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Topic: Faslodex Girls Thread 2014

Forum: Stage IV/Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Jan 2, 2014 04:16PM - edited Apr 28, 2017 07:19PM by pajim

pajim wrote:

Tips for taking Faslodex without pain:

ABSOLUTE MUSTS:

  • Warm up the syringes. At least room temperature. Armpits work well, as does belly skin.
  • Take the weight off the leg on the side of the shot. Relax that cheek/leg as much as possible.
  • Inject SLOWLY! It should take at least 30 seconds to empty each syringe.

General consensus as helpful:

  • Hydrate before and after the shots
  • Take a walk or massage the area afterwards in order to get the castor oil and fulvestrant moving.
  • If you get an allergic-type reaction (itchy, swelling), take Benadryl before the injection (or if skin rash use hydrocortisone cream afterwards).

Side-effects are more squishy so I'll post a list of ones we've seen on the thread next – would all the rest of you ladies please post your comments on this just below? That way any people coming new to the thread can find it all on the first page.

Here's some information on how to handle large-volume injections .

Best wishes to the Fanny Pack of the future! May Faslodex keep you NED for a long time.

Dx 4/20/2008, IDC, Right, 4cm, Stage IIIA, Grade 2, 1/15 nodes, ER+/PR+, HER2- Dx 2/1/2013, IDC, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 2/27/2013 Femara (letrozole) Hormonal Therapy 4/22/2013 Faslodex (fulvestrant) Targeted Therapy 2/25/2016 Ibrance (palbociclib) Chemotherapy 6/19/2017 Xeloda (capecitabine) Targeted Therapy 8/15/2018 Verzenio Chemotherapy 1/2/2019 Halaven (eribulin) Chemotherapy 12/30/2019 CMF
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Posts 3091 - 3105 (3,105 total)

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Mar 24, 2020 01:51PM lulubee wrote:

GrannaX, I am thrilled to hear your news! Best news all day. Maybe week.

8/07: ILC & IDC, multi-focal/multicentric, ER+PR+ Her2-, no nodes. BMX+lat flap. 10/10: STAGE IV ILC bones, ovary & pericardium. 12/13 progression: bones & bile duct. 12/16 progression: bones & pericardium. 8/18 progression: bones. Hormonal Therapy 11/6/2010 Femara (letrozole) Surgery 11/6/2010 Prophylactic ovary removal Hormonal Therapy 2/1/2012 Faslodex (fulvestrant) Hormonal Therapy 5/15/2012 Aromasin (exemestane) Targeted Therapy 5/15/2012 Afinitor (everolimus) Chemotherapy 10/1/2013 Xeloda (capecitabine) Chemotherapy 1/26/2017 Taxol (paclitaxel) Chemotherapy 8/27/2018 Halaven (eribulin) Hormonal Therapy 3/13/2019 Faslodex (fulvestrant) Targeted Therapy 3/13/2019 Verzenio
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Mar 24, 2020 05:22PM gailmary wrote:

YaY Grannax. You know that gives us hope. And even less fearful if we ever need Y90.

GAILMARY

Dx 11/25/2008, IDC, Left, 2cm, Stage IIA, Grade 1, 2/12 nodes, ER+/PR+, HER2- (IHC) Dx 4/13/2017, Stage IV, metastasized to bone Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole) Radiation Therapy
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Mar 25, 2020 11:08AM nopink2019 wrote:

Where do you get your shots? stomach or butt? I've had shots for 5 months, always both @same time in butt. (Wonderful idea, they inject at same time. push together slowly, then remove together. Takes away anticipation.) Not terrible, but how is it in stomach?

Dx 2008, IDC, Stage IA, Grade 3, ER+/PR-, HER2- Dx 8/2019, Stage IV, metastasized to bone/liver/lungs, ER+/PR-, HER2- Targeted Therapy Kisqali Hormonal Therapy Faslodex (fulvestrant)
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Mar 25, 2020 11:57AM - edited Mar 25, 2020 12:32PM by ShetlandPony

The manufacturer's instructions say

“FASLODEX 500 mg should be administered intramuscularly into the buttocks (gluteal area) slowly (1 - 2 minutes per injection) as two 5 mL injections, one in each buttock..."


An article Best Practices for IM Injection of Fulvestrant also says gluteal, and says the ventrogluteal site is safer as it avoids the area with the sciatic nerve. But not all nurses are trained/comfortable with this site:

https://voice.ons.org/conferences/best-practices-for-im-injection-of-fulvestrant

An article in EPMonthly about intramuscular injections generally mentions buttock, thighs, and shoulder. But not stomach.

“The ventrogluteal site, rectus femoris and vastus lateralis location are the preferred location for large volume deep muscle IM injections. These injection locations allow for a high degree of safety, reliability and accessibility when a patient is lying supine, prone or in side lying position. The sites can support large volumes from 2 to 5mL and absorb quickly into the bloodstream.“

I was shocked when a nurse asked if I wanted buttocks or stomach. I can't imagine that working, having it in the abdomen.

2011 Stage I ILC ER+PR+ Her2- 1.5 cm grade 1, ITCs sn . Lumpectomy, radiation, tamoxifen. 2014 Stage IV ILC ER+PR+Her2- grade 2, mets to breast , liver. Taxol NEAD. 2015,2016 Ibrance+letrozole. 2017 Faslodex+Afnitor; Xeloda. 2018,2019 Xeloda NEAD
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Mar 25, 2020 12:19PM Imagine wrote:

Grannax

That is great news, I have wondered why they don’t start with just Falsodex first and then add the CD4K inhibitors like Ibrance if there isn’t improvement. I had to start both in Jan.

Karen Dx 7/7/2007, IDC, Right, 2cm, Stage IIA, Grade 2, 0/9 nodes, ER+/PR+, HER2- Radiation Therapy 8/7/2007 Chemotherapy 9/7/2007 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery Lumpectomy: Right Hormonal Therapy Faslodex (fulvestrant)
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Mar 25, 2020 01:27PM nopink2019 wrote:

Shetlandpony, thanks for the good info. I didn't know if I was missing something or not. Since it it recommended into muscle, I'll just stick with glutes.

Dx 2008, IDC, Stage IA, Grade 3, ER+/PR-, HER2- Dx 8/2019, Stage IV, metastasized to bone/liver/lungs, ER+/PR-, HER2- Targeted Therapy Kisqali Hormonal Therapy Faslodex (fulvestrant)
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Mar 25, 2020 02:00PM ShetlandPony wrote:

“Stick with glutes” Pun intended? Winking

2011 Stage I ILC ER+PR+ Her2- 1.5 cm grade 1, ITCs sn . Lumpectomy, radiation, tamoxifen. 2014 Stage IV ILC ER+PR+Her2- grade 2, mets to breast , liver. Taxol NEAD. 2015,2016 Ibrance+letrozole. 2017 Faslodex+Afnitor; Xeloda. 2018,2019 Xeloda NEAD
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Mar 25, 2020 04:38PM gailmary wrote:

Karen, my MO said we coukd knock it out fast if we use the CD4K inhibitor too and then maintain with just faslodex and then if tumor markers rise add it back in.

I suppose they do what makes sense to them. Lots of options.

Dx 11/25/2008, IDC, Left, 2cm, Stage IIA, Grade 1, 2/12 nodes, ER+/PR+, HER2- (IHC) Dx 4/13/2017, Stage IV, metastasized to bone Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole) Radiation Therapy
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Mar 25, 2020 10:38PM jobur wrote:

spicedlife- Where is your pain? Back? Sciatica? Early in my Fas career one of the nurses at my cancer center hit a nerve that caused sciatic pain for me for about a year. It did go away eventually. That is one of the advantages of getting it in the hip rather than the butt, no nerves there. Be sure to read the article Tina2 posted (maybe take a copy with you next time you get shots?) and Shetland's comments above. Hope you feel better soon.

nopink2019- Never heard of getting Fas in the stomach. I would steer clear of that nurse, scary!

grannax- Woohoo on your great scan! Hope you are celebrating.

Shetland- How is the Summit trial going for you? I (vaguely) remember your comments when I was asking about being HER2- but having the ERBB mutation. How long have you been on the trial and how are you finding this combo in terms of se's? Wishing you well.

"What do you know, and what do you just believe?" Linda Hogan "Power" Surgery 7/1/2014 Lumpectomy: Left Dx 8/1/2014, IDC, Left, 1cm, Stage IV, metastasized to bone, Grade 2, 4/7 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 8/4/2014 Arimidex (anastrozole) Hormonal Therapy 4/30/2015 Faslodex (fulvestrant) Targeted Therapy 8/17/2015 Ibrance (palbociclib) Dx 11/20/2018, IDC, 1cm, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Hormonal Therapy 12/4/2018 Aromasin (exemestane) Targeted Therapy 1/1/2019 Afinitor (everolimus) Hormonal Therapy 7/16/2019 Faslodex (fulvestrant) Targeted Therapy 7/18/2019
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Mar 26, 2020 02:43PM - edited Mar 26, 2020 02:44PM by ShetlandPony

Hi, jobur! How are you doing now? I looked at your last few posts on BCO and saw you had trouble with nausea and vomiting on Piqray and some wonky labs.

To answer your questions, I have been on the SUMMIT trial six weeks. It feels like six months. Some of that time, in the first weeks, I went off the neratinib because I had nausea, vomiting, and grade 2/3 diarrhea; became bedridden; and had to go to the ER for fluids (at leftfoot's nudge via PM). If I had known more, or frankly if the trial nurse had been properly looking out for me, it would not have gotten so bad. But anyway, on my third try, I insisted on re-starting with half the dose the trial designated, and my onc prescribed a new anti-D med and a different nurse. For a while I used both zofran and a scopolamine patch. I have now successfully moved up to two-thirds dose and use budesonide, Imodium occasionally, and zofran. Will probably drop the zofran soon. So now I feel pretty good, and it has been worth persisting because I just got labs that show both tumor markers have dropped very low. My onc says this looks spectacular! Scan in a couple weeks.

SUMMIT Basket Trial: Faslodex, Herceptin, and neratinib (Nerlynx) for Her2 mutated mbc

2011 Stage I ILC ER+PR+ Her2- 1.5 cm grade 1, ITCs sn . Lumpectomy, radiation, tamoxifen. 2014 Stage IV ILC ER+PR+Her2- grade 2, mets to breast , liver. Taxol NEAD. 2015,2016 Ibrance+letrozole. 2017 Faslodex+Afnitor; Xeloda. 2018,2019 Xeloda NEAD
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Mar 26, 2020 02:52PM ShetlandPony wrote:

Grannax2, I responded to your good news on another thread, but there’s no harm in saying Congratualtions again! Isn’ it nice to know those darn shots did some good?

2011 Stage I ILC ER+PR+ Her2- 1.5 cm grade 1, ITCs sn . Lumpectomy, radiation, tamoxifen. 2014 Stage IV ILC ER+PR+Her2- grade 2, mets to breast , liver. Taxol NEAD. 2015,2016 Ibrance+letrozole. 2017 Faslodex+Afnitor; Xeloda. 2018,2019 Xeloda NEAD
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Mar 28, 2020 03:17PM Grannax2 wrote:

Absolutely, Shetland! 💞

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Mar 30, 2020 10:59PM jobur wrote:

Shetland, Sounds like you have had a rough time on this trial. So sorry to hear this, but hopefully the new meds, reduced dose and new nurse will keep you feeling "pretty good" or better. So the neratinib seems to have been the culprit behind most of your issues? After all that fun I'm happy to hear your tumor markers have dropped so much. Looking forward to hearing good news from your scan. I had a rough month or 2 with GI issues and pancreatitis but am now back on a reduced dose of Piqray and feeling pretty good too.

"What do you know, and what do you just believe?" Linda Hogan "Power" Surgery 7/1/2014 Lumpectomy: Left Dx 8/1/2014, IDC, Left, 1cm, Stage IV, metastasized to bone, Grade 2, 4/7 nodes, mets, ER+/PR+, HER2- Hormonal Therapy 8/4/2014 Arimidex (anastrozole) Hormonal Therapy 4/30/2015 Faslodex (fulvestrant) Targeted Therapy 8/17/2015 Ibrance (palbociclib) Dx 11/20/2018, IDC, 1cm, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Hormonal Therapy 12/4/2018 Aromasin (exemestane) Targeted Therapy 1/1/2019 Afinitor (everolimus) Hormonal Therapy 7/16/2019 Faslodex (fulvestrant) Targeted Therapy 7/18/2019
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Mar 30, 2020 11:51PM ShetlandPony wrote:

I’m so relieved to hear you are doing better, jobur . Yikes, pancreatitis and GI issues. Yes, neratinib was the culprit. Yay for dose reductions.

2011 Stage I ILC ER+PR+ Her2- 1.5 cm grade 1, ITCs sn . Lumpectomy, radiation, tamoxifen. 2014 Stage IV ILC ER+PR+Her2- grade 2, mets to breast , liver. Taxol NEAD. 2015,2016 Ibrance+letrozole. 2017 Faslodex+Afnitor; Xeloda. 2018,2019 Xeloda NEAD
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18 hours ago spicedlife wrote:

@ Jobur, turns out that a fragment of the last disc in my spine had a fragment that broke off and was pressing on the nerves.

Neurosurgeon got me referred to a pain and wellness Dr who agreed to give me an injection into that disc or to my spine, not sure. I am so much better!



Surgery 3/4/2012 Lumpectomy: Right; Lymph node removal: Right, Sentinel Surgery 4/15/2012 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 6/3/2012 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 10/7/2012 Femara (letrozole) Surgery 11/4/2012 Reconstruction (left): DIEP flap, Nipple reconstruction; Reconstruction (right): DIEP flap, Nipple reconstruction Surgery 3/15/2013 Reconstruction (left): DIEP flap, Nipple reconstruction; Reconstruction (right): DIEP flap, Nipple reconstruction Dx 11/30/2017, IDC, Stage IV, metastasized to bone, Grade 2, 1/15 nodes, ER+/PR+, HER2- (FISH)

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