Topic: How are people with liver mets doing?

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Aug 16, 2013 07:02PM

Posted on: Aug 16, 2013 07:02PM

blondie1 wrote:

I continue to be very scared once I found my liver mets progressed after having to go off doxil. I am hoping to find some support in alleviating my deep seated fears by hearing other stories of people living and dealing with liver mets. My onc says I have such a petite frame (105) that an enlarged liver will definitely cause me some pain until chemo takes care of it.

How are others doing and getting through this with a positive attitude?

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Oct 20, 2017 06:50PM - edited Oct 21, 2017 04:52AM by zarovka

Mom - It is a good question what I mean by Rads. I mean something like Stereotactic Body Radiation Treatment (SBRT). SBRT is a type of radiation that is tuned to provoke an immune response. There may be others.

The RO may feel that she's going to get an adequate immune response with the approach she is taking. You do want them thinking about it and talking about it and explaining to you whether their radiation is going to release neo-antigens. I recalled that some kind of PDL-1 inhibitor is lined up so this radiation treatment is a huge opportunity. They may be thinking this already.

I don't know if the Y90 provokes the immune response in the same way. It doesn't matter as long as she is getting radiation somewhere that floods her system with cancer neoantigens and gives her newly activated immune system something to attack.

Grannax - I've been thinking about your rashes and my rashes . I kinda think my current rashes are a response to the cancer being attacked. These rashes occurred only AFTER the liver mets got hit with chemo and hyperthermia. My skin sensitivity is most likely the liver dealing with the carnage of a dying tumor. I would not be surprised if that is the case for you as the Y90 effect takes a while to play out.

It's a lot like TM's ... more of an indicator that something is going on than exactly what is going on. We interpret them from context and experience. I am expecting you will find that your liver just got upset when it had to deal with the mess after a Y90 treatment ... and took it out on your face. Your liver is likely hard at work tidying things up. We'll know with time.

On a related topic my CEA is developing into a useful took to monitor my cancer. CA 15-3 and 27.29 have been useless for me. Depends what antigens your cancer sheds. Oddly, CEA is rarely reliable with MBC, but here are my last CEA numbers in context. After doubling monthly for several months, my CEA dropped slightly after 2 weeks of low dose chemo combined with hyperthermia.

The purpose of the initial treatment is to down-regulate immunosuppression and not treat the cancer directly. The chemo doses I was taking are not considered an effective dose for treating cancer. The hyperthermia doses I am getting are sufficient to kill cancer directly. Difficult to parse what is causing what, but it is sure nice to see my CEA did not double again.


>Z<

Ibrance/Letrozol Feb '16 -Sep '17. Adoptive Cell Therapy Oct 2017. Jan 2018 SBRT to sternum met and liver mets. Jan 2018 start Faslodex. Dx 12/28/2015, IDC, Left, 4cm, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 1/17/2016 Femara (letrozole) Targeted Therapy 2/2/2016 Ibrance (palbociclib)
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Oct 21, 2017 04:41AM - edited Oct 21, 2017 04:49AM by zarovka

Before treatment yesterday my daughter and I did a ninja training at the dojo of a clan than goes back 100's of years. As a side effect of chemo I've lost weight and acquired the aspect of a Japanese demon, both of which are totally awesome events. Made my appointment with 10 minutes to spare on Friday. I've got no time for this cr@#P, and less and less patience every day.

On Monday, I will be lucky if I have to wade to my appointment through a class I hurricane (or typhoons as they are called here). Typhoon Lin made landfall in southern Japan as a Class 3 storm. The current thinking is that it will chill a bit by Monday. I asked whether the clinic would close if it remains class 3 or increases to class 4 (both of which are possible) and they said no, just jump on the metro and show up at your appointment time. They don't even blink for typhoons here they are so frequent.

>Z<



Ibrance/Letrozol Feb '16 -Sep '17. Adoptive Cell Therapy Oct 2017. Jan 2018 SBRT to sternum met and liver mets. Jan 2018 start Faslodex. Dx 12/28/2015, IDC, Left, 4cm, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 1/17/2016 Femara (letrozole) Targeted Therapy 2/2/2016 Ibrance (palbociclib)
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Oct 21, 2017 06:35AM LindaE54 wrote:

Momall - no words of wisdom from me but you certainly are getting info from a lot of smart ladies and gent on this thread. You and Dani are always in my thoughts.

Visit with MO yesterday and TMs are still on the rise. MO is adding two chemos to my current Epirubicin. (CEF = cyclophosphamide, Epirubicin, Fluorouracil) Anybody had this trio as stage IV?

Linda - dx at 54. Decision to stop all treatments on 9 Jan 2018 Dx 11/26/2013, IDC, Left, 1cm, Stage IV, metastasized to bone/liver/other, Grade 3, mets, ER+/PR+, HER2- Radiation Therapy 12/19/2013 External: Bone Hormonal Therapy 12/30/2013 Femara (letrozole) Hormonal Therapy 5/28/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 5/29/2014 External: Bone Radiation Therapy 8/28/2014 External: Bone Hormonal Therapy 9/25/2014 Femara (letrozole) Radiation Therapy 12/14/2014 External: Bone Hormonal Therapy 2/17/2017 Faslodex (fulvestrant) Chemotherapy 5/15/2017 Taxol (paclitaxel) Radiation Therapy 6/5/2017 External: Bone Chemotherapy 10/3/2017 Ellence (epirubicin) Chemotherapy 10/22/2017 CEF Chemotherapy 12/27/2017 Halaven (eribulin)
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Oct 21, 2017 09:54AM Kandy wrote:

Z, I'm also thankful your car didn't double again. If I could only stop mine from doubling. It's amazing how they think nothing of the typhoons. You and your daughter please be careful. We are all here supporting and praying for a positive outcome for you.

Dx 1/20/2009, IDC, 1cm, Stage IIIA, Grade 3, 4/9 nodes, ER+/PR+, HER2- Surgery 2/26/2009 Lumpectomy: Left; Lymph node removal: Left, Underarm/Axillary Chemotherapy 3/9/2009 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Gemzar (gemcitabine), Navelbine (vinorelbine) Radiation Therapy 10/7/2009 Breast, Lymph nodes Hormonal Therapy 1/4/2010 Arimidex (anastrozole) Dx 10/31/2013, IDC, Stage IV, Grade 3, ER+/PR+, HER2- Radiation Therapy 11/18/2013 3DCRT: Bone Hormonal Therapy 12/3/2013 Faslodex (fulvestrant) Targeted Therapy 10/7/2016 Afinitor (everolimus) Hormonal Therapy 10/31/2016 Aromasin (exemestane) Chemotherapy 2/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 5/8/2017 Carboplatin (Paraplatin) Chemotherapy 8/15/2017 Halaven (eribulin) Targeted Therapy
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Oct 21, 2017 10:32AM Grannax2 wrote:

Z. I think I get it. Even at 5 months out, my liver might still be "cleaning up"" Basically, for some, if the liver gets mad it can cause a skin rash or other symptoms that don't seem related. I hope you're right. I'm due for a PET in November.

Your pics from Japan are amazing. How much longer will you be there? Praying for your treatment to work and for you to feel better. Vicki

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Oct 21, 2017 01:31PM nkb wrote:

Z- love the mask

Kandy- did you ever ask your MO about Ibrance or Abemaciclib

Dx 12/2011, ILC, Both breasts, 6cm+, Stage IIIC, Grade 2, 34/40 nodes, ER+/PR+, HER2- Surgery 2/4/2012 Lymph node removal; Lymph node removal (Left): Underarm/Axillary; Lymph node removal (Right): Underarm/Axillary; Mastectomy; Mastectomy (Left); Mastectomy (Right) Chemotherapy 2/28/2012 AC + T (Taxol) Radiation Therapy 9/11/2012 Hormonal Therapy 10/21/2012 Arimidex (anastrozole) Dx 5/2017, ILC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 6/1/2017 Faslodex (fulvestrant) Targeted Therapy 6/1/2017 Ibrance (palbociclib) Targeted Therapy 3/13/2019 Afinitor (everolimus) Hormonal Therapy 3/13/2019 Aromasin (exemestane) Chemotherapy 3/10/2020 Xeloda (capecitabine)
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Oct 21, 2017 02:23PM Wendy3 wrote:

morning everyone I have a quick question when your livers started to progress did any of you experience burping and flu like symptoms. I'm one month out from chemo and I fear it's starting up again😩. Been feeling weak and dizzy and burping like crazy. I was hoping for a bit more time before having to get on the chemo band wagon gain. At least some eyelashes first..

Dx 5/13/2015, IDC, Right, 2cm, Stage IV, metastasized to bone, ER+/PR+, HER2- Hormonal Therapy Faslodex (fulvestrant), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 21, 2017 02:26PM Wendy3 wrote:

Wow Z you and your daughter stay safe. The building must be built very well there to survive through these storms over and over. Great that you are still able to get out and do stuff love the picture very cool. How are you feeling about the treatment so far? I need to catch up on my reading.

Dx 5/13/2015, IDC, Right, 2cm, Stage IV, metastasized to bone, ER+/PR+, HER2- Hormonal Therapy Faslodex (fulvestrant), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 21, 2017 02:35PM Blume wrote:

Wendy I have had progression in my liver but not with those symptoms, actually no symptoms at all. Hoping it's nothing and you pick up and feel better real soon.

Dx 7/24/2010, Left, 3cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2- Surgery 7/31/2010 Lumpectomy: Left Chemotherapy 9/1/2010 Other Radiation Therapy 1/4/2011 Whole breast: Breast Hormonal Therapy 3/3/2011 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 9/4/2014 Arimidex (anastrozole) Dx 3/15/2017, Stage IV, metastasized to bone/liver/other, ER+/PR+, HER2- Chemotherapy 3/15/2017 Taxol (paclitaxel) Radiation Therapy 4/19/2017 External: Bone Hormonal Therapy 7/25/2017 Femara (letrozole) Targeted Therapy 7/25/2017 Ibrance (palbociclib)
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Oct 21, 2017 03:16PM AnimalCrackers wrote:

Wendy - do you still have your gallbladder? Burping is one of the first signs of gallbladder troubles. Just a thought.

Cathy, Diagnosed de novo bone mets June 2014 at age 52. Progression to Liver 2017. Progression to bone mets Sept. 2018. Bisphoshonate (Zometa) infusions every 3 months. Participated in 2 clinical trials, including an AKT1 inhibitor. Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali Hormonal Therapy 12/19/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 12/19/2017 Dx 8/20/2018, IDC, Stage IV, metastasized to bone Radiation Therapy 8/20/2018 External: Bone Chemotherapy Taxol (paclitaxel) Surgery

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