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Nov 19, 2014 10:34PM
Hi ladies, I may be at a crossroads and it may be time to change meds...need your experience and your input...please.
Here's the history:
I had Stage II BC in 2002. Was diagnosed Stage IV nine years later with mets to sternum and lungs.
Xeloda worked for approx. a year to reduce tumors greatly, then cancer growth
Tamoxifen worked for 10 mo or so and got me to NED, then had some cancer activity.
Afinitor and Aromasin combo worked for approx 15 mo and got me to NED again. My tumor markers kept rising but scans were still clear. So my onc and I (after much discussion) decided to leave me on Afinitor and Aromasin because it may still be working and just add Faslodex to the mix. I've had 5 Faslodex injections total (3 months on Faslodex) Now, my tumor markers are rising again. They rose a lot this last month...almost 30 points. I've heard Faslodex can take a long time before it lowers TMs. My onc even said it can take a while. He said I should do 2 more injections and then a scan. If we see cancer growth, he feels I should do IV chemo (most likely Doxil) next. I've pushed off IV chemo for 3 1/2 years now and really am not anxious to start it. I did all that with my Stage II cancer long ago. But, I know eventually, it is probably what I will have to do.
I've also heard of ladies who have tried all the hormonals first before switching to IV chemo. I've only been on Tamoxifen, Aromasin, and Faslodex. My onc feels like if this current one isn't working, it probably is time to switch to a chemo.
What is your experience? Have any of you had success with Faslodex and how long before it worked? I don't want to give up on a treatment too early. Anyone had Faslodex NOT work? How long did you try? Did any of you go through MORE hormonals before going to IV chemo? Or, do you think it is better to switch gears if the cancer is growing and hit it with chemo for a while? Any of your experiences will help me.
Also, anyone on Doxil? What do you think? What is it like?
I'm hoping and praying that with a little extra time the Faslodex will work, but would love to hear your thoughts just in case!
Thank you all so much!
10/24/2002, IDC, 2cm, Stage IIB, 3/14 nodes, ER-/PR-, HER2-
11/13/2002 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left, Right; Reconstruction (left); Reconstruction (right)
12/22/2002 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel)
7/7/2011, IDC, 3cm, Stage IV, metastasized to bone/liver/lungs, mets
7/15/2011 Xeloda (capecitabine)
6/6/2012 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
6/6/2013 Aromasin (exemestane)
6/6/2013 Afinitor (everolimus)
4/28/2015 Femara (letrozole)
4/29/2015 Ibrance (palbociclib)
11/9/2015 Kadcyla (T-DM1, ado-trastuzumab)
5/31/2019 Xeloda (capecitabine)
5/31/2019 Tykerb (lapatinib)
6/1/2019 Arimidex (anastrozole)
1/28/2020 Enhertu (fam-trastuzumab deruxtecan-nxki)