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Topic: Ibrance (Palbociclib)

Forum: Stage IV and Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Feb 24, 2015 08:21PM - edited Dec 11, 2017 01:43PM by Moderators

Romansma wrote:

A bottle of Ibrance came in the mail today. I will start taking it tonight with Femara. Hoping that others starting on this drug will join me here to talk about side effects and how to avoid or treat them. So far, I've been warned about low white counts. I run very low as it is, probably because of my extensive bone mets. Anyone currently on Ibrance?

Edited by Mods to add Mod Note: Unfortunately, Romansma passed away in 2016. Our thoughts are with all who loved Hope.

Edited by Mods to add:

For more information on this medication, see the main Breastcancer.org site's section on Ibrance for information on how it works, who it's for, what to expect, and side effects. Also, read the latest research on the Research News on Ibrance pages.

Pfizer Oncology Together is a first-of-its-kind program for patients taking Pfizer Oncology medicines that offers dedicated social workers called 'Care Champions' to help navigate the complexities that accompany treatment, such as identifying resources to help find emotional support, and workplace transition, transportation and financial assistance.

For cancer patients taking a Pfizer Oncology medicine (e.g. Ibrance) or caregivers, please visit www.PfizerOncologyTogether.com.

For live support call: 1-877-744-5675

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 27, 2015 02:26PM Lenn13ka wrote:

Trial paperwork says 1 - 10% temporary hair loss. They refer to it as an "occasional" side effect. I am only one month in ... So far no hair loss.

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Feb 27, 2015 08:28PM nancyh wrote:

I had my counts checked yesterday and white counts are lower, but not enough for neupogen (yet). My platelets were quite a bit lower, seems like that's one of the main side effects. No nausea for me either, though maybe taking in the evening with dinner is key. So far, I'd say this drug combo is a piece of cake, crossing fingers and toes that it will be effective.

Have a great weekend, gals!

Stage 4 in 2009, mets to liver, lungs, bones, and brain. Dx 8/12/2002, IDC, 1cm, Stage IIB, 3/12 nodes, ER+/PR+, HER2- Chemotherapy 9/30/2002 AC Chemotherapy 12/31/2002 Taxol (paclitaxel) Hormonal Therapy 4/30/2003 Dx 4/2/2007, IDC, 1cm, Stage II, ER+/PR+, HER2- Chemotherapy 5/31/2007 CMF Targeted Therapy 8/31/2009 Avastin (bevacizumab) Chemotherapy 8/31/2009 Abraxane (albumin-bound or nab-paclitaxel) Dx 9/1/2009, IDC, Stage IV, metastasized to brain/bone/liver/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 5/31/2010 Femara (letrozole) Chemotherapy 8/31/2011 Xeloda (capecitabine) Hormonal Therapy 12/31/2011 Faslodex (fulvestrant) Chemotherapy 5/31/2012 Navelbine (vinorelbine) Chemotherapy 4/30/2013 Gemzar (gemcitabine) Hormonal Therapy 5/31/2013 Aromasin (exemestane) Targeted Therapy 7/31/2013 Afinitor (everolimus) Chemotherapy 10/27/2013 Halaven (eribulin) Chemotherapy 11/11/2014 Taxotere (docetaxel) Chemotherapy 9/30/2015 Adriamycin (doxorubicin) Targeted Therapy Ibrance (palbociclib)
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Feb 27, 2015 08:30PM nancyh wrote:

Oh - and I can't comment on hair loss as I have no hair thanks to begin with having just done 5 cycles of taxotere.

Happy

Stage 4 in 2009, mets to liver, lungs, bones, and brain. Dx 8/12/2002, IDC, 1cm, Stage IIB, 3/12 nodes, ER+/PR+, HER2- Chemotherapy 9/30/2002 AC Chemotherapy 12/31/2002 Taxol (paclitaxel) Hormonal Therapy 4/30/2003 Dx 4/2/2007, IDC, 1cm, Stage II, ER+/PR+, HER2- Chemotherapy 5/31/2007 CMF Targeted Therapy 8/31/2009 Avastin (bevacizumab) Chemotherapy 8/31/2009 Abraxane (albumin-bound or nab-paclitaxel) Dx 9/1/2009, IDC, Stage IV, metastasized to brain/bone/liver/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 5/31/2010 Femara (letrozole) Chemotherapy 8/31/2011 Xeloda (capecitabine) Hormonal Therapy 12/31/2011 Faslodex (fulvestrant) Chemotherapy 5/31/2012 Navelbine (vinorelbine) Chemotherapy 4/30/2013 Gemzar (gemcitabine) Hormonal Therapy 5/31/2013 Aromasin (exemestane) Targeted Therapy 7/31/2013 Afinitor (everolimus) Chemotherapy 10/27/2013 Halaven (eribulin) Chemotherapy 11/11/2014 Taxotere (docetaxel) Chemotherapy 9/30/2015 Adriamycin (doxorubicin) Targeted Therapy Ibrance (palbociclib)
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Feb 28, 2015 10:02AM SusanAnn wrote:

Hi Thinkpositive

When I started this study (Palbociclib/faslodex) my hair was very thick, a year later it has thinned quite a bit. Not sure if this is the same for everyone.

Dx 11/10/2010, IDC, 1cm, Stage I, 0/2 nodes, ER+/PR+, HER2- Surgery 1/11/2011 Lymph node removal: Left, Sentinel; Mastectomy: Left; Reconstruction (left): DIEP flap Chemotherapy 3/17/2011 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 6/9/2011 Arimidex (anastrozole) Dx 11/4/2013, IDC, Left, Stage IIIC, ER+/PR+, HER2- Targeted Therapy 11/20/2013 Ibrance (palbociclib) Dx 6/1/2015, IDC, Left, Stage IV, ER+/PR+, HER2- Hormonal Therapy 6/3/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 9/17/2015, IDC, Left, Stage IV Chemotherapy 9/17/2015 Xeloda (capecitabine)
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Feb 28, 2015 10:16AM SusanAnn wrote:

Hi 3Holly

Just wanted to let you know that for me OTC Cortizone 10 takes care of the itching. Don't use the gel version as it burns, especially if its bleeding! I wish you all the best and hope that you get on Ibrance also. The combo of both drugs seems to be very effective for a lot of people with very few side affects!

Dx 11/10/2010, IDC, 1cm, Stage I, 0/2 nodes, ER+/PR+, HER2- Surgery 1/11/2011 Lymph node removal: Left, Sentinel; Mastectomy: Left; Reconstruction (left): DIEP flap Chemotherapy 3/17/2011 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 6/9/2011 Arimidex (anastrozole) Dx 11/4/2013, IDC, Left, Stage IIIC, ER+/PR+, HER2- Targeted Therapy 11/20/2013 Ibrance (palbociclib) Dx 6/1/2015, IDC, Left, Stage IV, ER+/PR+, HER2- Hormonal Therapy 6/3/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 9/17/2015, IDC, Left, Stage IV Chemotherapy 9/17/2015 Xeloda (capecitabine)
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Feb 28, 2015 11:08AM 3Holly wrote:

SusanAnn,

Thank you so much for this advice, it is so helpful! I need to take care of these bumps since they keep popping up ever since starting the Faslodex, and I don't want infection. I am so glad to hear the Ibrance is helping you and so many others. Hopefully I will hear soon that this will be my next step.


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Feb 28, 2015 11:32AM linda714 wrote:

3Holly,

I have been on the femera/ibrance since June. For three months I was getting the itchy sores and bleeding cause you cant help scratching. It even had my eyes itching very badly. Last month they biopsied the sores and it showed to be reaction to Ibrance. They changed my dosage to 100 mg. So far thru one month no rash or sores. Hope this helps. They also gave me hydrocortisone OINTMENT2.5%.

Linda

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Feb 28, 2015 03:28PM eshinall wrote:

I started on Ibrance on Feb 15 and am having my labs drawn on Tuesday (the 3rd). Slight nausea for a few days, and now some fatigue, but everything has been very tolerable. Let's just hope that it will be effective. I've failed most of the hormonal/endocrine and was JUST ready to switch to Gemzar after failing Abraxane after just 5 months. Praying for stability.

Liz

Dx 8/20/2008, IDC, <1cm, Stage IA, Grade 3, 0/8 nodes, ER+/PR+, HER2- Surgery 9/10/2008 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Hormonal Therapy 9/30/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 7/26/2012, IDC, 2cm, Stage IV, Grade 3, ER+/PR-, HER2- Hormonal Therapy 7/31/2012 Femara (letrozole) Hormonal Therapy 8/14/2012 Femara (letrozole), Zoladex (goserelin) Targeted Therapy 12/16/2012 Afinitor (everolimus) Hormonal Therapy 12/16/2012 Aromasin (exemestane) Chemotherapy 11/9/2013 Xeloda (capecitabine) Chemotherapy 8/25/2014 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 2/14/2015 Ibrance (palbociclib) Chemotherapy 6/4/2015 Halaven (eribulin)
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Feb 28, 2015 05:08PM daisylover wrote:

I did 6 months on the feasibility trial for Palbociclib (Ibrance). I did have extensive hair loss (and one eyebrow). I have had alopecia areata for 6 years - usually one spot at a time, nickel to quarter size, which grows back after a few months. On Palbo, I lost an eyebrow (never before) and about 1/3 of the hair on my head - many diffuse bald areas as well as thinning. When the trial nurse asked me about hair loss, I tried to demur saying that I experience alopecia (usually extremely limited hair loss). She told me that many women were experiencing hair loss. I have NO idea how many she meant. My dramatic hair loss is very unusual for me. After 1+ 1/2 months off Palbo, I am beginning to see signs of future regrowth (changes in follicles), I hope... Hope this helps.

Dx 10/22/2013, ILC, 3cm, Stage IIB, Grade 1, 2/12 nodes, ER+/PR+, HER2- Hormonal Therapy 3/13/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Feb 28, 2015 05:48PM car2tenn wrote:

Hello ladies on Ibrance...I have just been taken off of Arimidex after 13 months...I start Ibrance and Femara next week. I will be happy to report regularly on any side effects. The only way I am able to have this medication is that my husband is Air Force retired and thus through TriCare for Life the payment will be made...The physician and I were surprised that the insurance will cover it as I understand on the open market it is $5000 month. thanks for this thread...Carolyn from Music City

carolyn Dx 12/5/2013, IDC, Right, 1cm, Stage IV, metastasized to bone/liver, Grade 2, mets, ER+, HER2- Dx 12/15/2013, IDC, Left, 1cm, Stage IV, Grade 2, mets, ER+/PR-, HER2+ Hormonal Therapy 12/26/2013 Arimidex (anastrozole) Radiation Therapy 3/2/2014 Bone Hormonal Therapy 3/4/2015 Femara (letrozole) Chemotherapy 9/11/2015 Other Chemotherapy 1/8/2016 Taxol (paclitaxel) Targeted Therapy Ibrance (palbociclib)
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Mar 1, 2015 02:06AM - edited Mar 1, 2015 02:06AM by Romansma

It's actually closer to $10k per month which is on par with Afinitor. Great information being shared here. I'm a bit concerned with the reports of hair loss. Do weknow what then percentage of women experiencing hairs loss is?



Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 1, 2015 05:15AM justjudie wrote:

Hello Ladies,,

I have had a very rough time on Ibrance due to lowered white cells and dangerously low platelets. I have been fighting this rotten Cancer for five years next month, so my body has pretty much been thru the mill chemo wise. I had to wait to start this combo (Ibrance and Femara) because my platelets were low. As Ibrance is known to be a problem with platelets my doc waited, hoping the platelets would improve. Well, they did not and after one month on the drug my platelets were constantly going down every time I had a blood test. Think it was biweekly and then weekly blood tests. Finally, when I completed the first cycle they continued to fall even tho I was off the drug. As of last week I went down to a count of 28, My doc got very alarmed and ordered a transfusion of platelets only. The next week I went down AGAIN. To 5!! We all. ( onc, DH and I were all very scared as you can bleed out when that low). Now he ordered another platelet pac and two units of regular blood transfusions because my whites had now gone down significantly as well. I am beyond fatigued. So exhausted I can hardly move. It was last night that I had the final transfusions. I don't know where we will go from here

Judie Dx 3/31/2010, IDC, Stage IV, mets, ER+/PR+, HER2-
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Mar 1, 2015 06:00AM Romansma wrote:

Ah Judie, I'm sorry. I really hope your doc can get a handle on this for you.



Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 1, 2015 09:24AM - edited Mar 1, 2015 11:45PM by 3Holly

Linda,

Thank you very much for that information - since I am not yet on Ibrance, I know the itchy bumps are from the Faslodex (hopefully it won't be a double whammy when and if I get the Ibrance, but I agree the dosage will probably be critical, and that is probably what my doc is trying to decide on). Maybe dosage depends on the person's size, allergies, and other factors, hopefully these hospitals are sharing their results so that they can figure out the safest dose for everyone.

Judie,

I am praying that your blood counts come back soon and that you feel some relief.


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Mar 1, 2015 08:46PM ibcmets wrote:

Judie,

Maybe if they reduce your dosage, you may do better as 3Holly says. Hope you recover & your onc gets you on something that works well for you.

Terri

6/2009 stage IV diagnosis w bone mets ,Xgeva , 2015 brain mets, liver metastasis
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Mar 1, 2015 09:41PM Lenn13ka wrote:

I am 3 days into the off week and my energy level definitely improved immediately. Blood test next Friday and then I start the cycle again. I will be interested to see blood counts next week. Week 3 was the the only problem in this first cycle and I will be interested to see what they say about the dosage when I go to Dana Farber on Friday. I do agree they still have some work to do to figuring that out.

Good luck to everyone on this new drug. Thanks Romansma for starting this thread. 1-10% for hair loss according to DF paperwork.

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Mar 1, 2015 10:41PM Romansma wrote:

I've had increasing hot flashes this week. As irritating as they are, I'm happy. Probably means the Femara has some effectiveness. Hopefully

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 2, 2015 12:02AM nancyh wrote:

Judie - so good to hear from you, though I'm sorry about your low platelet count. Those are some scary low counts you've had, I hope between giving you extra platelets and perhaps reducing your dose of Palbo they will be able to give you enough of a boost to allow you to stay on this drug. I think of you often and hope you are doing okay.

Stage 4 in 2009, mets to liver, lungs, bones, and brain. Dx 8/12/2002, IDC, 1cm, Stage IIB, 3/12 nodes, ER+/PR+, HER2- Chemotherapy 9/30/2002 AC Chemotherapy 12/31/2002 Taxol (paclitaxel) Hormonal Therapy 4/30/2003 Dx 4/2/2007, IDC, 1cm, Stage II, ER+/PR+, HER2- Chemotherapy 5/31/2007 CMF Targeted Therapy 8/31/2009 Avastin (bevacizumab) Chemotherapy 8/31/2009 Abraxane (albumin-bound or nab-paclitaxel) Dx 9/1/2009, IDC, Stage IV, metastasized to brain/bone/liver/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 5/31/2010 Femara (letrozole) Chemotherapy 8/31/2011 Xeloda (capecitabine) Hormonal Therapy 12/31/2011 Faslodex (fulvestrant) Chemotherapy 5/31/2012 Navelbine (vinorelbine) Chemotherapy 4/30/2013 Gemzar (gemcitabine) Hormonal Therapy 5/31/2013 Aromasin (exemestane) Targeted Therapy 7/31/2013 Afinitor (everolimus) Chemotherapy 10/27/2013 Halaven (eribulin) Chemotherapy 11/11/2014 Taxotere (docetaxel) Chemotherapy 9/30/2015 Adriamycin (doxorubicin) Targeted Therapy Ibrance (palbociclib)
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Mar 2, 2015 05:27AM justjudie wrote:

Thank all of you for the good wishes and suggestions. I will definitely discuss possible lower dose with my onc. That sounds like a very good idea. The drug sounds so promising I would hate to have to get off it completely.

Hi Nancy, I think of you a lot too and always wish you well. If I head up Seattle way to see my son I will call you and see if we could have coffee together again. That was fun!

Judie Dx 3/31/2010, IDC, Stage IV, mets, ER+/PR+, HER2-
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Mar 2, 2015 10:37AM pearlady wrote:

I just started on this combo last week so no real side effects yet.  Noted the various comments on low platlets. 

When I was on Abraxane my holistic pharmacist recommended Ashwagandha.  My onc was not even aware of this at the time, but now he recommends this.  I took it twice a day before meals and it really did help with the platelets.  Not sure if it helps with the low white cell count, but some things I've read say that it does.  Anyway, it is said to help for many things including immune system.  I just ordered a new supply to take with the Ibrance/Femara.

http://www.zhion.com/herb/Ashwagandha.html

Hormonal Therapy 6/29/1997 Dx 8/8/1997, IDC, 6cm+, Stage IIIB, Grade 1, 6/22 nodes, ER+/PR+, HER2+ Targeted Therapy 8/12/2001 Herceptin (trastuzumab) Dx 9/13/2001, IDC, Stage IV, Grade 1, ER+/PR+, HER2+ Hormonal Therapy 9/21/2001 Arimidex (anastrozole) Hormonal Therapy 11/1/2003 Femara (letrozole) Hormonal Therapy 1/5/2009 Aromasin (exemestane) Hormonal Therapy 1/5/2010 Targeted Therapy 4/4/2012 Afinitor (everolimus) Targeted Therapy 7/5/2012 Afinitor (everolimus) Targeted Therapy 7/10/2012 Perjeta (pertuzumab) Chemotherapy 8/12/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/22/2014 Halaven (eribulin) Targeted Therapy 3/1/2015 Ibrance (palbociclib) Hormonal Therapy 3/3/2015 Femara (letrozole) Targeted Therapy Perjeta (pertuzumab) Hormonal Therapy Chemotherapy Targeted Therapy
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Mar 2, 2015 09:22PM Sue2009 wrote:

hi, I am in clinical trial w/ palbociclib & faslodex, monthly, starting 9th round. Getting x-geva every 3 months. My ANC takes a hit from 1 st month started, so we knew I was on Palbo. Due to immuno suppression, I have had c-diff infections & yeast infections. Fatigue is another problem too. I get scans every 2 months, so far my mets is only in my bones.

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Mar 6, 2015 10:26AM Romansma wrote:

I can feel fatigue building. Very tired. Vivid dreams too. Anyone having more vivid dreams, or just me

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 6, 2015 10:46AM - edited Mar 6, 2015 10:57AM by Romansma

I just did some poking around. Looks like vivid dreams and nightmares are a recognized SE of the Letrozole/Femara. Fun! On the good side, it seems to indicate the Femara is probably working. My hot flashes are really rolling too! Wonder if it's the Ibrance enhancing the Femara? I took Femara with Faslodex last year and progressed pretty quickly. We shall see

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 6, 2015 12:23PM ramade wrote:

Thanks for suggesting this thread Romansma, it looks like I could still have ibrance added, I'll find themoney if necessary.

Ramade

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Mar 6, 2015 03:26PM pearlady wrote:

I do feel some fatigue.  But I think part of it is that I have trouble sleeping.  I haven't had any issues with dreams as yet, but I've only been on this for two weeks.  I guess I may have something to look forward to.

Hormonal Therapy 6/29/1997 Dx 8/8/1997, IDC, 6cm+, Stage IIIB, Grade 1, 6/22 nodes, ER+/PR+, HER2+ Targeted Therapy 8/12/2001 Herceptin (trastuzumab) Dx 9/13/2001, IDC, Stage IV, Grade 1, ER+/PR+, HER2+ Hormonal Therapy 9/21/2001 Arimidex (anastrozole) Hormonal Therapy 11/1/2003 Femara (letrozole) Hormonal Therapy 1/5/2009 Aromasin (exemestane) Hormonal Therapy 1/5/2010 Targeted Therapy 4/4/2012 Afinitor (everolimus) Targeted Therapy 7/5/2012 Afinitor (everolimus) Targeted Therapy 7/10/2012 Perjeta (pertuzumab) Chemotherapy 8/12/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/22/2014 Halaven (eribulin) Targeted Therapy 3/1/2015 Ibrance (palbociclib) Hormonal Therapy 3/3/2015 Femara (letrozole) Targeted Therapy Perjeta (pertuzumab) Hormonal Therapy Chemotherapy Targeted Therapy
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Mar 6, 2015 06:57PM PattyPeppermint wrote:

rest up Romansma. Sounds like it is working. Yea !!!!!

To God be the glory! Live, laugh, love... Life is way too short. Dx 6/2013, Stage IV, ER+/PR+, HER2- Hormonal Therapy 6/28/2013 Femara (letrozole) Radiation Therapy 7/4/2013 Bone Hormonal Therapy 7/31/2015 Faslodex (fulvestrant) Targeted Therapy 7/31/2015 Ibrance (palbociclib) Chemotherapy 6/30/2016 Xeloda (capecitabine)
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Mar 7, 2015 10:51AM Romansma wrote:

Hey Patty! Thanks for popping in. I sure hope you are back home, feeling better!

Starting week 3 and so far, increased hot flashes, some vivid dreams/nightmares, and increasing fatigue. My cbc came back with lowered wbc, platelets, but not crazy low. I can handle this! Hope it's working!


Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Mar 7, 2015 06:54PM Lenn13ka wrote:

I had my one month visit at Dana Farber since being on this drug. My week off was fine. I felt great. There will be no dose change this month. My awesome MO there said that what side effects you have on the first 1-3 months is what you will have on this med. They are not seeing many changes or " funky" things happening after that. Most of the adjustments they are doing are in the first few months. It seems like you either get Neutropenia or you don't. My mid month blood counts were not that bad either... A little lower but bounced right back on the off week. Glad to hear this is going well for you Romansma. I do have my first cold in two years....can't shake it.. But winter has been long here in MA. Heating with wood.... Tired of the cold! Maybebe my




OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Mar 7, 2015 06:55PM Lenn13ka wrote:

I meant to say: maybe my body is tired of the cold!

OncotypeDX 17 Dx 4/2/2013, <1cm, Stage IIA, Grade 2, 1/5 nodes, ER+/PR+, HER2- Surgery 4/19/2013 Lumpectomy: Right; Lymph node removal: Right, Sentinel Radiation Therapy 5/27/2013 Breast, Lymph nodes Hormonal Therapy 6/18/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/1/2015 Ibrance (palbociclib) Hormonal Therapy 11/16/2015 Arimidex (anastrozole)
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Mar 9, 2015 12:11PM Romansma wrote:

Hope that cold is going away, Lenn. I'm still doing good. Getting very fatigued! It will be an interesting week. But, if this is as bad as it gets, I'm grateful. So far, this has been a piece of cake when compared to Afinitor, or even Xeloda. Just hope it's doing the job

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)

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