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All TopicsForum: Stage IV and Metastatic Breast Cancer ONLY → Topic: Ibrance (Palbociclib)

Topic: Ibrance (Palbociclib)

Forum: Stage IV and Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Feb 24, 2015 08:21PM - edited Aug 29, 2017 02:18PM by Moderators

Romansma wrote:

A bottle of Ibrance came in the mail today. I will start taking it tonight with Femara. Hoping that others starting on this drug will join me here to talk about side effects and how to avoid or treat them. So far, I've been warned about low white counts. I run very low as it is, probably because of my extensive bone mets. Anyone currently on Ibrance?

Edited by Mods to add Mod Note: Unfortunately, Romansma passed away in 2016. Our thoughts are with all who loved Hope.

Edited by Mods to add:

For more information on this medication, see the main Breastcancer.org site's section on Ibrance for information on how it works, who it's for, what to expect, and side effects. Also, read the latest research on the Research News on Ibrance pages.

If you're having trouble paying for Ibrance, Pfizer (the manufacturer of Ibrance) RxPathways offers a range of support services for eligible patients. Visit www.PfizerRxPathways.com.

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 24, 2015 08:31PM sandilee wrote:

No, but I just want to wish you luck. I hope it does the trick and treats you kindly. {{hugs}}

- 4/2015- Mets to liver. 6/2011-Mets to spine, ribs, and skull, 6/2011 radiation, Xgeva and Faslodex 7/2011 Dx 11/2007, IDC, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR-, HER2- Hormonal Therapy 1/10/2008 Aromasin (exemestane) Dx 6/2011, IDC, mets Radiation Therapy 6/30/2011 Bone Hormonal Therapy 7/15/2011 Faslodex (fulvestrant) Hormonal Therapy 4/10/2015 Femara (letrozole) Targeted Therapy 4/20/2015 Ibrance (palbociclib) Chemotherapy 8/3/2015 Xeloda (capecitabine) Hormonal Therapy 3/11/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 24, 2015 08:36PM Romansma wrote:

Thank you Sandilee! I'm hoping to be an overachiever on this! Exceptional response is what I'm after!




Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 24, 2015 09:13PM Lenn13ka wrote:

Romansma,

Sorry for posting on this Stage 4 forum. I am in a phase 2 clinical trial at Dana Farber/MGH combining Palbociclib and Hormone therapy for early stage BC. I am just finishing up my first month. I would love to join a conversation about side effects, as I have only talked to one other person on this site who has been on the drug. I am taking the standard dose and have already had my 14 day blood work completed. There are about 80 people enrolled in this trial. However, I don't want to intrude here, so want to make sure it is OK.


OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 24, 2015 09:24PM Romansma wrote:

Yes, please join us. Side effects shouldn't be too different between the stages, although PFS and OS will be. Do you take with or without food? Morning or evening

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 24, 2015 10:08PM Lenn13ka wrote:

They want you to take it with food the same time every day. I have been taking it at 6:00 pm. I guess according to the trial nurse it gets absorbed better. My blood counts were a little off on day 14 but not enough to make any changes.The first couple of weeks I had no issues at all. Really tired yesterday and today but only have 2 days left in this period and then a week off, so it will be interesting to see if you rebound that week. Back at Dana Farber next Friday for more blood work

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 25, 2015 12:53AM nancyh wrote:

Hey Romansma, thanks for starting this thread.

By some miracle, I was able to get palbociclib (with Femara) via expanded access on clinical trial. I started a couple weeks ago and have had zero side effects. I take both pills in the evening with food. This drug combo is a long shot for me as I've exhausted all the endocrine therapies, but even if I get a couple months break from chemo, I'll be happy.

Look forward to hearing others' experience.

Stage 4 in 2009, mets to liver, lungs, bones, and brain. Dx 8/12/2002, IDC, 1cm, Stage IIB, 3/12 nodes, ER+/PR+, HER2- Chemotherapy 9/30/2002 AC Chemotherapy 12/31/2002 Taxol (paclitaxel) Hormonal Therapy 4/30/2003 Dx 4/2/2007, IDC, 1cm, Stage II, ER+/PR+, HER2- Chemotherapy 5/31/2007 CMF Targeted Therapy 8/31/2009 Avastin (bevacizumab) Chemotherapy 8/31/2009 Abraxane (albumin-bound or nab-paclitaxel) Dx 9/1/2009, IDC, Stage IV, metastasized to brain/bone/liver/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 5/31/2010 Femara (letrozole) Chemotherapy 8/31/2011 Xeloda (capecitabine) Hormonal Therapy 12/31/2011 Faslodex (fulvestrant) Chemotherapy 5/31/2012 Navelbine (vinorelbine) Chemotherapy 4/30/2013 Gemzar (gemcitabine) Hormonal Therapy 5/31/2013 Aromasin (exemestane) Targeted Therapy 7/31/2013 Afinitor (everolimus) Chemotherapy 10/27/2013 Halaven (eribulin) Chemotherapy 11/11/2014 Taxotere (docetaxel) Chemotherapy 9/30/2015 Adriamycin (doxorubicin) Targeted Therapy Ibrance (palbociclib)
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Feb 25, 2015 12:15PM brandall wrote:

I have been on a trial since last June where I may or may not be on palbociclib. I personally feel I might be on the placebo arm because I have had zero side effects. I'm taking it with faslodex and I haven't really had any side effects from that either. Sorry I can't be more helpful. I'm on a message board for people who were on the CDK 4/6 inhibitors and most people only report the low white blood counts. HTH!

Brandi - Mother of 2 - Daughter age 6, Son age 3; Liver mets Dx 7/24/2012, IDC, Stage IV, Grade 3, 7/17 nodes, mets, ER+/PR-, HER2- Surgery 8/2/2012 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/11/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/1/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 3/20/2013 Prophylactic ovary removal Hormonal Therapy 2/21/2014 Femara (letrozole) Hormonal Therapy 5/31/2014 Faslodex (fulvestrant) Targeted Therapy 4/9/2015 Afinitor (everolimus) Hormonal Therapy Aromasin (exemestane)
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Feb 25, 2015 12:26PM Romansma wrote:

Ok, good. Decided to take my dose right after dinner last night. Good to know that's what others are doing too. There were no instructions with the packaging when it was delivered.

I am not taking this on trial and yes, it's a bit of a long shot for me too, but I'm not interested in chemo right now.

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 25, 2015 03:02PM Springlakegirl wrote:

Romansma,

I just noticed this thread! I have just been approved to receive Palbociclib/Letrozole, and will start on it as soon as I can. My pharmacy is trying to get the drug, but it shouldn't take too long. Thank you for starting this thread, and please continue to post any side effects you may be experiencing. I will join this conversation as soon as I start. Thanks!

http://deniseneish.com/

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Feb 25, 2015 03:45PM Lenn13ka wrote:

I will try and share as much information as I can from the trial I am on as I will be followed pretty closely . I have access to the trial nurse and see a Dr. Once/month. The trial is basically about the side effects of the drug and is a feasibility study on whether palbociclib can be tolerated enough to become part of standard treatment

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 25, 2015 07:17PM Romansma wrote:

Springlakegirl, I was told you could only get Ibrance through a specialty pharmacy. Is that what you are doing? If not, you might call MO and ask them to check. When I went on Afinitor last year, my MO gave me a prescription to get filled which was not the way to do it. It could only be filled by specialty pharmacy, too. It wasted a few days for me.



Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 25, 2015 08:03PM Springlakegirl wrote:

Yes, they are getting it through a specialty pharmacy. Thank you!

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Feb 25, 2015 10:14PM Romansma wrote:

Great! Should only take a few days. Day 2 is down the hatch! I haven't noticed anything different.


Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 26, 2015 01:39AM SusanAnn wrote:

Hi everyone, I am presently in the Palbociclib, Phase 3 trial with Faslodex since Nov 21, 2013. If I may be of some help in any way, I would love to join in! Don't want to intrude unless everyone is ok with it.

Dx 11/10/2010, IDC, 1cm, Stage I, 0/2 nodes, ER+/PR+, HER2- Surgery 1/10/2011 Lymph node removal: Left, Sentinel; Mastectomy: Left; Reconstruction (left): DIEP flap Chemotherapy 3/16/2011 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 6/8/2011 Arimidex (anastrozole) Dx 11/4/2013, IDC, Left, Stage IIIC, ER+/PR+, HER2- Targeted Therapy 11/19/2013 Ibrance (palbociclib) Dx 6/1/2015, IDC, Left, Stage IV, ER+/PR+, HER2- Hormonal Therapy 6/3/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 9/17/2015, IDC, Left, Stage IV Chemotherapy 9/17/2015 Xeloda (capecitabine)
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Feb 26, 2015 08:47AM - edited Feb 26, 2015 08:47AM by Romansma

Welcome, Susan. Please share anything you have experienced. I'm a newbie on Ibrance and don't really know what to expect.


Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 26, 2015 09:18AM Lenn13ka wrote:

The first two weeks I had absolutely no side effects. This week however, each day I have felt increasing fatigue, almost like mono. My last day in the cycle is today and then my week off. I am interested to see if you bounce back during the off week. Like all these drugs, they don't take weight into account with the dosing and wonder if you are smaller should you have a lower dose? So much to learn about this drug and how it works. But, we need these trials to make progress. Glad to see something moving through the pipeline Faster, especially for you stage 4 ladies.

After my first month, I will have a LIST of questions when I go back to DF next week.


OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 26, 2015 11:34AM Romansma wrote:

Good to know, Lenn. Thanksfor sharing.



Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 26, 2015 11:48AM daisylover wrote:

Lenn, my energy bounced back on my weeks off - my neutrophil counts also came back up, in the beginning enough to stay on the trial. I believe that it helps to exercise - even though it's difficult through the fatigue. (There are 2 dose reductions allowed on the feasibility trial. They may make you wait a cycle or 2 to reduce.) Try to steer clear of people with colds - after at least 5 years without a respiratory infection (children and hubby getting sick many times), I had 3 intense infections within 2 months on Palbo. I even required inhalers to shake one. I became very in tune to who had the sniffles... Hope the fatigue levels off for you.

Dx 10/22/2013, ILC, 3cm, Stage IIB, Grade 1, 2/12 nodes, ER+/PR+, HER2- Hormonal Therapy 3/12/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 26, 2015 06:42PM Lenn13ka wrote:

Thanks for the info. Daisy.... Looking forward to the week off. I usually exercise everyday ( yoga/cross country skiing, etc. but definitely pushing to do it this week.) I didn't fight it today ... Did nothing much.

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 26, 2015 07:45PM SusanAnn wrote:

When I first started this study, my only complaint was a headache and slight nausea for the first two weeks, then the fatigue set in. The final part of the cycle ((off meds for a week) did and still gives me tiny red pimples usually on my legs and arms that itch non stop. My WBC slowly started to go down, including RBC, HGB and HCT every month. WBC hovers around 2.3 to 2.6. Even though its quite low I have never gotten a cold or flu, although I am always careful about staying away from anyone who appears sick! I just want to encourage all of you that for me it has been very doable, in spite of the fatigue. Lenn mentioned exercise every day - if you are able to do it, then I feel it would help with the fatigue. For me I have been on this drug combo Palbociclib/Faslodex for over a year and my cancer has for the most part neither progressed not has it shrunk. There are many others in this study whose cancer has shrunk substantially and they are continuing to do well! I wish all of you the very best on this drug! Romansma I hope that you are an overachiever!!!

Dx 11/10/2010, IDC, 1cm, Stage I, 0/2 nodes, ER+/PR+, HER2- Surgery 1/10/2011 Lymph node removal: Left, Sentinel; Mastectomy: Left; Reconstruction (left): DIEP flap Chemotherapy 3/16/2011 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 6/8/2011 Arimidex (anastrozole) Dx 11/4/2013, IDC, Left, Stage IIIC, ER+/PR+, HER2- Targeted Therapy 11/19/2013 Ibrance (palbociclib) Dx 6/1/2015, IDC, Left, Stage IV, ER+/PR+, HER2- Hormonal Therapy 6/3/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 9/17/2015, IDC, Left, Stage IV Chemotherapy 9/17/2015 Xeloda (capecitabine)
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Feb 26, 2015 09:52PM LolaHank wrote:

Hi ladies, I took my second dose today. So far, feeling fine. My onco wants bloodwork done weekly while on this. So glad to be here and listen to everyones opinion!

Sarah Dx 8/8/2008, ILC, Right, 2cm, Stage IIIA, 16/18 nodes, ER+/PR+, HER2- Surgery 9/15/2008 Mastectomy: Left, Right; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 11/11/2008 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 3/17/2009 Breast, Lymph nodes Hormonal Therapy 5/17/2009 Dx 10/6/2014, ILC, Stage IV, mets, ER+/PR+, HER2-
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Feb 27, 2015 12:31AM Romansma wrote:

Does getting out of bed to get the remote count for exercise? Kidding, sorta. Too much pain for real exercise, but I stay active taking care of kids and dogs and traveling and living. My MO is worried about WBC for me. I hover at 2.1-2.6 without any treatment. Probably because of the extensive bone mets. Worried that I will have to take too many breaks to let my blood counts recover. Oh well, cross that bridge when I come to it. Day 3 down the hatch!



Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 27, 2015 08:22AM Lenn13ka wrote:

Romansma - Kids, dogs and remote all count in my book! Everything I hear about the drug is that they can work with the dosage in order to keep you on the cycle rather than have you go off. I know that was true in the Paloma trial and not too many had to drop out. Yeah for day 3 !!! When will they do your blood counts?You do sound like an overachiever!

Welcome SMR...


OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 27, 2015 08:27AM - edited Feb 27, 2015 08:32AM by 3Holly

Hi SusanAnn,

I have been on Faslodex shots and have been getting those red bumps as well, and they bleed (they are very itchy so I can't resist scratching them a little). I am not (yet anyway) on the Ibrance so it must be the Faslodex causing the red bumps, hopefully the Ibrance doesn't cause more of them. I hope they don't get infected if I go on Ibrance since low WBC can cause infection. Still waiting to hear from the doc on the Ibrance, and thank you everyone for sharing your experience - good luck everyone!

Romansma, I agree you are handling a lot, I could not handle caring for a dog along with kids (these winter storms alone have done me in!)


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Feb 27, 2015 10:35AM Romansma wrote:

Good morning! I am having my blood drawn next week, so we will know how it's effecting wbc pretty early on. Hope you hear soon, Susan. Did I mention 4 dogs? Only 3 kids still at home, so that's getting easier. Yup, I am cra cra! We live near the beach, so no snow here. Headed to the mountains tonight to take in a little snow at Big Bear Lake. Hope we get snowed in and have to play cards all day in our jammies! I have to say, my mood has been soaring since getting off Xeloda and starting Ibrance. Feeling so hopeful! Have an good day everyone.

Hope

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 27, 2015 10:51AM pearlady wrote:

Romansma I have just started on Ibrance also along with Halevan.  My onc mentioned taking me off of the Halevan if he sees the results he expects with the Ibrance/Femara.  I can only pray that we all get good results. 

I do neupogen two days in a row after my Halevan to keep up my WBC and my onc wants me to continue to do neupogen with the Ibrance, even if I go off of Halevan.  Not sure how much and when he will have me do the neupogen, but we are going to discuss.  I'm wondering if anyone else does neupogen.  I have not really noticed any side effects and my WBC have stayed within normal range.

I have noticed slight nauseau for several hours after taking the Ibrance, but I am okay with that.  I think of it as weight control.

Hormonal Therapy 6/28/1997 Dx 8/8/1997, IDC, 6cm+, Stage IIIB, Grade 1, 6/22 nodes, ER+/PR+, HER2+ Targeted Therapy 8/11/2001 Herceptin (trastuzumab) Dx 9/13/2001, IDC, Stage IV, Grade 1, ER+/PR+, HER2+ Hormonal Therapy 9/20/2001 Arimidex (anastrozole) Hormonal Therapy 10/31/2003 Femara (letrozole) Hormonal Therapy 1/4/2009 Aromasin (exemestane) Hormonal Therapy 1/4/2010 Targeted Therapy 4/3/2012 Afinitor (everolimus) Targeted Therapy 7/4/2012 Afinitor (everolimus) Targeted Therapy 7/9/2012 Perjeta (pertuzumab) Chemotherapy 8/11/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/21/2014 Halaven (eribulin) Targeted Therapy 2/28/2015 Ibrance (palbociclib) Hormonal Therapy 3/2/2015 Femara (letrozole) Targeted Therapy Perjeta (pertuzumab) Hormonal Therapy Chemotherapy Targeted Therapy
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Feb 27, 2015 11:13AM Romansma wrote:

I haven't noticed any nausea, but I'm taking it at night. Maybe I'm sleeping through it. My husband woke me up 2 nights ago around 3am because I was making a weird moaning sound. I think it was because of the back and hip pain, but who knows. Maybe I was having one of THOSE dreams! Doubt it! Menopause has took care of that

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 27, 2015 11:51AM pearlady wrote:

Romansma thank you.  I had been taking in the morning, but think I will switch to taking at night.  You're right, you probably sleep through the nauseau.  I took Afinitor at night and never had any nausea.

Hormonal Therapy 6/28/1997 Dx 8/8/1997, IDC, 6cm+, Stage IIIB, Grade 1, 6/22 nodes, ER+/PR+, HER2+ Targeted Therapy 8/11/2001 Herceptin (trastuzumab) Dx 9/13/2001, IDC, Stage IV, Grade 1, ER+/PR+, HER2+ Hormonal Therapy 9/20/2001 Arimidex (anastrozole) Hormonal Therapy 10/31/2003 Femara (letrozole) Hormonal Therapy 1/4/2009 Aromasin (exemestane) Hormonal Therapy 1/4/2010 Targeted Therapy 4/3/2012 Afinitor (everolimus) Targeted Therapy 7/4/2012 Afinitor (everolimus) Targeted Therapy 7/9/2012 Perjeta (pertuzumab) Chemotherapy 8/11/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/21/2014 Halaven (eribulin) Targeted Therapy 2/28/2015 Ibrance (palbociclib) Hormonal Therapy 3/2/2015 Femara (letrozole) Targeted Therapy Perjeta (pertuzumab) Hormonal Therapy Chemotherapy Targeted Therapy
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Feb 27, 2015 01:07PM thinkpositive wrote:

Hi

Can anyone tell me if you lose your hair on Ibrance? I saw that hair loss was one of the side effects.

Thanks!!

Dx 10/15/2012, IDC, Left, Stage IIIB, 10/18 nodes, ER+/PR+, HER2- Chemotherapy 11/13/2012 AC + T (Taxol) Surgery 3/12/2013 Mastectomy: Left Radiation Therapy 5/27/2013 Breast Hormonal Therapy 6/20/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 2/18/2015, IDC, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Hormonal Therapy 3/7/2015 Femara (letrozole) Targeted Therapy 3/17/2015 Ibrance (palbociclib) Hormonal Therapy 7/24/2016 Faslodex (fulvestrant) Chemotherapy 9/13/2016 Xeloda (capecitabine)
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Feb 27, 2015 01:40PM pearlady wrote:

Don't know first hand about hair loss.  The pharmacist at CVS Caremark told me that it is listed as one of the possible side effects, but only a small percentage of women lose their hair.  Hope this is the case.  Would be interested to hear from those in trials who have firsthand experience.

Hormonal Therapy 6/28/1997 Dx 8/8/1997, IDC, 6cm+, Stage IIIB, Grade 1, 6/22 nodes, ER+/PR+, HER2+ Targeted Therapy 8/11/2001 Herceptin (trastuzumab) Dx 9/13/2001, IDC, Stage IV, Grade 1, ER+/PR+, HER2+ Hormonal Therapy 9/20/2001 Arimidex (anastrozole) Hormonal Therapy 10/31/2003 Femara (letrozole) Hormonal Therapy 1/4/2009 Aromasin (exemestane) Hormonal Therapy 1/4/2010 Targeted Therapy 4/3/2012 Afinitor (everolimus) Targeted Therapy 7/4/2012 Afinitor (everolimus) Targeted Therapy 7/9/2012 Perjeta (pertuzumab) Chemotherapy 8/11/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/21/2014 Halaven (eribulin) Targeted Therapy 2/28/2015 Ibrance (palbociclib) Hormonal Therapy 3/2/2015 Femara (letrozole) Targeted Therapy Perjeta (pertuzumab) Hormonal Therapy Chemotherapy Targeted Therapy

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