have ringing in my ears.

All I am already on a reduced dose. 100mg

Bev I take it right after I eat. They say to take it with food.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Mar 25, 2021 01:45PM candy-678 wrote:

Nicole- Pardon me, but basic question. Do you have a GI doc? Not a cancer doc, but a basic GI doc. Just saying. Maybe they could help with your stomach issues. If you are using Protonix scheduled, Pepcid as needed, and Pepto and still having issues maybe some other prescription med for the GI system would be good. Maybe would work a different way. You mentioned belching and the pain eases up. Maybe something for gas, air, motility. IDK. Just asking. Thinking out of the box.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 8/1/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Hormonal Therapy 9/4/2021 Zoladex (goserelin) Targeted Therapy 9/4/2021 Lynparza
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Mar 25, 2021 03:33PM NicoleRod wrote:

My MO knows I stopped she is calling me later today.

Candy I have a GI doc and called. They are calling in this pink stuff (forget the name) its suppose to coat stomach and help but I have used it before and it didn't. If it doesn't this time they said I will have to have a telemed appt to discuss. They are thinking it might get better now that I stopped the cancer med

I have been off all cancer meds for 3 months and only on this for about 10 day so going off today is not gonna make that much difference...its not like it was already working. My concern is that now...because of the damage done originally from the Eribulin (which I didn't know I thought no big deal silent GERD (no pain) I just would lose my voice) then the Y90 exacerbated that ...now I feel ANYTHING is going to cause me tremendous pain. :(. If that is the case my fight is done. I cannot live in that kind of pain.


Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Mar 25, 2021 04:56PM candy-678 wrote:

Nicole- Pink stuff probably Carafate. Coats the stomach, yeah. If it doesn't work this time, and it may work, then get appt and discuss. I would think there would be something they could do/give to allow you to take your cancer meds. I want to fight for you. Your cancer was doing good, right? I thought I read that last scans looked good. So we need to get your GI issues controlled so you can continue on the cancer meds. Don't give up yet. Gentle hug from here.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 8/1/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Hormonal Therapy 9/4/2021 Zoladex (goserelin) Targeted Therapy 9/4/2021 Lynparza
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Mar 25, 2021 08:30PM HopeandGratitude wrote:

Nicole - Holding you in my heart ❤️. I pray that the Lord guides the doctors in their efforts for finding a solution that willallow you to take your cancer medications and free you from your terrible pain. Don’t be so sure it’s time to give in.

Dx 3/1/2002, ILC, Left, 6cm+, Stage IIIB, Grade 3, 0/14 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 3/27/2002 CEF Chemotherapy 6/4/2002 AT Surgery 8/28/2002 Mastectomy: Left; Reconstruction (left): Free TRAM flap, Nipple reconstruction, Nipple tattoo Radiation Therapy 10/15/2002 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 1/4/2003 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 1/12/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 2/14/2018 Lumpectomy: Left; Lymph node removal: Left Chemotherapy 4/3/2018 CMF Chemotherapy 8/5/2018 Taxol (paclitaxel) Radiation Therapy 10/9/2018 External: Breast, Lymph nodes, Chest wall Dx 3/13/2019, IDC, 1cm, Stage IV, metastasized to liver, Grade 3, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/13/2019 Femara (letrozole) Targeted Therapy 3/24/2019 Ibrance (palbociclib) Targeted Therapy 10/24/2019 Verzenio Dx 3/18/2020, IDC, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/20/2020 Aromasin (exemestane) Hormonal Therapy 4/6/2020 Faslodex (fulvestrant)
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Mar 26, 2021 03:33AM leftfootforward wrote:

Hugs Nicole.

Dx 12/13/2010, IDC, 3cm, Stage IIIA, Grade 2, 1/16 nodes, ER-/PR-, HER2+ Dx 12/4/2012, IDC, Stage IV, 0/0 nodes, ER-/PR-, HER2+
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Mar 26, 2021 07:22AM Kattysmith wrote:

My heart is giving you a gentle hug, Nicole


First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Mar 26, 2021 12:27PM thrivingmama wrote:

Hi everyone. I haven't been on here in a while (life has been busy with kids at home during the pandemic! :)).

I am wondering if anyone has been on Trodelvy at a lower dose and then increased it with success? Also, does anyone have experience with both Trodelvy and Enhertu? I posted yesterday on the Trodelvy thread, but haven't had any responses yet.

I was on Trodelvy June 2020-Jan 2021. I was on a 50% dose the entire time, and I had a really spectacular response, but unfortunately had progression in January. We debated going up in dose, but decided instead to try Abraxane. While I had one of the larger liver tumors respond to Abraxane, the rest have increased in size and activity, so I need to move on. I am again thinking about going back to Trodelvy, but at a higher dose. I am also looking into access to Enhertu. So curious if anyone has any experience or words of wisdom.

I am heavily pre-treated and the Phase I trial world seems quiet right now....

Thanks for any thoughts :)

Jan '18: Diagnosed Stage IV w/ 2 liver mets. NED April-Oct. Stopped chemo. Jan '19: new liver mets + spread to bones. Restarted GemCarbo + Xgeva. Worked well for 6 months, then progressed. Currently on Eribulin, which is holding me stable Dx 12/2016, IDC: Tubular/IBC, Left, Stage IIIC, Grade 2, ER+/PR+, HER2- Chemotherapy 1/11/2017 AC + T (Taxol) Surgery 6/11/2017 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left; Reconstruction (left): DIEP flap Hormonal Therapy 7/14/2017 Faslodex (fulvestrant) Radiation Therapy 7/17/2017 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy 9/13/2017 Ibrance (palbociclib) Hormonal Therapy 9/13/2017 Dx 1/2018, Stage IV, metastasized to liver, Grade 3, ER-/PR-, HER2- Chemotherapy 2/7/2018 Carboplatin (Paraplatin), Gemzar (gemcitabine) Dx 1/2019, IDC: Tubular, Stage IV, metastasized to bone/liver Chemotherapy Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Mar 26, 2021 01:20PM BlueGirlRedState wrote:

Nicole - Sending hugs and wishes that you start feeling better. It is ok to complain. How else are we going to find out about SEs, options for treating, including a different drug. SEs are real, and sometimes this site seems like the only place to discuss them.

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Mar 26, 2021 02:14PM Rosie24 wrote:

Nicole, Thinking of you and hoping you’re feeling some improvement in your pain. I can understand that you can’t live with the pain you’ve been having but I still have hope for you to get past this. I bet your new pup is cuter every day

Dx 1/23/2019, DCIS/IDC, Left, 3cm, Stage IV, metastasized to liver, Grade 2, ER+/PR-, HER2- (FISH) Hormonal Therapy 1/24/2019 Femara (letrozole) Targeted Therapy 1/24/2019 Ibrance (palbociclib) Surgery 12/3/2019 Lumpectomy: Left Surgery 12/3/2019 Lymph node removal: Sentinel Dx 1/6/2022, IDC, Stage IV, metastasized to liver, ER-/PR-, HER2- Radiation Therapy Whole-breast
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Mar 26, 2021 05:39PM NicoleRod wrote:

Thanks all...


I spoke to my MO yesterday she agreed to stop the Verzenio and try to get my stomach under control. I was about 10 days or so in on it...she said it is usually after the 2nd week that GI issues start...though MOSTLY its usually diarrhea...She couldn't believe I am actually constipated on it. She asked if in a week or so if my stomach is better would I want to try the Affinitor after all....it doesn't have the same issues..(of course it has different ones though)...I said I will be willing to.

My stomach is still bad today but not as bad right at the moment as yesterday. The Sucralfate does seem to help a little but only for a short time...I am also doing Tums.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/29/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Mar 26, 2021 05:44PM BevJen wrote:

Nicole,

Happy that the pain is somewhat better. If I'm not mistaken, one of the SEs of Protonix can be constipation, so maybe that, combined with your usual issues, is why you are constipated on Verzenio. Hope the extra stuff is helping you -- Tums, etc.

Hope you have a good weekend.

Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Mar 26, 2021 10:36PM Bliss58 wrote:

Nicole, glad you're doing better, but sorry Verzenio has constipated you. I didn't have diarrhea with it either. We think it may not be working for me now though or maybe it's doing battle with the liver tumors; I hope.

I've been lucky to never have cancer pain, but had a couple days discomfort in the liver area then the 3rd day sharp pains that MO prescribed Tramadol to control. Saw her yesterday and my TMs are up a bit, otherwise, labs look good. So now we'll scan and see where we go from here.

Dx at 56 06/2015, IDC left, 4cm, de novo mets to bone; dx 04/2020 progression to liver. Dx 6/1/2015, IDC, Left, 4cm, Stage IIIA, Grade 2, ER+/PR+, HER2+ (FISH) Dx 6/30/2015, Stage IV, metastasized to bone Radiation Therapy 12/16/2015 External: Bone Surgery 2/17/2016 Lymph node removal: Sentinel; Mastectomy: Left Radiation Therapy 5/9/2016 External: Lymph nodes, Chest wall Hormonal Therapy 2/1/2018 Aromasin (exemestane) Dx 4/2020, IDC, Stage IV, metastasized to liver, Grade 3, ER+/PR+, HER2+ (IHC)
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Mar 27, 2021 08:00AM - edited Mar 27, 2021 10:22AM by HopeandGratitude

Bliss58 - please remind us when your scan time is close. Keeping you in my prayers

Dx 3/1/2002, ILC, Left, 6cm+, Stage IIIB, Grade 3, 0/14 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 3/27/2002 CEF Chemotherapy 6/4/2002 AT Surgery 8/28/2002 Mastectomy: Left; Reconstruction (left): Free TRAM flap, Nipple reconstruction, Nipple tattoo Radiation Therapy 10/15/2002 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 1/4/2003 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 1/12/2018, IDC, Left, 2cm, Stage IIIB, Grade 3, 1/1 nodes, ER+/PR+, HER2- (FISH) Surgery 2/14/2018 Lumpectomy: Left; Lymph node removal: Left Chemotherapy 4/3/2018 CMF Chemotherapy 8/5/2018 Taxol (paclitaxel) Radiation Therapy 10/9/2018 External: Breast, Lymph nodes, Chest wall Dx 3/13/2019, IDC, 1cm, Stage IV, metastasized to liver, Grade 3, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/13/2019 Femara (letrozole) Targeted Therapy 3/24/2019 Ibrance (palbociclib) Targeted Therapy 10/24/2019 Verzenio Dx 3/18/2020, IDC, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/20/2020 Aromasin (exemestane) Hormonal Therapy 4/6/2020 Faslodex (fulvestrant)
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Mar 27, 2021 09:48AM Grannax2 wrote:

Nicole. I’ve had Gerd/ reflux for about 20 years. I’ve been on all the different ProtonPump Inhibitors(PPI). They have kept me mostly pain free. Mine was caused/ made worse by toxic chemotherapies through the years. The worst ones I call “ acid attacks’ they would last for hours sometimes, so painful. I was sure I was having a heart attack. Keeping it under control is key. The one I’m on now is Omeprazole 40 mg daily. If chemo makes it worse, I take two. This way, over all these years and so many different chemos, I’ve been able to tolerate most of the TX I’ve been give. I’ve been doing this for 30 years, I’ve had lots of different types of chemo. It has to get in your system and stay in your system so that it can work consistently for years. Don’t give up.

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Mar 27, 2021 10:13AM Grannax2 wrote:

Random question. My daughter keep bringing up a crazy sounding TX. She says there’s even a clinical trial at MDA. It uses dog dewormer, seriously? She even told me about some friend of a friend who went to the Feed Store to buy his own dewormer! I was just flabbergasted. Have any of you heard of this as a TX for MBC?

Unfortunately, I’m at that place where I don’t know what’s next. I had my second infusion of my fourth cycle of Eribulin, next week scans, next week results. Praying for it to be working but what if it isn’t? What’s next? I know of nothing that matches my MBC, not even any clinical trials I have made a decision that I will not travel to for a CT. I’d rather stay here with my family. If there is a local one that has any real chance of working on me, I will agree to do it.

My magnesium was low again last week, even after having one gram by IV. So I had another IV on Wednesday. Eribulin is so hard on my magnesium. Other than that, I’m tolerating it okay. Extreme fatigue but that’s my new normal.

My friend got my new “ mostly tomato” garden planted for me. She even put in an automatic watering system. I’m looking forward to watching it grow and produce.

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Mar 27, 2021 10:15AM Grannax2 wrote:

I also have cucumbers and onions. Cantaloupes will be planted soon. Yu

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Mar 27, 2021 10:30AM candy-678 wrote:

Pocket duty for Grannax.

Bliss let us know when your scans are.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 8/1/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Hormonal Therapy 9/4/2021 Zoladex (goserelin) Targeted Therapy 9/4/2021 Lynparza
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Mar 27, 2021 10:38AM BevJen wrote:

Grannax,

I've not heard of a clinical trial with the dewormer medication, but that's definitely a thing. Google Jane McLelland and you will come up with plenty. There's even a thread on here about it -- though I don't think it was as active as it had been last year --

https://community.breastcancer.org/forum/8/topics/...

It will take you a while to read through, but it has a lot of info. Some guy in the US (Joe something) used this while on a trial for keytruda at MD Anderson and he has been in remission since.

If there is a trial at MD Anderson, I'd be all over that if I were you. Or at least look into it.


Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Mar 27, 2021 11:03AM Chicagoan wrote:

Grannax,

Check out Joe Tippen's story: https://www.mycancerstory.rocks/single-post/2016/0...

He was in a trial at MD Anderson after being given 3 months to live. A vet friend suggested that he add FenBen since the vet had seen it be very effective against tumors in animals. Joe tried it without telling the trial doctors. He was the only person in the trial who got better so he confessed what he did and is alive to this day.

I created a FenBen thread several months ago in the Stage 4 section but it got over run by people who are not Stage 4 and mixed up with the Jane MacLellan protocol. I plan to try FenBen if standard treatments stop working for me. I'll start another Stage 4 thread at that time. I follow other people using FenBen-it works for some people, not for others but if I am given three months to live, I'd certainly roll the dice on it.

Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/26/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/26/2016 Ibrance (palbociclib)

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