Skin mets

hi grannyof3

Ive had skin mets at the beginning which dissapeared with chemo.. Not dead 😆:))) Dr Google gets confused most of the times.. BCO is a better reference for all the info you're looking for.

MO has never impled any concern about my skinmets theoughout the 4,5 years of my treatment and I agree with Rose that they are in fact a visual reference to whta's going on..

Hope they disseapear very soon with your new treatment. No worries, there are a handful of good therapies to keep you alive with good QOL. Hang on!

Hugs

Ebru

Grannyof3,

I've come across a few ladies here with skin mets, but not many. My MO gave me the "chronic disease" talk in 2010, and that's exactly what it's become. I know how scary it is, but have faith. I hate that you were so close to that 5 year mark... I was diagnosed at stage iv so I don't know that feeling. But I'm still here, Ebru's still here, and I hope and pray you will be around for many years to come!!!!

Happy 4th of July and (((hugs))) to you...

Rose

I am sorry to hear you are dealing with skin mets, which is not all that uncommon. I would strongly suggest that yu consider getting them biopsied, as the skin mets may have a different ER, PR and/or HER2 profile than mets elsewhere.

Below from my MBC Guide is a list of possible therapies which I hope may be helpful for discussing with your doctor.You (and others) are welcome to request a complimentary copy of the 120+ page booklet by visiting the top of this page: https://community.breastcancer.org/forum/8/topics/831507?page=2#idx_32

As described below, therapies for skin metastasis may include:

• Cryotherapy
• ElectroChemoTherapy (ECT)
• Imiquimod Cream
• Laser Ablation
• Medihoney
• Miltex (Miltefosine)
• Other:
  • Laser Ablation
  • Radiofrequency Ablation
  • Radiotherapy
  • Systemic therapy
  • Surgery

• Cryotherapy, which refers to a treatment in which surface skin lesions are frozen, often by using liquid nitrogen, may sometimes be used to destroy skin lesions.From: http://dermnetnz.org/lesions/metastasis.html

• A new treatment called ElectroChemoTherapy (ECT) has been proposed as a complementary therapeutic technique for controlling cutaneous and subcutaneous metastasis.ECT is a non-thermal tumor ablation therapy providing electric currents (electric pulses) to cancer cells.The procedure increases cell membrane permeability, and enhances the penetration of drugs into the cancer cells.Bleomycin, an "antitumor antibiotic" and cisplatin may be the most suitable candidates for the combined use with ECT.In one small observational study, 12 breast cancer patients with skin metastases were given Bleomycin followed by the application of brief electric pulses to the tumor area.There was a Complete Response of 75.3%, a Partial Response in 17%, and no change in 7.7%.No serious ECT-related adverse events were reported.From:http://www.biomedcentral.com/1471-2482/12/S1/S6 For those with ulcerating breast tumors, electrochemotherapy may help control bleeding, pain and discharge, and the treatment can be repeated if needed.

• One small study indicated that Imiquimod Cream applied topically may be helpful against skin metastasis in about 20% of patients:From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580198/

• Medihoney: At the 2010 Symposium on Advanced Wound Care (SAWC) and the Wound Healing Society (WHS), an international conference drawing clinicians from all over the globe, a clinician presented a series of cases illustrating the benefits of MEDIHONEY® dressings not only in the treatment of fungating tumor wounds but in eliminating their odor and the stigma that goes with it. MEDIHONEY® dressings are a unique line of products whose active ingredient is medical-grade active Leptospermum honey (ALH) that can succeed in alleviating wounds when other treatments have failed.From: http://www.news-medical.net/news/20100417/Honey-beneficial-for-treatment-of-fungating-tumor-wounds.aspx

• A topical therapy called Miltex (Miltefosine) may be helpful if it is available.In a small study, 25 patients were treated, most of whom had been heavily pre-treated.A response was seen in 9 patients with skin lesions from metastatic breast cancer (1 complete response, 2 partial responses, 6 minor responses) giving a total response rate of 36%, with stable disease in 11 patients (44%) and progressive disease in 5 (20%). From: http://link.springer.com/article/10.1007/s002800051114?LI=true and http://dermnetnz.org/lesions/metastasis.html

• In some cases, the literature about treating skin metastasis indicates that surgical excision, which might be followed by radiotherapy and/or systemic treatment, may be viable.And when surgical excision is not possible, there may be several therapeutic options such as laser ablation, radiofrequency ablation (which uses a needle that carries an electric current to heat the tumor to destroy it), or radiotherapy.

Hi All,

Strange I should find this thread today. I just had two areas on my arm biopsied. I'll know in a few weeks what's up with them. Good to know that this thread exists. Wishing everyone well!

Suzy (Stllivin)

Glad you already got used to this 'new normal state' of mbc..

Life does go on, somehow.. Better to enjoy! )

Hugs

Ebru

hi all, I was dx with a recurrence in my lymph nodes in may. Then a biopsy on this this red patch on my boob that's been there for a yr without changing has turned out to be pos. Since the biopsy, my entire breast has turned red. I'm on Ibrance and worried it ain't working.

Is the breast being pink/ red skin mets? Anybody else experience the spreading or shrinking of redness on Ibrance?

Any info...

Thx D

Can anyone give skin mets information? Is it a rash, or bumps on the skin? Does it itch? How much do they spread, if at all? I don't really want to do a google search, as someone above mentioned, it can get scary.

Hi everyone,

Got good news last week. Both my bone scan and CT scan came back clear. So the extent of recurrence of the cancer is in my skin. My oncologist has described me as a paradox!

So I started on Kadcyla on Tuesday and and really hoping and praying that it gets the mets under control. They started off as an innocuous looking red rash. Firstly I was given hydrocortisone cream for a week but it didn't make any difference. The mets then turned papular in appearance and very much thickened almost like psoriasis plaques. They have spread from the mastectomy scar to my arm pit which is really annoying as my bra rubs on them and it like chaffing. I got some Urgotul dressings this week which ease the discomfort.

Wishing you all well

Mini

Doing a bit of Autumnal decorating

I've had skin mets too. Presented as lumps beneath the skin that gradually grew into the skin & formed scabby tops - sort of like crusty, skin pre-cancers. Several removed by surgery and several more during a big, post-mastectomy radiation blast. Have a largish area of smallish lesions in my chest wall now, they aren't breaking through the skin and forming open sores, since the skin is so fragile and no more radiation or surgery. My friends that have had open, bleeding, gangrenous sores have really suffered. Nearly impossible to dress & treat. Pain control is difficult.

MILTEX is a topical drug for skin mets that is hard to get in USA, but used in Europe. You may be able to find it or get it from abroad?

Best, Stephnie

DIvine Ms:

There are three types of skin cancers: Basal cell cancer, Squamous cell cancer and Melanoma. Melanoma used to be one of the worst skin cancers you could get, but they are having good success with many of the new treatments for cancer including immunotherapy.

Basal cell carcinoma is a type of skin cancer. It is the most common form of cancer in the United States. Most skin cancers are basal cell cancer. Basal cell carcinoma is almost always a slow-growing form of skin cancer. It rarely spreads to other parts of the body. Treatment is important because BCC can grow wide and deep, destroying skin tissue and bone.

Squamous cell cancer - is the second most common type of skin cancer after the Basal cell cancer. It spreads faster than the basal cell cancer, but is less aggressive than a melanoma in its invasion over the body. It is possible to get SCC on any part of the body, including the inside of the mouth, lips, and genitals. One of the places that squamous cell cancer lands is in the esophagus, and yes, they use Herceptin to treat it. It's also been found in ovarian, prostate, gastric, pancreatic, bladder and certain lung cancers. Again targeted HER2 therapy has been used to treat it.

Remember that HER stands for Human Epidermal Growth Factor Receptor. The skin is composed of two layers: the Dermis and the Epidermis. I have heard oncologists discuss EGFR ( epidermal growth factor receptor) inhibitors, and the effectiveness of anti-HER 2 therapy depends on its ability to work on other cancers beside breast cancer. The other organs I listed have linings called endothelial cells and they function like the epidermis of the skin.

Not all HER2+ breast cancer is squamous cell cancer, but probably all squamous cell cancer in the breast is HER2+

Skin metastasis occurs when cancerous cells break away from the primary tumour and make their way to the skin through the blood circulation or lymphatic system. Most malignant tumours can produce skin metastasis, but some are more likely to do so than others. When the following cancers have metastasised, they have quite a high chance of affecting the skin.

• Melanoma – 45% chance of developing skin metastasis (but only 15 to 20% of melanomas metastasise, so the overall chance of a skin metastasis is about 7-10%)
• Breast cancer – 30%
• Nasal sinus cancers – 20%
• Cancer of the larynx – 16%
• Cancer of the oral cavity – 12%

Joan, I would ask to have new biopsies to see if your cancer is still estrogen sensitive.

Round 2 with skin mets for me. Like Amarantha I also have IBC. Taxol cleared up the skin completely the first time - even though 75% of my breast had fungated by the time I started chemo (talk about your worst nightmare, it just kept growing every day), within 5 months of starting Taxol I had all new unblemished pretty skin that looked as if nothing had ever happened.

Didn't last long though - about two months after completing chemo I noticed skin changes again, just some blotchy red areas at first. Breast MRI didn't show anything concerning given my history so I tried not to worry, but my skin continued to get worse until there was no denying it. Apparently even though Herceptin/Perjeta works well on my mets (liver has completed resolved and skeleton continues to show healing) and new biopsies confirmed it is still HER2+, the skin changes were an early sign of a full-blown recurrence of IBC which quickly once again involved the breast, chest wall, skin and now lymph nodes throughout my body (oddly enough, the ones in the axilla don't show any sign of metabolic activity). It's spreading fast again, and after consults everyone agreed that systemic treatment is the only way to go and that we'd try Taxol again in hopes that I have the same response I had the first time. Hoping it starts working soon because pain level has gone from an annoying 3-4 to a solid 7 just over the past two weeks and I'm trying to convince myself it's just tumor flare.