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Jan 19, 2021 05:32PM
I'm new here, although I've been lurking for a couple months. This is my first post.
I'm 36 and was diagnosed de novo with bone mets in Nov 2020 (too many for rads, apparently). I was supposed to start my 3rd round of Ibrance tomorrow (after the one week off, bloodwork done yesterday) and my MO called today to tell me first - great news, in that my bone mets look to be healing (as per CT scan from last week) meaning the meds are working well ..... but then he goes on to say that my liver (err...enzymes? I missed which count it was, related to the liver) was four times higher than average. He didn't seem too worried - we'd take a break off of Ibrance for two weeks, repeat bloodwork, and if the liver-whatever count goes down, then it's likely the Ibrance that's causing it, and we'll look at either going to a lower dose or moving to a different targeted therapy. But what I couldn't help thinking was - if I move to a second targeted therapy, does that mean I already blew threw my first? My MO originally said you have about 3 tries at the targeted therapy before you max out and need to switch to chemo as a last stop (I understand that there are different forms of chemo to work through too, but I just would not like to need to do chemo any time soon, as you can imagine).
He also said that it's rare to get liver damage from the Ibrance (I thought I read somewhere in an article that it was about 3% of patients reported it) and I cannot tell you how angry I am if this is the case. So Ibrance is working on my bone mets, but my body may not be able to handle it - and on top of that, the WAY in which it cant handle it is ALSO RARE??? I'm already 36 with MBC and I feel like everything over the past few months has been like... oh, well, maybe it won't be the worst case scenario. But no. It WAS cancer. and then it WAS metastatic. I'm having a hard time believing the liver stuff will be anything else than terrible news somehow.
I've been trying to do research all day to find anyone else in a similar situation but it seems that ppl take breaks or lower dosages of Ibrance mostly due to the more common reason of white blood cell counts. Has anyone had experience with liver problems due to Ibrance, or know anyone who has?
Does is make sense to do the terrifying math that - my MO said many people get about a good 2+ extra years on Ibrance... but if that's the case and I originally had 2+ years (hypothetically) PLUS two more possible targeted therapies.... does blowing through my Ibrance this quickly (IF that's the case) mean that I thus have a shorter life span? Or is it possible to get a few (or many?) years off of the second targeted therapy if the first hates your body?
I'm really hoping my liver stuff is due to something else that is easily remedied but I have no idea what that could be. And really. What are the odds that something coincidently made it pop up now..
Thank you so much anyone for any support or advice. Sometimes I think the hardest part of all of this is dealing with the unknown (when/why/how/how long). I'd love to be just making the best of every day right now, just in case, but this stupid pandemic is putting a giant wrench if all of that too. I'm at least grateful to be in an area of Canada with currently low case loads, but I also just needed to vent at how shitty it is.
10/28/2020, IDC, Right, ER+/PR+, HER2-
11/9/2020, IDC, Stage IV, metastasized to bone
11/24/2020 Ibrance (palbociclib)
11/24/2020 Femara (letrozole), Zoladex (goserelin)